Functions of cell surface galectin-glycoprotein lattices
Programmed remodeling of cell surface glycans by the sequential action of specific glycosyltransferases can control biological processes by generating or masking ligands for endogenous lectins. Galectins, a family of animal lectins with affinity for β-galactosides, can form multivalent complexes wit...
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2007
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 20563caa a22016217a 4500 | ||
|---|---|---|---|
| 001 | PAPER-6360 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230607131851.0 | ||
| 008 | 190411s2007 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-35548938481 | |
| 024 | 7 | |2 cas |a Galectins; Membrane Glycoproteins; Multiprotein Complexes | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a COSBE | ||
| 100 | 1 | |a Rabinovich, G.A. | |
| 245 | 1 | 0 | |a Functions of cell surface galectin-glycoprotein lattices |
| 260 | |c 2007 | ||
| 270 | 1 | 0 | |m Rabinovich, G.A.; Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental IBYME, CONICET, Vuelta de Obligado 2490, C1428ADN Buenos Aires, Argentina; email: gabyrabi@ciudad.com.ar |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Miceli, M.C., Moran, M., Chung, C.D., Patel, V.P., Low, T., Zinnanti, W., Co-stimulation and counter-stimulation: lipid raft clustering controls TCR signaling and functional outcomes (2001) Semin Immunol, 13, pp. 115-128 | ||
| 504 | |a Cooper, D.N., Galectinomics: finding themes in complexity (2002) Biochim Biophys Acta, 1572, pp. 209-231 | ||
| 504 | |a Liu, F.T., Rabinovich, G.A., Galectins as modulators of tumour progression (2005) Nat Rev Cancer, 5, pp. 29-41 | ||
| 504 | |a Vasta, G.R., Ahmed, H., Odom, E.W., Structural and functional diversity of lectin repertoires in invertebrates, protochordates and ectothermic vertebrates (2004) Curr Opin Struct Biol, 14, pp. 617-630 | ||
| 504 | |a Brewer, C.F., Miceli, M.C., Baum, L.G., Clusters, bundles, arrays and lattices: novel mechanisms for lectin-saccharide-mediated cellular interactions (2002) Curr Opin Struct Biol, 12, pp. 616-623 | ||
| 504 | |a Toscano, M.A., Ilarregui, J.M., Bianco, G.A., Campagna, L., Croci, D.O., Salatino, M., Rabinovich, G.A., Dissecting the pathophysiologic role of endogenous lectins: glycan-binding proteins with cytokine-like activity? (2007) Cytokine Growth Factor Rev, 18, pp. 57-71 | ||
| 504 | |a Hirabayashi, J., Hashidate, T., Arata, Y., Nishi, N., Nakamura, T., Hirashima, M., Urashima, T., Muller, W.E., Oligosaccharide specificity of galectins: a search by frontal affinity chromatography (2002) Biochim Biophys Acta, 1572, pp. 232-254 | ||
| 504 | |a Patnaik, S.K., Potvin, B., Carlsson, S., Sturm, D., Leffler, H., Stanley, P., Complex N-glycans are the major ligands for galectin-1, -3, and -8 on Chinese hamster ovary cells (2006) Glycobiology, 16, pp. 305-317 | ||
| 504 | |a Dam, T.K., Gabius, H.J., Andre, S., Kaltner, H., Lensch, M., Brewer, C.F., Galectins bind to the multivalent glycoprotein asialofetuin with enhanced affinities and a gradient of decreasing binding constants (2005) Biochemistry, 44, pp. 12564-12571 | ||
| 504 | |a Lau, K.S., Partridge, E.A., Grigorian, A., Silvescu, C.I., Reinhold, V.N., Demetriou, M., Dennis, J.W., Complex N-glycan number and degree of branching cooperate to regulate cell proliferation and differentiation (2007) Cell, 129, pp. 123-134. , An elegant study showing a fine-tuning mechanism for switching from growth to arrest in cells based on the flux of UDP-GlcNAc through the Golgi and the extent of N-glycan branching of growth factor receptors | ||
| 504 | |a Partridge, E.A., Le Roy, C., Di Guglielmo, G.M., Pawling, J., Cheung, P., Granovsky, M., Nabi, I.R., Dennis, J.W., Regulation of cytokine receptors by Golgi N-glycan processing and endocytosis (2004) Science, 306, pp. 120-124 | ||
| 504 | |a Morris, S., Ahmad, N., Andre, S., Kaltner, H., Gabius, H.J., Brenowitz, M., Brewer, F., Quaternary solution structures of galectins-1, -3, and -7 (2004) Glycobiology, 14, pp. 293-300 | ||
| 504 | |a Ahmad, N., Gabius, H.J., Andre, S., Kaltner, H., Sabesan, S., Roy, R., Liu, B., Brewer, C.F., Galectin-3 precipitates as a pentamer with synthetic multivalent carbohydrates and forms heterogeneous cross-linked complexes (2004) J Biol Chem, 279, pp. 10841-10847 | ||
| 504 | |a Chen, H.Y., Sharma, B.B., Yu, L., Zuberi, R., Weng, I.C., Kawakami, Y., Kawakami, T., Liu, F.T., Role of galectin-3 in mast cell functions: galectin-3-deficient mast cells exhibit impaired mediator release and defective JNK expression (2006) J Immunol, 177, pp. 4991-4997 | ||
| 504 | |a Nieminen, J., Kuno, A., Hirabayashi, J., Sato, S., Visualization of galectin-3 oligomerization on the surface of neutrophils and endothelial cells using fluorescence resonance energy transfer (2007) J Biol Chem, 282, pp. 1374-1383. , An innovative study demonstrating the oligomerization of galectin-3 using fluorescence resonance energy transfer (FRET). The authors detected FRET signals during galectin-3-lattice formation on neutrophils and endothelial cells | ||
| 504 | |a Nieminen, J., St-Pierre, C., Sato, S., Galectin-3 interacts with naive and primed neutrophils, inducing innate immune responses (2005) J Leukoc Biol, 78, pp. 1127-1135 | ||
| 504 | |a Stillman, B.N., Hsu, D.K., Pang, M., Brewer, C.F., Johnson, P., Liu, F.T., Baum, L.G., Galectin-3 and galectin-1 bind distinct cell surface glycoprotein receptors to induce T cell death (2006) J Immunol, 176, pp. 778-789 | ||
| 504 | |a Daniels, M.A., Hogquist, K.A., Jameson, S.C., Sweet 'n' sour: the impact of differential glycosylation on T cell responses (2002) Nat Immunol, 3, pp. 903-910 | ||
| 504 | |a Hernandez, J.D., Nguyen, J.T., He, J., Wang, W., Ardman, B., Green, J.M., Fukuda, M., Baum, L.G., Galectin-1 binds different CD43 glycoforms to cluster CD43 and regulate T cell death (2006) J Immunol, 177, pp. 5328-5336 | ||
| 504 | |a Siebert, H.C., Andre, S., Lu, S.Y., Frank, M., Kaltner, H., van Kuik, J.A., Korchagina, E.Y., Kaptein, R., Unique conformer selection of human growth-regulatory lectin galectin-1 for ganglioside GM1 versus bacterial toxins (2003) Biochemistry, 42, pp. 14762-14773 | ||
| 504 | |a Ohtsubo, K., Takamatsu, S., Minowa, M.T., Yoshida, A., Takeuchi, M., Marth, J.D., Dietary and genetic control of glucose transporter 2 glycosylation promotes insulin secretion in suppressing diabetes (2005) Cell, 123, pp. 1307-1321. , The authors describe a novel mechanism, based on galectin-9-glycoprotein lattice formation, by which glycosylation controls cell-surface expression of the glucose transporter 2 (GLUT-2) on the surface of β-cells, providing a link among receptor glycosylation, glucose metabolism and insulin production | ||
| 504 | |a Park, H.J., Partridge, E., Cheung, P., Pawling, J., Donovan, R., Wrana, J.L., Dennis, J.W., Chemical enhancers of cytokine signaling that suppress microfilament turnover and tumor cell growth (2006) Cancer Res, 66, pp. 3558-3566 | ||
| 504 | |a Lagana, A., Goetz, J.G., Cheung, P., Raz, A., Dennis, J.W., Nabi, I.R., Galectin binding to Mgat5-modified N-glycans regulates fibronectin matrix remodeling in tumor cells (2006) Mol Cell Biol, 26, pp. 3181-3193 | ||
| 504 | |a Rabinovich, G.A., Gruppi, A., Galectins as immunoregulators during infectious processes: from microbial invasion to the resolution of the disease (2005) Parasite Immunol, 27, pp. 103-114 | ||
| 504 | |a Pelletier, I., Hashidate, T., Urashima, T., Nishi, N., Nakamura, T., Futai, M., Arata, Y., Hirabayashi, J., Specific recognition of Leishmania major poly-beta-galactosyl epitopes by galectin-9: possible implication of galectin-9 in interaction between L. major and host cells (2003) J Biol Chem, 278, pp. 22223-22230 | ||
| 504 | |a Pelletier, I., Sato, S., Specific recognition and cleavage of galectin-3 by Leishmania major through species-specific polygalactose epitope (2002) J Biol Chem, 277, pp. 17663-17670 | ||
| 504 | |a Levroney, E.L., Aguilar, H.C., Fulcher, J.A., Kohatsu, L., Pace, K.E., Pang, M., Gurney, K.B., Lee, B., Novel innate immune functions for galectin-1: galectin-1 inhibits cell fusion by Nipah virus envelope glycoproteins and augments dendritic cell secretion of proinflammatory cytokines (2005) J Immunol, 175, pp. 413-420 | ||
| 504 | |a Ouellet, M., Mercier, S., Pelletier, I., Bounou, S., Roy, J., Hirabayashi, J., Sato, S., Tremblay, M.J., Galectin-1 acts as a soluble host factor that promotes HIV-1 infectivity through stabilization of virus attachment to host cells (2005) J Immunol, 174, pp. 4120-4126 | ||
| 504 | |a Tasumi, S., Vasta G, A galectin of unique domain organization from hemocytes of the eastern oyster (Crassostrea virginica) is a receptor for the protistan parasite Perkinsus marinus (2007) J Immunol, 179, pp. 3086-3098 | ||
| 504 | |a Fernandez, G.C., Ilarregui, J.M., Rubel, C.J., Toscano, M.A., Gomez, S.A., Beigier Bompadre, M., Isturiz, M.A., Palermo, M.S., Galectin-3 and soluble fibrinogen act in concert to modulate neutrophil activation and survival: involvement of alternative MAPK pathways (2005) Glycobiology, 15, pp. 519-527 | ||
| 504 | |a Barrionuevo, P., Beigier-Bompadre, M., Ilarregui, J.M., Toscano, M.A., Bianco, G.A., Isturiz, M.A., Rabinovich, G.A., A novel function for galectin-1 at the crossroad of innate and adaptive immunity: galectin-1 regulates monocyte/macrophage physiology through a nonapoptotic ERK-dependent pathway (2007) J Immunol, 178, pp. 436-445 | ||
| 504 | |a Demetriou, M., Granovsky, M., Quaggin, S., Dennis, J.W., Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation (2001) Nature, 409, pp. 733-739 | ||
| 504 | |a Morgan, R., Gao, G., Pawling, J., Dennis, J.W., Demetriou, M., Li, B., N-Acetylglucosaminyltransferase V (Mgat5)-mediated N-glycosylation negatively regulates Th1 cytokine production by T cells (2004) J Immunol, 173, pp. 7200-7208 | ||
| 504 | |a Grigorian, A., Lee, S.U., Tian, W., Chen, I.J., Gao, G., Mendelsohn, R., Dennis, J.W., Demetriou M, Control of T cell mediated autoimmunity by metabolite flux to N-glycan biosynthesis (2007) J Biol Chem, 282, pp. 20027-20035 | ||
| 504 | |a Fukumori, T., Takenaka, Y., Yoshii, T., Kim, H.R., Hogan, V., Inohara, H., Kagawa, S., Raz, A., CD29 and CD7 mediate galectin-3-induced type II T-cell apoptosis (2003) Cancer Res, 63, pp. 8302-8311 | ||
| 504 | |a Lu, L.H., Nakagawa, R., Kashio, Y., Ito, A., Shoji, H., Nishi, N., Hirashima, M., Nakamura, T., Characterization of galectin-9-induced death of Jurkat T cells (2007) J Biochem (Tokyo), 141, pp. 157-172 | ||
| 504 | |a Sturm, A., Lensch, M., Andre, S., Kaltner, H., Wiedenmann, B., Rosewicz, S., Dignass, A.U., Gabius, H.J., Human galectin-2: novel inducer of T cell apoptosis with distinct profile of caspase activation (2004) J Immunol, 173, pp. 3825-3837 | ||
| 504 | |a Daniels, M.A., Devine, L., Miller, J.D., Moser, J.M., Lukacher, A.E., Altman, J.D., Kavathas, P., Jameson, S.C., CD8 binding to MHC class I molecules is influenced by T cell maturation and glycosylation (2001) Immunity, 15, pp. 1051-1061 | ||
| 504 | |a Hernandez, J.D., Klein, J., Van Dyken, S.J., Marth, J.D., Baum, L.G., T-cell activation results in microheterogeneous changes in glycosylation of CD45 (2007) Int Immunol, 19, pp. 847-856 | ||
| 504 | |a Toscano, M.A., Bianco, G.A., Ilarregui, J.M., Croci, D.O., Correale, J., Hernandez, J.D., Zwirner, N.W., Baum, L.G., Differential glycosylation of T(H)1, T(H)2 and T(H)-17 effector cells selectively regulates susceptibility to cell death (2007) Nat Immunol, 8, pp. 825-834 | ||
| 504 | |a Comelli, E.M., Sutton-Smith, M., Yan, Q., Amado, M., Panico, M., Gilmartin, T., Whisenant, T., Goldberg, D., Activation of murine CD4+ and CD8+ T lymphocytes leads to dramatic remodeling of N-linked glycans (2006) J Immunol, 177, pp. 2431-2440 | ||
| 504 | |a van der Leij, J., van den Berg, A., Harms, G., Eschbach, H., Vos, H., Zwiers, P., van Weeghel, R., Visser, L., Strongly enhanced IL-10 production using stable galectin-1 homodimers (2007) Mol Immunol, 44, pp. 506-513 | ||
| 504 | |a Toscano, M.A., Commodaro, A.G., Ilarregui, J.M., Bianco, G.A., Liberman, A., Serra, H.M., Hirabayashi, J., Rabinovich, G.A., Galectin-1 suppresses autoimmune retinal disease by promoting concomitant Th2- and T regulatory-mediated anti-inflammatory responses (2006) J Immunol, 176, pp. 6323-6332 | ||
| 504 | |a Perone, M.J., Bertera, S., Tawadrous, Z.S., Shufesky, W.J., Piganelli, J.D., Baum, L.G., Trucco, M., Morelli, A.E., Dendritic cells expressing transgenic galectin-1 delay onset of autoimmune diabetes in mice (2006) J Immunol, 177, pp. 5278-5289 | ||
| 504 | |a Rubinstein, N., Alvarez, M., Zwirner, N.W., Toscano, M.A., Ilarregui, J.M., Bravo, A., Mordoh, J., Rabinovich, G.A., Targeted inhibition of galectin-1 gene expression in tumor cells results in heightened T cell-mediated rejection; a potential mechanism of tumor-immune privilege (2004) Cancer Cell, 5, pp. 241-251 | ||
| 504 | |a Zhu, C., Anderson, A.C., Schubart, A., Xiong, H., Imitola, J., Khoury, S.J., Zheng, X.X., Kuchroo, V.K., The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity (2005) Nat Immunol, 6, pp. 1245-1252. , An innovative work identifying galectin-9 as a novel binding partner for Tim-3 and describing the relevance of this interaction in the regulation of Th1-mediated autoimmune inflammation | ||
| 504 | |a Stowell, S.R., Karmakar, S., Stowell, C.J., Dias-Baruffi, M., McEver, R.P., Cummings, R.D., Human galectin-1, -2, and -4 induce surface exposure of phosphatidylserine in activated human neutrophils but not in activated T cells (2007) Blood, 109, pp. 219-227 | ||
| 504 | |a Hokama, A., Mizoguchi, E., Sugimoto, K., Shimomura, Y., Tanaka, Y., Yoshida, M., Rietdijk, S.T., Terhorst, C., Induced reactivity of intestinal CD4(+) T cells with an epithelial cell lectin, galectin-4, contributes to exacerbation of intestinal inflammation (2004) Immunity, 20, pp. 681-693 | ||
| 504 | |a Garin, M.I., Chu, C.C., Golshayan, D., Cernuda-Morollon, E., Wait, R., Lechler, R.I., Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells (2007) Blood, 109, pp. 2058-2065 | ||
| 504 | |a Kubach, J., Lutter, P., Bopp, T., Stoll, S., Becker, C., Huter, E., Richter, C., Knop, J., Human CD4+CD25+ regulatory T cells: proteome analysis identifies galectin-10 as a novel marker essential for their anergy and suppressive function (2007) Blood, 110, pp. 1550-1558. , Ref. 49 and 50 clearly demonstrate the contribution of galectins to the suppressive activity of CD4+CD25+ regulatory T cells | ||
| 504 | |a Gauthier, L., Rossi, B., Roux, F., Termine, E., Schiff, C., Galectin-1 is a stromal cell ligand of the pre-B cell receptor (BCR) implicated in synapse formation between pre-B and stromal cells and in pre-BCR triggering (2002) Proc Natl Acad Sci U S A, 99, pp. 13014-13019 | ||
| 504 | |a Rossi, B., Espeli, M., Schiff, C., Gauthier, L., Clustering of pre-B cell integrins induces galectin-1-dependent pre-B cell receptor relocalization and activation (2006) J Immunol, 177, pp. 796-803. , The authors describe the relevance of galectin-1-glycoprotein lattices in pre-B/stromal cell synapse formation, pre-BCR receptor segregation and activation | ||
| 504 | |a Yu, X., Siegel, R., Roeder, R.G., Interaction of the B cell-specific transcriptional coactivator OCA-B and galectin-1 and a possible role in regulating BCR-mediated B cell proliferation (2006) J Biol Chem, 281, pp. 15505-15516 | ||
| 504 | |a Clark, A.G., Chen, S., Zhang, H., Brady, G.F., Ungewitter, E.K., Bradley, J.K., Sackey, F.N., Foster, M.H., Multifunctional regulators of cell growth are differentially expressed in anergic murine B cells (2007) Mol Immunol, 44, pp. 1274-1285 | ||
| 520 | 3 | |a Programmed remodeling of cell surface glycans by the sequential action of specific glycosyltransferases can control biological processes by generating or masking ligands for endogenous lectins. Galectins, a family of animal lectins with affinity for β-galactosides, can form multivalent complexes with cell surface glycoconjugates and deliver a variety of intracellular signals to modulate cell activation, differentiation, and survival. Recent efforts involving genetic or biochemical manipulation of O-glycosylation and N-glycosylation pathways, as well as blockade of the synthesis of endogenous galectins, have illuminated essential roles for galectin-glycoprotein lattices in the control of biological processes including receptor turnover and endocytosis, host-pathogen interactions, and immune cell activation and homeostasis. © 2007 Elsevier Ltd. All rights reserved. |l eng | |
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires, M091 | ||
| 536 | |a Detalles de la financiación: R01 GM070589-01 | ||
| 536 | |a Detalles de la financiación: National Science Foundation, NA05NMF4571243 | ||
| 536 | |a Detalles de la financiación: National Oceanic and Atmospheric Administration, F32GM083352 | ||
| 536 | |a Detalles de la financiación: National Science and Technology Development Agency, PICT 2003-05-13787 | ||
| 536 | |a Detalles de la financiación: National Institutes of Health, IOB 0618409 | ||
| 536 | |a Detalles de la financiación: Cancer Research Institute | ||
| 536 | |a Detalles de la financiación: National Institute of General Medical Sciences | ||
| 536 | |a Detalles de la financiación: We thank members of the Rabinovich and Vasta Laboratories for critical comments and discussion. We apologize to the many authors whose excellent papers could not be cited in this review for space limitations. Work in GAR's Laboratory is supported by The Cancer Research Institute ‘Elaine R Shepard Memorial Investigator’, National Agency for Promotion of Science and Technology (PICT 2003-05-13787), University of Buenos Aires (M091), and a Program of Fundación Sales/CONICET. Work in GRV's Laboratory is supported by grants R01 GM070589-01 from the National Institutes of Health, IOB 0618409 from the National Science Foundation, and NA05NMF4571243 from the National Oceanic and Atmospheric Administration. SSJ is supported by grant F32GM083352 from the National Institute of General Medical Sciences. | ||
| 593 | |a Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental IBYME, CONICET, Vuelta de Obligado 2490, C1428ADN Buenos Aires, Argentina | ||
| 593 | |a Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, C1428ADN Buenos Aires, Argentina | ||
| 593 | |a Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, MD 21202, United States | ||
| 690 | 1 | 0 | |a B LYMPHOCYTE RECEPTOR |
| 690 | 1 | 0 | |a BETA GALACTOSIDE |
| 690 | 1 | 0 | |a GALECTIN |
| 690 | 1 | 0 | |a GLYCOCONJUGATE |
| 690 | 1 | 0 | |a GLYCOPROTEIN |
| 690 | 1 | 0 | |a T LYMPHOCYTE RECEPTOR |
| 690 | 1 | 0 | |a BINDING AFFINITY |
| 690 | 1 | 0 | |a CELL ACTIVATION |
| 690 | 1 | 0 | |a CELL DEATH |
| 690 | 1 | 0 | |a CELL DIFFERENTIATION |
| 690 | 1 | 0 | |a CELL SURFACE |
| 690 | 1 | 0 | |a CELL SURVIVAL |
| 690 | 1 | 0 | |a COMPLEX FORMATION |
| 690 | 1 | 0 | |a ENDOCYTOSIS |
| 690 | 1 | 0 | |a GLYCOSYLATION |
| 690 | 1 | 0 | |a HELPER CELL |
| 690 | 1 | 0 | |a HOST PATHOGEN INTERACTION |
| 690 | 1 | 0 | |a IMMUNOCOMPETENT CELL |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a OYSTER |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROTEIN CARBOHYDRATE INTERACTION |
| 690 | 1 | 0 | |a PROTEIN FUNCTION |
| 690 | 1 | 0 | |a PROTEIN PROTEIN INTERACTION |
| 690 | 1 | 0 | |a PROTEIN STRUCTURE |
| 690 | 1 | 0 | |a PROTEIN SYNTHESIS |
| 690 | 1 | 0 | |a REGULATORY MECHANISM |
| 690 | 1 | 0 | |a REVIEW |
| 690 | 1 | 0 | |a SIGNAL TRANSDUCTION |
| 690 | 1 | 0 | |a TANDEM REPEAT |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a B-LYMPHOCYTES |
| 690 | 1 | 0 | |a CELL MEMBRANE |
| 690 | 1 | 0 | |a GALECTINS |
| 690 | 1 | 0 | |a HOST-PATHOGEN INTERACTIONS |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a IMMUNITY, NATURAL |
| 690 | 1 | 0 | |a MEMBRANE GLYCOPROTEINS |
| 690 | 1 | 0 | |a MODELS, MOLECULAR |
| 690 | 1 | 0 | |a MULTIPROTEIN COMPLEXES |
| 690 | 1 | 0 | |a T-LYMPHOCYTES |
| 690 | 1 | 0 | |a ANIMALIA |
| 650 | 1 | 7 | |2 spines |a HOMEOSTASIS |
| 700 | 1 | |a Toscano, M.A. | |
| 700 | 1 | |a Jackson, S.S. | |
| 700 | 1 | |a Vasta, G.R. | |
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