Cyanide intoxication-III. On the analogous and different effects provoked by non-lethal and lethal challenged doses

1. 1. The effect of acute cyanide administration to mice in a lethal and a non-lethal dose and the anti-cyanide effect of S-adenosyl-l-methionine (SAM) and thiosulphate were investigated. 2. 2. The poisoning action was determined by measuring cytochrome oxidase, rhodanese and δ-aminolevulinic acid d...

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Autor principal: Buzaleh, A.M
Otros Autores: Vazquez, E.S, Del Carmen Batlle, A.M
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: 1990
Acceso en línea:Registro en Scopus
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024 7 |2 scopus  |a 2-s2.0-0025099440 
024 7 |2 cas  |a Cyanides; Cytochrome-c Oxidase, EC 1.9.3.1; Porphobilinogen Synthase, EC 4.2.1.24; Proteins; S-Adenosylmethionine, 29908-03-0; Sulfur Radioisotopes; Thiocyanates; Thiosulfate Sulfurtransferase, EC 2.8.1.1; Thiosulfates 
040 |a Scopus  |b spa  |c AR-BaUEN  |d AR-BaUEN 
030 |a GEPHD 
100 1 |a Buzaleh, A.M. 
245 1 0 |a Cyanide intoxication-III. On the analogous and different effects provoked by non-lethal and lethal challenged doses 
260 |c 1990 
270 1 0 |m Buzaleh, A.M.; Centro de Investigaciones sobre Porfirinas, Porfirias (CIPYP)-CONICET-Facultad de Ciencias Exactas y Naturales, University of Buenos Aires (UBA)Argentina 
506 |2 openaire  |e Política editorial 
504 |a Batlle, Ferramola, Grinstein, Purification and general properties of δ-aminolevulate dehydratase from cow liver (1977) Biochem. J., 104, pp. 244-249 
504 |a Buzaleh, Vázquez, Batlle, (1990) In vitro effect of cyanide, thiosulphate and S-adenosyl-l-methionine on the activity of rhodanese and other enzymes, , In preparation 
504 |a Guilbault, Kramer, Specific Detection and Determination of Cyanide Using Various Quinone Derivatives. (1965) Analytical Chemistry, 37, pp. 1395-1399 
504 |a Himwich, Saunders, Enzymatic conversion of cyanide to thiocyanate. (1948) Am J Physiol, 153, pp. 348-354 
504 |a Isom, Way, Lethality of cyanide in the absence of inhibition of liver cytochrome oxidase (1976) Biochemical Pharmacology, 25, pp. 605-608 
504 |a Koh, The Determination of Micro Amounts of Polythionates. I. A Photometric Method for the Determination of Pentathionate by Means of Its Cyanolysis (1965) Bulletin of the Chemical Society of Japan, 38, pp. 1510-1515 
504 |a Lowry, Rosebrough, Farr, Randall, Protein measurement with the Folin phenol reagent. (1951) J Biol Chem, 193, pp. 265-275 
504 |a Pettersen, Cohen, Antagonism of cyanide poisoning by chlorpromazine and sodium thiosulfate*1 (1985) Toxicology and Applied Pharmacology, 81, pp. 265-273 
504 |a Rutkowski, Roebuck, Smith, Effects of protein-free diet and food deprivation on hepatic rhodanese activity, serum proteins and acute cyanide lethality in mice. (1985) J Nutr, 115, pp. 132-137 
504 |a Schubert, Brill, Antagonism of experimental cyanide toxicity in relation to the in vitro activity of cytochrome oxidase (1978) J. Pharmac. Exp. Ther., 162, pp. 352-359 
504 |a Solomonson, Cyanide as metabolic inhibitor (1982) Cyanide in Biology, pp. 11-28. , Academic Press, London 
504 |a Sörbo, Crystalline Rhodanese. I. Purification and Physicochemical Examination. (1953) Acta Chemica Scandinavica, 7, pp. 1129-1136 
504 |a Sylvester, Saunders, Hayton, Way, Alteration on the pharmacokinetics of sodium cyanide by sodium thiosulphate (1981) Proc. West. Pharmac. Soc., 24, pp. 135-136 
504 |a Westley, Rhodanese and the sulfane pool (1980) Enzymatic Basis of Detoxication, 2, pp. 245-263. , Academic Press, London, chapter 13 
504 |a Westley, Rhodanese (1981) Methods in Enzymology, 77, pp. 285-291. , Academic Press, New York 
504 |a Yonetani, Ray, STUDIES ON CYTOCHROME OXIDASE. VI. KINETICS OF THE AEROBIC OXIDATION OF FERROCYTOCHROME C BY CYTOCHROME OXIDASE. (1965) J Biol Chem, 240, pp. 3392-3398 
520 3 |a 1. 1. The effect of acute cyanide administration to mice in a lethal and a non-lethal dose and the anti-cyanide effect of S-adenosyl-l-methionine (SAM) and thiosulphate were investigated. 2. 2. The poisoning action was determined by measuring cytochrome oxidase, rhodanese and δ-aminolevulinic acid dehydratase (ALA-D) activity. 3. 3. The toxic metabolizing degree was investigated by measuring plasma and urine thiocyanate levels. 4. 4. The state of the sulfane sulfur pool was investigated by determining cyanide labile-sulfur levels. 5. 5. These results support the belief that rhodanese plays a fundamental role in the detoxification process only when high levels of cyanide are administered. © 1990.  |l eng 
536 |a Detalles de la financiación: Secretaria de Ciencia y Tecnica, Universidad de Buenos Aires 
536 |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas 
536 |a Detalles de la financiación: Acknowledgements--A. M. del C. Batlle holds the post of ScientificR esearchin the ArgentineN ationalResearch Council (CONICET); E. V~izqueza nd A. M. Buzaleha re researcfhe llowsa t theC ONICET. This work was supported by grantsf rom the CONICET, the SECYT, Secretaridae SaludP Oblicad el Ministeriod e BienestaSr ocial,U BA and Banco de la Nacirn ArgentinaW. e wish to expresso ur grattitudteo Lic. S. Afonso for the excellendt rawingsW. e are gratefutlo PromecoL aboratoriesB,u enosA ires,A rgen-tine,f or kindly providingit s pharmaceuticparle paratioonf S-adenosyl-L-methion(iTnrea ns-Metil). 
593 |a Centro de Investigaciones sobre Porfirinas, Porfirias (CIPYP)-CONICET-Facultad de Ciencias Exactas y Naturales, University of Buenos Aires (UBA), Argentina 
690 1 0 |a CYTOCHROME C OXIDASE 
690 1 0 |a PORPHOBILINOGEN SYNTHASE 
690 1 0 |a S ADENOSYLMETHIONINE 
690 1 0 |a THIOCYANATE 
690 1 0 |a THIOSULFATE 
690 1 0 |a THIOSULFATE SULFURTRANSFERASE 
690 1 0 |a ANIMAL EXPERIMENT 
690 1 0 |a ARTICLE 
690 1 0 |a CONTROLLED STUDY 
690 1 0 |a CYANIDE POISONING 
690 1 0 |a DETOXIFICATION 
690 1 0 |a INTRAPERITONEAL DRUG ADMINISTRATION 
690 1 0 |a MOUSE 
690 1 0 |a NONHUMAN 
690 1 0 |a PRIORITY JOURNAL 
690 1 0 |a ANIMAL 
690 1 0 |a CYANIDES 
690 1 0 |a CYTOCHROME-C OXIDASE 
690 1 0 |a LETHAL DOSE 50 
690 1 0 |a MICE 
690 1 0 |a PORPHOBILINOGEN SYNTHASE 
690 1 0 |a PROTEINS 
690 1 0 |a S-ADENOSYLMETHIONINE 
690 1 0 |a SULFUR RADIOISOTOPES 
690 1 0 |a SUPPORT, NON-U.S. GOV'T 
690 1 0 |a THIOCYANATES 
690 1 0 |a THIOSULFATE SULFURTRANSFERASE 
690 1 0 |a THIOSULFATES 
700 1 |a Vazquez, E.S. 
700 1 |a Del Carmen Batlle, A.M. 
773 0 |d 1990  |g v. 21  |h pp. 27-32  |k n. 1  |p Gen. Pharmacol. Vasc. Syst.  |x 03063623  |w (AR-BaUEN)CENRE-4808  |t General Pharmacology 
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856 4 0 |u https://hdl.handle.net/20.500.12110/paper_03063623_v21_n1_p27_Buzaleh  |y Handle 
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