Down-modulation of erbB2 activity is necessary but not enough in the differentiation of 3T3-L1 preadipocytes
The high incidence of obesity-related pathologies, led to the study of the mechanisms involved in preadipose cell proliferation and differentiation. Here, we demonstrate that modulation of erbB2, plays a fundamental role during proliferation and adipogenic induction of preadipocytes. Using 3T3-L1 ce...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
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Wiley-Liss Inc.
2008
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 15311caa a22016337a 4500 | ||
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| 001 | PAPER-5958 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203538.0 | ||
| 008 | 190411s2008 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-46449121073 | |
| 024 | 7 | |2 cas |a 2 (2 amino 3 methoxyphenyl)chromone, 167869-21-8; anthra[1,9 cd]pyrazol 6(2h) one, 129-56-6; dexamethasone, 50-02-2; epidermal growth factor, 59459-45-9, 62229-50-9; epidermal growth factor receptor, 79079-06-4; epidermal growth factor receptor 2, 137632-09-8; isobutylmethylxanthine, 28822-58-4; mitogen activated protein kinase, 142243-02-5; mitogen activated protein kinase kinase, 142805-58-1; protein tyrosine kinase, 80449-02-1; stress activated protein kinase, 155215-87-5; mitogen activated protein kinase, 142243-02-5; Mitogen-Activated Protein Kinases, EC 2.7.1.37; Receptor, Epidermal Growth Factor, EC 2.7.1.112; Receptor, erbB-2, EC 2.7.1.112 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a JCEBD | ||
| 100 | 1 | |a Pagano, E. | |
| 245 | 1 | 0 | |a Down-modulation of erbB2 activity is necessary but not enough in the differentiation of 3T3-L1 preadipocytes |
| 260 | |b Wiley-Liss Inc. |c 2008 | ||
| 270 | 1 | 0 | |m Pagano, E.; Laboratorio de Química de Proteoglicanos Y Matriz Extracelular, IByME, Vuelta de Obligado, 2490, (1428) Buenos Aires, Argentina; email: eleonora_pagano@yahoo.com.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a The high incidence of obesity-related pathologies, led to the study of the mechanisms involved in preadipose cell proliferation and differentiation. Here, we demonstrate that modulation of erbB2, plays a fundamental role during proliferation and adipogenic induction of preadipocytes. Using 3T3-L1 cells as model, we demonstrate that EGF (10 nM, 5 min) in addition to stimulate receptor tyrosine phosphorylation of both erbB2 and EGFR, is able to induce the heterodimer erbB2-EGFR. We treated proliferating 3T3-L1 cells with two inhibitors, AG 825 (IC50 0.35 μM, 54 times more selective for erbB2 than for EGFR, IC50 19 μM), and AG 879 (IC50 of 1 μM for erbB2 versus 500 μM for EGFR). We found that both inhibited the proliferation on a dose-dependent basis, reaching a 30% maximal inhibition at 100 μM (P < 0.001) for AG825, and a 20% maximal inhibition at 10 μM (P < 0.001) for AG 879. These results involve erbB2 in 3T3-L1 proliferation. When studying the differentiation process, we found that the action of MIX-Dexa immediately activates MEK, JNK and p38 kinases. We observed that PD98059 and SP600125 (MEK-ERK and JNK inhibitors, respectively) added 1 h prior to the MIX-Dexa induction produced a decrease in erbB2 expression after 6 h, which is even greater than the one produced by the inducers, MIX-Dexa. This work supports erbB2 as a key factor in 3T3-L1 adipogenesis, acting mostly and not only during the proliferative phase but also during the differentiation through modulation of both its expression and activity. © 2007 Wiley-Liss, Inc. |l eng | |
| 593 | |a Laboratorio de Química de Proteoglicanos Y Matriz Extracelular, IByME, Buenos Aires, Argentina | ||
| 593 | |a IFIBYNE, Universidad de Buenos Aires, Facultad de Ciencias Exactas Y Naturales (FCEyN, UBA), Buenos Aires, Argentina | ||
| 593 | |a Department of Biological Chemistry, Universidad de Buenos Aires, Facultad de Ciencias Exactas Y Naturales (FCEyN, UBA), Buenos Aires, Argentina | ||
| 593 | |a Department of Molecular Biology | ||
| 593 | |a Laboratorio de Química de Proteoglicanos Y Matriz Extracelular, IByME, Vuelta de Obligado, 2490, (1428) Buenos Aires, Argentina | ||
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| 690 | 1 | 0 | |a TYRPHOSTIN |
| 690 | 1 | 0 | |a TYRPHOSTIN AG 879 |
| 690 | 1 | 0 | |a UNCLASSIFIED DRUG |
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