The expression of the mitochondrial gene MT-ND4 is downregulated in cystic fibrosis
Cystic fibrosis (CF) is a disease produced by mutations in the CFTR channel. We have previously reported that the CFTR chloride transport activity indirectly regulates the differential expression of several genes, including SRC and MUC1. Here we report that MT-ND4, a mitochondrial gene encoding a su...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
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2007
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 09988caa a22011417a 4500 | ||
|---|---|---|---|
| 001 | PAPER-6601 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203617.0 | ||
| 008 | 190411s2007 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-33947644153 | |
| 024 | 7 | |2 cas |a glibenclamide, 10238-21-8; reduced nicotinamide adenine dinucleotide dehydrogenase (ubiquinone), 9028-04-0; 3-((3-trifluoromethyl)phenyl)-5-((3-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone; Benzoic Acids; CFTR protein, human; Cystic Fibrosis Transmembrane Conductance Regulator, 126880-72-6; Glyburide, 10238-21-8; NADH Dehydrogenase, 1.6.99.3; NADH dehydrogenase subunit 4, 1.6.5.3; Thiazolidines | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a BBRCA | ||
| 100 | 1 | |a Valdivieso, A.G. | |
| 245 | 1 | 4 | |a The expression of the mitochondrial gene MT-ND4 is downregulated in cystic fibrosis |
| 260 | |c 2007 | ||
| 270 | 1 | 0 | |m Santa-Coloma, T.A.; Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (FCEyN, UBA)Argentina; email: tsantacoloma@gmail.com |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Riordan, J.R., Rommens, J.M., Kerem, B., Alon, N., Rozmahel, R., Grzelczak, Z., Zielenski, J., Tsui, L.-C., Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA (1989) Science, 245, pp. 1066-1073 | ||
| 504 | |a Liang, P., Pardee, A.B., Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction (1992) Science, 257, pp. 967-971 | ||
| 504 | |a Gonzalez-Guerrico, A.M., Cafferata, E.G., Radrizzani, M., Marcucci, F., Gruenert, D., Pivetta, O.H., Favaloro, R.R., Santa-Coloma, T.A., Tyrosine kinase c-Src constitutes a bridge between cystic fibrosis transmembrane regulator channel failure and MUC1 overexpression in cystic fibrosis (2002) J. Biol. Chem., 277, pp. 17239-17247 | ||
| 504 | |a Lei, D.C., Kunzelmann, K., Koslowsky, T., Yezzi, M.J., Escobar, L.C., Xu, Z., Ellison, A.R., Gruenert, D.C., Episomal expression of wild-type CFTR corrects cAMP-dependent chloride transport in respiratory epithelial cells (1996) Gene Ther., 3, pp. 427-436 | ||
| 504 | |a Hirst, J., Carroll, J., Fearnley, I.M., Shannon, R.J., Walker, J.E., The nuclear encoded subunits of complex I from bovine heart mitochondria (2003) Biochim. Biophys. Acta., 1604, pp. 135-150 | ||
| 504 | |a Liang, P., Averboukh, L., Pardee, A.B., Distribution and cloning of eukaryotic mRNAs by means of differential display: refinements and optimization (1993) Nucleic Acids Res., 21, pp. 3269-3275 | ||
| 504 | |a Cafferata, E.G., Gonzalez-Guerrico, A.M., Pivetta, O.H., Santa-Coloma, T.A., Identification by differential display of a mRNA specifically induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in T84 human colon carcinoma cells (1996) Cell Mol. Biol. (Noisy-le-grand), 42, pp. 797-804 | ||
| 504 | |a Miller, F.J., Rosenfeldt, F.L., Zhang, C., Linnane, A.W., Nagley, P., Precise determination of mitochondrial DNA copy number in human skeletal and cardiac muscle by a PCR-based assay: lack of change of copy number with age (2003) Nucleic Acids Res., 31, pp. e61 | ||
| 504 | |a Ma, T., Thiagarajah, J.R., Yang, H., Sonawane, N.D., Folli, C., Galietta, L.J., Verkman, A.S., Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion (2002) J. Clin. Invest., 110, pp. 1651-1658 | ||
| 504 | |a Degli Esposti, M., Carelli, V., Ghelli, A., Ratta, M., Crimi, M., Sangiorgi, S., Montagna, P., Cortelli, P., Functional alterations of the mitochondrially encoded ND4 subunit associated with Leber's hereditary optic neuropathy (1994) FEBS Lett., 352, pp. 375-379 | ||
| 504 | |a Shapiro, B.L., Feigal, R.J., Lam, L.F., Mitochondrial NADH dehydrogenase in cystic fibrosis (1979) Proc. Natl. Acad. Sci .USA, 76, pp. 2979-2983 | ||
| 504 | |a Shapiro, B.L., Lam, L.F., Feigal, R.J., Mitochondrial NADH dehydrogenase in cystic fibrosis: enzyme kinetics in cultured fibroblasts (1982) Am. J. Hum. Genet., 34, pp. 846-852 | ||
| 504 | |a Dechecchi, M.C., Girella, E., Cabrini, G., Berton, G., The Km of NADH dehydrogenase is decreased in mitochondria of cystic fibrosis cells (1988) Enzyme, 40, pp. 45-50 | ||
| 504 | |a Shapiro, B.L., Evidence for a mitochondrial lesion in cystic fibrosis (1989) Life Sci., 44, pp. 1327-1334 | ||
| 504 | |a Shapiro, B.L., Mitochondrial dysfunction, energy expenditure, and cystic fibrosis (1988) Lancet, 2, p. 289 | ||
| 504 | |a Gattermann, N., Dadak, M., Hofhaus, G., Wulfert, M., Berneburg, M., Loeffler, M.L., Simmonds, H.A., Severe impairment of nucleotide synthesis through inhibition of mitochondrial respiration (2004) Nucleosides Nucleotides Nucleic Acids, 23, pp. 1275-1279 | ||
| 504 | |a de Meer, K., Jeneson, J.A., Gulmans, V.A., van der Laag, J., Berger, R., Efficiency of oxidative work performance of skeletal muscle in patients with cystic fibrosis (1995) Thorax, 50, pp. 980-983 | ||
| 504 | |a DiMauro, S., Exercise intolerance and the mitochondrial respiratory chain (1999) Ital J. Neurol. Sci., 20, pp. 387-393 | ||
| 520 | 3 | |a Cystic fibrosis (CF) is a disease produced by mutations in the CFTR channel. We have previously reported that the CFTR chloride transport activity indirectly regulates the differential expression of several genes, including SRC and MUC1. Here we report that MT-ND4, a mitochondrial gene encoding a subunit of the mitochondrial Complex I (mtCx-I), is also a CFTR-dependent gene. A reduced expression of MT-ND4 was observed in CFDE cells (derived from a CF patient) when compared to CFDE cells ectopically expressing wild-type CFTR. The differential expression of MT-ND4 in CF was confirmed by RT-PCR. In situ hybridizations of deparaffinized human lung tissue slices derived from wt-CFTR or CF patients also showed downregulation of ND4 in CF. In addition, the CFTR chloride transport inhibitors glibenclamide and CFTR(inh)-172 also reduced MT-ND4 expression in CFDE cells ectopically expressing wt CFTR. These results suggest that the CFTR chloride transport activity indirectly up-regulates MT-ND4 expression. © 2007 Elsevier Inc. All rights reserved. |l eng | |
| 536 | |a Detalles de la financiación: National Science and Technology Development Agency, PICT 05-13970 | ||
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires, X-138, X-156, TW67 | ||
| 536 | |a Detalles de la financiación: National Council for Scientific Research, PIP694/98 | ||
| 536 | |a Detalles de la financiación: The CFDE and CFDE/6RepCFTR cells were a gift from Dr. Dieter Gruenert. Human lung slices, from pathological archives, were generously provided by Dr. Guillermo Gallo, from the ``Hospital de Pediatría Prof. Dr. Juan P. Garrahan” and by Dr. Sergio V. Perrone, from the ``Fundación Favaloro”, Buenos Aires, Argentina. This work was supported by grants from the University of Buenos Aires (TW67, X-138, and X-156), the National Research Council of Argentina (PIP694/98), the National Agency for the Promotion of Science and Technology (PICT 05-13970), and the Ministry of Health of Argentina (Fellowship Carrillo-Oñativia, 2003–2004) to TASC. | ||
| 593 | |a Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (FCEyN, UBA), Argentina | ||
| 593 | |a Instituto de Investigaciones Bioquímicas (IIB) de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas (IIBBA, CONICET), IIB Fundación Campomar (now Fundación Instituto Leloir), Argentina | ||
| 593 | |a Facultad de Ciencias Médicas, Programa de Investigaciones Biomédicas, Pontificia Universidad Católica Argentina, Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a CFDE |
| 690 | 1 | 0 | |a CFTR |
| 690 | 1 | 0 | |a CFTR(INH)-172 |
| 690 | 1 | 0 | |a CYSTIC FIBROSIS |
| 690 | 1 | 0 | |a GLIBENCLAMIDE |
| 690 | 1 | 0 | |a MITOCHONDRIA |
| 690 | 1 | 0 | |a MITOCHONDRIAL EXPRESSED GENES |
| 690 | 1 | 0 | |a MT-ND4 |
| 690 | 1 | 0 | |a GLIBENCLAMIDE |
| 690 | 1 | 0 | |a REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE) |
| 690 | 1 | 0 | |a TRANSMEMBRANE CONDUCTANCE REGULATOR |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a CYSTIC FIBROSIS |
| 690 | 1 | 0 | |a HISTOPATHOLOGY |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a HUMAN CELL |
| 690 | 1 | 0 | |a HUMAN TISSUE |
| 690 | 1 | 0 | |a IN SITU HYBRIDIZATION |
| 690 | 1 | 0 | |a MITOCHONDRIAL GENE |
| 690 | 1 | 0 | |a MT ND4 GENE |
| 690 | 1 | 0 | |a NUCLEOTIDE SEQUENCE |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROTEIN EXPRESSION |
| 690 | 1 | 0 | |a BASE SEQUENCE |
| 690 | 1 | 0 | |a BENZOIC ACIDS |
| 690 | 1 | 0 | |a CELL LINE |
| 690 | 1 | 0 | |a CYSTIC FIBROSIS |
| 690 | 1 | 0 | |a CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR |
| 690 | 1 | 0 | |a DOWN-REGULATION |
| 690 | 1 | 0 | |a GENE EXPRESSION |
| 690 | 1 | 0 | |a GLYBURIDE |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a IN SITU HYBRIDIZATION |
| 690 | 1 | 0 | |a LUNG |
| 690 | 1 | 0 | |a MOLECULAR SEQUENCE DATA |
| 690 | 1 | 0 | |a NADH DEHYDROGENASE |
| 690 | 1 | 0 | |a THIAZOLIDINES |
| 700 | 1 | |a Marcucci, F. | |
| 700 | 1 | |a Taminelli, G. | |
| 700 | 1 | |a Guerrico, A.G. | |
| 700 | 1 | |a Álvarez, S. | |
| 700 | 1 | |a Teiber, M.L. | |
| 700 | 1 | |a Dankert, M.A. | |
| 700 | 1 | |a Santa-Coloma, T.A. | |
| 773 | 0 | |d 2007 |g v. 356 |h pp. 805-809 |k n. 3 |p Biochem. Biophys. Res. Commun. |x 0006291X |w (AR-BaUEN)CENRE-905 |t Biochemical and Biophysical Research Communications | |
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