Trypanosoma cruzi: In vitro and in vivo antiproliferative effects of epigallocatechin gallate (EGCg)
The trypanocidal activity of catechins on Trypanosoma cruzi bloodstream trypomastigotes has been previously reported. Herein, we present the effect of epigallocatechin gallate (EGCg) on parasitemia and survival in a murine model of acute Chagas' disease as well as on the epimastigote form of th...
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2007
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 12456caa a22013937a 4500 | ||
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| 001 | PAPER-6365 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203603.0 | ||
| 008 | 190411s2007 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-34548252803 | |
| 024 | 7 | |2 cas |a epigallocatechin gallate, 989-51-5; Antioxidants; Catechin, 154-23-4; epigallocatechin gallate, 989-51-5; Trypanocidal Agents | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a EXPAA | ||
| 100 | 1 | |a Güida, M.C. | |
| 245 | 1 | 0 | |a Trypanosoma cruzi: In vitro and in vivo antiproliferative effects of epigallocatechin gallate (EGCg) |
| 260 | |c 2007 | ||
| 270 | 1 | 0 | |m Güida, M.C.; Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Facultad de Ciencias Exactas y Naturales (CONICET-UBA), 1428 Buenos Aires, Argentina; email: mcguida@dna.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a The trypanocidal activity of catechins on Trypanosoma cruzi bloodstream trypomastigotes has been previously reported. Herein, we present the effect of epigallocatechin gallate (EGCg) on parasitemia and survival in a murine model of acute Chagas' disease as well as on the epimastigote form of the parasite. Upon intraperitoneal administration of daily doses of 0.8 mg/kg/day of EGCg for 45 days, mice survival rates increased from 11% to 60%, while parasitemia diminished to 50%. No side effects were observed in EGCg-treated animals. Fifty percent inhibition of epimastigotes growth was achieved with 311 μM EGCg 120 h after drug addition. No lysis, total culture growth inhibition or morphological changes were observed upon addition of 1-3 mM EGCg at 24 h. This treatment also produced oligosomal fragmentation of epimastigotes DNA, suggesting a programmed cell death (PCD)-like process. All these findings point out EGCg as a potential new lead compound for chemotherapy of Chagas' disease. © 2007 Elsevier Inc. All rights reserved. |l eng | |
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires | ||
| 536 | |a Detalles de la financiación: Agencia Nacional de Promoción Científica y Tecnológica | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: This study was supported by Consejo Nacional de Investigaciones Científicas y Técnicas, CONICET (Argentina), University of Buenos Aires (Argentina) and Agencia Nacional de Promoción Científica y Tecnológica (Argentina). C. Paveto, M.M. Flawiá and H.N. Torres are members of Scientific Investigator Career of CONICET; M.C. Güida is a postgraduate fellow of CONICET. M.I. Esteva is a researcher of the Instituto Nacional de Parasitología Dr Mario Fatala Chabén. We thank María del Carmen Aranda for technical assistance. | ||
| 593 | |a Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Facultad de Ciencias Exactas y Naturales (CONICET-UBA), 1428 Buenos Aires, Argentina | ||
| 593 | |a Instituto Nacional de Parasitología Dr. Mario Fatala Chabén, 1063 Buenos Aires, Argentina | ||
| 593 | |a Unidad de hígado y transplante, Hospital Universitario Austral, Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a EPIGALLOCATECHIN GALLATE |
| 690 | 1 | 0 | |a PCD |
| 690 | 1 | 0 | |a PROGRAMMED CELL DEATH |
| 690 | 1 | 0 | |a TRYPANOCIDE CHAGAS' DISEASE |
| 690 | 1 | 0 | |a EPIGALLOCATECHIN GALLATE |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ANIMAL MODEL |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a APOPTOSIS |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CHAGAS DISEASE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a DRUG MECHANISM |
| 690 | 1 | 0 | |a FRAGMENTATION REACTION |
| 690 | 1 | 0 | |a GROWTH INHIBITION |
| 690 | 1 | 0 | |a HISTOPATHOLOGY |
| 690 | 1 | 0 | |a IN VITRO STUDY |
| 690 | 1 | 0 | |a IN VIVO STUDY |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MOUSE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PARASITEMIA |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a SURVIVAL RATE |
| 690 | 1 | 0 | |a TRYPANOSOMA CRUZI |
| 690 | 1 | 0 | |a TRYPOMASTIGOTE |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a ANTIOXIDANTS |
| 690 | 1 | 0 | |a CATECHIN |
| 690 | 1 | 0 | |a CHAGAS DISEASE |
| 690 | 1 | 0 | |a DISEASE MODELS, ANIMAL |
| 690 | 1 | 0 | |a DNA FRAGMENTATION |
| 690 | 1 | 0 | |a DOSE-RESPONSE RELATIONSHIP, DRUG |
| 690 | 1 | 0 | |a HEPATOCYTES |
| 690 | 1 | 0 | |a IN SITU NICK-END LABELING |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MICE |
| 690 | 1 | 0 | |a MICE, INBRED BALB C |
| 690 | 1 | 0 | |a PARASITEMIA |
| 690 | 1 | 0 | |a RANDOM ALLOCATION |
| 690 | 1 | 0 | |a TRYPANOCIDAL AGENTS |
| 690 | 1 | 0 | |a TRYPANOSOMA CRUZI |
| 690 | 1 | 0 | |a ANIMALIA |
| 690 | 1 | 0 | |a MURINAE |
| 690 | 1 | 0 | |a MUS |
| 690 | 1 | 0 | |a TRYPANOSOMA CRUZI |
| 700 | 1 | |a Esteva, M.I. | |
| 700 | 1 | |a Camino, A. | |
| 700 | 1 | |a Flawiá, M.M. | |
| 700 | 1 | |a Torres, H.N. | |
| 700 | 1 | |a Paveto, C. | |
| 773 | 0 | |d 2007 |g v. 117 |h pp. 188-194 |k n. 2 |p Exp. Parasitol. |x 00144894 |w (AR-BaUEN)CENRE-4717 |t Experimental Parasitology | |
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