Decrease in salivary secretion by radiation mediated by nitric oxide and prostaglandins
Objective: In the present work, we evaluated the effect of exposing the submandibular glands (SMG) to radiation, studying different functional parameters such as salivary secretion, nitric oxide (NO) production, reactive oxygen species formation, prostaglandin (PGE) content and apoptosis. Methods: W...
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| Otros Autores: | , , , , , , , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
2006
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 10594caa a22013097a 4500 | ||
|---|---|---|---|
| 001 | PAPER-7048 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203646.0 | ||
| 008 | 190411s2006 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-33746849277 | |
| 024 | 7 | |2 cas |a inducible nitric oxide synthase, 501433-35-8; nitric oxide, 10102-43-9; nitric oxide synthase, 125978-95-2; noradrenalin, 1407-84-7, 51-41-2; Nitric Oxide, 10102-43-9; Nitric Oxide Synthase Type II, 1.14.13.39; Prostaglandins | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a NROIE | ||
| 100 | 1 | |a De La Cal, C. | |
| 245 | 1 | 0 | |a Decrease in salivary secretion by radiation mediated by nitric oxide and prostaglandins |
| 260 | |c 2006 | ||
| 270 | 1 | 0 | |m Rettori, V.; Centro de Estudios Farmacológicos Y Botánicos (CEFyBO), Facultad de Medicina, UBA, Paraguay 2155, CP 1121, Buenos Aires, Argentina; email: vrettori@yahoo.com |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Dreizen, S., Daly, T.E., Drane, J.B., Brown, L.R., Oral complications of cancer radiotherapy (1977) Postgrad Med, 61, pp. 85-92 | ||
| 504 | |a Franzen, L., Funegard, U., Ericson, T., Heriksson, R., Parotid gland function during and following radiotherapy of malignancies in the head and neck: A consecutive study of salivary flow and patient discomfort (1992) Eur J Cancer, 28, pp. 457-462 | ||
| 504 | |a Valdez, I.H., Atkinson, J.C., Ship, J.A., Fox, P.C., Major salivary gland function in patients with radiation-induced xerostomia: Flow rates and sialochemistry (1993) Int J Radiat Oncol Biol Phys, 25, pp. 41-47 | ||
| 504 | |a Nagler, R.M., Baum, B.J., Miller, G., Fox, P.C., Long term salivary effects of single-dose head and neck irradiation in the rat (1998) Arch Oral Biol, 43, pp. 297-303 | ||
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| 504 | |a Vijayalaxmi, Reiter, R.J., Tan, D.X., Herman, T.S., Thomas Jr., C.R., Melatonin as a radioprotective agent: A review (2004) Int J Radiat Oncol Biol Phys, 59, pp. 639-653 | ||
| 504 | |a Sarkela, T., Berthiaume, J., Elfering, S., Gybina, A., Giuvili, C., The modulation of oxygen radical production by nitric oxide in mitochondria (2001) J Biol Chem, 276, pp. 6945-6949 | ||
| 504 | |a Torres, J., Wilson, M.T., Interactions between nitric oxide and cytochrome-c oxydase turnover (1996) Nitric Oxide and the Cell Proliferation, Differentiation and Death, pp. 23-30. , Moncada S, Nistico G, Bagetta G, Higgs EA (eds): London, Portland Press Proceedings | ||
| 504 | |a Wong, M.L., Rettori, V., Al-Shekhlee, A., Bongiorno, P.B., Canteros, G., McCann, S.M., Gold, P.W., Licinio, J., Inducible nitric oxide synthase gene expression in the brain during systemic inflammation (1996) Nat Med, 2, pp. 581-584 | ||
| 504 | |a Lohinai, Z., Szekely, A.D., Soos, L., Feher, E., Distribution of nitric oxide synthase containing elements in the feline submandibular gland (1995) Neurosci Lett, 192, pp. 9-12 | ||
| 504 | |a Lomniczi, A., Suburo, A.M., Elverdin, J.C., Mastronardi, C.A., Diaz, S., Rettori, V., McCann, S.M., Role of nitric oxide in salivary secretion (1998) Neuroimmunomodulation, 5, pp. 226-233 | ||
| 504 | |a Rettori, V., Lomniczi, A., Elverdin, J.C., Suburo, A.M., Faletti, A., Franchi, A., McCann, S.M., Control of salivary secretion by nitric oxide and its role in neuroimmunomodulation (2000) Ann NY Acad Sci, 917, pp. 258-267 | ||
| 504 | |a Yu, Y.H., Modulating effects of prostaglandins on parasympathetic mediated secretory activity at rat salivary gland (1986) Prostaglandins, 31, pp. 1087-1097 | ||
| 504 | |a Lomniczi, A., Mohn, C., Faletti, A., Franchi, A., McCann, S.M., Rettori, V., Elverdin, J.C., Suburo, A.M., Inhibition of salivary secretion by lipopolysaccharide: Possible role of prostaglandins (2001) Am J Physiol Endocrinol Metab, 281, pp. 405-411 | ||
| 504 | |a Bredt, D., Snyder, H., Isolation of nitric oxide synthase, a calmodulin-requiring enzyme (1990) Proc Natl Acad Sci, 87, pp. 682-685. , USA | ||
| 504 | |a Faletti, A., Perez Martínez, S., Perotti, C., Gimeno, M., Activity of ovarian nitric oxide synthase (NOS) during ovulatory process in the rat: Relationship with prostaglandins (PGs) production (1999) Nitric Oxide, 3, pp. 340-347 | ||
| 504 | |a Buege, J.A., Aust, S.D., Microsomal lipid peroxidation (1978) Methods Enzymol, 52, pp. 302-310 | ||
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| 504 | |a Paardekooper, G.M.R.M., Cammelli, S., Zeilstra, L.J.W., Coppes, R.P., Konings, A.W.T., Radiation-induced apoptosis in relation to acute impairment of rat salivary gland funtion (1998) Int J Radiat Biol, 73, pp. 641-648 | ||
| 520 | 3 | |a Objective: In the present work, we evaluated the effect of exposing the submandibular glands (SMG) to radiation, studying different functional parameters such as salivary secretion, nitric oxide (NO) production, reactive oxygen species formation, prostaglandin (PGE) content and apoptosis. Methods: We irradiated rats in the head and neck region with a single dose of γ-ray radiation of 15 Gy. Two hours after radiation, we measured norepinephrine- induced salivary secretion. After that, the SMG were dissected, and in this tissue, we measured the activity of NO synthase (NOS), the PGE content, the amount of reactive oxygen species, apoptotic cells and mitochondrial inducible NOS (iNOS) expression. Results: We found that radiation decreased salivary secretion when 10 and 30 μg/kg of norepinephrine was administered via the right femoral vein. We observed that iNOS activity was reduced and PGE content increased after radiation in SMG, indicating that NO and PGEs may participate in salivary secretion. The expression of mitochondrial NOS was increased after radiation leading to the formation of large amounts of NO that acts as a proapoptotic signal. In fact, we observed an augmentation in apoptotic cells. In this study, we also observed an increase in lipid peroxidation induced by radiation that may contribute to tissue damage. Conclusions: Our results indicate that radiation induced a decrease in salivary secretion and SMG iNOS activity, meanwhile the PGE content, the lipid peroxidation and apoptosis increased in the tissue. These modifications decrease salivary secretion. Copyright © 2006 S. Karger AG. |l eng | |
| 593 | |a Cátedra de Fisiología, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a Cátedra de Bioquímica, Facultad de Odontología, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a Centro de Estudios Farmacológicos Y Botánicos, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a Instituto de Oncología Angel H. Roffo, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a Departamento Biodiversidad Y Biología Experimental and IFIBYNE-CONICET, Facultad de Ciencias Exactas Y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a Centro de Estudios Farmacológicos Y Botánicos (CEFyBO), Facultad de Medicina, UBA, Paraguay 2155, CP 1121, Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a APOPTOSIS |
| 690 | 1 | 0 | |a NITRIC OXIDE SYNTHASE |
| 690 | 1 | 0 | |a SUBMANDIBULAR GLANDS |
| 690 | 1 | 0 | |a XEROSTOMIA |
| 690 | 1 | 0 | |a INDUCIBLE NITRIC OXIDE SYNTHASE |
| 690 | 1 | 0 | |a NITRIC OXIDE |
| 690 | 1 | 0 | |a NITRIC OXIDE SYNTHASE |
| 690 | 1 | 0 | |a NORADRENALIN |
| 690 | 1 | 0 | |a PROSTAGLANDIN |
| 690 | 1 | 0 | |a REACTIVE OXYGEN METABOLITE |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a APOPTOSIS |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a ENZYME ACTIVITY |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a FEMORAL VEIN |
| 690 | 1 | 0 | |a GAMMA RADIATION |
| 690 | 1 | 0 | |a IRRADIATION |
| 690 | 1 | 0 | |a LIPID PEROXIDATION |
| 690 | 1 | 0 | |a MITOCHONDRION |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROTEIN EXPRESSION |
| 690 | 1 | 0 | |a RADIATION |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a SALIVATION |
| 690 | 1 | 0 | |a SUBMANDIBULAR GLAND |
| 690 | 1 | 0 | |a TISSUE INJURY |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a APOPTOSIS |
| 690 | 1 | 0 | |a DISEASE MODELS, ANIMAL |
| 690 | 1 | 0 | |a DOWN-REGULATION |
| 690 | 1 | 0 | |a EPITHELIAL CELLS |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a HEAD AND NECK NEOPLASMS |
| 690 | 1 | 0 | |a LIPID PEROXIDATION |
| 690 | 1 | 0 | |a NITRIC OXIDE |
| 690 | 1 | 0 | |a NITRIC OXIDE SYNTHASE TYPE II |
| 690 | 1 | 0 | |a OXIDATIVE STRESS |
| 690 | 1 | 0 | |a PROSTAGLANDINS |
| 690 | 1 | 0 | |a RADIOTHERAPY |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a SUBMANDIBULAR GLAND |
| 690 | 1 | 0 | |a XEROSTOMIA |
| 650 | 1 | 7 | |2 spines |a SALIVA |
| 700 | 1 | |a Lomniczi, A. | |
| 700 | 1 | |a Mohn, C.E. | |
| 700 | 1 | |a De Laurentiis, A. | |
| 700 | 1 | |a Casal, M. | |
| 700 | 1 | |a Chiarenza, A. | |
| 700 | 1 | |a Paz, D. | |
| 700 | 1 | |a McCann, S.M. | |
| 700 | 1 | |a Rettori, V. | |
| 700 | 1 | |a Elverdín, J.C. | |
| 773 | 0 | |d 2006 |g v. 13 |h pp. 19-27 |k n. 1 |p NeuroImmunomodulation |x 10217401 |t NeuroImmunoModulation | |
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