Metronidazole-induced alterations in murine spermatozoa morphology
The aim of this work was to assess the effect of metronidazole (MTZ) on the stages of the seminiferous epithelial cycle and spermatozoa morphology when the drug is administered in human therapeutic doses to 60-day-old CFW male mice. The frequency of the stages was established by counting spermatocyt...
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2007
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| LEADER | 14828caa a22015017a 4500 | ||
|---|---|---|---|
| 001 | PAPER-6749 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203628.0 | ||
| 008 | 140217s2007 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-33846866082 | |
| 024 | 7 | |2 pubmed |a 17184970 | |
| 024 | 7 | |2 cas |a metronidazole, 39322-38-8, 443-48-1; Antiprotozoal Agents; Metronidazole, 443-48-1 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a REPTE | ||
| 100 | 1 | |a Mudry, M.D. | |
| 245 | 1 | 0 | |a Metronidazole-induced alterations in murine spermatozoa morphology |
| 260 | |c 2007 | ||
| 270 | 1 | 0 | |m Palermo, A.M.; GIBE (Grupo de Investigación en Biología Evolutiva), Departamento Ecología, Genética y Evolución, Facultad de Ciencias Exactas y Naturales (FCEyN)Argentina; email: apalermo@citefa.gov.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a The aim of this work was to assess the effect of metronidazole (MTZ) on the stages of the seminiferous epithelial cycle and spermatozoa morphology when the drug is administered in human therapeutic doses to 60-day-old CFW male mice. The frequency of the stages was established by counting spermatocytes in pachytene and spermatids. Abnormalities in the flagellum or the head, lack of maturity and multiple malformations, were considered in the morphological analysis. Murine control strain was compared with MTZ treated group (v.ip 130 mg/kg/bw) both kept in standard captivity conditions. Cellular composition or number of stages in the seminiferous tubules were not altered in MTZ exposed animals, though the number of cells in stages I, V and XII was increased. The sperm cell morphology was severely affected by the treatment with potentially serious consequences on the normal fertilization process. Thus, the MTZ has to be considered as a conceivable thread regarding male fertility. © 2006 Elsevier Inc. All rights reserved. |l eng | |
| 593 | |a GIBE (Grupo de Investigación en Biología Evolutiva), Departamento Ecología, Genética y Evolución, Facultad de Ciencias Exactas y Naturales (FCEyN), Argentina | ||
| 593 | |a CITEFA (Instituto de Investigaciones Cientificas y Tecnicas de las FFAA), Villa Martelli, Buenos Aires, Argentina | ||
| 593 | |a CIR (Centro de Investigaciones en Reproducción), Departamento Histología, Embriología y Genética, Facultad de Medicina, Universidad de Buenos Aires, Argentina | ||
| 593 | |a CIGETOX (Centro de Investigaciones en Genética Toxicológica), Departamento de Bioquímica Clínica, Facultad de Farmacia y Bioquímica, Argentina | ||
| 593 | |a Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina | ||
| 690 | 1 | 0 | |a CFW MALE MICE |
| 690 | 1 | 0 | |a HUMAN THERAPEUTIC DOSE |
| 690 | 1 | 0 | |a METRONIDAZOLE (MTZ) |
| 690 | 1 | 0 | |a SEMINIFEROUS EPITHELIUM CYCLE |
| 690 | 1 | 0 | |a SPERMATOZOA MORPHOLOGY |
| 690 | 1 | 0 | |a METRONIDAZOLE |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ANIMAL MODEL |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CELL COUNT |
| 690 | 1 | 0 | |a CELL CYCLE |
| 690 | 1 | 0 | |a CELL MATURATION |
| 690 | 1 | 0 | |a CELL STRUCTURE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a EPITHELIUM CELL |
| 690 | 1 | 0 | |a FERTILIZATION |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MALE FERTILITY |
| 690 | 1 | 0 | |a MORPHOLOGICAL TRAIT |
| 690 | 1 | 0 | |a MOUSE |
| 690 | 1 | 0 | |a MULTIPLE MALFORMATION SYNDROME |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PACHYTENE |
| 690 | 1 | 0 | |a SEMINIFEROUS TUBULE EPITHELIUM |
| 690 | 1 | 0 | |a SPERMATOZOON |
| 690 | 1 | 0 | |a SPERMATOZOON TAIL |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a ANTIPROTOZOAL AGENTS |
| 690 | 1 | 0 | |a CELL COUNT |
| 690 | 1 | 0 | |a FERTILITY |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a METRONIDAZOLE |
| 690 | 1 | 0 | |a MICE |
| 690 | 1 | 0 | |a MICE, INBRED STRAINS |
| 690 | 1 | 0 | |a PACHYTENE STAGE |
| 690 | 1 | 0 | |a SEMINIFEROUS TUBULES |
| 690 | 1 | 0 | |a SPERMATIDS |
| 690 | 1 | 0 | |a SPERMATOZOA |
| 690 | 1 | 0 | |a ANIMALIA |
| 690 | 1 | 0 | |a MURINAE |
| 690 | 1 | 0 | |a MUS |
| 700 | 1 | |a Palermo, A.M. | |
| 700 | 1 | |a Merani, M.S. | |
| 700 | 1 | |a Carballo, M.A. | |
| 773 | 0 | |d 2007 |g v. 23 |h pp. 246-252 |k n. 2 |p Reprod. Toxicol. |x 08906238 |w (AR-BaUEN)CENRE-6661 |t Reproductive Toxicology | |
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| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_08906238_v23_n2_p246_Mudry |y Handle |
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