Roscovitine inhibits ongoing DNA synthesis in human cervical cancer
The effect of roscovitine, a purine analogue and cyclin dependent kinase inhibitor, on DNA synthesis rate in tissue mini-units obtained from human cervical cancers was investigated. Roscovitine (100 μM) gave a DNA synthesis rate inhibition by 61% (P<0.0001; range 23-93%) within 30 min of incubati...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
2002
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 11896caa a22012977a 4500 | ||
|---|---|---|---|
| 001 | PAPER-5333 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203458.0 | ||
| 008 | 190411s2002 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-18344377661 | |
| 024 | 7 | |2 cas |a Antineoplastic Agents; Cyclin-Dependent Kinases, EC 2.7.1.37; DNA, 9007-49-2; Enzyme Inhibitors; Purines; roscovitine | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a CALED | ||
| 100 | 1 | |a Vitali, L. | |
| 245 | 1 | 0 | |a Roscovitine inhibits ongoing DNA synthesis in human cervical cancer |
| 260 | |c 2002 | ||
| 270 | 1 | 0 | |m Idoyaga Vargas, V.; Inst. Invest. Bioquimi. Fund. Campo., FCEyN, UBA, Patricias Argentinas 435, (C. P. 1405) Buenos Aires, Argentina; email: vidoyagav@leloir.org.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Keys, H.M., Bundy, B.N., Stehman, F.B., Muderspach, L.I., Chape, W.E., Suggs III, C.L., Walker, J.L., Gersell, D., Cisplatin, radiation, and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage IB cervical carcinoma (1999) N. Engl. J. Med., 340, pp. 1154-1161 | ||
| 504 | |a Fletcher, G.H., Clinical dose-response curves of human malignant epithelial tumours (1973) Br. J. Radiol., 46, pp. 1-12 | ||
| 504 | |a Hreshchyshyn, M.M., Aron, B.S., Boronow, R.C., Franklin III, E.W., Shingleton, H.M., Blessing, J.A., Hydroxyurea or placebo combined with radiation to treat stages IIIB and IV cervical cancer confined to the pelvis (1979) Int. J. Radiat. Oncol. Biol. Phys., 5, pp. 317-322 | ||
| 504 | |a Rose, P.G., Bundy, B.N., Watkins, E.B., Thigpen, J.T., Deppe, G., Maiman, M.A., Clarke-Person, D.L., Insalaco, S., Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer (1999) N. Engl. J. Med., 340, pp. 1144-1153 | ||
| 504 | |a Bergmark, K., vall-Lundqvist, E., Dickman, P.W., Henningsohn, L., Steineck, G., Vaginal changes and sexuality in women with a history of cervical cancer (1999) N. Engl. J. Med., 340, pp. 1383-1389 | ||
| 504 | |a Meijer, L., Borgne, A., Mulner, O., Chong, J.P.J., Blow, J.J., Inagaki, N., Inagaki, M., Moulinoux, J.-P., Biochemical and cellular effect of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5 (1997) Eur. J. Biochem., 243, pp. 527-536 | ||
| 504 | |a Schutte, B., Nieland, L., Van Engeland, M., Henfling, M.E.R., Meijer, L., Ramaekers, F.C.S., The effect of the cyclin-dependent kinase inhibitor olomoucine on cell cycle kinetics (1997) Exp. Cell Res., 236, pp. 4-15 | ||
| 504 | |a Pippin, J.W., Qu, Q., Meijer, L., Shankland, S.J., Direct in vivo inhibition of the nuclear cell cycle cascade in experimental mesangial proliferative glomerulonephritis with Roscovitine, a novel cyclin-dependent kinase antagonist (1997) J. Clin. Invest., 100, pp. 2512-2520 | ||
| 504 | |a Meijer, L., Chemical inhibitors of cyclin-dependent kinases (1996) Trends Cell. Biol., 6, pp. 393-397 | ||
| 504 | |a Yakisich, J.S., Sidén, Å., Idoyaga Vargas, V., Eneroth, P., Cruz, M., Inhibition of DNA synthesis in human gliomas by roscovitine (1999) NeuroReport, 10, pp. 2563-2567 | ||
| 504 | |a Kim, Y.T., Cho, N.H., Park, S.W., Kim, J.W., Underexpression of cyclin-dependent kinase (CDK) inhibitors in cervical carcinoma (1998) Gynecol. Oncol., 71, pp. 38-45 | ||
| 504 | |a Sano, T., Oyama, T., Kashiwabara, K., Fukuda, T., Nakajima, T., Expression status of p16 protein is associated with human papillomavirus oncogenic potential in cervical and genital lesions (1998) Am. J. Pathol., 153, pp. 1741-1748 | ||
| 504 | |a Funk, J.O., Waga, S., Harry, J.B., Espling, E., Stillman, B., Galloway, D.A., Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein (1997) Oncogene, 11, pp. 2090-2100 | ||
| 504 | |a Jones, D.L., Alani, R.M., Munger, K., The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21Cip1-mediated inhibition of cdk2 (1997) Genes Dev., 11, pp. 2101-2111 | ||
| 504 | |a Yakisich, J.S., Sidén, Å., Idoyaga Vargas, V., Eneroth, P., Cruz, M., Fast and sensitive method for simultaneous measurement of cell proliferation rate and drug sensitivity in rat cerebral cortex (1998) Exp. Neurol., 151, pp. 194-202 | ||
| 504 | |a Yakisich, J.S., Sidén, Å., Idoyaga Vargas, V., Eneroth, P., Cruz, M., Early inhibition of DNA synthesis in the developing rat cerebral cortex by the purine analogues olomoucine and roscovitine (1998) Biochem. Biophys. Res. Commun., 243, pp. 674-677 | ||
| 504 | |a Knockaert, M., Gray, N., Damiens, E., Chang, Y.T., Grellier, P., Grant, K., Fergusson, D., Meijer, L., Intracellular targets of cyclin-dependent kinase inhibitors: Identification by affinity chromatography using immobilised ligands (2000) Chem. Biol., 7, pp. 411-422 | ||
| 504 | |a Bosch, F.X., Manos, M.M., Munoz, N., Sherman, M., Jansen, A.M., Peto, J., Schiffman, M.H., Wheeler, C., Prevalence of human papillomavirus in cervical cancer: A worldwide perspective (1995) J. Natl. Cancer Inst., 87, pp. 796-802 | ||
| 504 | |a Zur Hausen, H., Papillomavirus infections - A major cause of human cancers (1996) Biochim. Biophys. Acta, 1288, pp. F55-F78 | ||
| 504 | |a Garbe, J., Wong, M., Wigington, D., Yaswen, P., Stampfer, M., Viral oncogenes accelerates conversion to immortality of cultured conditionally immortal human mammary epithelial cells (1999) Oncogene, 18, pp. 2169-2180 | ||
| 504 | |a Zehbe, I., Räatsch, A., Alunni-Fabronni, M., Burzlaf, A., Bakos, E., Durst, M., Wilander, E., Tommasino, M., Overriding of cyclin-dependent kinase inhibitors by high and low risk human papillomavirus types: Evidence for an in vivo role in cervical lesions (1999) Oncogene, 18, pp. 2201-2211 | ||
| 504 | |a Duensing, S., Lee, L.Y., Basile, J., Piboonniyom, S., Gonzalez, S., Crum, C.P., Munger, K., The human papillomavirus type 16 E6 and E/ oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell cycle (2000) Proc. Natl. Acad. Sci. USA, 97, pp. 10002-10007 | ||
| 504 | |a Duensing, S., Duensing, A., Crum, C.P., Munger, K., Human papillomavirus type 16 E7 oncoprotein-induced abnormal centrosome synthesis is an early event in the evolving malignant phenotype (2001) Cancer Res., 61, pp. 2356-2360 | ||
| 504 | |a Schang, L.M., Rosemberg, A., Schaffer, P.A., Transcripcion of herpes simplex virus immediate-early and early genes is inhibited by roscovitine, an inhibitor specific for cellular cyclin-dependent kinases (1999) J. Virol., 73, pp. 2161-2172 | ||
| 504 | |a Schang, L.M., Phillips, J., Schaffer, P.A., Requirement for cellular cyclin-dependent kinase in herpes simplex virus replication and transcription (1999) J. Virol., 72, pp. 5626-5637 | ||
| 504 | |a Bresnahan, W.A., Boldogh, I., Chi, P., Thompson, E.A., Albrecht, T., Inhibition of cellular Cdk2 activity blocks human cytomegalovirus replication (1997) Virology, 231, pp. 239-247 | ||
| 504 | |a Wang, D., De la Fuente, C., Deng, L., Wang, L., Zilberman, I., Eadie, C., Healey, M., Kashanchi, F., Inhibition of human immunodeficiency virus type 1 transcription by chemical cyclin-dependent kinase inhibitors (2001) J. Virol., 75, pp. 7266-7279 | ||
| 520 | 3 | |a The effect of roscovitine, a purine analogue and cyclin dependent kinase inhibitor, on DNA synthesis rate in tissue mini-units obtained from human cervical cancers was investigated. Roscovitine (100 μM) gave a DNA synthesis rate inhibition by 61% (P<0.0001; range 23-93%) within 30 min of incubation. This inhibitory effect was concentration-dependent. The results suggest that the inhibition of tumor DNA synthesis rate is due to a direct effect on the DNA synthesis machinery via presently unknown mechanisms. In addition, the potential application of CDKs inhibitors as preventive agents is discussed. © 2002 Elsevier Science Ireland Ltd. All rights reserved. |l eng | |
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires | ||
| 536 | |a Detalles de la financiación: Minerva Foundation | ||
| 536 | |a Detalles de la financiación: Karolinska Institutet, KI | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: This study was supported by grants from the Consejo Nacional de Investigaciones CientÍficas y Técnicas (CONICET) as well as University of Buenos Aires, the Avanzar Foundation, the Karolinska Institute, the Minerva Foundation, and the Swedish Medical Association. The access to resources at the Clinical Research Center, Novum, is gratefully acknowledged. | ||
| 593 | |a Instituto de Investigaciones Bioquimicas Fundacion Campomar, FCEyN, UBA, Patricias Argentinas 435, Buenos Aires, Argentina | ||
| 593 | |a Applied Biochemistry, Clinical Research Center, Karolinska Institute, Novum, Huddinge, Sweden | ||
| 593 | |a Department of Neurology, Huddinge University Hospital, Karolinska Institute, Huddinge, Sweden | ||
| 593 | |a Hospital Municipal de OncologÍa Marie Curie, Buenos Aires, Argentina | ||
| 593 | |a Instituto de Terapia Radiante, La Plata, Argentina | ||
| 690 | 1 | 0 | |a CERVICAL CANCER |
| 690 | 1 | 0 | |a CYCLIN DEPENDENT KINASES |
| 690 | 1 | 0 | |a DNA SYNTHESIS |
| 690 | 1 | 0 | |a ROSCOVITINE |
| 690 | 1 | 0 | |a ROSCOVITINE |
| 690 | 1 | 0 | |a ADULT |
| 690 | 1 | 0 | |a AGED |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CANCER CHEMOTHERAPY |
| 690 | 1 | 0 | |a CANCER STAGING |
| 690 | 1 | 0 | |a CELL PROLIFERATION |
| 690 | 1 | 0 | |a CLINICAL ARTICLE |
| 690 | 1 | 0 | |a CONCENTRATION RESPONSE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a DNA SYNTHESIS |
| 690 | 1 | 0 | |a DNA SYNTHESIS INHIBITION |
| 690 | 1 | 0 | |a DRUG EFFECT |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a HUMAN TISSUE |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a UTERINE CERVIX CANCER |
| 690 | 1 | 0 | |a ADULT |
| 690 | 1 | 0 | |a AGED |
| 690 | 1 | 0 | |a ANTINEOPLASTIC AGENTS |
| 690 | 1 | 0 | |a CYCLIN-DEPENDENT KINASES |
| 690 | 1 | 0 | |a DNA |
| 690 | 1 | 0 | |a DOSE-RESPONSE RELATIONSHIP, DRUG |
| 690 | 1 | 0 | |a ENZYME INHIBITORS |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a MIDDLE AGED |
| 690 | 1 | 0 | |a PURINES |
| 690 | 1 | 0 | |a TIME FACTORS |
| 690 | 1 | 0 | |a UTERINE CERVICAL NEOPLASMS |
| 700 | 1 | |a Yakisich, J.Sebastian | |
| 700 | 1 | |a Vita, M.F. | |
| 700 | 1 | |a Fernandez, A. | |
| 700 | 1 | |a Settembrini, L. | |
| 700 | 1 | |a Siden, A. | |
| 700 | 1 | |a Cruz, M. | |
| 700 | 1 | |a Carminatti, H. | |
| 700 | 1 | |a Casas, O. | |
| 700 | 1 | |a Idoyaga Vargas, V. | |
| 773 | 0 | |d 2002 |g v. 180 |h pp. 7-12 |k n. 1 |p Cancer Lett. |x 03043835 |w (AR-BaUEN)CENRE-4108 |t Cancer Letters | |
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| 856 | 4 | 0 | |u https://doi.org/10.1016/S0304-3835(01)00827-8 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_03043835_v180_n1_p7_Vitali |y Handle |
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| 999 | |c 66286 | ||