Triterpenic acids and flavonoids from Satureja parvifolia, evaluation of their antiprotozoal activity
Bioassay-guided fractionation of a Satureja parvifolia MeOH extract led to the isolation of eriodictyol, luteolin and ursolic and oleanolic acids as its active components against Plasmodium falciparum K1. This is the first time these compounds are reported as constituents of S. parvifolia. Ursolic a...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
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2006
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| Acceso en línea: | Registro en Scopus Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 09009caa a22011417a 4500 | ||
|---|---|---|---|
| 001 | PAPER-7277 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203701.0 | ||
| 008 | 140217s2006 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-33646539466 | |
| 024 | 7 | |2 pubmed |a 16729575 | |
| 024 | 7 | |2 cas |a chloroquine, 132-73-0, 3545-67-3, 50-63-5, 54-05-7; eriodictyol, 552-58-9; methanol, 67-56-1; oleanolic acid, 508-02-1; ursolic acid, 77-52-1; Antiprotozoal Agents; Chloroquine, 54-05-7; eriodictyol, 552-58-9; Flavanones; Flavonoids; Methanol, 67-56-1; Oleanolic Acid, 508-02-1; Triterpenes; ursolic acid, 77-52-1 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a ZNCBD | ||
| 100 | 1 | |a Van Baren, C. | |
| 245 | 1 | 0 | |a Triterpenic acids and flavonoids from Satureja parvifolia, evaluation of their antiprotozoal activity |
| 260 | |c 2006 | ||
| 270 | 1 | 0 | |m Martino, V.; Cátedra de Farmacognosia, Instituto de Química Y Metabolismo del Fármaco IQUIMEFA (UBA-CONICET), Universidad de Buenos Aires, Junín 956, 1113 Buenos Aires, Argentina; email: vmartino@ffyb.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Abe, F., Yamauchi, T., Nagao, T., Kinjo, J., Okabe, H., Akahane, H., Ursolic acid as trypanocidal constituent in rosemary (2002) Biol. Pharm. Bull., 25, pp. 1485-1487 | ||
| 504 | |a Asres, K., Bucar, F., Knauder, E., Yardley, V., Kendrick, H., Croft, S., In vitro antiprotozoal activity of extract and compounds from the stem bark of Combretum molle (2001) Phytother. Res., 15, pp. 613-617 | ||
| 504 | |a Bandoni, A., Mendiondo, M., Rondina, R., Coussio, J., Survey of argentine medicinal plants. I. Folklore and phytochemical screening (1972) Lloydia, 3, pp. 69-78 | ||
| 504 | |a Cunha, W.R., Martins, C., Da Silva Ferreira, D., Miller Crotti, A.E., Peporine Lopes, N., Alburquerque, S., In vitro trypanocidal activity of triterpenes from Miconia species (2003) Planta Med, 69, pp. 470-472 | ||
| 504 | |a Debenedetti, S., Muschietti, L., Van Baren, C., Clavin, M., Broussalis, A., Martino, V., Houghton, P., Steele, J., In vitro antiplasmodial activity of Argentinian plants (2002) J. Etnopharmacol., 80, pp. 163-166 | ||
| 504 | |a Galvez, M., Martin-Cordero, C., Lopez-Lázaro, M., Cortés, F., Ayuso, M.J., Cytotoxic effect of Plantago spp. on cancer cell lines (2003) J. Ethnopharmacol., 88, pp. 125-130 | ||
| 504 | |a Grael, C.F.F., Vichnewski, W., De Petto Souza, G.E., Lopes, J.L.C., Albuquerque, S., Cunha, W.R., A study of the trypanocidal and analgesic properties from Lychnophora granmongolense (Duarte) Semir & Leitão Filho (2000) Phytother. Res., 14, pp. 203-206 | ||
| 504 | |a Grael, C.F.F., Albuquerque, S., Lopes, J.L.C., Chemical constituents of Lychnophora pohlii and trypanocidal activity of crude plant extracts and of isolated compounds (2005) Fitoterapia, 76, pp. 73-82 | ||
| 504 | |a Gujer, R., Magnolato, D., Self, R., Glucosylated flavonoids and other phenolic compounds from Sorghum (1986) Phytochemistry, 25, pp. 1431-1436 | ||
| 504 | |a Hernández, N.E., Tereschuk, M.L., Abdala, L.R., Antimicrobial activity of flavonoids in medicinal plants from Tafí del Valle (Tucumán, Argentina) (2000) J. Ethnopharmacol., 73, pp. 317-322 | ||
| 504 | |a Hnatyszyn, O., Moscatelli, V., García, J., Rondina, R., Costa, M., Arranz, C., Balaszczuk, A., Coussio, J.D., Argentinian plant extracts with relaxant effect on the smooth muscle of the corpus cavernosum of guinea pig (2003) Phytomedicine, 10, pp. 669-674 | ||
| 504 | |a Mabry, T.J., Markham, K.R., Tomas, M.B., (1970) The Systematic Identification of Flavonoids, p. 95. , Springer Verlag, Heidelberg | ||
| 504 | |a Mongelli, E., Martino, V., Coussio, J., Ciccia, G., Screening of Argentine medicinal plants using the brine shrimp microwell cytotoxicity assay (1996) Int. J. Pharmacognosy, 34, pp. 249-254 | ||
| 504 | |a Muschietti, L., Van Baren, C., Coussio, J., Vila, R., Clos, M., Cañigueral, S., Adzet, T., Chemical composition of the leaf oil of Satureja odora and Satureja parvifolia (1996) J. Essent. Oil Res., 8, pp. 681-684 | ||
| 504 | |a Orfila, E.N., Las especies de la flora medicinal argentina conocidas por "Muña-muña" (1972) Rev. Farm., 114, pp. 3-12 | ||
| 504 | |a Salem, M.M., Werbovetz, K.A., Antiprotozoal compounds from Psorothamnus polydenius (2005) J. Nat. Prod., 68, pp. 108-111 | ||
| 504 | |a Steele, J.C., Warhurst, D.C., Kirby, G.C., Simmonds, M.S.J., In vitro and in vivo evaluation of betulinic acid as an antimalarial (1999) Phytother. Res., 13, pp. 115-119 | ||
| 504 | |a Suksamrarn, A., Tanachatchairatana, T., Kanokmedhakul, S., Antiplasmodial triterpenes from twigs of Gardenia saxatilis (2003) J. Ethnopharmacol., 88, pp. 275-277 | ||
| 504 | |a Taketa, A.T., Gnoato, S.C.B., Gosmann, G., Pires, V.S., Schenkel, E.P., Guillaume, D., Triterpenoids from Brazilian Ilex species and their in vitro antitrypanosomal activity (2004) J. Nat. Prod., 67, pp. 1697-1700 | ||
| 504 | |a Viturro, C., Molina, A., Guy, I., Charles, B., Guinaudeaeu, H., Fournet, A., Essential oils of Satureja boliviana and S. parvifolia growing in the region of Jujuy, Argentina (2000) Flavour Fragr. J., 15, pp. 377-382 | ||
| 504 | |a Zygadlo, J., Grosso, R., Comparative study of the antifungal activity of essential oils from aromatic plants growing wild in the central region of Argentina (1995) Flavour Fragr. J., 10, pp. 113-118 | ||
| 520 | 3 | |a Bioassay-guided fractionation of a Satureja parvifolia MeOH extract led to the isolation of eriodictyol, luteolin and ursolic and oleanolic acids as its active components against Plasmodium falciparum K1. This is the first time these compounds are reported as constituents of S. parvifolia. Ursolic acid showed an IC 50 of 4.9 μg/ml, luteolin 6.4 μg/ml, oleanolic acid 9.3 μg/ml and eriodictyol 17.2 μg/ml. Antiplasmodial activity of eriodictyol and luteolin is reported here for the first time. Besides, the four compounds showed activity against P. falciparum 3D7 strain and Trypanosoma brucei rhodesiense. Eriodictyol showed moderate activity on all the parasites but was the most selective compound as a result of its rather low cytotoxicity (IC 50 174.2 μg/ml) on the mammalian KB cell line. © 2006 Verlag der Zeitschrift für Naturforschung. |l eng | |
| 593 | |a Cátedra de Farmacognosia, Instituto de Química Y Metabolismo del Fármaco IQUIMEFA (UBA-CONICET), Universidad de Buenos Aires, Junín 956, 1113 Buenos Aires, Argentina | ||
| 593 | |a Department of Pharmacy, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SEI 8WA, United Kingdom | ||
| 593 | |a Cátedra de Farmacognosia, Facultad de Ciencias Exactas Y Naturales, Universidad Nacional de La Plata, calle 47 y 115, 1900 La Plata, Argentina | ||
| 593 | |a Parasitology Department, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1, United Kingdom | ||
| 690 | 1 | 0 | |a ANTIPROTOZOAL COMPOUNDS |
| 690 | 1 | 0 | |a SATUREJA PARVIFOLIA |
| 690 | 1 | 0 | |a ANTIPROTOZOAL AGENT |
| 690 | 1 | 0 | |a CHLOROQUINE |
| 690 | 1 | 0 | |a ERIODICTYOL |
| 690 | 1 | 0 | |a FLAVANONE DERIVATIVE |
| 690 | 1 | 0 | |a FLAVONOID |
| 690 | 1 | 0 | |a METHANOL |
| 690 | 1 | 0 | |a OLEANOLIC ACID |
| 690 | 1 | 0 | |a TRITERPENE |
| 690 | 1 | 0 | |a URSOLIC ACID |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CELL SURVIVAL |
| 690 | 1 | 0 | |a CHEMISTRY |
| 690 | 1 | 0 | |a DRUG EFFECT |
| 690 | 1 | 0 | |a ISOLATION AND PURIFICATION |
| 690 | 1 | 0 | |a MASS FRAGMENTOGRAPHY |
| 690 | 1 | 0 | |a PHYTOTHERAPY |
| 690 | 1 | 0 | |a PLANT |
| 690 | 1 | 0 | |a PLASMODIUM FALCIPARUM |
| 690 | 1 | 0 | |a SAVORY |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a ANTIPROTOZOAL AGENTS |
| 690 | 1 | 0 | |a CELL SURVIVAL |
| 690 | 1 | 0 | |a CHLOROQUINE |
| 690 | 1 | 0 | |a FLAVANONES |
| 690 | 1 | 0 | |a FLAVONOIDS |
| 690 | 1 | 0 | |a GAS CHROMATOGRAPHY-MASS SPECTROMETRY |
| 690 | 1 | 0 | |a METHANOL |
| 690 | 1 | 0 | |a OLEANOLIC ACID |
| 690 | 1 | 0 | |a PHYTOTHERAPY |
| 690 | 1 | 0 | |a PLANT COMPONENTS, AERIAL |
| 690 | 1 | 0 | |a PLASMODIUM FALCIPARUM |
| 690 | 1 | 0 | |a SATUREJA |
| 690 | 1 | 0 | |a TRITERPENES |
| 690 | 1 | 0 | |a MAMMALIA |
| 690 | 1 | 0 | |a PLASMODIUM FALCIPARUM |
| 690 | 1 | 0 | |a SATUREJA |
| 690 | 1 | 0 | |a TRYPANOSOMA BRUCEI RHODESIENSE |
| 700 | 1 | |a Anao, I. | |
| 700 | 1 | |a Lira, P.D.L. | |
| 700 | 1 | |a Debenedetti, S. | |
| 700 | 1 | |a Houghton, P. | |
| 700 | 1 | |a Croft, S. | |
| 700 | 1 | |a Martino, V. | |
| 773 | 0 | |d 2006 |g v. 61 |h pp. 189-192 |k n. 3-4 |p Z. Naturforsch. Sect. C J. Biosci. |x 09395075 |t Zeitschrift fur Naturforschung - Section C Journal of Biosciences | |
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| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_09395075_v61_n3-4_p189_VanBaren |y Handle |
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