Activation of nitric oxide synthase through muscarinic receptors in rat parotid gland
Muscarinic receptors play an important role in secretory and vasodilator responses in rat salivary glands. Nitric oxide synthase (NOS) activity was found coupled to muscarinic receptor activation as well as to nitric oxide-mediated amylase secretion elicited by carbachol. Parotid glands presented a...
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| Formato: | Capítulo de libro |
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2002
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 12042caa a22013937a 4500 | ||
|---|---|---|---|
| 001 | PAPER-5402 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203503.0 | ||
| 008 | 190411s2002 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0037192537 | |
| 024 | 7 | |2 cas |a 4-diphenylacetoxy-1,1-dimethylpiperidinium, 81405-11-0; Amylases, EC 3.2.1.-; Atropine, 51-55-8; Carbachol, 51-83-2; Enzyme Inhibitors; Muscarinic Antagonists; NG-Nitroarginine Methyl Ester, 50903-99-6; Nitric Oxide Synthase, EC 1.14.13.39; Nitric Oxide, 10102-43-9; Piperidines; Pirenzepine, 28797-61-7; Quinuclidinyl Benzilate, 6581-06-2; Receptors, Muscarinic | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a EJPHA | ||
| 100 | 1 | |a Rosignoli, F. | |
| 245 | 1 | 0 | |a Activation of nitric oxide synthase through muscarinic receptors in rat parotid gland |
| 260 | |c 2002 | ||
| 270 | 1 | 0 | |m Pérez Leirós, C.; Departamento de Quimica Biologica, Facul. Ciencias Exactas y Naturales, Universidad de Buenos Aires-CONICET, (1428) Buenos Aires, Argentina; email: cpleiros@qb.fcen.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Rosignoli, F., Goren, N., Pérez Leirós, C., Alterations in nitric oxide synthase activity and expression in submandibular glands of NOD mice (2001) Clin. Immunol., 101, pp. 86-93 | ||
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| 504 | |a Watson, M., Roeske, W.R., Yamamura, H.I., [3H] Pirenzepine and (-)-[3H] quinuclidinyl benzilate binding to rat cerebral cortical and cardiac muscarinic cholinergic sites: II. Characterization and regulation of antagonist binding to putative muscarinic subtypes (1986) J. Pharmacol. Exp. Ther., 237, pp. 419-427 | ||
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| 504 | |a Wojcik, J.D., Grand, R.J., Kimberg, D.V., Amylase secretion by rabbit parotid gland: Role of cyclic AMP and cyclic GMP (1975) Biochim. Biophys. Acta, 411, pp. 250-262 | ||
| 520 | 3 | |a Muscarinic receptors play an important role in secretory and vasodilator responses in rat salivary glands. Nitric oxide synthase (NOS) activity was found coupled to muscarinic receptor activation as well as to nitric oxide-mediated amylase secretion elicited by carbachol. Parotid glands presented a predominant M3 and a minor muscarinic M1 acetylcholine receptor population, though carbachol stimulated NOS activity only through muscarinic M3 receptors as revealed in the presence of 4-diphenylacetoxy-N-methylpiperidine methiodide (4-DAMP) and pirenzepine. Amylase secretion induced by carbachol appeared to be partly mediated by nitric oxide and nitric oxide-induced signaling since N-nitro-L-arginine methyl ester (L-NAME) inhibited the effect as well as did methylene blue. A negative regulation of NOS by protein kinase C activation in the presence of a high concentration of carbachol was seen in parotid glands and this inhibition was paralleled by amylase secretion. © 2002 Elsevier Science B.V. All rights reserved. |l eng | |
| 536 | |a Detalles de la financiación: Fundación Alberto J. Roemmers | ||
| 536 | |a Detalles de la financiación: This work was supported by grants Beca Carrillo-Oñativia 2000 and 2001 from the Ministerio de Salud of Argentina and Fundación Alberto J. Roemmers, 2000–2002, Buenos Aires, Argentina. | ||
| 593 | |a Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Ciudad Universitaria, Pabellon II, 4 piso, (1428) Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a AMYLASE SECRETION |
| 690 | 1 | 0 | |a NITRIC OXIDE (NO) SIGNALING |
| 690 | 1 | 0 | |a NITRIC OXIDE (NO) SYNTHASE |
| 690 | 1 | 0 | |a PAROTID GLAND |
| 690 | 1 | 0 | |a 4 DIPHENYLACETOXY 1 METHYLPIPERIDINE |
| 690 | 1 | 0 | |a AMYLASE |
| 690 | 1 | 0 | |a CARBACHOL |
| 690 | 1 | 0 | |a METHYLENE BLUE |
| 690 | 1 | 0 | |a MUSCARINIC M1 RECEPTOR |
| 690 | 1 | 0 | |a MUSCARINIC M3 RECEPTOR |
| 690 | 1 | 0 | |a N(G) NITROARGININE METHYL ESTER |
| 690 | 1 | 0 | |a NITRIC OXIDE |
| 690 | 1 | 0 | |a NITRIC OXIDE SYNTHASE |
| 690 | 1 | 0 | |a PHORBOL 13 ACETATE 12 MYRISTATE |
| 690 | 1 | 0 | |a PIRENZEPINE |
| 690 | 1 | 0 | |a PROTEIN KINASE C |
| 690 | 1 | 0 | |a AMYLASE RELEASE |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CONCENTRATION RESPONSE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a DRUG MECHANISM |
| 690 | 1 | 0 | |a ENZYME ACTIVATION |
| 690 | 1 | 0 | |a ENZYME ACTIVITY |
| 690 | 1 | 0 | |a ENZYME INHIBITION |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PAROTID GLAND |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a RECEPTOR DENSITY |
| 690 | 1 | 0 | |a SIGNAL TRANSDUCTION |
| 690 | 1 | 0 | |a AMYLASES |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a ATROPINE |
| 690 | 1 | 0 | |a BINDING, COMPETITIVE |
| 690 | 1 | 0 | |a CARBACHOL |
| 690 | 1 | 0 | |a CELL MEMBRANE |
| 690 | 1 | 0 | |a DOSE-RESPONSE RELATIONSHIP, DRUG |
| 690 | 1 | 0 | |a ENZYME ACTIVATION |
| 690 | 1 | 0 | |a ENZYME INHIBITORS |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MUSCARINIC ANTAGONISTS |
| 690 | 1 | 0 | |a NG-NITROARGININE METHYL ESTER |
| 690 | 1 | 0 | |a NITRIC OXIDE |
| 690 | 1 | 0 | |a NITRIC OXIDE SYNTHASE |
| 690 | 1 | 0 | |a PAROTID GLAND |
| 690 | 1 | 0 | |a PIPERIDINES |
| 690 | 1 | 0 | |a PIRENZEPINE |
| 690 | 1 | 0 | |a QUINUCLIDINYL BENZILATE |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a RATS, WISTAR |
| 690 | 1 | 0 | |a RECEPTORS, MUSCARINIC |
| 690 | 1 | 0 | |a SPECIFIC PATHOGEN-FREE ORGANISMS |
| 700 | 1 | |a Pérez Leirós, C. | |
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