Angiotensin II and the transcription factor Rel/NF-κB link environmental water shortage with memory improvement
One of the essential requirements even in the most ancient life forms is to be able to preserve body fluid medium. In line with such requirement, animals need to perform different behaviors to cope with water shortages. As angiotensin II (ANGII) is involved on a widespread range of functions in vert...
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2002
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| LEADER | 21434caa a22016697a 4500 | ||
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| 001 | PAPER-5093 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203443.0 | ||
| 008 | 190411s2002 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0037121661 | |
| 024 | 7 | |2 cas |a angiotensin, 1407-47-2; saralasin, 34273-10-4; sodium, 7440-23-5 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a NRSCD | ||
| 100 | 1 | |a Frenkel, L. | |
| 245 | 1 | 0 | |a Angiotensin II and the transcription factor Rel/NF-κB link environmental water shortage with memory improvement |
| 260 | |b Elsevier Ltd |c 2002 | ||
| 270 | 1 | 0 | |m Delorenzi, A.; Depto. de Fisiol., Biol. Molec./Cel., Universidad de Buenos Aires, Ciudad Universitaria, Buenos Aires, Argentina; email: delorenzi@fbmc.fcen.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Abbott, N.J., Comparative physiology of the blood-brain barrier (1992) Physiology and Pharmacology of the Blood-Brain Barrier, pp. 371-396. , Bradbury, M.W.B. (Ed.). Springer, Berlin | ||
| 504 | |a Applewhite, B.P., Gardner, F.T., Lapan, E., Physiology of habituation learning in protozoan (1969) Trans. N. Y. Acad. Sci., 31, pp. 842-849 | ||
| 504 | |a Belcheva, I., Ternianov, A., Georgiev, V., Lateralized learning and memory effects of angiotensin II microinjected into the rat CA1 hippocampal area (2000) Peptides, 21, pp. 407-411 | ||
| 504 | |a Berón de Astrada, M., Maldonado, H., Two related forms of long-term habituation in the crab Chasmagnathus are differentially affected by scopolamine (1999) Pharmacol. Biochem. Behav., 63, pp. 109-118 | ||
| 504 | |a Bicker, G., Menzel, R., Chemical codes for the control of behaviour in arthropods (1989) Nature, 33, pp. 33-39 | ||
| 504 | |a Blair-West, J.R., Burns, P., Denton, D.A., Ferraro, T., McBurnie, M.I., Tarjan, E., Weisinger, R.S., Thirst induced by increasing brain sodium concentration is mediated by brain angiotensin (1994) Brain Res., 637, pp. 335-338 | ||
| 504 | |a Braszko, J.J., The contribution of AT1 and AT2 angiotensin receptors to its cognitive effects (1996) Acta Neurobiol. Exp., 56, pp. 49-54 | ||
| 504 | |a Braszko, J.J., Kulakowska, A., Winnicka, M.M., Karwowska-Polecka, W., CGP 42112A abolishes facilitation of recognition caused by angiotensin II and angiotensin II (3-7) in rats (1997) Acta Neurobiol. Exp. (Warszaw), 57, pp. 227-234 | ||
| 504 | |a Braszko, J.J., Paslawski, L., Karwowska-Polecka, W., Holownia, A., Trandolapril attenuates acquisition of conditioned avoidance in rats (2000) Pol. J. Pharmacol., 52, pp. 195-201 | ||
| 504 | |a Braszko, J.J., Wisniewski, K., Effect of angiotensin II and saralasin on motor activity and the passive avoidance behavior of rats (1988) Peptides, 9, pp. 475-479 | ||
| 504 | |a Brunner, D., Maldonado, H., Habituation in the crab Chasmagnathus granulatus: Effect of morphine and naloxone (1988) Comp. Physiol. A, 162, pp. 687-694 | ||
| 504 | |a Cahill, L., McGaugh, J.L., Modulation of memory storage (1996) Curr. Opin. Neurobiol., 6, pp. 237-242 | ||
| 504 | |a Cornell, M.J., Williams, T.A., Lamango, N.S., Coates, D., Corvol, P., Soubrier, F., Hoheisel, J., Isaac, R.E., Cloning and expression of an evolutionary conserved single-domain angiotensin converting enzyme from Drosophila melanogaster (1995) J. Biol. Chem., 270, pp. 13613-13619 | ||
| 504 | |a Delorenzi, A., Dimant, B., Frenkel, L., Nahmod, V.E., Nässel, D.R., Maldonado, H., High environmental salinity induces memory enhancement and increases levels of brain angiotensin-like peptides in the crab Chasmagnathus granulatus (2000) J. Exp. Biol., 203, pp. 3369-3379 | ||
| 504 | |a Delorenzi, A., Locatelli, F., Romano, A., Nahmod, V.E., Maldonado, H., Angiotensin II (3-8) induces long-term memory improvement in the crab Chasmagnathus (1997) Neurosci. Lett., 226, pp. 143-146 | ||
| 504 | |a Delorenzi, A., Maldonado, H., Memory enhancement by the angiotensinergic system in the crab Chasmagnathus is mediated by endogenous angiotensin II (1999) Neurosci. Lett., 266, pp. 1-4 | ||
| 504 | |a Delorenzi, A., Pedreira, M.E., Romano, A., Garcia, S.I., Pirola, C.J., Nahmod, V.E., Maldonado, H., Angiotensin II enhances long-term memory in the crab Chasmagnathus (1996) Brain Res. Bull., 41, pp. 211-220 | ||
| 504 | |a Delorenzi, A., Pedreira, M.E., Romano, A., Pirola, C.J., Nahmod, V.E., Maldonado, H., Acute administration of angiotensin II improves long-term habituation in the crab Chasmagnathus (1995) Neurosci. Lett., 196, pp. 193-196 | ||
| 504 | |a DeNoble, V.J., DeNoble, K.F., Spencer, K.R., Chiu, A.T., Wong, P.C., Timmermans, P.B., Non-peptide angiotensin II receptor antagonist and angiotensin-converting enzyme inhibitor: Effect on a renin-induced deficit of a passive avoidance response in rats (1991) Brain Res., 561, pp. 230-235 | ||
| 504 | |a Domeney, A.M., Angiotensin converting enzyme inhibitors as potential cognitive enhancing agents (1994) J. Psychiatry Neurosci., 19, pp. 46-50 | ||
| 504 | |a Fischer-Ferraro, C., Nahmod, V.E., Goldstein, D.J., Finkielman, S., Angiotensin and renin in rat and dog brain (1971) J. Exp. Med. 1, 133, pp. 353-361 | ||
| 504 | |a Fitzsimons, J.T., Angiotensin, thirst and sodium appetite (1998) Physiol. Rev., 78, pp. 583-686 | ||
| 504 | |a Flood, J.F., Smith, G.E., Morley, J.E., Modulation of memory processing by cholecystokinin: Dependence on the vagus nerve (1987) Science, 15, pp. 832-834 | ||
| 504 | |a Floyd, P.D., Li, L., Rubakhin, S.S., Sweedler, J.V., Horn, C.C., Kupfermann, I., Alexeeva, V.Y., Vilim, F.S., Insulin prohormone processing, distribution, and relation to metabolism in Aplysia californica (1999) J. Neurosci., 19, pp. 7732-7741 | ||
| 504 | |a Freudenthal, R., Locatelli, F., Hermitte, G., Maldonado, H., Lafourcade, C., Delorenzi, A., Romano, A., Kappa-B like DNA-binding activity is enhanced after spaced training that induces long-term memory in the crab Chasmagnathus (1998) Neurosci. Lett., 242, pp. 143-146 | ||
| 504 | |a Freudenthal, R., Romano, A., Participation of Rel/NF-kB transcription factors in long-term memory in the crab Chasmagnathus (2000) Brain Res., 855, pp. 274-281 | ||
| 504 | |a Fujino, Y., Nagahama, T., Oumi, T., Ukena, K., Morishita, F., Furukawa, Y., Matsushima, O., Nomoto, K., Possible functions of oxytocin/vasopressin-superfamily peptides in annelids with special reference to reproduction and osmoregulation (1999) J. Exp. Zool., 284, pp. 401-406 | ||
| 504 | |a Galli, S.M., Phillips, M.I., Interactions of angiotensin II and atrial natriuretic peptide in the brain: Fish to rodent (1996) Proc. Soc. Exp. Biol. Med., 213, pp. 128-137 | ||
| 504 | |a Georgiev, V.P., Yonkov, D.I., Kambourova, T.S., Interactions between angiotensin II and baclofen in shuttle-box and passive avoidance performance (1988) Neuropeptides, 12, pp. 155-158 | ||
| 504 | |a Gonzalez, G.C., Roger, I., Gonzalez, E., Martinez-Padron, M., Moore, G.J., Lukowiak, K., Angiotensinogen-like epitopes are present in the CNS of Aplysia californica and co-localize with urotensin I- and urotensin II-like immunoreactivities in the cerebral ganglia (1995) NeuroReport, 6, pp. 541-544 | ||
| 504 | |a Guilles, R., Pequeux, R., Interactions of chemical and osmotic regulation with the environment (1983) The Biology of Crustacea, 8, pp. 109-177. , Vernberg, F.J., Vernberg, W.B. (Eds.). Bliss, Academic Press, New York, Ch. 4 | ||
| 504 | |a Hermitte, G., Pedreira, M.E., Tomsic, D., Maldonado, H., Context shift and protein synthesis inhibition disrupt long-term habituation after spaced, but not massed, training in the crab Chasmagnathus (1999) Neurobiol. Learn. Mem., 71, pp. 34-49 | ||
| 504 | |a Hoeger, U., Florey, E., Catecholamine degradation in the hemolymph of the chinese crab, Eriocheir sinensis (1989) Comp. Biochem. Physiol. C, 92, pp. 323-327 | ||
| 504 | |a Keller-Wood, M.K., Stenstrom, B., Shinsako, J., Phillips, M.I., Interaction between CRF and AngII in control ACTH and adrenal steroids (1986) Am. J. Physiol., 250, pp. 306-402 | ||
| 504 | |a Koller, M., Krause, H.P., Hoffmeister, F., Ganten, D., Endogenous brain angiotensin II disrupts passive avoidance behavior in rats (1979) Neurosci. Lett., 14, pp. 71-75 | ||
| 504 | |a Kravitz, E.A., Hormonal control of behavior: Amines and the biasing of behavioral output in lobsters (1988) Science, 241, pp. 1775-1781 | ||
| 504 | |a Lamango, N.S., Sajid, M., Isaac, R.E., The endopeptidase activity and the activation by Cl- of angiotensin-converting enzyme is evolutionary conserved: Purification and properties of an angiotensin-converting enzyme from the housefly, Musca domestica (1996) Biochem. J., 314, pp. 639-646 | ||
| 504 | |a Laurent, V., Bulet, P., Salzet, M.A., Comparison of the leech Theromyzon tessulatom angiotensin I-like molecule with forms of vertebrate angiotensinogens: A hormonal system conserved in the course of evolution (1995) Neurosci. Lett., 190, pp. 175-178 | ||
| 504 | |a Locatelli, F., LaFourcade, C., Maldonado, H., Romano, A., Characterization of cAMP-dependent protein kinase isoforms in the brain of the crab Chasmagnathus (2001) J. Comp. Physiol. B, 171, pp. 33-40 | ||
| 504 | |a Locatelli, F., Maldonado, H., Romano, A., Two critical periods for cAMP-dependent protein kinase activity during long-term memory consolidation in the crab Chasmagnathus (2002) Neurobiol. Learn. Mem., 77, pp. 234-249 | ||
| 504 | |a Lowry, O.H., Rosebrough, N.J., Farr, A.L., Randall, R.J., Protein measurement with the Folin-phenol reagent (1951) J. Biol. Chem., 193, pp. 265-275 | ||
| 504 | |a Lozada, M., Romano, A., Maldonado, H., Long-term habituation to a danger stimulus in the crab Chasmagnathus granulatus (1990) Physiol. Behav., 47, pp. 35-41 | ||
| 504 | |a Luquet, C.M., Ansaldo, M., Acid-base balance of ionic regulation during emersion in the estuarine intertidal crab Chasmagnathus granulata Dana (Decapoda: Grapsidae) (1997) Comp. Biochem. Physiol., 117, pp. 407-410 | ||
| 504 | |a Makra, M.E., Prior, D.J., Angiotensin II can initiate contact-rehydratation in terrestrial slug (1985) J. Exp. Biol., 119, pp. 385-388 | ||
| 504 | |a Maldonado, H., Crustaceans as model to investigate memory illustrated by extensive behavioral and physiological studies in Chasmagnathus (2002) The Crustacean Nervous System, pp. 314-327. , Wiese, K. (Ed.). Springer, Berlin | ||
| 504 | |a Maldonado, H., Romano, A., Tomsic, D., Long-term habituation (LTH) in the crab Chasmagnathus: A model for behavioral and mechanistic studies of memory (1997) Braz. J. Med. Biol. Res., 30, pp. 813-826 | ||
| 504 | |a Mattson, M., Culmsee, C., Yu, Z.F., Canadola, S., Roles of nuclear factor κB in neuronal survival and plasticity (2000) Neurochemistry, 74, pp. 443-456 | ||
| 504 | |a Merlo, E., Freudenthal, R., Romano, A., The IkappaB kinase inhibitor sulfasalazine impairs long-term memory in the crab Chasmagnathus (2002) Neuroscience, 112, pp. 161-172 | ||
| 504 | |a Morgan, J.M., Routtenberg, A., Angiotensin injected into the neostriatum after learning disrupts retention performance (1977) Science, 196, pp. 87-89 | ||
| 504 | |a Morley, J.E., The role of peptides in appetite regulation across species (1995) Am. Zool., 35, pp. 437-445 | ||
| 504 | |a Nahmod, V.E., Finkielman, S., Gorodner, O.S., Goldstein, D.J., On the neuronal localization and the physiological variations of brain angiotensin (1977) Central Actions of Angiotensin and Related Hormones, pp. 573-579. , Buckley, J.P., Ferrario, C.M. (Eds.). A Wheaton and Co | ||
| 504 | |a Nässel, D.R., Peptidergic neurohormonal control systems in invertebrates (1996) Curr. Opin. Neurobiol., 6, pp. 842-850 | ||
| 504 | |a Nishimura, H., Angiotensin receptors - Evolutionary overview and perspectives (2001) Comp. Biochem. Physiol. A, 128, pp. 11-30 | ||
| 504 | |a Pedreira, M.E., Dimant, B., Maldonado, H., Inhibitors of protein and RNA synthesis block context memory and long-term habituation in the crab Chasmagnathus (1996) Pharmacol. Biochem. Behav., 54, pp. 611-617 | ||
| 504 | |a Pedreira, M.E., Dimant, B., Tomsic, D., Quesada-Allue, L.A., Maldonado, H., Cycloheximide inhibits context memory and long-term habituation in the crab Chasmagnathus (1995) Pharmacol. Biochem. Behav., 52, pp. 385-395 | ||
| 504 | |a Peeke, H.V., Veno, A., Response independent habituation of territorial aggression in the three-spined stickleback (Gasterosteus aculeatus) (1976) Z. Tierpsychol., 40, pp. 53-58 | ||
| 504 | |a Pereyra, P., Gonzalez Portino, E., Maldonado, H., Long-lasting and context-specific freezing preference is acquired after spaced repeated presentations of a danger stimulus in the crab Chasmagnathus (2000) Neurobiol. Learn. Mem., 74, pp. 119-134 | ||
| 504 | |a Povolones, M., Trank, K., Thanos, D., Ambron, R.T., An NF-kappaB-like transcription factor in axoplasm is rapidly inactivated after injury in Aplysia (1997) J. Neurosci., 17, pp. 4915-4920 | ||
| 504 | |a Raghavendra, V., Chopra, K., Kulkarni, S.K., Comparative studies on the memory-enhancing actions of captopril and losartan in mice using inhibitory shock avoidance paradigm (2001) Neuropeptides, 35, pp. 65-69 | ||
| 504 | |a Rescorla, R.A., Behavioral studies of pavlovian conditioning (1988) Annu. Rev. Neurosci., 1, pp. 320-352 | ||
| 504 | |a Romano, A., Delorenzi, A., Pedreira, M.E., Tomsic, D., Maldonado, H., Acute administration of a permeant analog of cAMP and a phosphodiesterase inhibitor improve long-term habituation in the crab Chasmagnathus (1996) Behav. Brain Res., 75, pp. 119-125 | ||
| 504 | |a Romano, A., Locatelli, F., Delorenzi, A., Pedreira, M.E., Maldonado, H., Effects of activation and inhibition of cAMP-dependent protein kinase on long-term habituation in the crab Chasmagnathus (1996) Brain Res., 735, pp. 131-140 | ||
| 504 | |a Rosenthal, R., Rosnow, R., (1985) Contrast Analysis: Focused Comparisons in the Analysis of Variance, , Cambridge University Press, New York | ||
| 504 | |a Ruiz-Ortega, M., Lorenzo, O., Ruperez, M., Konig, S., Wittig, B., Egido, J., Angiotensin II activates nuclear transcription factor κB through AT1 and AT2 in vascular smooth muscle cells (2000) Circ. Res., 86, pp. 1266-1272 | ||
| 504 | |a Salzet, M., Deloffre, L., Breton, C., Vieau, D., Schoofs, L., The angiotensin system elements in invertebrates (2001) Brain Res. Rev., 36, pp. 35-45 | ||
| 504 | |a Schmitt, A.S.C., Santos, E.A., Behaviour and hemolymphatic ionic composition of the intertidial crab Chasmagnathus granulata Dana, 1851 (Crustacea: Decapoda) during emersion (1993) Comp. Biochem. Physiol., 106, pp. 337-342 | ||
| 504 | |a Schoofs, L., Veelaert, D., De Loof, A., Huybrechts, R., Isaac, E., Immunocytochemical distribution of angiotensin I-converting enzyme-like immunoreactivity in the brain and testis of insects (1998) Brain Res., 785, pp. 215-227 | ||
| 504 | |a Smiley, J.W., Doig, M.T., Distribution and characterization of angiotensin-converting enzyme-like activity in tissues of the blue crab Callinectes sapidus (1994) Comp. Biochem. Phys. A, 108, pp. 491-496 | ||
| 504 | |a Sudilovsky, A., Turnbull, B., Croog, S.H., Crook, T., Angiotensin converting enzyme and memory: Preclinical and clinical data (1987) Int. J. Neurol., 21-22, pp. 145-162 | ||
| 504 | |a Tomsic, D., Maldonado, H., Rakitin, A., Morphine and GABA: Effects on perception, escape response and long-term habituation to a danger stimulus in the crab Chasmagnathus (1991) Brain Res. Bull., 26, pp. 699-706 | ||
| 504 | |a Tomsic, D., Pedreira, M.E., Romano, A., Hermitte, G., Maldonado, H., Context-US association as a determinant of long-term habituation in the crab Chasmagnathus (1998) Ann. Learn. Behav., 26, pp. 196-209 | ||
| 504 | |a Troncoso, J., Maldonado, H., Two related forms of memory in the crab Chasmagnathus are differentially affected by NMDA receptor antagonists (2002) Pharmacol. Biochem. Behav., 72, pp. 251-265 | ||
| 504 | |a Walther, T., Voigt, J.P., Fukamizu, A., Fink, H., Bader, M., Learning and anxiety in angiotensin-deficient mice (1999) Behav. Brain Res., 100, pp. 1-4 | ||
| 504 | |a Winnicka, M.M., 6-OHDA bilateral lesions to the amygdala abolish the memory enhancing effect of angiotensin II in rats (1998) Pharmacol. Res., 38, pp. 53-58 | ||
| 504 | |a Winnicka, M.M., Wisniewski, K., Disruption of temporo-entorhinal connections abolishes recognition memory-enhancing effect of angiotensins in rats (1999) Gen. Pharmacol., 33, pp. 91-97 | ||
| 504 | |a Wright, J.W., Harding, J.W., Regulatory role of brain angiotensins in the control of physiological and behavioral responses (1992) Brain Res. Rev., 17, pp. 227-262 | ||
| 504 | |a Wright, J.W., Harding, J.W., Brain angiotensin receptor subtypes in the control of physiological and behavioral responses (1994) Neurosci. Behav. Rev., 18, pp. 21-53 | ||
| 504 | |a Wright, J.W., Harding, J.W., Important role for angiotensin III and IV in the brain renin-angiotensin system (1997) Brain Res. Rev., 25, pp. 96-124 | ||
| 520 | 3 | |a One of the essential requirements even in the most ancient life forms is to be able to preserve body fluid medium. In line with such requirement, animals need to perform different behaviors to cope with water shortages. As angiotensin II (ANGII) is involved on a widespread range of functions in vertebrates, including memory modulation, an integrative role, in response to an environmental water shortage, has been envisioned. Previous work on the semi-terrestrial and brackish-water crab Chasmagnathus granulatus showed that endogenous ANGII enhanced an associative long-term memory and, in addition, that high salinity environment induces both an increase of brain ANGII levels and memory improvement. Here, we show that in the crab Chasmagnathus air exposure transiently increases blood sodium concentration, significantly increases brain ANGII immunoreactivity, and has a facilitatory effect on memory that is abolished by a non-selective ANGII receptor antagonist, saralasin. Furthermore, Rel/NF-κB, a transcription factor activated by ANGII in mammals and during memory consolidation in Chasmagnathus brain, is induced in the crab's brain by air exposure. Moreover, nuclear brain NF-κB is activated by ANGII, and this effect is reversed by saralasin. Our results constitute the first demonstration in an invertebrate that cognitive functions are modulated by an environmental stimulus through a neuropeptide and give evolutionary support to the role of angiotensins in memory processes. Moreover, these results suggest that angiotensinergic system is preserved across evolution not only in its structure and molecular mechanisms, but also in its capability of coordinating specific adaptative responses. © 2002 IBRO. Published by Elsevier Science Ltd. All rights reserved. |l eng | |
| 536 | |a Detalles de la financiación: Agencia Nacional de Promoción Científica y Tecnológica, 1-06041, PICT 1-06602 | ||
| 536 | |a Detalles de la financiación: We thank A. Alvarez and A. Vidal for technical assistance. The use of flame spectrophotometer was kindly provided by Dr. E. Rodriguez. We are grateful to Dr. G. Gallizia for critical comments and Dr. L. Orelli for helping with the manuscript. We thank members of the Laboratorio de Neurobiologı́a de la Memoria for discussion and comments. Supported by Agencia Nacional de Promoción Cientı́fica y Tecnológica, PICT 1-06602 and 1-06041. | ||
| 593 | |a Laboratorio de Neurobiología de la Memoria, Departamento de Fisiología, Ciudad Universitaria, Pabellón II (C1428EHA), Buenos Aires, Argentina | ||
| 593 | |a Laboratorio de Sustancias Vasoactivas, Instituto de Investigaciones Médicas, Universidad de Buenos Aires, Donato Alvarez 3150, Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a ANGIOTENSIN |
| 690 | 1 | 0 | |a INVERTEBRATE |
| 690 | 1 | 0 | |a MEMORY |
| 690 | 1 | 0 | |a NEUROPEPTIDE |
| 690 | 1 | 0 | |a NF-ΚB OSMOREGULATION |
| 690 | 1 | 0 | |a ANGIOTENSIN |
| 690 | 1 | 0 | |a ANGIOTENSIN RECEPTOR ANTAGONIST |
| 690 | 1 | 0 | |a IMMUNOGLOBULIN ENHANCER BINDING PROTEIN |
| 690 | 1 | 0 | |a SARALASIN |
| 690 | 1 | 0 | |a SODIUM |
| 690 | 1 | 0 | |a TRANSCRIPTION FACTOR |
| 690 | 1 | 0 | |a TRANSCRIPTION FACTOR REL |
| 690 | 1 | 0 | |a UNCLASSIFIED DRUG |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a COGNITION |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a CRAB |
| 690 | 1 | 0 | |a ENVIRONMENTAL EXPOSURE |
| 690 | 1 | 0 | |a IMMUNOREACTIVITY |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MEMORY CONSOLIDATION |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROTEIN FUNCTION |
| 690 | 1 | 0 | |a SODIUM BLOOD LEVEL |
| 700 | 1 | |a Freudenthal, R. | |
| 700 | 1 | |a Romano, A. | |
| 700 | 1 | |a Nahmod, V.E | |
| 700 | 1 | |a Maldonado, H. | |
| 700 | 1 | |a Delorenzi, A. | |
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