Plasmodium falciparum biosynthesizes sulfoglycosphingolipids
Sulfated glycosphingolipids are present on the surface of a variety of cells. They are active participants in adhesion processes in many systems and appear to be involved in the regulation of cell proliferation, differentiation and other developmental cellular events. However, the body of knowledge...
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2007
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| LEADER | 16201caa a22014177a 4500 | ||
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| 001 | PAPER-6512 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203612.0 | ||
| 008 | 190411s2007 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-34249984441 | |
| 024 | 7 | |2 cas |a carbon 14, 14762-75-5; glucose, 50-99-7, 84778-64-3; palmitic acid, 57-10-3; 1-phenyl-2-palmitoylamino-3-morpholino-1-propanol; Antimalarials; Carbon Radioisotopes; Glucose, 50-99-7; Morpholines; Palmitic Acid, 57-10-3; sodium sulfate, 7757-82-6; Sphingolipids; Sulfates; Sulfoglycosphingolipids | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a MBIPD | ||
| 100 | 1 | |a Landoni, M. | |
| 245 | 1 | 0 | |a Plasmodium falciparum biosynthesizes sulfoglycosphingolipids |
| 260 | |c 2007 | ||
| 270 | 1 | 0 | |m Couto, A.S.; CIHIDECAR, Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón II, Buenos Aires, 1428, Argentina; email: acouto@qo.fcen.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a Sulfated glycosphingolipids are present on the surface of a variety of cells. They are active participants in adhesion processes in many systems and appear to be involved in the regulation of cell proliferation, differentiation and other developmental cellular events. However, the body of knowledge about synthesis, structure, and function of glycolipids in parasitic protozoa is very limited so far. In this work, we show by metabolic incorporation of [14C]palmitic acid, [14C]glucose and Na235SO4 that sulfoglycosphingolipids are biosynthesized in the three intraerythrocytic stages of Plasmodium falciparum. After saponification, purification of the labelled acidic components was achieved and two components named SPf1 and SPf2 were characterized. Chemical degradations and TLC analysis pointed out to sulfolipidic structures. Analysis by UV-MALDI-TOF mass spectrometry in the negative ion mode using nor-harmane as matrix showed for SPf2 a structure consisting in a disulfated hexose linked to a 20:1 sphingosine acylated with C18:0 fatty acid. Interestingly, parasite treatment with low concentrations of d,l-threo-phenyl-2-palmitoylamino-3-morpholino-1-propanol (PPMP) caused an arrest on parasite development associated to the inhibition of sulfoglycolipid biosynthesis. Taking into account that sulfoglycolipidic structures are currently involved in adhesion processes, our findings open the possibility to study the participation of this type of structures in the described aggregation phenomena in severe malaria and may contribute to clarify the pathogenesis of the disease. This report shows for the first time the synthesis of sulfoglycolipids in Apicomplexa. © 2007 Elsevier B.V. All rights reserved. |l eng | |
| 536 | |a Detalles de la financiación: Conselho Nacional de Desenvolvimento Científico e Tecnológico, CNPq | ||
| 536 | |a Detalles de la financiación: Ehime University | ||
| 536 | |a Detalles de la financiación: Fundação de Amparo à Pesquisa do Estado de São Paulo | ||
| 536 | |a Detalles de la financiación: Agencia Nacional de Promoción Científica y Tecnológica, Pict 06-06545 | ||
| 536 | |a Detalles de la financiación: Heiwa Nakajima Foundation, HNF | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: United Graduate School of Agricultural Sciences, Kagoshima University | ||
| 536 | |a Detalles de la financiación: This work was supported by grants from: UBA; CONICET and Agencia Nacional de Promoción Científica y Tecnológica (Pict 06-06545), Argentina; FAPESP, CNPq, Brazil. ASC, VGD, and RE-B are members of the Research Council CONICET (Argentina) and ML, CONICET fellow. Mass spectrometry was performed as part of the Academic Agreement between RE-B and HN with the facilities of the High Resolution Liquid Chromatography-integrated Mass Spectrometer System Laboratory of the United Graduate School of Agricultural Sciences (Ehime University, Japan) and partially supported by Heiwa Nakajima Foundation. | ||
| 593 | |a CIHIDECAR, Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón II, Buenos Aires, 1428, Argentina | ||
| 593 | |a Departamento de Investigación, Instituto Nacional de Parasitología 'Dr Mario Fatala Chaben', ANLIS-Malbrán, Buenos Aires, Argentina | ||
| 593 | |a Departamento de Parasitología, Instituto de Ciencias Biomédicas, Universidade de São Paulo, São Paulo, Brazil | ||
| 593 | |a College of Agriculture, Ehime University, Matsuyama CP, 790-8566, Japan | ||
| 690 | 1 | 0 | |a GLYCOCONJUGATES |
| 690 | 1 | 0 | |a PLASMODIUM FALCIPARUM |
| 690 | 1 | 0 | |a SULFOGLYCOSPHINGOLIPIDS |
| 690 | 1 | 0 | |a CARBON 14 |
| 690 | 1 | 0 | |a GLUCOSE |
| 690 | 1 | 0 | |a PALMITIC ACID |
| 690 | 1 | 0 | |a SULFATIDE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a BIOSYNTHESIS |
| 690 | 1 | 0 | |a LIPOGENESIS |
| 690 | 1 | 0 | |a MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a THIN LAYER CHROMATOGRAPHY |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a ANTIMALARIALS |
| 690 | 1 | 0 | |a CARBON RADIOISOTOPES |
| 690 | 1 | 0 | |a CHROMATOGRAPHY, THIN LAYER |
| 690 | 1 | 0 | |a GLUCOSE |
| 690 | 1 | 0 | |a MASS SPECTROMETRY |
| 690 | 1 | 0 | |a MORPHOLINES |
| 690 | 1 | 0 | |a PALMITIC ACID |
| 690 | 1 | 0 | |a PLASMODIUM FALCIPARUM |
| 690 | 1 | 0 | |a SPHINGOLIPIDS |
| 690 | 1 | 0 | |a SULFATES |
| 690 | 1 | 0 | |a SULFOGLYCOSPHINGOLIPIDS |
| 690 | 1 | 0 | |a APICOMPLEXA |
| 690 | 1 | 0 | |a PLASMODIUM FALCIPARUM |
| 690 | 1 | 0 | |a PROTOZOA |
| 650 | 1 | 7 | |2 spines |a MALARIA |
| 700 | 1 | |a Duschak, V.G. | |
| 700 | 1 | |a Peres, V.J. | |
| 700 | 1 | |a Nonami, H. | |
| 700 | 1 | |a Erra-Balsells, R. | |
| 700 | 1 | |a Katzin, A.M. | |
| 700 | 1 | |a Couto, A.S. | |
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