Therapeutic action of meliacine, a plant-derived antiviral, on HSV-induced ocular disease in mice
Ocular herpes simplex virus type-1 (HSV-1) infections remain an important cause of corneal disease which may result in a loss of vision. Meliacine (MA), an antiviral activity present in crude leaf extracts of Melia azedarach L. that inhibits HSV-1 multiplication in vitro, was studied in a murine her...
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Academic Press
2002
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| LEADER | 08536caa a22009617a 4500 | ||
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| 001 | PAPER-5170 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203447.0 | ||
| 008 | 190411s2002 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0036399650 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a EXERA | ||
| 100 | 1 | |a Paula Pifarré, M. | |
| 245 | 1 | 0 | |a Therapeutic action of meliacine, a plant-derived antiviral, on HSV-induced ocular disease in mice |
| 260 | |b Academic Press |c 2002 | ||
| 270 | 1 | 0 | |m Alché, L.E.; Lab. de Virología, Depto. de Quimica Biologica, Ciudad Universitaria, 1428 Buenos Aires, Argentina; email: lalche@qb.fcen.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Alché, L.E., Berra, A., Veloso, M.J., Coto, C.E., Treatment with meliacine, a plant derived antiviral, prevents the development of herpetic stromal keratitis in mice (2000) J. Med. Virol., 61, pp. 474-480 | ||
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| 504 | |a Cassady, K.A., Whitley, R.J., New therapeutic approaches to the alphaherpesvirus infections (1997) J. Antimicrob. Chemother., 39, pp. 119-128 | ||
| 504 | |a Courrèges, M.C., Benencia, F., Coto, C.E., Massouh, E.J., Coulombié, F.C., In vitro antiphagocytic effect of Melia azedarach L. leaf extracts on mouse peritoneal exudate cells (1994) J. Ethnopharmacol., 43, pp. 135-140 | ||
| 504 | |a Courrèges, M.C., Baenencia, F., Coulombié, F.C., Coto, C.E., In vitro and in vivo activities of Melia azedarach L. aqueous leaf extracts on murine lymphocytes (1998) Phytomedicine, 5, pp. 47-53 | ||
| 504 | |a Deshpande, S.P., Zheng, M., Daheshia, M., Rouse, B.T., Pathogenesis of herpes simplex virus-induced ocular immunoinflammatory lesions in B-cell-deficient mice (2000) J. Virol., 74, pp. 3517-3524 | ||
| 504 | |a Foster, C.S., Rodríguez-García, A.R., Pedroza-Seres, M., Berra, A., Heiligenhaus, A., Soukiasian, S., Jayaraman, S., Murine herpes simplex virus keratitis is accentuated by CD4+, Vβ8.2TH2 T cells (1994) Trans. Am. Ophthalmol. Soc., 92, pp. 325-350 | ||
| 504 | |a Fujihara, T., Hayashi, K., Lactoferrin inhibits herpes simplex virus type-1 (HSV-1) infection to mouse cornea (1995) Arch. Virol., 140, pp. 1469-1472 | ||
| 504 | |a Gordon, Y.J., The evolution of antiviral therapy for external ocular viral infections over twenty-five years (2000) Cornea, 19, pp. 673-680 | ||
| 504 | |a Hendricks, R.L., An immunologist's view of herpes simplex keratitis: Thygeson Lecture 1996, presented at the Ocular Microbiology and Immunology Group Meeting, October 26, 1996 (1997) Cornea, 16, pp. 503-506 | ||
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| 504 | |a Hu, S., Dutt, J., Zhao, T., Foster, C.S., Tetrandrine potently inhibits herpes simplex virus type-1-induced keratitis in Balb/c mice (1997) Ocular Immunol. Inflam., 5, pp. 173-180 | ||
| 504 | |a Kaufman, H.E., Treatment of viral diseases of the cornea and external eye (2000) Prog. Retin. Eye Res., 19, pp. 69-85 | ||
| 504 | |a Liu, T., Tang, Q., Hendricks, R.L., Inflammatory infiltration of the trigeminal ganglion after herpes simplex virus type 1 corneal infection (1996) J. Virol., 70, pp. 264-271 | ||
| 504 | |a Piraino, F., Brandt, C.R., Isolation and partial characterization of an antiviral, RC-183, from the edible mushroom Rozites caperata (1999) Antiviral Res., 43, pp. 67-78 | ||
| 504 | |a Smith, T.J., Ackland-Berglund, C.E., Leib, D.A., Herpes simplex virus virion host shutoff (vhs) activity alters periocular disease in mice (2000) J. Virol., 74, pp. 3598-3604 | ||
| 504 | |a Suzuki, T., Sano, Y., Kinoshita, S., Effects of 1α, 25-dihydroxyvitamin D3 on Langerhans cell migration and corneal neovascularization in mice (2000) Invest. Ophtalmol. Vis. Sci., 41, pp. 154-158 | ||
| 504 | |a Whitley, R.J., Herpes simplex virus (1996) Fields Virology, pp. 2297-2342. , Fields, B. N., Ed. Raven: New York, NY, U.S.A | ||
| 504 | |a Zhao, Z.-S., Granucci, F., Yeh, L., Schaffer, P.A., Cantor, H., Molecular mimicry by herpes simplex virus-type 1: Autoimmune disease after viral infection (1998) Science, 279, pp. 1344-1347 | ||
| 520 | 3 | |a Ocular herpes simplex virus type-1 (HSV-1) infections remain an important cause of corneal disease which may result in a loss of vision. Meliacine (MA), an antiviral activity present in crude leaf extracts of Melia azedarach L. that inhibits HSV-1 multiplication in vitro, was studied in a murine herpetic stromal keratitis experimental model. Adult Balb/c mice were inoculated with HSV-1 at their corneas after abrasion. MA was administered topically three times a day for 3 consecutive days, beginning at 24 and 96 hr after infection. Infected animals treated or not with MA were monitored for the development of ocular disease by a binocular microscope for 16 days. MA significantly reduced the incidence and the severity of blepharitis, neovascularization and stromal keratitis with respect to untreated infected mice, regardless the schedule of treatment assayed. Histological examination of corneas from MA-treated animals revealed no tissue damage, whereas corneal samples from untreated infected mice showed inflammation, vascularization and necrosis. In uninfected mice treated with MA, we found no evidence of corneal damage and histopathological studies showed no changes in the corneas of these mice. Treatment with MA at 24 hours post-infection (h.p.i.) reduced viral multiplication in the eye by 1-1.5 orders of magnitude. Studies on latency revealed that MA sligthly affected the establishment of a latent infection. Thus, MA proved to exert an antiviral action on the development of herpetic stromal keratitis when supplied by post-treatment. Unexpectedly, treatment with MA after 96 h.p.i prevented ocular disease, suggesting an in vivo immunomodulating activity of MA. © 2002 Elsevier Science Ltd. |l eng | |
| 536 | |a Detalles de la financiación: UBA X-051 | ||
| 536 | |a Detalles de la financiación: This work was supported by grants from the University of Buenos Aires UBA X-051. | ||
| 593 | |a Dept. of Biochem., Sch. of Sci., Univ. of Buenos Aires, Pabellon II, Buenos Aires 1428, Argentina | ||
| 593 | |a Laboratory of Ocular Immunology, School of Medicine, University of Buenos Aires, J.E. Uriburu 950, Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a HERPES SIMPLEX VIRUS |
| 690 | 1 | 0 | |a IN VIVO |
| 690 | 1 | 0 | |a LATENCY |
| 690 | 1 | 0 | |a MELIA AZEDARACH L. |
| 690 | 1 | 0 | |a MURINE MODEL |
| 690 | 1 | 0 | |a PLANT ANTIVIRAL |
| 690 | 1 | 0 | |a STROMAL KERATITIS |
| 690 | 1 | 0 | |a MELIA AZEDARACH EXTRACT |
| 690 | 1 | 0 | |a MELIACINE |
| 690 | 1 | 0 | |a PLANT EXTRACT |
| 690 | 1 | 0 | |a UNCLASSIFIED DRUG |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ANIMAL MODEL |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a ANTIVIRAL ACTIVITY |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a DISEASE SEVERITY |
| 690 | 1 | 0 | |a HERPES SIMPLEX VIRUS 1 |
| 690 | 1 | 0 | |a HISTOPATHOLOGY |
| 690 | 1 | 0 | |a IMMUNOMODULATION |
| 690 | 1 | 0 | |a INOCULATION |
| 690 | 1 | 0 | |a KERATITIS |
| 690 | 1 | 0 | |a MICROSCOPY |
| 690 | 1 | 0 | |a MOUSE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a VASCULARIZATION |
| 650 | 1 | 7 | |2 spines |a NECROSIS |
| 700 | 1 | |a Berra, A. | |
| 700 | 1 | |a Coto, C.E. | |
| 700 | 1 | |a Alché, L.E. | |
| 773 | 0 | |d Academic Press, 2002 |g v. 75 |h pp. 327-334 |k n. 3 |p Exp. Eye Res. |x 00144835 |w (AR-BaUEN)CENRE-4712 |t Experimental Eye Research | |
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