Control of dendritic cell maturation and function by triiodothyronine
Accumulating evidence indicates a functional crosstalk between immune and endocrine mechanisms in the modulation of innate and adaptive immunity. However, the impact of thyroid hormones (THs) in the initiation of adaptive immune responses has not yet been examined. Here we investigated the presence...
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| Otros Autores: | , , , , , , , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
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2008
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 20084caa a22018497a 4500 | ||
|---|---|---|---|
| 001 | PAPER-5986 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203540.0 | ||
| 008 | 190411s2008 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-42049109284 | |
| 024 | 7 | |2 cas |a gamma interferon, 82115-62-6; interleukin 12, 138415-13-1; liothyronine, 6138-47-2, 6893-02-3; protein, 67254-75-5; Interleukin-12, 187348-17-0; Receptors, Thyroid Hormone; Triiodothyronine, 6893-02-3 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a FAJOE | ||
| 100 | 1 | |a Mascanfroni, I. | |
| 245 | 1 | 0 | |a Control of dendritic cell maturation and function by triiodothyronine |
| 260 | |c 2008 | ||
| 270 | 1 | 0 | |m Pellizas, C. G.; CIBICI-CONICET, Departamento de Bioquímica Clínica, Ciudad Universitaria, Haya de la Torre Esq. Medina Allende, 5000 Córdoba, Argentina; email: claudia@mail.fcq.unc.edu.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a Accumulating evidence indicates a functional crosstalk between immune and endocrine mechanisms in the modulation of innate and adaptive immunity. However, the impact of thyroid hormones (THs) in the initiation of adaptive immune responses has not yet been examined. Here we investigated the presence of thyroid hormone receptors (TRs) and the impact of THs in the physiology of mouse dendritic cells (DCs), specialized antigen-presenting cells with the unique capacity to fully activate naive T cells and orchestrate adaptive immunity. Both immature and lipopolysaccharide-matured bone marrow-derived DCs expressed TRs at mRNA and protein levels, showing a preferential cytoplasmic localization. Remarkably, physiological levels of triiodothyronine (T3) stimulated the expression of DC maturation markers (major histocompatability complex II, CD80, CD86, and CD40), markedly increased the secretion of interleukin-12, and stimulated the ability of DCs to induce naive T cell proliferation and IFN-γ production in allogeneic T cell cultures. Analysis of the mechanisms involved in these effects revealed the ability of T3 to influence the cytoplasmicnuclear shuttling of nuclear factor-κB on primed DCs. Our study provides the first evidence for the presence of TRs on bone marrow-derived DCs and the ability of THs to regulate DC maturation and function. These results have profound implications in immunopathology, including cancer and autoimmune manifestations of the thyroid gland at the crossroads of the immune and endocrine systems. © FASEB. |l eng | |
| 593 | |a Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Departamento de Bioquímica Clínica, Universidad Nacional de Córdoba, Córdoba, Argentina | ||
| 593 | |a Laboratorio de Inmunopatología, Instituto de Biología Y Medicina Experimental (IBYME) CONICET, Facultad de Ciencias Exactas Y Naturales, Buenos Aires, Argentina | ||
| 593 | |a Cátedra de Genética Y Biología Molecular, Facultad de Farmacia Y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a CIBICI-CONICET, Departamento de Bioquímica Clínica, Ciudad Universitaria, Haya de la Torre Esq. Medina Allende, 5000 Córdoba, Argentina | ||
| 690 | 1 | 0 | |a ADAPTIVE IMMUNITY |
| 690 | 1 | 0 | |a ANTIGEN PRESENTATION |
| 690 | 1 | 0 | |a THYROID HORMONES |
| 690 | 1 | 0 | |a B7 ANTIGEN |
| 690 | 1 | 0 | |a CD40 ANTIGEN |
| 690 | 1 | 0 | |a CD86 ANTIGEN |
| 690 | 1 | 0 | |a CELL MARKER |
| 690 | 1 | 0 | |a GAMMA INTERFERON |
| 690 | 1 | 0 | |a IMMUNOGLOBULIN ENHANCER BINDING PROTEIN |
| 690 | 1 | 0 | |a INTERLEUKIN 12 |
| 690 | 1 | 0 | |a LIOTHYRONINE |
| 690 | 1 | 0 | |a LIPOPOLYSACCHARIDE |
| 690 | 1 | 0 | |a MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2 |
| 690 | 1 | 0 | |a MESSENGER RNA |
| 690 | 1 | 0 | |a PROTEIN |
| 690 | 1 | 0 | |a THYROID HORMONE RECEPTOR |
| 690 | 1 | 0 | |a ADAPTIVE IMMUNITY |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ANTIGEN PRESENTING CELL |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a AUTOIMMUNE DISEASE |
| 690 | 1 | 0 | |a BONE MARROW |
| 690 | 1 | 0 | |a CELL CULTURE |
| 690 | 1 | 0 | |a CELL FUNCTION |
| 690 | 1 | 0 | |a CELL MATURATION |
| 690 | 1 | 0 | |a CYTOKINE RELEASE |
| 690 | 1 | 0 | |a CYTOPLASM |
| 690 | 1 | 0 | |a DENDRITIC CELL |
| 690 | 1 | 0 | |a ENDOCRINE SYSTEM |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a IMMUNE SYSTEM |
| 690 | 1 | 0 | |a IMMUNOPATHOLOGY |
| 690 | 1 | 0 | |a INTERFERON PRODUCTION |
| 690 | 1 | 0 | |a LYMPHOCYTE PROLIFERATION |
| 690 | 1 | 0 | |a MOUSE |
| 690 | 1 | 0 | |a NEOPLASM |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a T LYMPHOCYTE ACTIVATION |
| 690 | 1 | 0 | |a THYROID GLAND |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a BONE MARROW CELLS |
| 690 | 1 | 0 | |a CELL DIFFERENTIATION |
| 690 | 1 | 0 | |a CERCOPITHECUS AETHIOPS |
| 690 | 1 | 0 | |a COS CELLS |
| 690 | 1 | 0 | |a CYTOSOL |
| 690 | 1 | 0 | |a DENDRITIC CELLS |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a FLOW CYTOMETRY |
| 690 | 1 | 0 | |a INTERLEUKIN-12 |
| 690 | 1 | 0 | |a MICE |
| 690 | 1 | 0 | |a RECEPTORS, THYROID HORMONE |
| 690 | 1 | 0 | |a T-LYMPHOCYTES |
| 690 | 1 | 0 | |a TRANSFECTION |
| 690 | 1 | 0 | |a TRIIODOTHYRONINE |
| 700 | 1 | |a Montesinos, M.D.M. | |
| 700 | 1 | |a Susperreguy, S. | |
| 700 | 1 | |a Cervi, L. | |
| 700 | 1 | |a Ilarregui, J.M. | |
| 700 | 1 | |a Ramseyer, V.D. | |
| 700 | 1 | |a Masini-Repiso, A.M. | |
| 700 | 1 | |a Targovnik, H.M. | |
| 700 | 1 | |a Rabinovich, G.A. | |
| 700 | 1 | |a Pellizas, C.G. | |
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