The lethal principle of Poa huecu (Coiron Blanco): a plant indigenous to Argentina
A. B. Pomilio, R. D. Rofi, M. P. Gambino, C. A. Mazzini and R. T. Debenedetti de Langenheim. The lethal principle of Poa huecu (Coiron Blanco): a plant indigenous to Argentina. Toxicon 27, 1251-1262, 1989.-The lethality of Poa huecu, a plant toxic to cattle and sheep, was followed by injection of ch...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
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1989
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 09548caa a22010937a 4500 | ||
|---|---|---|---|
| 001 | PAPER-623 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518202958.0 | ||
| 008 | 190411s1989 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0024910340 | |
| 024 | 7 | |2 cas |a Amino Acids; Carbohydrates; Plant Extracts | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a TOXIA | ||
| 100 | 1 | |a Pomilio, A.B. | |
| 245 | 1 | 4 | |a The lethal principle of Poa huecu (Coiron Blanco): a plant indigenous to Argentina |
| 260 | |c 1989 | ||
| 270 | 1 | 0 | |m Pomilio, A.B.; Departamento de Quimica Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellon 2, Ciudad Universitaria, 1428 Buenos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Aasen, Cluvenor, Finnie, Kellock, Smith, Alkaloids as a possible cause of ryegrass staggers in grazing livestock (1969) Australian Journal of Agricultural Research, 20, pp. 71-86 | ||
| 504 | |a Acosta, “l Huecú” (1913) Bol. Minist. Agric. Rep. Argentina, 16, pp. 1-14 | ||
| 504 | |a Bacon, Lyons, Porter, Robbins, Ergot toxicity from endophyte-infected grasses a review (1986) Agronomy Journal, 78, pp. 106-116 | ||
| 504 | |a Bonazzi, Ortiz, “Intoxicación experimental de ovinos con Poa huecu” (1979) Informe técnico No. 10, Instituto Nacional de Tecnología Agropecuaria (INTA), Estación Experimental de San Carlos de Bariloche, Argentina | ||
| 504 | |a Corbellini, Ruksan, Miquet, Blanco Viera, Etchegoyen, Sala de Miguel, Carrillo, Reproducción experimental del “Mal de Huecú” en ovinos. I. Caracterización clínica, anatomo-histo-patológica, hematológica y bioquímica de la intoxicación (1981) Rev. Inv. Agrop. INTA, 16, pp. 159-170 | ||
| 504 | |a Dubois, Gilles, Hamilton, Rebers, Smith, Colorimetric method for determination of sugars and related substances (1956) Analyt. Chem., 28, pp. 350-356 | ||
| 504 | |a Laemmli, Cleavage of structural proteins during the assembly of the head of bacteriophage T4 (1970) Nature, Lond., 227, pp. 680-685 | ||
| 504 | |a Lowry, Rosebrough, Farr, Randall, Protein measurement with the folin phenol reagent (1951) J. biol. Chem., 193, pp. 265-275 | ||
| 504 | |a Lyons, Plattner, Bacon, Occurrence of peptide and clavine ergot alkaloids in tall fescue grass (1986) Science, 232, pp. 487-489 | ||
| 504 | |a Morgan-Jones, Gams, Notes on Hyphomycetes. XLI. An endophyte of Festuca arundinacea and the anamorph of Epichloe typhina, new taxa in one of two new sections of Acremonium (1982) Mycotaxon, 15, pp. 311-318 | ||
| 504 | |a Nicora, Gramineae (1978) Flora Patagónica, 8, pp. 177-179. , Colección Científica del Instituto Nacional de Tecnología Agropecuaria (INTA), Buenos Aires, Part III | ||
| 504 | |a Parodi, Las Gramineas tóxicas para el ganado en la República Argentina (1950) Rev. Arg. Agron., 17, pp. 163-227 | ||
| 504 | |a Rofi, Pomilio, Sterols and flavone from Poa huecu (1982) Fitoterapia (Milano), 53, pp. 183-187 | ||
| 504 | |a Rofi, Pomilio, 3′,5,7-Trihydroxy-4′,5′-dimethoxyflavone and other phenolics from Poa huecu (1985) Phytochemistry, 24, pp. 2131-2132 | ||
| 504 | |a Rofi, Pomilio, Triterpenoids and other components of Poa huecu (1987) J. nat. Products, 50, pp. 767-768 | ||
| 504 | |a Rofi, Pomilio, Luteolin 6-C-β-ristobioside from Poa annua (1987) Phytochemistry, 26, pp. 859-860 | ||
| 504 | |a Sharon, Glycoproteins—II: isolation and characterization (1975) Complex Carbohydrates. Their Chemistry, Biosynthesis, and Functions, p. 48. , Addison-Wesley, Reading, MA | ||
| 504 | |a Siegel, Latch, Johnson, Acremonium fungal endophytes in tall fescue and perennial ryegrass: significance and control (1985) Plant Dis., 69, pp. 179-183 | ||
| 504 | |a Tomes, Viale, Buschi, Rofi, Schteingart, Iñigo, Zallocchi, Pomilio, Antimicrobial screening of some Argentine higher plants. Part II (1986) Fitoterapia (Milano), 57, pp. 46-50 | ||
| 504 | |a White, Jr, Cole, Endophyte-host associations in forage grasses I Distribution of fungal endophytes in some species of Lolium and Festuca (1985) Mycologia, 77, pp. 323-327 | ||
| 504 | |a White, Jr, Cole, Endophyte-host associations in forage grasses. II. Taxonomic observations on the endophyte of Festuca arundinacea (1985) Mycologia, 77, pp. 484-485 | ||
| 504 | |a White, Jr, Cole, Endophyte-host associations in forage grasses IV The endophyte of Festuca versuta (1986) Mycologia, 78, pp. 102-107 | ||
| 520 | 3 | |a A. B. Pomilio, R. D. Rofi, M. P. Gambino, C. A. Mazzini and R. T. Debenedetti de Langenheim. The lethal principle of Poa huecu (Coiron Blanco): a plant indigenous to Argentina. Toxicon 27, 1251-1262, 1989.-The lethality of Poa huecu, a plant toxic to cattle and sheep, was followed by injection of chromatographic fractions in mice. The lethal aqueous extract was administered i.p. to Rockland mice of either sex and produced motor incoordination, transient ataxia, rough hair coat, tremors and muscle contractions and, occasionally, blindness. Doses greater than 1.5 g/kg mouse were always lethal. Fractionation of this lethal extract included dialysis, column chromatography on Sephadex G-25 and fractional precipitation with ethanol. Precipitates obtained with 70% and 85% ethanol were further purified on a DEAE-cellulose column. Eight fractions were obtained, each was injected into mice. Only fractions 3-6 were toxic. Fraction 3 produced slight hepatosis and hyperemia in the liver and gliosis in the brain. None of the other tissues exhibited histological lesions. Fractions 4 and 5 caused death of all animals within 30 min to 4 hr after injection. Polyacrylamide gel electrophoresis and acid hydrolysis showed that fractions 4 and 5 contained a glycoprotein of nearly the same mol. wt (67,000-94,000). Microscopic pathology in the mice treated with the lethal glycoprotein of fraction 4 included hyperemia in the kidneys, megakaryocytes in the spleen, slight hepatosis and focal coagulative necrosis with nuclear pyknosis and karyonexis in the liver, gliosis, intracellular brain edema with axon degeneration and swollen astrocytes in the brain. These brain injuries may relate to the motor incoordination of cattle that causes a delayed righting reflex. The major monosaccharides of the lethal glycoprotein are glucose and mannose, while rhamnose, arabinose, xylose and galactose are present in low percentages. Proline and the acidic amino acids (glutamic and aspartic acids) are the most abundant in the peptidic residue. © 1989. |l eng | |
| 536 | |a Detalles de la financiación: Comisión de Investigaciones Científicas | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: Acknowledgement.~Thanks are due to Ing. At.~tEOO V~uEZ (INTA, Zapala, Argentina) for supplying plant material; to Dr E. G. N~coxA (Instituto de Botânica Darwinion, Buenos Aires, Argentina) for identification of this plant material; to Dr G. J. WYttrtE DE MAx~rtta~ (Multilab SRL, Argentina) for supplying some of the mice; to Prof. Dr Axruxo A. VITAt.e (UBA, Argentina) for his helpful assistance in taking micrographs; and to CONICET (Argentina) for financial support. One of us (R.D .R.) also thanks CIC (Argentina) for a research fellowship. | ||
| 593 | |a Departamento de Quimica Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellon 2, Ciudad Universitaria, 1428 Buenos Aires, Argentina | ||
| 593 | |a Facultad de Ciencias Agrarias, Universidad Católica Argentina, Buenos Aires, Argentina | ||
| 593 | |a Facultad de Ciencias Veterinarias, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a PLANT TOXIN |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a ATAXIA |
| 690 | 1 | 0 | |a BLINDNESS |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a LETHALITY |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MOUSE |
| 690 | 1 | 0 | |a MUSCLE CONTRACTION |
| 690 | 1 | 0 | |a NEUROTOXICITY |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a TREMOR |
| 690 | 1 | 0 | |a AMINO ACIDS |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a BRAIN |
| 690 | 1 | 0 | |a CARBOHYDRATES |
| 690 | 1 | 0 | |a CHEMISTRY |
| 690 | 1 | 0 | |a CHROMATOGRAPHY, GEL |
| 690 | 1 | 0 | |a ELECTROPHORESIS, POLYACRYLAMIDE GEL |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a FRACTIONAL PRECIPITATION |
| 690 | 1 | 0 | |a HYDROLYSIS |
| 690 | 1 | 0 | |a LIVER |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MICE |
| 690 | 1 | 0 | |a PLANT EXTRACTS |
| 690 | 1 | 0 | |a PLANTS, TOXIC |
| 690 | 1 | 0 | |a SUPPORT, NON-U.S. GOV'T |
| 690 | 1 | 0 | |a ANIMALIA |
| 690 | 1 | 0 | |a ATAXIA |
| 690 | 1 | 0 | |a BOS TAURUS |
| 690 | 1 | 0 | |a OVIS ARIES |
| 690 | 1 | 0 | |a POA |
| 651 | 4 | |a ARGENTINA | |
| 700 | 1 | |a Rofi, R.D. | |
| 700 | 1 | |a Gambino, M.P. | |
| 700 | 1 | |a Mazzini, C.A. | |
| 700 | 1 | |a De Lange nheim, R.T.D. | |
| 773 | 0 | |d 1989 |g v. 27 |h pp. 1251-1262 |k n. 12 |p Toxicon |x 00410101 |w (AR-BaUEN)CENRE-7050 |t Toxicon | |
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| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00410101_v27_n12_p1251_Pomilio |y Handle |
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