Cyanide intoxication-III. On the analogous and different effects provoked by non-lethal and lethal challenged doses
1. 1. The effect of acute cyanide administration to mice in a lethal and a non-lethal dose and the anti-cyanide effect of S-adenosyl-l-methionine (SAM) and thiosulphate were investigated. 2. 2. The poisoning action was determined by measuring cytochrome oxidase, rhodanese and δ-aminolevulinic acid d...
Guardado en:
| Autor principal: | |
|---|---|
| Otros Autores: | , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1990
|
| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| Sumario: | 1. 1. The effect of acute cyanide administration to mice in a lethal and a non-lethal dose and the anti-cyanide effect of S-adenosyl-l-methionine (SAM) and thiosulphate were investigated. 2. 2. The poisoning action was determined by measuring cytochrome oxidase, rhodanese and δ-aminolevulinic acid dehydratase (ALA-D) activity. 3. 3. The toxic metabolizing degree was investigated by measuring plasma and urine thiocyanate levels. 4. 4. The state of the sulfane sulfur pool was investigated by determining cyanide labile-sulfur levels. 5. 5. These results support the belief that rhodanese plays a fundamental role in the detoxification process only when high levels of cyanide are administered. © 1990. |
|---|---|
| Bibliografía: | Batlle, Ferramola, Grinstein, Purification and general properties of δ-aminolevulate dehydratase from cow liver (1977) Biochem. J., 104, pp. 244-249 Buzaleh, Vázquez, Batlle, (1990) In vitro effect of cyanide, thiosulphate and S-adenosyl-l-methionine on the activity of rhodanese and other enzymes, , In preparation Guilbault, Kramer, Specific Detection and Determination of Cyanide Using Various Quinone Derivatives. (1965) Analytical Chemistry, 37, pp. 1395-1399 Himwich, Saunders, Enzymatic conversion of cyanide to thiocyanate. (1948) Am J Physiol, 153, pp. 348-354 Isom, Way, Lethality of cyanide in the absence of inhibition of liver cytochrome oxidase (1976) Biochemical Pharmacology, 25, pp. 605-608 Koh, The Determination of Micro Amounts of Polythionates. I. A Photometric Method for the Determination of Pentathionate by Means of Its Cyanolysis (1965) Bulletin of the Chemical Society of Japan, 38, pp. 1510-1515 Lowry, Rosebrough, Farr, Randall, Protein measurement with the Folin phenol reagent. (1951) J Biol Chem, 193, pp. 265-275 Pettersen, Cohen, Antagonism of cyanide poisoning by chlorpromazine and sodium thiosulfate*1 (1985) Toxicology and Applied Pharmacology, 81, pp. 265-273 Rutkowski, Roebuck, Smith, Effects of protein-free diet and food deprivation on hepatic rhodanese activity, serum proteins and acute cyanide lethality in mice. (1985) J Nutr, 115, pp. 132-137 Schubert, Brill, Antagonism of experimental cyanide toxicity in relation to the in vitro activity of cytochrome oxidase (1978) J. Pharmac. Exp. Ther., 162, pp. 352-359 Solomonson, Cyanide as metabolic inhibitor (1982) Cyanide in Biology, pp. 11-28. , Academic Press, London Sörbo, Crystalline Rhodanese. I. Purification and Physicochemical Examination. (1953) Acta Chemica Scandinavica, 7, pp. 1129-1136 Sylvester, Saunders, Hayton, Way, Alteration on the pharmacokinetics of sodium cyanide by sodium thiosulphate (1981) Proc. West. Pharmac. Soc., 24, pp. 135-136 Westley, Rhodanese and the sulfane pool (1980) Enzymatic Basis of Detoxication, 2, pp. 245-263. , Academic Press, London, chapter 13 Westley, Rhodanese (1981) Methods in Enzymology, 77, pp. 285-291. , Academic Press, New York Yonetani, Ray, STUDIES ON CYTOCHROME OXIDASE. VI. KINETICS OF THE AEROBIC OXIDATION OF FERROCYTOCHROME C BY CYTOCHROME OXIDASE. (1965) J Biol Chem, 240, pp. 3392-3398 |
| ISSN: | 03063623 |
| DOI: | 10.1016/0306-3623(90)90590-I |