Stable ornithine decarboxylase in promastigotes of Leishmania mexicana
Studies on the decarboxylation of ornithine in Leishmania mexicana have shown that this activity corresponds to a true ornithine decarboxylase rather than to an oxidative decarboxylation or aminotransferase reaction, both of which also give rise to the release of CO2. The stoichiometric relationship...
Guardado en:
| Autor principal: | |
|---|---|
| Otros Autores: | , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1989
|
| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 06429caa a22008417a 4500 | ||
|---|---|---|---|
| 001 | PAPER-729 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203003.0 | ||
| 008 | 190411s1989 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0024373507 | |
| 024 | 7 | |2 cas |a ornithine decarboxylase, 9024-60-6; arginine decarboxylase, EC 4.1.1.19; Carboxy-Lyases, EC 4.1.1.; Ornithine Decarboxylase, EC 4.1.1.17; Pyridoxal Phosphate, 54-47-7 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a BBRCA | ||
| 100 | 1 | |a Sanchez, C.P. | |
| 245 | 1 | 0 | |a Stable ornithine decarboxylase in promastigotes of Leishmania mexicana |
| 260 | |c 1989 | ||
| 270 | 1 | 0 | |m Sánchez, C.P.; Instituto de Investigaciones Bioquimicas Fundacion Campomar, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires A. Machado 151, 1405 Buenos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Jänne, Pössö, Raina, (1978) Biochim. Biophys. Acta, 473, pp. 241-293 | ||
| 504 | |a Pegg, (1988) Cancer Res, 48, pp. 759-774 | ||
| 504 | |a Heby, (1981) Differentiation, 19, pp. 1-20 | ||
| 504 | |a Sunkara, Baylin, Luck, (1987) Inhibition of Polyamine Metabolism. Biological Significance and Basis for New Therapies, pp. 121-140. , P.P. McCann, A.E. Pegg, A. Sjoerdsma, Academic Press, Orlando, FL | ||
| 504 | |a Talpaz, Plager, Quesda, Benjamin, Kantarjian, Gutterman, (1986) Eur. J. Cancer Clin. Oncol, 22, pp. 685-689 | ||
| 504 | |a Bacchi, Nathan, Hutner, McCann, (1980) Science, 210, pp. 332-334 | ||
| 504 | |a Hanson, Bradford, Chapman, Waits, McCann, Sjoerdsma, (1982) Am. J. Vet. Res, 43, pp. 1651-1653 | ||
| 504 | |a Assaraf, Golenser, Spira, Bachrach, (1984) Biochem. J, 222, pp. 815-819 | ||
| 504 | |a Bacchi, McCann, (1987) Inhibition of Polyamine Metabolism. Biological Significance and Basis for New Therapies, pp. 317-344. , P.P. McCann, A.E. Pegg, A. Sjoerdsma, Academic Press, Orlando, FL | ||
| 504 | |a Phillips, Coffino, Wang, (1987) J. Biol. Chem, 262, pp. 8721-8727 | ||
| 504 | |a Warren, (1960) J. Parasitol, 46, pp. 529-538 | ||
| 504 | |a Cataldi, Algranati, Polyamines and regulation of ornithine biosynthesis in Escherichia coli. (1989) J Bacteriol, , in press | ||
| 504 | |a Camargo, Coelho, Moraes, Figuereido, Trypanosoma spp., Leishmania spp. and Leptomonas spp.: Enzymes of ornithine-arginine metabolism (1978) Experimental Parasitology, 46, pp. 141-144 | ||
| 504 | |a Smith, Marshall, (1988) Phytochemistry, 27, pp. 703-710 | ||
| 504 | |a Murphy, Brosnan, (1976) Biochem. J, 157, pp. 33-39 | ||
| 504 | |a Kim, Sobota, Bitonti, McCann, Byers, (1987) J. Protozool, 34, pp. 278-284 | ||
| 504 | |a Metcalf, Bey, Danzing, Jung, Casara, Vevert, (1978) J. Am. Chem. Soc, 100, pp. 2551-2553 | ||
| 504 | |a Kitz, Wilson, (1962) J. Biol. Chem, 237, pp. 3245-3249 | ||
| 504 | |a Kanamoto, Utsonomiya, Kameji, Hayashi, (1986) Eur. J. Biochem, 154, pp. 539-544 | ||
| 504 | |a Pegg, (1986) Biochem. J, 234, pp. 249-262 | ||
| 504 | |a Rogers, Wells, Rechsteiner, (1986) Science, 234, pp. 364-368 | ||
| 520 | 3 | |a Studies on the decarboxylation of ornithine in Leishmania mexicana have shown that this activity corresponds to a true ornithine decarboxylase rather than to an oxidative decarboxylation or aminotransferase reaction, both of which also give rise to the release of CO2. The stoichiometric relationship between substrate and products has indicated that extracts of L. mexicana were able to catalyse the formation of an unknown compound besides putrescine and CO2. The addition of cycloheximide to cultures of L. mexicana allowed us to demonstrate that ornithine decarboxylase degradation in vivo was extremely slow in this parasite. This remarkable stability of the enzyme is only comparable to that found in Trypanosoma brucei and contrasts with the high turnover rate of ornithine decarboxylases of different mammalian cells. © 1989. |l eng | |
| 536 | |a Detalles de la financiación: SAREC | ||
| 536 | |a Detalles de la financiación: World Health Organization | ||
| 536 | |a Detalles de la financiación: Secretaria de Ciencia y Tecnica, Universidad de Buenos Aires | ||
| 536 | |a Detalles de la financiación: We are indebted to Dr. B. Franke de Cazzulo and L. Sferco for parasite cultures and Dr. S.H. Goldemberg for helpful discussions. This work was partially supported by grants from the Swedish Agency for Research Cooperation with Ueveloping Countries (SAREC), WHO Special Programme for Research and Training in Tropical Diseases, Secretaria de Ciencia y Tecnica and the Consejo National Investigaciones Cientificas y Tecnicas (Argentina). C.P. Sa/ncher is a fellow N.S. Gonzalez and I.D. Algranati are career investigators of the latter institution. | ||
| 593 | |a Instituto de Investigaciones Bioquimicas Fundacion Campomar, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires A. Machado 151, 1405 Buenos Aires, Argentina | ||
| 593 | |a CONICET, A. Machado 151, 1405 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a ORNITHINE DECARBOXYLASE |
| 690 | 1 | 0 | |a LEISHMANIA MEXICANA |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROTEIN STABILITY |
| 690 | 1 | 0 | |a PROTOZOON |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a CARBOXY-LYASES |
| 690 | 1 | 0 | |a CELL-FREE SYSTEM |
| 690 | 1 | 0 | |a KINETICS |
| 690 | 1 | 0 | |a LEISHMANIA MEXICANA |
| 690 | 1 | 0 | |a ORNITHINE DECARBOXYLASE |
| 690 | 1 | 0 | |a PROTEIN DENATURATION |
| 690 | 1 | 0 | |a PYRIDOXAL PHOSPHATE |
| 690 | 1 | 0 | |a SUBSTRATE SPECIFICITY |
| 690 | 1 | 0 | |a SUPPORT, NON-U.S. GOV'T |
| 700 | 1 | |a Gonzalez, N.S. | |
| 700 | 1 | |a Algranati, I.D. | |
| 773 | 0 | |d 1989 |g v. 161 |h pp. 754-761 |k n. 2 |p Biochem. Biophys. Res. Commun. |x 0006291X |w (AR-BaUEN)CENRE-905 |t Biochemical and Biophysical Research Communications | |
| 856 | 4 | 1 | |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-0024373507&doi=10.1016%2f0006-291X%2889%2992664-8&partnerID=40&md5=a2dc35e983f3b8bd90cdef8ae8b246a2 |y Registro en Scopus |
| 856 | 4 | 0 | |u https://doi.org/10.1016/0006-291X(89)92664-8 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_0006291X_v161_n2_p754_Sanchez |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0006291X_v161_n2_p754_Sanchez |y Registro en la Biblioteca Digital |
| 961 | |a paper_0006291X_v161_n2_p754_Sanchez |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 963 | |a VARI | ||
| 999 | |c 61682 | ||