Spectrofluorimetric assay for the photodegradation products of alprazolam
A new spectrofluorimetric assay for the photodegradation products of the ansiolytic drug alprazolam is described. Alprazolam was found to be highly photolabile and special care should be taken to avoid light exposure during alprazolam storage and handling. The photostability of alprazolam was evalua...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
2002
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 08042caa a22011417a 4500 | ||
|---|---|---|---|
| 001 | PAPER-5211 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203451.0 | ||
| 008 | 190411s2002 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0037201641 | |
| 024 | 7 | |2 cas |a Alprazolam, 28981-97-7 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a JPBAD | ||
| 100 | 1 | |a Nudelman, N.S. | |
| 245 | 1 | 0 | |a Spectrofluorimetric assay for the photodegradation products of alprazolam |
| 260 | |c 2002 | ||
| 270 | 1 | 0 | |m Nudelman, N.S.; Depto. Quimica Organica, Facultad de Cie. Exactas y Natur., Universidad de Buenos Aires, 1428 Buenos Aires, Argentina; email: nudelman@qo.fcen.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a A new spectrofluorimetric assay for the photodegradation products of the ansiolytic drug alprazolam is described. Alprazolam was found to be highly photolabile and special care should be taken to avoid light exposure during alprazolam storage and handling. The photostability of alprazolam was evaluated at pH 2.0, 3.6 and 5.0. The drug was exposed to UVA-UVB radiations, the photodegradation of alprazolam was followed by high-performance liquid chromatographic (HPLC) and the developed spectrofluorimetric assay allowed determination of the photodegradation products at very low concentrations (≥10-5 M). The photoinstability was found to increase with the pH value decreasing, consequently acidic media should be avoided during the drug-development process. © 2002 Elsevier Science B.V. All rights reserved. |l eng | |
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires | ||
| 536 | |a Detalles de la financiación: Cancer Genomics Centre | ||
| 536 | |a Detalles de la financiación: National Research Council | ||
| 536 | |a Detalles de la financiación: Departamento Administrativo de Ciencia, Tecnología e Innovación, COLCIENCIAS | ||
| 536 | |a Detalles de la financiación: Agency for Science, Technology and Research | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: CGC is a grateful recipient of a COLCIENCIAS fellowship. Financial support by the Agency for the Promotion of Science and Technology; the University of Buenos Aires and the National Research Council (CONICET) from Argentine is gratefully acknowledged. | ||
| 593 | |a Depto. Quimica Organica, Facultad de Ciencias Exactas y Naturales, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a ALPRAZOLAM PHOTOSTABILITY |
| 690 | 1 | 0 | |a ALPRAZOLAM QUALITY CONTROL |
| 690 | 1 | 0 | |a ALPRAZOLAM STABILITY |
| 690 | 1 | 0 | |a BENZODIAZEPINE PHOTOTOXICITY |
| 690 | 1 | 0 | |a SPECTROFLUORIMETRIC ASSAY |
| 690 | 1 | 0 | |a ALPRAZOLAM |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a DRUG DEGRADATION |
| 690 | 1 | 0 | |a DRUG DETERMINATION |
| 690 | 1 | 0 | |a DRUG SCREENING |
| 690 | 1 | 0 | |a DRUG STABILITY |
| 690 | 1 | 0 | |a DRUG STORAGE |
| 690 | 1 | 0 | |a FLUORESCENCE |
| 690 | 1 | 0 | |a HIGH PERFORMANCE LIQUID CHROMATOGRAPHY |
| 690 | 1 | 0 | |a LIGHT EXPOSURE |
| 690 | 1 | 0 | |a PHOTODEGRADATION |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a SPECTROFLUOROMETRY |
| 690 | 1 | 0 | |a TABLET |
| 690 | 1 | 0 | |a ULTRAVIOLET A RADIATION |
| 690 | 1 | 0 | |a ULTRAVIOLET B RADIATION |
| 690 | 1 | 0 | |a VALIDATION PROCESS |
| 690 | 1 | 0 | |a ALPRAZOLAM |
| 690 | 1 | 0 | |a DRUG STABILITY |
| 690 | 1 | 0 | |a LIGHT |
| 690 | 1 | 0 | |a SPECTROMETRY, FLUORESCENCE |
| 650 | 1 | 7 | |2 spines |a PH |
| 700 | 1 | |a Gallardo Cabrera, C. | |
| 773 | 0 | |d 2002 |g v. 30 |h pp. 887-893 |k n. 3 |p J. Pharm. Biomed. Anal. |x 07317085 |w (AR-BaUEN)CENRE-5736 |t Journal of Pharmaceutical and Biomedical Analysis | |
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| 856 | 4 | 0 | |u https://doi.org/10.1016/S0731-7085(02)00351-5 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_07317085_v30_n3_p887_Nudelman |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07317085_v30_n3_p887_Nudelman |y Registro en la Biblioteca Digital |
| 961 | |a paper_07317085_v30_n3_p887_Nudelman |b paper |c PE | ||
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| 999 | |c 66164 | ||