Biosynthesis of digitoxin in Digitalis purpurea
Simultaneous administration of a mixture of [21-3H]-3β, 20ξ-dihydroxy-23-nor-5β-cholanoic acid and [21-14C]-3β-hydroxy-5β-pregnan-20-one to Digitalis purpurea intact plants produced double labelled digitoxin. The 3H: 14C ratio of the cardenolide was considerably higher than the 3H: 14C ratio of the...
Guardado en:
| Autor principal: | |
|---|---|
| Otros Autores: | , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1989
|
| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| Sumario: | Simultaneous administration of a mixture of [21-3H]-3β, 20ξ-dihydroxy-23-nor-5β-cholanoic acid and [21-14C]-3β-hydroxy-5β-pregnan-20-one to Digitalis purpurea intact plants produced double labelled digitoxin. The 3H: 14C ratio of the cardenolide was considerably higher than the 3H: 14C ratio of the administered substrates. This result indicates that in the main biosynthetic pathway from a 20-keto-pregnane to a cardenolide the introduction of an acetate unit at C-20 should occur before the hydroxylation at C-21. © 1989. |
|---|---|
| Bibliografía: | Euw, Reichstein, Die Biosynthese des Digitoxigenins, Herkunft des C-20. Glykoside und Aglykone, 253. Mitteilung (1964) Helvetica Chimica Acta, 47, p. 711 Tschesche, Lilienweiss, (1964) Z. Naturforsch., 19 b, p. 265 Leete, Gregory, Gros, (1965) J. Am. Chem. Soc., 87, p. 3475 Tschesche, Hulpke, Scholten, (1967) Z. Naturforsch., 22 b, p. 677 Tschesche, Becker, Hombach, (1968) Z. Naturforsch., 23 b, p. 1615 Maier, Seldes, Gros, (1986) Phytochemistry, 25, p. 1327 Garraffo, Deluca, Seldes, Gros, (1985) J. Lab. Compds. Radiopharm., 22, p. 673 Maier, Seldes, Gros, (1985) J. Lab. Compds. Radiopharm., 22, p. 467 Deluca, Seldes, Gros, (1987) Z. Naturforsch., 42 c, p. 77 Caspi, Lewis, (1967) Science, 156, p. 519 Bennett, Sauer, Heftmann, (1968) Phytochemistry, 7, p. 41 Caspi, Hornby, (1968) Phytochemistry, 7, p. 423 Caspi, Wickramasinghe, Lewis, (1968) Biochem. J., 108, p. 499 |
| ISSN: | 00319422 |
| DOI: | 10.1016/0031-9422(89)85019-8 |