Effect of nitroxyl on the hamster retinal nitridergic pathway
There is a growing body of evidence on the role of nitric oxide (NO) in retinal physiology. Recently, interest has developed in the functional role of an alternative redox form of NO, namely nitroxyl (HNO/NO-), because it is formed by a number of diverse biochemical reactions. The aim of the present...
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2007
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| 024 | 7 | |2 cas |a arginine, 1119-34-2, 15595-35-4, 7004-12-8, 74-79-3; cyclic GMP, 7665-99-8; glutathione, 70-18-8; nitric oxide, 10102-43-9; nitric oxide synthase, 125978-95-2; Antioxidants; Arginine, 74-79-3; Cyclic GMP, 7665-99-8; Glutathione, 70-18-8; Nitric Oxide, 10102-43-9; Nitric Oxide Synthase, 1.14.13.39; Nitrites; Nitrogen Oxides; Quaternary Ammonium Compounds; S-Nitrosothiols; diethylammonium-1-(N,N-diethylamino)diazen-1-ium-1,2-diolate; nitroxyl, 14332-28-6; oxyhyponitrite, 18550-55-5 | |
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| 100 | 1 | |a Sáenz, D.A. | |
| 245 | 1 | 0 | |a Effect of nitroxyl on the hamster retinal nitridergic pathway |
| 260 | |c 2007 | ||
| 270 | 1 | 0 | |m Rosenstein, R.E.; Laboratorio de Neuroquímica Retiniana y Oftalmología Experimental, Departamento de Bioquímica Humana, Facultad de Medicina, Buenos Aires, Argentina; email: ruthr@fmed.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a There is a growing body of evidence on the role of nitric oxide (NO) in retinal physiology. Recently, interest has developed in the functional role of an alternative redox form of NO, namely nitroxyl (HNO/NO-), because it is formed by a number of diverse biochemical reactions. The aim of the present report was to comparatively analyze the effect of HNO and NO on the retinal nitridergic pathway in the golden hamster. For this purpose, sodium trioxodinitrate (Angeli's salt) and diethylammonium (Z)-1-(N,N-diethylamino)diazen-1-ium-1,2-diolate (DEA/NO) were used as HNO and NO releasers, respectively. Angeli's salt and DEA/NO significantly decreased nitric oxide synthase activity. In addition, Angeli's salt (but not DEA/NO) significantly decreased l-arginine uptake. DEA/NO significantly increased cGMP accumulation at low micromolar concentrations, while Angeli's salt affected this parameter with a threshold concentration of 200 μM. Although Angeli's salt and DEA/NO significantly diminished reduced glutathione and protein thiol levels in a similar way, DEA/NO was significantly more effective than AS in increasing S-nitrosothiol levels. None of these compounds increased retinal lipid peroxidation. These results suggest that HNO could regulate the hamster retinal nitridergic pathway by acting through a mechanism that only partly overlaps with that involved in NO response. © 2007 Elsevier Ltd. All rights reserved. |l eng | |
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires | ||
| 536 | |a Detalles de la financiación: Agencia Nacional de Promoción Científica y Tecnológica | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: This research was supported by grants from the Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT), University of Buenos Aires, and CONICET. | ||
| 593 | |a Laboratorio de Neuroquímica Retiniana y Oftalmología Experimental, Departamento de Bioquímica Humana, Facultad de Medicina, Buenos Aires, Argentina | ||
| 593 | |a Departamento de Química Inorgánica, Analítica y Química Física/INQUIMAE, Facultad de Ciencias Exactas y Naturales, Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a NITRIC OXIDE |
| 690 | 1 | 0 | |a NITROXYL |
| 690 | 1 | 0 | |a RETINA |
| 690 | 1 | 0 | |a AMINE |
| 690 | 1 | 0 | |a AMMONIUM DERIVATIVE |
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| 690 | 1 | 0 | |a CYCLIC GMP |
| 690 | 1 | 0 | |a DIETHYLAMMONIUM 1 (N,N DIETHYLAMINO)DIAZEN 1 IUM 1,2 DIOLATE |
| 690 | 1 | 0 | |a GLUTATHIONE |
| 690 | 1 | 0 | |a NITRIC ACID DERIVATIVE |
| 690 | 1 | 0 | |a NITRIC OXIDE |
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| 690 | 1 | 0 | |a NITROXYL |
| 690 | 1 | 0 | |a S NITROSOTHIOL |
| 690 | 1 | 0 | |a SODIUM DERIVATIVE |
| 690 | 1 | 0 | |a SODIUM TRIOXODINITRATE |
| 690 | 1 | 0 | |a THIOL |
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| 700 | 1 | |a Bari, S.E. | |
| 700 | 1 | |a Salido, E. | |
| 700 | 1 | |a Chianelli, M. | |
| 700 | 1 | |a Rosenstein, R.E. | |
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