A new strategy for neurochemical photodelivery: Metal-ligand heterolytic cleavage

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A new strategy to build caged-compounds is presented. The approach is based on heterolytic photocleavage of a metal-ligand bond in a coordination compound. A ruthenium polypyridine complex, containing the neurocompound 4-amino pyridine (4AP) is used as the core of the phototrigger. The biomolecule i...

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Detalles Bibliográficos
Autor principal: Zayat, L.
Otros Autores: Calero, C., Alborés, P., Baraldo, L., Etchenique, R.
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: 2003
Materias:
XENON
Acceso en línea:Registro en Scopus
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Biblioteca Central Dr. Luis F. Leloir (FCEN) de Universidad de Buenos Aires
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024 7 |2 cas  |a 4 aminopyridine, 1003-40-3, 504-24-5; xenon, 7440-63-3; 2,2'-Dipyridyl, 366-18-7; 4-Aminopyridine, 504-24-5; Drug Carriers; Organometallic Compounds; Potassium Channel Blockers; dichlorobis(2,2'-bipyridine)(4-aminopyridine)ruthenium 
040 |a Scopus  |b spa  |c AR-BaUEN  |d AR-BaUEN 
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100 1 |a Zayat, L. 
245 1 2 |a A new strategy for neurochemical photodelivery: Metal-ligand heterolytic cleavage 
260 |c 2003 
270 1 0 |m Etchenique, R.; Departamento de Quimica Inorganico, INQUIMAE, Universidad de Buenos Aires, AR1428EHA Buenos Aires, Argentina; email: rober@qi.fcen.uba.ar 
506 |2 openaire  |e Política editorial 
504 |a Adams, S.R., Tsien, R.Y., (1993) Annu. Rev. Physiol., 55, pp. 755-784 
504 |a Nicholls, J.G., Wallace, B., Fuchs, P.A., Martin, A.R., (2001) From Neuron to Brain, 4th Ed., , Sinauer Assoc: Sunderland, MA 
504 |a Givens, R.S., Weber, J.F.W., Conrad P.G. II, Orosz, G., Donahue, S.L., Thayer, S.A., (2000) J. Am. Chem. Soc., 122, pp. 2687-2697 
504 |a Balzani, V., Carassitti, V., (1970) Photochemistry of Coordination Compounds, , Academic Press: New York 
504 |a Velez, P., Gyorke, S., Escobar, A.L., Vergara, J., Fill, M., (1997) Biophys. J., 72, pp. 691-697 
504 |a De Leo, M., Ford, P.C., (1999) J. Am. Chem. Soc., 121, pp. 1980-1981 
504 |a Muller, M., Dierkes, P.W., Schlue, W.-R., (1999) Brain Res., 826, pp. 63-73 
504 |a Chun-Ying, D., Zhon-Lin, L., Xiao-Zeng, Y., Mak, T.C.W., (1999) J. Coord. Chem., 46, pp. 301-312 
504 |a Pinnick, D.V., Durham, B., (1984) Inorg. Chem., 23, pp. 1440-1445 
504 |a Dodsworth, E.S., Lever, A.B.P., (1986) Chem. Phys. Lett., 124, pp. 152-158 
504 |a Schlue, W.-R., Deitmer, J., (1980) J. Exp. Biol., 82, pp. 23-34 
504 |a Franz, A., Ronacher, B., (2002) J. Comput. Physiol. A, 188, pp. 261-271 
520 3 |a A new strategy to build caged-compounds is presented. The approach is based on heterolytic photocleavage of a metal-ligand bond in a coordination compound. A ruthenium polypyridine complex, containing the neurocompound 4-amino pyridine (4AP) is used as the core of the phototrigger. The biomolecule is released by irradiation with visible light (>480 nm). The liberated 4AP promotes the activation of a leech neuron by means of blocking its K+ channels. The syntesis, characterization, and the inherent advantages of this method are discussed. Copyright © 2003 American Chemical Society.  |l eng 
593 |a Departamento de Quimica Inorganico, INQUIMAE, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria Pabellón 2, AR1428EHA Buenos Aires, Argentina 
690 1 0 |a 4 AMINOPYRIDINE 
690 1 0 |a LIGAND 
690 1 0 |a METAL COMPLEX 
690 1 0 |a RUTHENIUM COMPLEX 
690 1 0 |a ACTION POTENTIAL 
690 1 0 |a ANIMAL CELL 
690 1 0 |a ANIMAL EXPERIMENT 
690 1 0 |a ANIMAL MODEL 
690 1 0 |a ARTICLE 
690 1 0 |a CELL ACTIVITY 
690 1 0 |a CONTROLLED STUDY 
690 1 0 |a COVALENT BOND 
690 1 0 |a CRYSTALLIZATION 
690 1 0 |a DIODE 
690 1 0 |a LEECH 
690 1 0 |a LIGHT ABSORPTION 
690 1 0 |a MEMBRANE PERMEABILITY 
690 1 0 |a MEMBRANE POTENTIAL 
690 1 0 |a NERVE CELL 
690 1 0 |a NEUROCHEMISTRY 
690 1 0 |a NONHUMAN 
690 1 0 |a NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY 
690 1 0 |a OXIDATION REDUCTION POTENTIAL 
690 1 0 |a PHOTOACTIVATION 
690 1 0 |a PHOTOCHEMISTRY 
690 1 0 |a QUANTUM YIELD 
690 1 0 |a SYNTHESIS 
690 1 0 |a 2,2'-DIPYRIDYL 
690 1 0 |a 4-AMINOPYRIDINE 
690 1 0 |a ACTION POTENTIALS 
690 1 0 |a ANIMALS 
690 1 0 |a DRUG CARRIERS 
690 1 0 |a GANGLIA 
690 1 0 |a LEECHES 
690 1 0 |a MEMBRANE POTENTIALS 
690 1 0 |a NEURONS 
690 1 0 |a ORGANOMETALLIC COMPOUNDS 
690 1 0 |a OXIDATION-REDUCTION 
690 1 0 |a PHOTOCHEMISTRY 
690 1 0 |a POTASSIUM CHANNEL BLOCKERS 
650 1 7 |2 spines  |a XENON 
700 1 |a Calero, C. 
700 1 |a Alborés, P. 
700 1 |a Baraldo, L. 
700 1 |a Etchenique, R. 
773 0 |d 2003  |g v. 125  |h pp. 882-883  |k n. 4  |p J. Am. Chem. Soc.  |x 00027863  |w (AR-BaUEN)CENRE-19  |t Journal of the American Chemical Society 
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856 4 0 |u https://doi.org/10.1021/ja0278943  |y DOI 
856 4 0 |u https://hdl.handle.net/20.500.12110/paper_00027863_v125_n4_p882_Zayat  |y Handle 
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