Photodynamic ultradeformable liposomes: Design and characterization
Hydrophobic ([tetrakis(2,4-dimetil-3-pentyloxi)-phthalocyaninate]zinc(II)) (ZnPc) and hydrophilic ([tetrakis(N,N,N-trimethylammoniumetoxi)-phthalocyaninate]zinc(II) tetraiodide) (ZnPcMet) phthalocyanines were synthesized and loaded in ultradeformable liposomes (UDL) of soybean phosphatidylcholine an...
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2007
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| LEADER | 22062caa a22019217a 4500 | ||
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| 001 | PAPER-6720 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203625.0 | ||
| 008 | 190411s2007 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-33846263014 | |
| 024 | 7 | |2 cas |a cholic acid, 32500-01-9, 361-09-1, 81-25-4; oxidoreductase, 9035-73-8, 9035-82-9, 9037-80-3, 9055-15-6; phosphatidylcholine, 55128-59-1, 8002-43-5; Indoles; Liposomes; Radiation-Sensitizing Agents; phthalocyanine, 574-93-6 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a IJPHD | ||
| 100 | 1 | |a Montanari, J. | |
| 245 | 1 | 0 | |a Photodynamic ultradeformable liposomes: Design and characterization |
| 260 | |c 2007 | ||
| 270 | 1 | 0 | |m Romero, E.L.; Laboratorio de Diseño de Estrategias de Targeting de Drogas (LDTD), Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes, Roque Saenz Peña 180, Bernal, B1876BXD Buenos Aires, Argentina; email: elromero@unq.edu.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a Hydrophobic ([tetrakis(2,4-dimetil-3-pentyloxi)-phthalocyaninate]zinc(II)) (ZnPc) and hydrophilic ([tetrakis(N,N,N-trimethylammoniumetoxi)-phthalocyaninate]zinc(II) tetraiodide) (ZnPcMet) phthalocyanines were synthesized and loaded in ultradeformable liposomes (UDL) of soybean phosphatidylcholine and sodium cholate (6:1, w/w, ratio), resulting 100 nm mean size vesicles of negative Zeta potential, with encapsulation efficiencies of 85 and 53%, enthalpy of phase transition of 5.33 and 158 J/mmol for ZnPc and ZnPcMet, respectively, indicating their deep and moderate partition into UD matrices. Matrix elasticity of UDL-phthalocyanines resulted 28-fold greater than that of non-UDL, leaking only 25% of its inner aqueous content after passage through a nanoporous barrier versus 100% leakage for non-UDL. UDL-ZnPc made ZnPc soluble in aqueous buffer while kept the monomeric state, rendering singlet oxygen quantum yield (ΦΔ) similar to that obtained in ethanol (0.61), whereas UDL-ZnPcMet had a four-fold higher ΦΔ than that of free ZnPcMet (0.21). Free phthalocyanines were non-toxic at 1 and 10 μM, both in dark or upon irradiation at 15 J/cm2 on Vero and J-774 cells (MTT assay). Only liposomal ZnPc at 10 μM was toxic for J-774 cells under both conditions. Aditionally, endo-lysosomal confinement of the HPTS dye was kept after irradiation at 15 J/cm2 in the presence of UDL-phtalocyanines. This could lead to improve effects of singlet oxygen against intra-vesicular pathogen targets inside the endo-lysosomal system. © 2006 Elsevier B.V. All rights reserved. |l eng | |
| 593 | |a Laboratorio de Diseño de Estrategias de Targeting de Drogas (LDTD), Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes, Roque Saenz Peña 180, Bernal, B1876BXD Buenos Aires, Argentina | ||
| 593 | |a Departamento de Química Inorgánica, Analítica y Química Física/INQUIMAE-CONICET, Facultad de Ciencias Exactas y Naturales, Ciudad Universitaria, Pabellon II, Argentina | ||
| 593 | |a Centre de Estudis Biofísics, Universitat Autónoma de Barcelona, 08193 Cerdanyola, Catalunya, Spain | ||
| 593 | |a Departament de Físicaquímica, Facultat de Farmácia, Universitat de Barcelona, Av. Joan XXIII, s/n, 08028 Barcelona, Catalunya, Spain | ||
| 690 | 1 | 0 | |a PHTHALOCYANINES |
| 690 | 1 | 0 | |a ULTRADEFORMABLE LIPOSOMES |
| 690 | 1 | 0 | |a CHOLIC ACID |
| 690 | 1 | 0 | |a LIPOSOME |
| 690 | 1 | 0 | |a OXIDOREDUCTASE |
| 690 | 1 | 0 | |a PHOSPHATIDYLCHOLINE |
| 690 | 1 | 0 | |a PHTHALOCYANINE DERIVATIVE |
| 690 | 1 | 0 | |a TETRAKIS(2,4 DIMETHYL 3 PENTYLOXY)PHTHALOCYANINATE ZINC |
| 690 | 1 | 0 | |a TETRAKIS(N,N,N TRIMETHYLAMMONIUMETHOXY)PHTHALOCYANINATE ZINC TETRAIODIDE |
| 690 | 1 | 0 | |a UNCLASSIFIED DRUG |
| 690 | 1 | 0 | |a ABSORPTION SPECTROSCOPY |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a DIFFERENTIAL SCANNING CALORIMETRY |
| 690 | 1 | 0 | |a DRUG CYTOTOXICITY |
| 690 | 1 | 0 | |a DRUG DELIVERY SYSTEM |
| 690 | 1 | 0 | |a DRUG STRUCTURE |
| 690 | 1 | 0 | |a ENCAPSULATION |
| 690 | 1 | 0 | |a FLUORESCENCE MICROSCOPY |
| 690 | 1 | 0 | |a HYDROPHILICITY |
| 690 | 1 | 0 | |a HYDROPHOBICITY |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PHASE TRANSITION |
| 690 | 1 | 0 | |a PHOTODYNAMICS |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a QUANTUM YIELD |
| 690 | 1 | 0 | |a THERMODYNAMICS |
| 690 | 1 | 0 | |a TRANSMISSION ELECTRON MICROSCOPY |
| 690 | 1 | 0 | |a VERO CELL |
| 690 | 1 | 0 | |a ZETA POTENTIAL |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a CALORIMETRY, DIFFERENTIAL SCANNING |
| 690 | 1 | 0 | |a CELL SURVIVAL |
| 690 | 1 | 0 | |a CERCOPITHECUS AETHIOPS |
| 690 | 1 | 0 | |a LEISHMANIASIS, CUTANEOUS |
| 690 | 1 | 0 | |a LIPOSOMES |
| 690 | 1 | 0 | |a MACROPHAGES |
| 690 | 1 | 0 | |a MICE |
| 690 | 1 | 0 | |a MICROSCOPY, ELECTRON, TRANSMISSION |
| 690 | 1 | 0 | |a NANOTECHNOLOGY |
| 690 | 1 | 0 | |a PHOTOCHEMOTHERAPY |
| 690 | 1 | 0 | |a RADIATION-SENSITIZING AGENTS |
| 690 | 1 | 0 | |a SPECTROMETRY, FLUORESCENCE |
| 690 | 1 | 0 | |a SPECTROPHOTOMETRY, ULTRAVIOLET |
| 690 | 1 | 0 | |a VERO CELLS |
| 650 | 1 | 7 | |2 spines |a INDOLES |
| 700 | 1 | |a Perez, A.P. | |
| 700 | 1 | |a Di Salvo, F. | |
| 700 | 1 | |a Diz, V. | |
| 700 | 1 | |a Barnadas, R. | |
| 700 | 1 | |a Dicelio, L. | |
| 700 | 1 | |a Doctorovich, F. | |
| 700 | 1 | |a Morilla, M.J. | |
| 700 | 1 | |a Romero, E.L. | |
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| 856 | 4 | 0 | |u https://doi.org/10.1016/j.ijpharm.2006.11.015 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_03785173_v330_n1-2_p183_Montanari |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03785173_v330_n1-2_p183_Montanari |y Registro en la Biblioteca Digital |
| 961 | |a paper_03785173_v330_n1-2_p183_Montanari |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 67673 | ||