5-Aminolevulinic acid-mediated photodynamic therapy on Hep-2 and MCF-7c3 cells
The cytotoxic effect of 5-aminolevulinic acid (ALA) induced protoporphyrin IX (PPIX) on two human carcinoma cell lines, MCF-7c3 cells and Hep 2 cells, was studied. In both cell lines, PPIX content depends on the ALA concentration and incubation time. The maximal PPIX content was higher in the MCF-7c...
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Begell House Inc.
2007
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 09024caa a22009617a 4500 | ||
|---|---|---|---|
| 001 | PAPER-6438 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203607.0 | ||
| 008 | 190411s2007 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-34548071136 | |
| 024 | 7 | |2 cas |a aminolevulinic acid, 106-60-5; deferoxamine, 70-51-9; protoporphyrin, 553-12-8 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a JEPOE | ||
| 100 | 1 | |a Alvarez, M.G. | |
| 245 | 1 | 0 | |a 5-Aminolevulinic acid-mediated photodynamic therapy on Hep-2 and MCF-7c3 cells |
| 260 | |b Begell House Inc. |c 2007 | ||
| 270 | 1 | 0 | |m Fukuda, H.; CIPYP-CONICETArgentina; email: hfukuda@qb.fcen.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Sassa, S., Regulation of the genes for heme pathway enzymes in erythroid and in non erythroid cells (1990) Int J Cell Cloning, 8, pp. 10-26 | ||
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| 504 | |a Peng, Q., Warloe, T., Berg, K., Moan, J., Kongshaug, M., Giercksky, K.E., Nesland, J.M., 5-Aminolevulinic acid-based photodynamic therapy: Clinical research and future challenges (1997) Cancer, 79, pp. 2282-2308 | ||
| 504 | |a Oleinick NL, Morris RL and Belichenko I. Apoptosis in response to photodynamic therapy: what, where, why and how. Photochem Photobiol Sci. 2002;1:1-22; Luo, Y., Kessel, D., Initiation of apoptosis versus necrosis by photodynamic therapy with chloro-aluminum phtalocyanine (1997) Photochem Photobiol, 66, pp. 479-483 | ||
| 504 | |a Merlin, J.L., Azzi, S., Lignon, D., Ramacci, C., Zeghari, N., Guillemin, F., MTT assays allow quick and reliable measurement of the response of human tumour cells to photodynamic therapy (1992) Eur J Cancer, 28, pp. 1452-1458 | ||
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| 504 | |a Schoenfeld, N., Mamet, R., Nordenberg, Y., Shafran, M., Babushkin, T., Malik, Z., Protoporphyrin biosynthesis in melanoma B 16 cells stimulated by 5-aminolevulinic acid and chemical inducers: Characterization of photodynamic inactivation (1994) Int J Cancer, 56, pp. 106-112 | ||
| 504 | |a Navone, N.M., Polo, C., Frisardi, A., Batlle, A.D.C., Mouse mammary carcinoma PBGase and hydroxymethylbilane synthetase (1991) Comp Biochem Physiol B, 98, pp. 67-71 | ||
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| 504 | |a Hanania, H., Malik, Z., The effect of EDTA and serum on endogenous porphyrins accumulation and photodynamic sensitization of human K562 leukemic cells (1992) Cancer Lett, 65, pp. 127-131 | ||
| 504 | |a Ortell, B., Tanew, A., Honigsmann, H., Lethal photosensitization by endogenous porphyrins of PAM cells-modification by desferrioxamine (1993) J Photochem Photobiol B: Biol, 17, pp. 273-278 | ||
| 504 | |a Berg, K., Anholt, H., Bech, O., Moan, J., The influence of iron chelators on the accumulation of Protoporphyrin IX in 5-aminolaevulinic acid-treated cells (1996) Br J Cancer, 74, pp. 688-697 | ||
| 504 | |a Liu, H., Xu, S., Zhang, C., Influence of CaNa2EDTA on topical 5-aminolevulinic acid photodynamic therapy (2004) Chin Med J, 117, pp. 922-926 | ||
| 504 | |a Fabris, C., Valduga, G., Miotto, G., Borsetto, L., Jori, G., Garbisa, S., Reddi, E., Photosensitization with zinc (II) phthalocyanine as a switch in the decision between apoptosis and necrosis (2001) Cancer Res, 61, pp. 7495-7500 | ||
| 504 | |a Kessel, D., Luo, Y., Mitochondrial photodamage and PDT-induced apoptosis (1998) J Photochem Photobiol B: Biol, 42, pp. 89-95 | ||
| 504 | |a Kessel, D., Luo, Y., Intracellular sites of photodamage as a factor in apoptotic cell death (2001) J Porphyrins Phtalocyanines, 5, pp. 181-184 | ||
| 504 | |a Kessel, D., Luo, Y., Photodynamic therapy: A mitochondrial inducer of apoptosis (1999) Cell Death Differ, 6, pp. 28-35 | ||
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| 504 | |a Villanueva, A., Durantini, E.N., Stockert, J.C., Rello, S., Vidania, R., Cañete, M., Juarranz, A., Rivarola, V., Photokilling of cultured tumor cells by the porphyrin derivative CF3 (2001) Anti-Cancer Drug Des, 16, pp. 279-290 | ||
| 504 | |a Milanesio, M.E., Álvarez, M.G., Silber, J.J., Rivarola, V., Durantini, E.N., Photodynamic activity of monocationic and non-charged methoxyphenylporphyrin derivatives in homogeneous and biological media (2003) Photochem Photobiol Sci, 2, pp. 926-933 | ||
| 504 | |a Alvarez, M.G., Principe, F., Milanesio, M.E., Durantini, E.N., Rivarola, V., Photodynamic damages induced by a monocationic porphyrin derivative in a human carcinoma cell line (2005) Int J Biochem Cell Biol, 37, pp. 2504-2512 | ||
| 520 | 3 | |a The cytotoxic effect of 5-aminolevulinic acid (ALA) induced protoporphyrin IX (PPIX) on two human carcinoma cell lines, MCF-7c3 cells and Hep 2 cells, was studied. In both cell lines, PPIX content depends on the ALA concentration and incubation time. The maximal PPIX content was higher in the MCF-7c3 cells, reaching a value of 8 μg/106 cells, compared to the Hep-2 cells, which accumulated 3.2 μg/106 cells. Treatment of cells with the iron chelator desferrioxamine prior to ALA exposure enhances the amount of PPIX, consequently diminishing enzymatic activity of ferroquelatase. Photo sensitization of the cells was in correlation with the PPIX content; therefore, conditions leading to 80% cell death in the MCF-7c3 cells provoke a 50% cell death in the Hep 2 cells. Using fluorescence microscopy, cell morphology was analyzed after incubation with 1 mM ALA during 5 hr and irradiation with 54 Jcm-2; 24 hr post-PDT, MCF-7c3 cells revealed the typical morphological changes of necrosis. Under the same conditions, Hep-2 cells produced chromatine fragmentation characteristic of apoptosis. PPIX accumulation was observed to occur in a perinuclear region in the MCF-7c3 cells; while in Hep-2 cells, it was localized in lysosomes. Different mechanisms of cell death were observed in both cell lines, depending on the different intracellular localization of PPIX. © 2007 by Begell House, Inc. |l eng | |
| 593 | |a Departamento de Biologia Molecular, Facultad de Ciencias Exactas Físico-Químicas Y Naturales, UNRC, Argentina | ||
| 593 | |a CIPYP-CONICET, Argentina | ||
| 593 | |a FCEN-Universidad de Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a 5-AMINOLEVULINIC ACID |
| 690 | 1 | 0 | |a APOPTOSIS |
| 690 | 1 | 0 | |a PHOTODYNAMIC THERAPY |
| 690 | 1 | 0 | |a PHOTOSENSITISATION |
| 690 | 1 | 0 | |a AMINOLEVULINIC ACID |
| 690 | 1 | 0 | |a DEFEROXAMINE |
| 690 | 1 | 0 | |a IRON CHELATING AGENT |
| 690 | 1 | 0 | |a PROTOPORPHYRIN |
| 690 | 1 | 0 | |a ANALYTIC METHOD |
| 690 | 1 | 0 | |a APOPTOSIS |
| 690 | 1 | 0 | |a CANCER CELL |
| 690 | 1 | 0 | |a CELL DEATH |
| 690 | 1 | 0 | |a CELL STRUCTURE |
| 690 | 1 | 0 | |a CHROMATIN |
| 690 | 1 | 0 | |a COMPARATIVE STUDY |
| 690 | 1 | 0 | |a CONFERENCE PAPER |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a FLUORESCENCE MICROSCOPY |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a HUMAN CELL |
| 690 | 1 | 0 | |a INCUBATION TIME |
| 690 | 1 | 0 | |a LYSOSOME |
| 690 | 1 | 0 | |a PHOTODYNAMIC THERAPY |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a RADIATION DOSE |
| 650 | 1 | 7 | |2 spines |a NECROSIS |
| 700 | 1 | |a Lacelli, M.S. | |
| 700 | 1 | |a Rivarola, V. | |
| 700 | 1 | |a Batlle, A. | |
| 700 | 1 | |a Fukuda, H. | |
| 773 | 0 | |d Begell House Inc., 2007 |g v. 26 |h pp. 75-82 |k n. 2 |p J. Environ. Pathol. Toxicol. Oncol. |x 07318898 |t Journal of Environmental Pathology, Toxicology and Oncology | |
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| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_07318898_v26_n2_p75_Alvarez |y Handle |
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