Ion transport in tumors under electrochemical treatment: In vivo, in vitro and in silico modeling
The electrochemical treatment of cancer (EChT) consists in the passage of a direct electric current through two or more electrodes inserted locally in the tumor tissue. The extreme pH changes induced have been proposed as the main tumor destruction mechanism. Here, we study ion transport during EChT...
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2007
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 14296caa a22016337a 4500 | ||
|---|---|---|---|
| 001 | PAPER-6299 | ||
| 003 | AR-BaUEN | ||
| 005 | 20251103082219.0 | ||
| 008 | 190411s2007 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-35348851889 | |
| 024 | 7 | |2 cas |a agar, 9002-18-0 | |
| 030 | |a BIOEF | ||
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 100 | 1 | |a Colombo, L. | |
| 245 | 1 | 0 | |a Ion transport in tumors under electrochemical treatment: In vivo, in vitro and in silico modeling |
| 260 | |c 2007 | ||
| 270 | 1 | 0 | |m Marshall, G.; Laboratorio de Sistemas Complejos, Departamento de Computación, FCEyN, C1428EGA Buenos Aires, Argentina; email: marshallg@arnet.com.ar |
| 504 | |a Nilsson, E., von Euler, H., Berendson, J., Thorne, A., Wersall, P., Naslund, I., Lagerstedt, A., Narfstrom, K., J. Olsson, electrochemical treatment of tumours (2000) Bioelectrochemistry, 51, pp. 1-11 | ||
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| 504 | |a Ramanujan, S., Pluen, A., McKee, T., Brown, E., Boucher, Y., Jain, R., Diffussion and convection in collagen gels: implications for transport in the tumor interstitium (2002) Biophysics Journal, 83 (3), pp. 1650-1660 | ||
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| 504 | |a Marshall, G., Mocskos, P., A growth model for ramified electrochemical deposition in the presence of diffusion, migration and electroconvection (1997) Physical Review E, Statistical, Nonlinear, and Soft Matter Physics, 55, p. 549 | ||
| 504 | |a Marshall, G., Mocskos, P., Swinney, H.L., Huth, J.M., Buoyancy and electrical driven convection (1999) Physical Review E, Statistical, Nonlinear, and Soft Matter Physics, 59, p. 2157 | ||
| 504 | |a Dengra, S., Marshall, G., Molina, F., Front tracking in thin-layer electrodeposition (2000) Journal of the Physical Society of Japan, 69 (3), pp. 963-971 | ||
| 504 | |a Gonzalez, G., Marshall, G., Molina, F.V., Dengra, S., Rosso, M., Viscosity effects in thin-layer electrodeposition (2001) Journal of The Electrochemical Society, 148 (7), pp. C479-C487 | ||
| 504 | |a Gonzalez, G., Marshall, G., Molina, F., Dengra, S., Transition from gravito- to electroconvective regimes in thin-layer electrodeposition (2002) Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics, 65 (5), p. 051607 | ||
| 504 | |a Marshall, G., Mocskos, E., Molina, F.V., Dengra, S., Three-dimensional nature of ion transport in thin-layer electrodeposition (2003) Physical Review E, Statistical, Nonlinear, and Soft Matter Physics, 68 (2), p. 021607 | ||
| 504 | |a Marshall, G., Molina, F., Soba, A., Ion transport in thin cell electrodeposition: modelling three-ion electrolytes in dense branched morphology under constant voltage and current conditions (2005) Electrochimica Acta, 50, pp. 3436-3445 | ||
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| 504 | |a Pluen, A., Boucher, Y., Ramanujan, S., McKee, T., Gohongi, T., di Tomaso, E., Brown, E., Jain, R., Role of tumor-host interactions in interstitial diffusion of macromolecules: cranial vs subcutaneous tumors (2001) Proceedings of the National Academy of Sciences, 98 (8), pp. 4628-4633 | ||
| 506 | |2 openaire |e Política editorial | ||
| 520 | 3 | |a The electrochemical treatment of cancer (EChT) consists in the passage of a direct electric current through two or more electrodes inserted locally in the tumor tissue. The extreme pH changes induced have been proposed as the main tumor destruction mechanism. Here, we study ion transport during EChT through a combined modeling methodology: in vivo modeling with BALB/c mice bearing a subcutaneous tumor, in vitro modeling with agar and collagen gels, and in silico modeling using the one-dimensional Nernst-Planck and Poisson equations for ion transport in a four-ion electrolyte. This combined modeling approach reveals that, under EChT modeling, an initial condition with almost neutral pH evolves between electrodes into extreme cathodic alkaline and anodic acidic fronts moving towards each other, leaving the possible existence of a biological pH region between them; towards the periphery, the pH decays to its neutral values. pH front tracking unveils a time scaling close to t1/2, signature of a diffusion-controlled process. These results could have significant implications in EChT optimal operative conditions and dose planning, in particular, in the way in which the evolving EChT pH region covers the active cancer cells spherical casket. © 2007 Elsevier B.V. All rights reserved. |l eng | |
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires | ||
| 536 | |a Detalles de la financiación: Agencia Nacional de Promoción Científica y Tecnológica | ||
| 536 | |a Detalles de la financiación: Microsoft | ||
| 536 | |a Detalles de la financiación: PIP 379/98, PICTR 184, X122/04 | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: We thank anonymous referees for their valuable comments. L. C., G. G., G. M., F. M. and C. S. are investigators at the Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). C. S. has a fellowship from the Agencia Nacional de Promoción Científica y Técnica (ANPCyT). A. S. is partially supported by University of Buenos Aires (UBA). P. T. has a fellowship from CONICET. This work was partially supported by grants from UBA-CyT X122/04, ANPCyT: PICTR 184, CONICET: PIP 379/98 and Microsoft RFP2006 Digital Inclusion in Health and Higher Education Project. | ||
| 593 | |a Depto. de Inmunobiología, Inst. de Oncología Angel H. Roffo, Universidad de Buenos Aires, C1417DTB Buenos Aires, Argentina | ||
| 593 | |a Laboratorio de Sistemas Complejos, Departamento de Computación, FCEyN, C1428EGA Buenos Aires, Argentina | ||
| 593 | |a INQUIMAE, FCEyN, Universidad de Buenos Aires, C1428EHA Buenos Aires, Argentina | ||
| 650 | 1 | 7 | |2 spines |a PH |
| 650 | 1 | 7 | |2 spines |a NECROSIS |
| 690 | 1 | 0 | |a COMPUTATIONAL MODELING |
| 690 | 1 | 0 | |a ELECTROCHEMICAL TREATMENT |
| 690 | 1 | 0 | |a ION TRANSPORT |
| 690 | 1 | 0 | |a TUMORS |
| 690 | 1 | 0 | |a CHARGE TRANSFER |
| 690 | 1 | 0 | |a COLLAGEN |
| 690 | 1 | 0 | |a COMPUTATIONAL METHODS |
| 690 | 1 | 0 | |a ELECTRIC CURRENTS |
| 690 | 1 | 0 | |a ELECTROCHEMISTRY |
| 690 | 1 | 0 | |a ELECTRODES |
| 690 | 1 | 0 | |a PATIENT TREATMENT |
| 690 | 1 | 0 | |a COMPUTATIONAL MODELING |
| 690 | 1 | 0 | |a ELECTROCHEMICAL TREATMENT |
| 690 | 1 | 0 | |a ION TRANSPORT |
| 690 | 1 | 0 | |a POISSON EQUATIONS |
| 690 | 1 | 0 | |a TUMORS |
| 690 | 1 | 0 | |a AGAR |
| 690 | 1 | 0 | |a COLLAGEN GEL |
| 690 | 1 | 0 | |a ELECTROLYTE |
| 690 | 1 | 0 | |a ACIDITY |
| 690 | 1 | 0 | |a ALKALINITY |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ANIMAL MODEL |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a BAGG ALBINO MOUSE |
| 690 | 1 | 0 | |a CANCER MODEL |
| 690 | 1 | 0 | |a COMPUTER MODEL |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a ELECTRIC CURRENT |
| 690 | 1 | 0 | |a ELECTROCHEMISTRY |
| 690 | 1 | 0 | |a ELECTRODE |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a HUMAN CELL |
| 690 | 1 | 0 | |a IN VITRO STUDY |
| 690 | 1 | 0 | |a IN VIVO STUDY |
| 690 | 1 | 0 | |a ION TRANSPORT |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MOUSE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a SUBCUTANEOUS TISSUE TUMOR |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a COMPUTATIONAL BIOLOGY |
| 690 | 1 | 0 | |a ELECTRIC CONDUCTIVITY |
| 690 | 1 | 0 | |a ELECTRIC STIMULATION |
| 690 | 1 | 0 | |a ELECTROCHEMISTRY |
| 690 | 1 | 0 | |a ELECTRODES |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a HYDROGEN-ION CONCENTRATION |
| 690 | 1 | 0 | |a ION TRANSPORT |
| 690 | 1 | 0 | |a MICE |
| 690 | 1 | 0 | |a MICE, INBRED BALB C |
| 690 | 1 | 0 | |a MODELS, BIOLOGICAL |
| 690 | 1 | 0 | |a NEOPLASMS |
| 690 | 1 | 0 | |a MUS |
| 700 | 1 | |a González, Graciela Alicia | |
| 700 | 1 | |a Marshall, Guillermo Ricardo | |
| 700 | 1 | |a Molina, F.V. | |
| 700 | 1 | |a Soba, Alejandro | |
| 700 | 1 | |a Suarez, C. | |
| 700 | 1 | |a Turjanski, P. | |
| 773 | 0 | |d 2007 |g v. 71 |h pp. 223-232 |k n. 2 |p Bioelectrochemistry |x 15675394 |w (AR-BaUEN)CENRE-3947 |t Bioelectrochemistry | |
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| 856 | 4 | 0 | |u https://doi.org/10.1016/j.bioelechem.2007.07.001 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_15675394_v71_n2_p223_Colombo |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15675394_v71_n2_p223_Colombo |y Registro en la Biblioteca Digital |
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