Cutaneous signs as parameter in teratogenicity by heavy metal intoxication
Teratogenic effects of heavy metals (Cd2+- and Pb 2+-acetates and Cu2+-sulphate) were studied on chick embryos, after the administration as a single dose. Test materials were injected into the yolk on day 12 of incubation. Tested concentrations were (nmole/g egg): Cd2+ Dose 1(D1): 0.16 and Dose 2 (D...
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| Formato: | Capítulo de libro |
| Lenguaje: | Español |
| Publicado: |
2007
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| Acceso en línea: | Registro en Scopus Handle Registro en la Biblioteca Digital |
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| LEADER | 08227caa a22009377a 4500 | ||
|---|---|---|---|
| 001 | PAPER-6792 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203630.0 | ||
| 008 | 190411s2007 xx ||||fo|||| 00| 0 spa|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-39049113572 | |
| 024 | 7 | |2 cas |a cadmium acetate, 543-90-8; copper sulfate, 7758-98-7, 7758-99-8; lead acetate, 15347-57-6, 301-04-2 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a RADEB | ||
| 100 | 1 | |a Pauza, N.L. | |
| 245 | 1 | 0 | |a Cutaneous signs as parameter in teratogenicity by heavy metal intoxication |
| 246 | 3 | 1 | |a Manifestaciones cutáneas como parámetro de teratogenicidad en la intoxicación con metales pesados |
| 260 | |c 2007 | ||
| 270 | 1 | 0 | |m Pauza, N.L.; Laboratorio de Porfirinas, Departamento de Química Biológica, Pabellón II, Ciudad Autónoma de Buenos Aires, Argentina; email: lpauza@qb.fcen.uba |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Vogiatz, A.K., Loumbourdis, N.S., Exposure of Rana ribunda to lead I. Study of lead accumulation in various tissues and hepatic a-aminolevulinic acid dehydratase activity (1999) J Appl Toxicol, 19 (1), pp. 25-29 | ||
| 504 | |a Jaffe, E.K., Martins, J., Li, J., Kervinen, J., Dunbrack Jr., R.L., The molecular mechanism of lead inhibition of human porphobilinogen synthase (2001) J Biol Chem, 276 (2), pp. 1531-1537 | ||
| 504 | |a Pauza, N.L., Sopena de Kracoff, Y., Ferramola de Sancovich, A.M., Sancovich, H.A., Ontogeny of 5-aminolevulinic dehydratase and porphobilinogen deaminase activities in the yolk sac membrane and liver of chick embryos (2002) Br Poult Sci, 43 (2), pp. 196-203 | ||
| 504 | |a Pauza, N.L., Sopena de Kracoff, Y.E., Ferramola de Sancovich, A.M., Sancovich, H.A., Estudios in vivo de la toxicidad del Pb2+,Cd2+ y Cu2+ y sus consecuencias en la biosíntesis del hemo (2004) Rev Argent Dermatol, 85, pp. 154-163 | ||
| 504 | |a Waalkes, M.P., Coogan, T.P., Barter, R.A., Toxicological principles of metal carcinogenesis with special emphasis on cadmium (1992) Crit Rev Toxicol, 22 (3-4), pp. 175-201 | ||
| 504 | |a Topalián, M.L., Castañé, P.M., Rovedani, M.G., Salivián, A., Principal component analysis of dissolved heavy metals in water of the Reconquista river (Buenos Aires, Argentina) (1999) Bull Environ Contam Toxicol, 63, pp. 484-490 | ||
| 504 | |a Loewy M, Kirs V, Carvajal G, Venturino y Pechen de D'Angelo AM. Groundwater contamination by azinphos methyl in the Northern Patagonic Region (Argentina). Sci Total Environ 1999; 225: 211-218; Goering, P.L., Lead-protein interactions as a basis for lead toxicity (1993) Neuro Toxicology, 14, pp. 45-60 | ||
| 504 | |a Da Fonseca, A., Nogueira Prista, L., (1987) Manual de Terapéutica Dermatológica y Cosmetológica, pp. 44-89. , Editorial Jims. Barcelona. España | ||
| 504 | |a Mas A y Arola L Cadmium and lead toxicity effects on zinc, copper, nickel and iron distribution in the developing chick embryo. Comp Biochem Physiol C 1985; 80 (1): 185-188; Beattie, J.H., Owen, H.L., Wallace, S.M., Arthur, J.R., Kwun, I.S., Hawksworth, G.M., Wallace, H.M., Metallothionein overexpression and resistance to toxic stress (2005) Toxicol Lett, 157 (1), pp. 69-78 | ||
| 504 | |a Cao, J., Henry, P.R., Guo, R.H., Toth, J.P., Littell, R.C., Miles, R.D., Ammerman, C.B., Chemical characteristics and relative bioavailability of supplemental organic zinc sources for poultry and ruminants (2000) J Anim Sci, 78 (8), pp. 2039-2054 | ||
| 504 | |a Long, A., Wang, W.X., Assimilation and bioconcentration of Ag and Cd by the marine black bream after waterborne and dietary metal exposure (2005) Environ Toxicol Chem, 24 (3), pp. 709-716 | ||
| 504 | |a Lead, D.B.E., (1990) Heavy Metals in Soils, pp. 177-196. , Editorial Alloway BJ Blackie Academic. Glasgow. Wiley. New York | ||
| 504 | |a Richards, M.P., Trace mineral metabolism in the avian embryo (1997) Poultry Science, 76, pp. 152-164 | ||
| 504 | |a Goering, P.L., Lead-protein interactions as a basis for lead toxicity (1988) Neuro Toxicol, 14, pp. 45-60 | ||
| 504 | |a Squitti, R., Pasqualetti, P., Cassetta, E., Dal Forno, G., Cesaretti, S., Pedace, F., Finazzi-Agro, A., Rossini, P.M., Elevation of serum copper levels discriminates Alzheimer's disease from vascular dementia (2003) Neurology, 60 (12), pp. 2013-2014 | ||
| 504 | |a Schumann, K., Classen, H.G., Dieter, H.H., Koning, J., Multhaup, G., Rukgauer, M., Summer, K.H., Biesalski, H.K., Hohenheim consensus workshop: Copper (2002) Eur J Clin Nutr, 56 (6), pp. 469-483 | ||
| 504 | |a Tapiero, H., Tew, K.D., Trace elements in human physiology and pathology: Zinc and metallothioneins (2003) Biomed Pharmacother, 57 (9), pp. 399-411 | ||
| 504 | |a Richards, M.P., Stock, M.K., Metcalfe, J., Effects of brief hypoxia on tissue trace element levels in the developing chick embryo (1991) Magnesium Trace Elem, 10, pp. 305-320 | ||
| 504 | |a Vallee, B.L., Ulmer, D.D., Biochemical effects of mercury, cadmium, and lead (1972) Ann Rev Biochem, 41, pp. 91-128 | ||
| 520 | 3 | |a Teratogenic effects of heavy metals (Cd2+- and Pb 2+-acetates and Cu2+-sulphate) were studied on chick embryos, after the administration as a single dose. Test materials were injected into the yolk on day 12 of incubation. Tested concentrations were (nmole/g egg): Cd2+ Dose 1(D1): 0.16 and Dose 2 (D2): 0.32; Pb2+: D1: 8.0 and D2: 16.0 and Cu2+: D1: 1.7 and D2: 3.3. Evaluations were performed after in ovo incubation for 12 and 60 hours. Embryonic mortality did not increase at the two dose levels of Cu2+ and Pb2+, while Cd2+ caused 30 and 86% of mortality, showing dose and time responses. Eggs treated with D2 of Cd2+ for 60 hs, significantly decreased the average of body mass embryo, when compared to the control group. Cd2+ administration was resposible for the most severe teratogenic signs compared to Cu2+ and Pb2+ treatments. It can be concluded that heavy metals are embryotoxic and teratogenics. We suggest that cutaneous and liver hemorrhages are the best signs to evaluate teratogenicity induced by Cd2+, Cu2+ and Pb2+. |l eng | |
| 593 | |a Universidad de Buenos Aires | ||
| 593 | |a Carrera de Ciencias Biológicas | ||
| 593 | |a Cátedra de Química Biológica | ||
| 593 | |a CONICET | ||
| 593 | |a Laboratorio de Porfirinas, Departamento de Química Biológica, Pabellón II, Ciudad Autónoma de Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a CHICK EMBRYOS |
| 690 | 1 | 0 | |a HEAVY METALS |
| 690 | 1 | 0 | |a TERATOGENIC EFFECTS |
| 690 | 1 | 0 | |a TOXIC EFFECTS |
| 690 | 1 | 0 | |a YOLK SAC MEMBRANE |
| 690 | 1 | 0 | |a CADMIUM ACETATE |
| 690 | 1 | 0 | |a COPPER SULFATE |
| 690 | 1 | 0 | |a LEAD ACETATE |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ANIMAL MODEL |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a BODY MASS |
| 690 | 1 | 0 | |a CHICK EMBRYO |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a EMBRYO |
| 690 | 1 | 0 | |a EMBRYO MORTALITY |
| 690 | 1 | 0 | |a HEAVY METAL POISONING |
| 690 | 1 | 0 | |a LIVER HEMORRHAGE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a SKIN BLEEDING |
| 690 | 1 | 0 | |a SKIN MANIFESTATION |
| 690 | 1 | 0 | |a TERATOGENICITY |
| 700 | 1 | |a Pérez Cotti, M.J. | |
| 700 | 1 | |a Godar, M.L. | |
| 700 | 1 | |a Sopena, Y. | |
| 700 | 1 | |a Ferramola De Sancovich, A.M. | |
| 700 | 1 | |a Sancovich, H.A. | |
| 773 | 0 | |d 2007 |g v. 88 |h pp. 28-37 |k n. 1 |p Rev. Argent. Dermatol. |x 03252787 |t Revista Argentina de Dermatologia | |
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| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_03252787_v88_n1_p28_Pauza |y Handle |
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