Antiviral effect of a synthetic brassinosteroid on the replication of vesicular stomatitis virus in Vero cells
The antiviral mode of action of the synthetic brassinosteroid (22S,23S)-3β-bromo-5α,22,23-trihydroxystigmastan-6-one (6b) against replication of vesicular stomatitis virus (VSV) in Vero cells was investigated. Time-related experiments showed that 6b mainly affects a late event of the virus growth cy...
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2007
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 08668caa a22010937a 4500 | ||
|---|---|---|---|
| 001 | PAPER-6700 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203624.0 | ||
| 008 | 190411s2007 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-33847001301 | |
| 024 | 7 | |2 cas |a Antiviral Agents; DNA, Viral; RNA, Viral; Steroids | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a IAAGE | ||
| 100 | 1 | |a Romanutti, C. | |
| 245 | 1 | 0 | |a Antiviral effect of a synthetic brassinosteroid on the replication of vesicular stomatitis virus in Vero cells |
| 260 | |c 2007 | ||
| 270 | 1 | 0 | |m Wachsman, M.B.; Laboratorio de Virología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Pabellon 2, Piso 4, C1428EGA Buenos Aires, Argentina; email: wachsman@qb.fcen.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Rose, J.K., Whitt, M.A., Rhabdoviridae: the viruses and their replication (2001) Fundamental virology 4, , Knipe D.M., and Howley P.M. (Eds), Lippincott Williams & Wilkins, Philadelphia, PA | ||
| 504 | |a (1999) Basic virology, , Wagner E.K., and Hewlett J. (Eds), Blackwell Science Inc., Cambridge, MA | ||
| 504 | |a Clouse, S.D., Sasse, J.M., Brassinosteroids: essential regulators of plant growth and development. (1998) Annu Rev Plant Physiol Plant Mol Biol, 49, pp. 427-451 | ||
| 504 | |a Fujioka, S., Sakurai, A., Brassinosteroids (1997) Nat Prod Rep, 14, pp. 1-10 | ||
| 504 | |a Wachsman, M.B., López, E.M.F., Ramírez, J.A., Galagovsky, L.R., Coto, C.E., Antiviral effect of brassinosteroids against herpes virus and arenaviruses (2000) Antivir Chem Chemother, 11, pp. 71-77 | ||
| 504 | |a Talarico, L.B., Ramirez, J.A., Galagovsky, L.R., Wachsman, M.B., Structure-activity relationship studies in a set of new brassinosteroid derivatives assayed against herpes simplex virus type 1 and 2 in cell cultures (2002) Med Chem Res, 11, pp. 434-444 | ||
| 504 | |a Wachsman, M.B., Ramírez, J.A., Galagovsky, L.R., Coto, C.E., Antiviral activity of brassinosteroids derivatives against measles virus in cell cultures (2002) Antivir Chem Chemother, 13, pp. 61-66 | ||
| 504 | |a Wachsman, M.B., Castilla, V., Talarico, L.B., Ramirez, J., Galagovsky, L.R., Coto, C.E., Antiherpetic mode of action of (22S,23S)-3β-bromo-5α,22,23-trihidroxiestigmastan-6-one in vitro (2004) Int J Antimicrob Agents, 23, pp. 524-526 | ||
| 504 | |a Castilla, V., Larzabal, M., Sgalippa, N.A., Wachsman, M.B., Coto, C.E., Antiviral mode of action of a synthetic brassinosteroid against Junin virus replication (2005) Antiviral Res, 68, pp. 88-95 | ||
| 504 | |a Wachsman, M.B., Ramírez, J.A., Talarico, L.B., Galagovsky, L.R., Coto, C.E., Antiviral activity of natural and synthetic brassinosteroids (2004) Curr Med Chem Anti Infect Agents, 3, pp. 163-179 | ||
| 504 | |a Teme Centurión, O.M., Galagovsky, L.R., Alternative synthesis of 24(S)-homoethylcastasterone from stigmasterol (1998) Anales de la Asociación Química Argentina, 86, pp. 104-109 | ||
| 504 | |a Denizot, F., Lang, R., Rapid colorimetric assay for cell growth and survival (1986) J Immunol Methods, 89, pp. 271-277 | ||
| 504 | |a Laemmli, U.K., Cleavage of structural proteins during the assembly of the head of bacteriophage T4 (1970) Nature, 227, pp. 680-685 | ||
| 504 | |a Marcus, P.I., Engelharrdt, D.L., Hunt, J.M., Sekellick, M.J., Interferon action: inhibition of vesicular stomatitis virus RNA synthesis induced by virion-bound polymerase (1971) Science, 174, pp. 593-598 | ||
| 504 | |a Dargan, D.J., Galt, C.B., Subak-Sharpe, J.H., The effect of cicloxolone sodium on the replication of vesicular stomatitis virus in BSC-1 cells (1992) J Gen Virol, 73, pp. 397-406 | ||
| 504 | |a Wehling, M., Specific nongenomic actions of steroid hormones (1997) Annu Rev Physiol, 59, pp. 365-393 | ||
| 504 | |a Falkenstein, E., Tillman, H.C., Christ, M., Feuring, M., Wehling, M., Multiple actions of steroid hormones-a focus on rapid, nongenomic effects (2000) Pharmacol Rev, 52, pp. 513-555 | ||
| 504 | |a Liu, D., Dillon, J.S., Dehydroepiandrosterone activates endothelial cell nitric-oxide synthase by a specific plasma membrane receptor coupled to Gα(i2,3) (2002) J Biol Chem, 277, pp. 21379-21388 | ||
| 504 | |a Mussig, C., Lisso, J., Coll-Garcia, D., Altman, T., Molecular analysis of brassinosteroid action (2006) Plant Biol, 9, pp. 291-296 | ||
| 504 | |a Sharma, A., Matsuoka, M., Tanaka, H., Komatsu, S., Antisense inhibition of a BRI1 receptor reveals additional protein kinase signaling components downstream to the perception of brassinosteroid in rice (2001) FEBS Lett, 507, pp. 346-350 | ||
| 504 | |a Khripach, V., Zhabinskii, V., De Groot, A., Twenty years of brassinosteroids: steroidal plant hormones warrant better crops for the XXI century (2000) Ann Bot (Lond), 86, pp. 441-447 | ||
| 504 | |a Michelini, F.M., Ramírez, J.A., Berra, A., Galagovsky, L.R., Alché, L.E., In vitro and in vivo antiherpetic activity of three new synthetic brassinosteroid analogues (2004) Steroids, 69, pp. 713-720 | ||
| 520 | 3 | |a The antiviral mode of action of the synthetic brassinosteroid (22S,23S)-3β-bromo-5α,22,23-trihydroxystigmastan-6-one (6b) against replication of vesicular stomatitis virus (VSV) in Vero cells was investigated. Time-related experiments showed that 6b mainly affects a late event of the virus growth cycle. Virus adsorption, internalisation and early RNA synthesis are not the target of the inhibitory action. Results obtained indicate that the antiviral compound adversely affects virus protein synthesis and viral mature particle formation. © 2006 Elsevier B.V. and the International Society of Chemotherapy. |l eng | |
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires | ||
| 536 | |a Detalles de la financiación: Umweltbundesamt, X 046 | ||
| 536 | |a Detalles de la financiación: National Research Council | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas, PIP 02236 | ||
| 536 | |a Detalles de la financiación: We thank Dr L.R. Galagovsky and J.A. Ramírez for providing the compound 6b. This work was supported by grants from the University of Buenos Aires, UBA, X 046, and the National Research Council, CONICET, PIP 02236. Dr Celia E. Coto is a member of the Scientific Career of CONICET, Argentina. | ||
| 593 | |a Laboratorio de Virología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Ciudad Universitaria, C1428EGA Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a (22S,23S)-3Β-BROMO-5Α,22,23-TRIHYDROXYSTIGMASTAN-6-ONE |
| 690 | 1 | 0 | |a ANTIVIRAL ACTIVITY |
| 690 | 1 | 0 | |a BRASSINOSTEROIDS |
| 690 | 1 | 0 | |a VESICULAR STOMATITIS VIRUS |
| 690 | 1 | 0 | |a 3BETA BROMO 5ALPHA,22,23 TRIHYDROXYSTIGMASTAN 6 ONE |
| 690 | 1 | 0 | |a BRASSINOSTEROID |
| 690 | 1 | 0 | |a STEROID HORMONE |
| 690 | 1 | 0 | |a UNCLASSIFIED DRUG |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ANTIVIRAL ACTIVITY |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a DOSE TIME EFFECT RELATION |
| 690 | 1 | 0 | |a INTERNALIZATION |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROTEIN SYNTHESIS |
| 690 | 1 | 0 | |a RNA SYNTHESIS |
| 690 | 1 | 0 | |a STOMATITIS |
| 690 | 1 | 0 | |a VERO CELL |
| 690 | 1 | 0 | |a VESICULAR STOMATITIS VIRUS |
| 690 | 1 | 0 | |a VIROGENESIS |
| 690 | 1 | 0 | |a VIRUS ADSORPTION |
| 690 | 1 | 0 | |a VIRUS INHIBITION |
| 690 | 1 | 0 | |a VIRUS REPLICATION |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a ANTIVIRAL AGENTS |
| 690 | 1 | 0 | |a BASE SEQUENCE |
| 690 | 1 | 0 | |a CERCOPITHECUS AETHIOPS |
| 690 | 1 | 0 | |a DNA, VIRAL |
| 690 | 1 | 0 | |a MOLECULAR STRUCTURE |
| 690 | 1 | 0 | |a RNA, VIRAL |
| 690 | 1 | 0 | |a STEROIDS |
| 690 | 1 | 0 | |a VERO CELLS |
| 690 | 1 | 0 | |a VESICULAR STOMATITIS-INDIANA VIRUS |
| 690 | 1 | 0 | |a VIRUS REPLICATION |
| 700 | 1 | |a Castilla, V. | |
| 700 | 1 | |a Coto, C.E. | |
| 700 | 1 | |a Wachsman, M.B. | |
| 773 | 0 | |d 2007 |g v. 29 |h pp. 311-316 |k n. 3 |p Int. J. Antimicrob. Agents |x 09248579 |w (AR-BaUEN)CENRE-5213 |t International Journal of Antimicrobial Agents | |
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| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_09248579_v29_n3_p311_Romanutti |y Handle |
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