Isolation and structural elucidation of degradation products of alprazolam: Photostability studies of alprazolam tablets
Accelerated thermal, hydrolytic, and photochemical degradations of alprazolam were performed under several reaction conditions. The stress studies revealed the photolability of the drug as the most adverse stability factor; the main photodegradation products were isolated and properly characterized...
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John Wiley and Sons Inc.
2002
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| LEADER | 12589caa a22011537a 4500 | ||
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| 001 | PAPER-5322 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203457.0 | ||
| 008 | 190411s2002 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0036076624 | |
| 024 | 7 | |2 cas |a alprazolam, 28981-97-7 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a JPMSA | ||
| 100 | 1 | |a Nudelman, N.S. | |
| 245 | 1 | 0 | |a Isolation and structural elucidation of degradation products of alprazolam: Photostability studies of alprazolam tablets |
| 260 | |b John Wiley and Sons Inc. |c 2002 | ||
| 270 | 1 | 0 | |m Nudelman, N.S.; Depto. Quimica Organica, Fac. de Ciencias Exact. y Naturales, Universidad de Buenos Aires, Pab. II, P.3 Ciudad Universitaria, 1428 Buenos Aires, Argentina; email: nudelman@qo.fcen.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a Accelerated thermal, hydrolytic, and photochemical degradations of alprazolam were performed under several reaction conditions. The stress studies revealed the photolability of the drug as the most adverse stability factor; the main photodegradation products were isolated and properly characterized as: triazolaminoquinoleine; 5-chloro-[5-methyl-4H-1,2,4-triazol-4-yl]benzophenone, and 1-methyl-6-phenyl-4h-s-triazo- [4,3-α][1,4]benzodiazepinone. Accelerated pH-dependent studies show that the photoinstability increases as the pH decreases; at pH 9.0, photodegradation does not occur, therefore, the photochemical degradation of alprazolam was performed in buffered solutions at pH 2.0 and 3.6. The higher rate of reaction was observed at pH = 2.0; consequently, acidic conditions should be avoided and appropriate light protection is recommended during the drug-development process, storage, and handling. The main degradation route for alprazolam tablets is also photochemical. © 2002 Wiley-Liss, Inc. |l eng | |
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires | ||
| 536 | |a Detalles de la financiación: National Research Council | ||
| 536 | |a Detalles de la financiación: Cancer Genomics Centre | ||
| 536 | |a Detalles de la financiación: Departamento Administrativo de Ciencia, Tecnología e Innovación, COLCIENCIAS | ||
| 536 | |a Detalles de la financiación: Agency for Science, Technology and Research | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: CGC is a grateful recipient of a COLCIENCIAS fellowship. The authors are indebted to Gador Lab. for the provision of AL and other drugs. Financial support from the University of Buenos Aires, the CONICET (National Research Council), and the Agency for the Promotion of Science and Technology from Argentine is acknowledged. | ||
| 593 | |a Depto. Química Orgánica, Facultad de Ciencias Exactas y Naturales, P.3 Ciudad Universitaria, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a ALPRAZOLAM |
| 690 | 1 | 0 | |a ALPRAZOLAM PHOTODEGRADATION PRODUCTS |
| 690 | 1 | 0 | |a ALPRAZOLAM STABILITY |
| 690 | 1 | 0 | |a PHOTOCHEMICAL DEGRADATION |
| 690 | 1 | 0 | |a TRIAZOLOBENZODIAZEPINES |
| 690 | 1 | 0 | |a ALPRAZOLAM |
| 690 | 1 | 0 | |a AMINOQUINOLINE DERIVATIVE |
| 690 | 1 | 0 | |a BENZODIAZEPINE DERIVATIVE |
| 690 | 1 | 0 | |a BENZOPHENONE DERIVATIVE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CHEMICAL REACTION KINETICS |
| 690 | 1 | 0 | |a DRUG DEGRADATION |
| 690 | 1 | 0 | |a DRUG ISOLATION |
| 690 | 1 | 0 | |a DRUG STABILITY |
| 690 | 1 | 0 | |a DRUG STORAGE |
| 690 | 1 | 0 | |a HYDROLYSIS |
| 690 | 1 | 0 | |a PHOTOCHEMISTRY |
| 690 | 1 | 0 | |a STRUCTURE ANALYSIS |
| 690 | 1 | 0 | |a TABLET |
| 690 | 1 | 0 | |a THERMOSTABILITY |
| 650 | 1 | 7 | |2 spines |a PH |
| 700 | 1 | |a Cabrera, C.G. | |
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