β-Carotene encapsulation in a mannitol matrix as affected by divalent cations and phosphate anion
The effects of addition of divalent cations and phosphate buffer on the degree of β-carotene encapsulation in a mannitol matrix during freeze-drying were analyzed. The degradation rate of encapsulated β-carotene as a function of % RH and its relationship with the physical state of the matrix during...
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2007
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| LEADER | 17224caa a22016817a 4500 | ||
|---|---|---|---|
| 001 | PAPER-6678 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203623.0 | ||
| 008 | 190411s2007 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-33846886346 | |
| 024 | 7 | |2 cas |a beta carotene, 7235-40-7; mannitol, 69-65-8, 87-78-5; phosphate, 14066-19-4, 14265-44-2; Anions; beta Carotene, 7235-40-7; Buffers; Cations, Divalent; Excipients; Glycine, 56-40-6; Mannitol, 69-65-8; Phosphates; Potassium Compounds; potassium phosphate, 16068-46-5; Vitamins; Water, 7732-18-5 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a IJPHD | ||
| 100 | 1 | |a Sutter, S.C. | |
| 245 | 1 | 0 | |a β-Carotene encapsulation in a mannitol matrix as affected by divalent cations and phosphate anion |
| 260 | |c 2007 | ||
| 270 | 1 | 0 | |m Buera, M.P.; Departamento de Industrias, Facultad Ciencias Exactas y Naturales, Universidad de Buenos Aires, 1428 Ciudad Universitaria, Buenos Aires, Argentina; email: pilar@di.fcen.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Angyal, S.J., Complex formation between sugars and metal ions (1973) Appl. Chem., 35, pp. 131-146 | ||
| 504 | |a Bendich, A., Olson, J.A., Biological actions of carotenoids (1989) FASEE J., 3, pp. 1927-1932 | ||
| 504 | |a Brazel, C.S., Microencapsulation offering solutions for the food industry (1999) Cereal Food World, 44. , pp. 338-390, 392-393 | ||
| 504 | |a Burger, A., Henck, J.O., Hetz, S., Rollinger, J.M., Weissnicht, A.A., Stottner, H., Energy/temperature diagram and compression behaviour of the polymorphs of d-mannitol (2000) J. Pharm. Sci., 89, pp. 457-468 | ||
| 504 | |a Carpenter, J.F., Hand, S.C., Crowe, L.M., Crowe, J.H., Cryoprotection of phosphofructokinase with organic solutes: characterization of enhanced protection 9 in the presence of divalent cations (1986) Arch. Biochem. Biophys., 250, pp. 505-512 | ||
| 504 | |a Carpenter, J.F., Crowe, L.M., Crowe, J.H., Stabilization of phosphofructokinase with sugars during freeze-drying: characterization of enhanced protection in the presence of divalent cations (1987) Biochem. Biophys. Acta, 923, pp. 109-115 | ||
| 504 | |a Carpenter, J.F., Martin, B., Crowe, L.M., Crowe, J.H., Stabilization of phosphofructokinase during air-drying with sugars and sugars transition metal mixtures (1987) Cryobiology, 24, pp. 455-464 | ||
| 504 | |a Cavatur, R.K., Vemuri, N.M., Pyne, A., Chrzan, Z., Toledo, Valasquez, D., Suryanatayanan, R., Crystallization behavior of mannitol in frozen aqueous solutions (2002) Pharm. Res., 19, pp. 894-900 | ||
| 504 | |a Chen, B.H., Studies of the stability of carotenoids in garland chrysanthemum as affected by microwave and conventional heating (1992) J. Food Prot., 55, pp. 296-300 | ||
| 504 | |a Constantino, H.R., Andya, J.D., Nguyen, P.E., Dasovich, N., Sweeney, T.D., Shire, S.J., Hsu, C.C., Maa, Y.F., Effect of mannitol crystallization and aerosol performance of a spray-dried pharmaceutical protein recombinant humanized anti-IgE monoclonal antibody (1998) J. Pharm. Sci., 87, pp. 1406-1408 | ||
| 504 | |a Crowe, J.H., Carpenter, J.F., Crowe, L.M., The role of vitrification in anhydrobiosis (1998) Annu. Rev. Physiol., 60, pp. 73-103 | ||
| 504 | |a Delgado Vargas, E., Jiménez, A.R., Paredes-López, O., Natural pigments. Carotenoids, anthocyanins and betalains-characteristics, biosynthesis, processing and stability (2000) Crit. Rev. Food Sci. Nutr., 40, pp. 173-289 | ||
| 504 | |a Desobry, S.A., Netto, F.M., Labuza, T.P., Comparison of spray-drying, drum drying and freeze-drying for β-carotene encapsulation and preservation (1997) J. Food Sci., 62, pp. 1158-1162 | ||
| 504 | |a Elizalde, B.E., Herrera, L., Buera, M.P., Retention of β-carotene encapsulated in a trehalose matrix as affected by moisture content and sugar crystallization (2002) J. Food Sci., 57, pp. 3039-3045 | ||
| 504 | |a Etzel, M.R., Judson King, C., Retention of volatile components during freeze-drying of substances containing emulsified oils (1980) J. Food Technol., 15, pp. 577-588 | ||
| 504 | |a Fakes, M.G., Dali, M.V., Haby, T.A., Morris, K.R., Varia, S.A., Serajuddin, T.M., Moisture sorption behavior of selected bulking agents used in lyophilized products (2000) PDA J. Pharm. Sci. Technol., 54, pp. 144-149 | ||
| 504 | |a Gejl-Hansen, F., Flink, J.M., Freeze-dried carbohydrate containing oil-in-water emulsions: microstructure and fat distribution (1977) J. Food Sci., 42, pp. 1049-1055 | ||
| 504 | |a Giovannucci, E., Tomatoes, tomato-based products, lycopene and cancer: review of the epidemiological literature (1999) J. Nat. Cancer Inst., 91, pp. 317-331 | ||
| 504 | |a Greenspan, L., Humidity fixed points of binary saturated aqueous solutions (1977) J. Res. Natl. Bureau Standards, 81 A, pp. 89-102 | ||
| 504 | |a Izutsu, K., Yashioka, S., Terao, T., Decreased protein stabilizing effects of cryoprotectants due to crystallization (1993) Pharm. Res., 10, pp. 1232-1237 | ||
| 504 | |a Izutsu, K., Yashioka, S., Terao, T., Effects of mannitol crystallinity on the stabilization of enzymes during freeze-drying (1994) Chem. Pharm. Bull., 42, pp. 5-8 | ||
| 504 | |a Izutsu, K., Kojima, S., Excipient crystallinity and its protein-structure stabilizing effect during freeze drying (2002) J. Pharm. Pharmacol., 54, pp. 1033-1039 | ||
| 504 | |a Izutsu, K., Ocheda, S.O., Aoyagi, N., Kojima, S., Effects of sodium tetraborato and boric acid on nonisothermal mannitol crystallization in frozen solutions and freeza-dried solids (2004) Int. J. Pharm., 273, pp. 85-93 | ||
| 504 | |a Johnson, R.E., Kirchhoff, C.E., Gaud, H.T., Mannitol-sucrose mixtures-versatile formulations for protein lyophilization (2002) J. Pharm. Sci., 91, pp. 914-922 | ||
| 504 | |a Karel, M., Saguy, I., Effects of water on diffusion in food systems (1991) Water Relationships of Foods, pp. 157-173. , Levine H., and Slade L. (Eds), Plenum Press, New York | ||
| 504 | |a Karel, M., Physical structure and quality of dehydrated foods (1991) Drying, pp. 26-35 | ||
| 504 | |a Kett, V.I., Fitzpatrick, S., Cooper, B., Craig, D.Q., An investigation into the subambient behaviour of aqueous mannitol solutions using differential scanning calorimetry, cold stage microscopy and X-ray diffractometry (2003) J. Pharm. Sci., 92, pp. 1919-1929 | ||
| 504 | |a Kim, A.I., Akers, M.J., Nail, S.L., The physical state of mannitol after freeze-drying: effects of mannitol concentration, freezing rate and a noncrystallizing cosolute (1998) J. Pharm. Sci., 87, pp. 931-935 | ||
| 504 | |a Labrousse, S., Roos, Y., Karel, M., Collapse and crystallization in amorphous matrices with encapsulated compounds (1992) Science des Aliments, 12, pp. 757-769 | ||
| 504 | |a Lamikanra, O., Feasibility of sulphite mediated β-carotene destruction in heterogeneous systems and carrots (1985) J. Food Process. Preserv., 9, pp. 209-215 | ||
| 504 | |a Levi, G., Karel, M., The effect of phase transitions on release of n-propanol entrapped in carbohydrate glasses (1995) J. Food Eng., 24, pp. 1-13 | ||
| 504 | |a Martini, A., Kune, R.E., Crivelente, M., Artico, R., Use of subambient differential scanning calorimetry to monitor the freeze-state behaviour of blends of excipients for freeze-drying (1997) PDA J. Pharm. Sci. Technol., 51, pp. 62-67 | ||
| 504 | |a Maa, Y.F., Constantino, H.R., Nguyen, P.A., Hsu, C.C., The effect of operating and formulations variables in the morphology of spray dried protein particles (1997) Pharm. Dev. Technol., 2, pp. 213-223 | ||
| 504 | |a Maa, Y.F., Nguyen, P.A., Andya, J.D., Dasovich, N., Sweeney, T.D., Shire, S.J., Hsu, C.C., Effect of spray drying and subsequent processing conditions on residual moisture content and physical/biochemical stability of protein inhalation powers (1998) Pharm. Res., 15, pp. 768-775 | ||
| 504 | |a Maa, Y.F., Nguyen, P.A., Hsu, C.C., Spray drying of air liquid interface sensitive recombinant human growth hormone (1998) J. Pharm. Sci., 87, pp. 152-159 | ||
| 504 | |a Mazzobre, M.F., Buera, M.P., Combined effects of trehalose and cations on the thermal resistance of β-galactosidase in freeze-dried systems (1999) Biochim. Biophys. Acta, 1473, pp. 337-344 | ||
| 504 | |a Moreau, D.L., Rosemberg, M., Oxidation stability of anhydrous milk fat microencaosulated in whey proteins (1996) J. Food Sci., 61, pp. 39-43 | ||
| 504 | |a Moreau, D.L., Rosemberg, M., Porosity of whey-based microcapsules containing anhydrous milk fat measured by gas replacement pycnometry (1998) J. Food Sci., 63, pp. 819-823 | ||
| 504 | |a Murakoshi, M., Kato, T., Misawa, N., Narisawa, T., Takasuka, N., Yano, M., Cancer prevention by carotenoids (1999) Pure Appl. Chem., 71, pp. 2273-2278 | ||
| 504 | |a Naesens, W., Tobback, P., Triglyceride distribution in a low moisture food model system (1984) J. Food Sci., 49. , pp. 934-938, 947 | ||
| 504 | |a Nail, S.L., Jiang, S., Chongprasert, S., Knopp, S.A., Fundamentals of freeze-drying (2002) Pharm. Biotechnol., 14, pp. 281-360 | ||
| 504 | |a Nishino, H., Tokuda, H., Satomi, Y., Masuda, M., Bu, P., Onozuka, M., Yamaguchi, S., Yano, M., Cancer prevention by carotenoids (1999) Pure Appl. Chem., 71, pp. 2273-2278 | ||
| 504 | |a Omatete, O.O., Judson King, C., Volatiles retention during rehumidification of freeze-dried food models (1978) J. Food Technol., 13, pp. 265-280 | ||
| 504 | |a Pikal, M.J., Dellerman, K.M., Roy, M.I., Riggin, R.M., The effects of formulation variables on the stability of freeze-dried human growth hormone (1991) Pharm. Res., 8, pp. 427-436 | ||
| 504 | |a Prado, S.M., Buera, M.P., Elizalde, B.E., Structural collapse prevents β-carotene loss in a super-cooled polymeric matrix (2006) J. Agric. Food Chem., 54, pp. 79-85 | ||
| 504 | |a Pyne, A., Sarana, R., Suryanarayanan, R., Crystallization of mannitol below T′g during freeze-drying in binary and ternary aqueous systems (2002) Pharm. Res., 19, pp. 901-908 | ||
| 504 | |a Pyne, A., Koustov, C.h., Suryanarayanan, R., Solute crystallization in mannitol-glycine systems. Implications on protein stabilization in freeze-dried formulations (2003) J. Pharm. Sci., 92, pp. 2272-2283 | ||
| 504 | |a Qui, Z.H., Xu, A., Starch-based ingredients for favor encapsulation (1999) Cereal Food World, 44, pp. 460-465 | ||
| 504 | |a Randolph, T., Phase separation of excipients during lyophilization: effects on protein stability (1997) J. Pharm. Sci., 86, pp. 1198-1203 | ||
| 504 | |a Rodríguez-Huezo, M.E., Pedroza-Islas, R., Prado-Barragán, L.A., Beristain, C.I., Vernon-Carter, E.J., Microencapsulation by spray-drying of multiple emulsions containing carotenoids (2004) J. Food Sci., 69, pp. 7-E351-7-E356 | ||
| 504 | |a Roos, Y.H., Karel, M., Plasticizing effect of water in thermal behavior and crystallization of amorphous food models (1991) J. Food Sci., 56, pp. 38-43 | ||
| 504 | |a Roos, Y.H., Effect of moisture in the thermal behavior of strawberries studied using differential scanning calorimetry (1987) J. Food Sci., 52, pp. 146-149 | ||
| 504 | |a Selim, K., Tsimidou, M., Biliaderis, C.G., Kinetic studies of saffron carotenoids encapsulated in amorphous polymer matrices (2000) Food Chem., 71, pp. 199-206 | ||
| 504 | |a Serris, G.S., Biliaderis, C.G., Degradation of beetroot pigment encapsulated in polymeric matrices (2001) J. Sci. Food Agric., 81, pp. 691-700 | ||
| 504 | |a Shimada, Y., Roos, Y., Karel, M., Oxidation of methyl linoleate encapsulated in amorphous lactose-based food model (1991) J. Agric. Food Chem., 39, pp. 637-641 | ||
| 504 | |a Szpylka, J., DeVries, J.W., Determination of beta-carotene in supplements and raw materials by reversed-phase high pressure liquid chromatography: collaborative study (2005) JAOAC Int., 88, pp. 1279-1291 | ||
| 504 | |a Suzuki, T., Imamura, K., Yamamoto, K., Satoh, T., Okazaki, M., (1997) J. Chem. Eng. Jon., 30, pp. 609-613 | ||
| 504 | |a Tant, M.R., Wilkes, G.L., An overview of the nonequilibrium behavior of polymers glasses (1981) Polym. Eng. Sci., 21, pp. 874-895 | ||
| 504 | |a Telang, C., Yu, I., Suryanarayanan, R., Effective inhibition of mannitol crystallization in frozen solutions by sodium chloride (2003) Pharm. Res., 20, pp. 660-667 | ||
| 504 | |a Yoshinari, T., Forbes, R.T., York, P., Karawahisma, Y., Crystallization of amorphous mannitol is retarded using boric acid (2003) Int. J. Pharm., 258, pp. 109-120 | ||
| 504 | |a Yu, I., Milton, N., Groleau, E.G., Mishra, D.S., Vansickle, R.E., Existence of a mannitol hydrate during freeze-drying and practical implications (1999) J. Pharm. Sci., 88, pp. 196-198 | ||
| 520 | 3 | |a The effects of addition of divalent cations and phosphate buffer on the degree of β-carotene encapsulation in a mannitol matrix during freeze-drying were analyzed. The degradation rate of encapsulated β-carotene as a function of % RH and its relationship with the physical state of the matrix during storage at 25 °C was also studied. The presence of phosphate salts significantly delayed mannitol crystallization at a highly satisfactory degree during freeze-drying and, consequently, the degree of β-carotene encapsulation increased. This effect was maintained over quite long time during storage of the freeze-dried samples at 25 °C. Unavoidable local variations in water content during 3 years storage caused the decrease of Tg values and made the crystallization degree to increase. The divalent cations showed a synergistic effect and also modified the kinetics of β-carotene degradation during storage, increasing its stability. The mechanism of crystallization inhibition likely includes a change in hydrogen bond network or/and change in molecular mobility in the presence of divalent cations and phosphate anions. The degradation rate of β-carotene in a mannitol/KH2PO4 matrix increased as increasing % RH until a value at which the samples collapsed (75% RH), and then the degradation rate decreased. Collapse phenomena may affect diffusion of oxygen from the surface to the inside of the matrix and increase retention of β-carotene. Surface color was not an appropriate indicator for β-carotene degradation, because it was mostly dependent on the optical properties of the matrix, which changed with the degree of matrix hydration and collapse. © 2006 Elsevier B.V. All rights reserved. |l eng | |
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires, EX 182, EX 274 | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas, ANPCYT-PICT 20545, PIP 2734 | ||
| 536 | |a Detalles de la financiación: The authors acknowledge financial support from Universidad de Buenos Aires (Projects EX 274 and EX 182), CONICET (PIP 2734) and ANPCYT-PICT 20545. | ||
| 593 | |a Departamento de Industrias, Facultad Ciencias Exactas y Naturales, Universidad de Buenos Aires, 1428 Ciudad Universitaria, Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a Β-CAROTENE |
| 690 | 1 | 0 | |a AMORPHOUS-STATE |
| 690 | 1 | 0 | |a CRYSTALLIZATION INHIBITOR |
| 690 | 1 | 0 | |a ENCAPSULATION |
| 690 | 1 | 0 | |a MANNITOL CRYSTALLIZATION |
| 690 | 1 | 0 | |a STORAGE STABILITY |
| 690 | 1 | 0 | |a BETA CAROTENE |
| 690 | 1 | 0 | |a BUFFER |
| 690 | 1 | 0 | |a DIVALENT CATION |
| 690 | 1 | 0 | |a MANNITOL |
| 690 | 1 | 0 | |a PHOSPHATE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CRYSTALLIZATION |
| 690 | 1 | 0 | |a DIFFERENTIAL SCANNING CALORIMETRY |
| 690 | 1 | 0 | |a DRUG DEGRADATION |
| 690 | 1 | 0 | |a DRUG STABILITY |
| 690 | 1 | 0 | |a ENCAPSULATION |
| 690 | 1 | 0 | |a FREEZE DRYING |
| 690 | 1 | 0 | |a GLASS TRANSITION TEMPERATURE |
| 690 | 1 | 0 | |a HYDRATION |
| 690 | 1 | 0 | |a HYDROGEN BOND |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a STORAGE TEMPERATURE |
| 690 | 1 | 0 | |a SURFACE PROPERTY |
| 690 | 1 | 0 | |a WATER CONTENT |
| 690 | 1 | 0 | |a ANIONS |
| 690 | 1 | 0 | |a BETA CAROTENE |
| 690 | 1 | 0 | |a BUFFERS |
| 690 | 1 | 0 | |a CATIONS, DIVALENT |
| 690 | 1 | 0 | |a CHEMISTRY, PHARMACEUTICAL |
| 690 | 1 | 0 | |a CRYSTALLIZATION |
| 690 | 1 | 0 | |a DRUG COMPOUNDING |
| 690 | 1 | 0 | |a DRUG STABILITY |
| 690 | 1 | 0 | |a DRUG STORAGE |
| 690 | 1 | 0 | |a EXCIPIENTS |
| 690 | 1 | 0 | |a FREEZE DRYING |
| 690 | 1 | 0 | |a GLYCINE |
| 690 | 1 | 0 | |a HUMIDITY |
| 690 | 1 | 0 | |a KINETICS |
| 690 | 1 | 0 | |a MANNITOL |
| 690 | 1 | 0 | |a MODELS, CHEMICAL |
| 690 | 1 | 0 | |a PHOSPHATES |
| 690 | 1 | 0 | |a POTASSIUM COMPOUNDS |
| 690 | 1 | 0 | |a SURFACE PROPERTIES |
| 690 | 1 | 0 | |a TECHNOLOGY, PHARMACEUTICAL |
| 690 | 1 | 0 | |a VITAMINS |
| 690 | 1 | 0 | |a WATER |
| 650 | 1 | 7 | |2 spines |a COLOR |
| 650 | 1 | 7 | |2 spines |a COLOR |
| 700 | 1 | |a Buera, M.P. | |
| 700 | 1 | |a Elizalde, B.E. | |
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