Cytogenetic evaluation of two nitroimidazole derivatives
5-Nitroimidazoles are a well-established group of antiprotozoal and antibacterial agents. Thanks to their antimicrobial activity these chemotherapeutic agents inhibit the growth of both anaerobic bacteria and certain anaerobic protozoa such as Trichomonas vaginalis, Entamoeba histolytica and Giardia...
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2003
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| LEADER | 15371caa a22016097a 4500 | ||
|---|---|---|---|
| 001 | PAPER-5069 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203441.0 | ||
| 008 | 190411s2003 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-12244272433 | |
| 024 | 7 | |2 cas |a metronidazole, 39322-38-8, 443-48-1; ornidazole, 16773-42-5; Antitrichomonal Agents; Metronidazole, 443-48-1; Ornidazole, 16773-42-5 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a TIVIE | ||
| 100 | 1 | |a López Nigro, M.M. | |
| 245 | 1 | 0 | |a Cytogenetic evaluation of two nitroimidazole derivatives |
| 260 | |c 2003 | ||
| 270 | 1 | 0 | |m Carballo, M.A.; CIGETOX-Citogenetica y Genet. T., Dpto de Bioquím. Clín., Facultad de Farmacia y B. (FFyB), Buenos Aires, Argentina; email: jorgezafuta@hotmail.com |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Reitz, M., Rumpf, M., Knitza, R., DNA single strand breaks in lymphocytes after metronidazole therapy (1991) Arzneimittel Forschung, 41, pp. 155-156 | ||
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| 504 | |a Walsh, J.S., Wang, R., Bagan, E., Wang, C.C., Wislocki, P., Miwa, G.T., Structural alterations that differentially affect the mutagenic and antitrichomonal activities of 5-nitroimidazoles (1987) Journal of Medicinal Chemistry, 30, pp. 150-156 | ||
| 520 | 3 | |a 5-Nitroimidazoles are a well-established group of antiprotozoal and antibacterial agents. Thanks to their antimicrobial activity these chemotherapeutic agents inhibit the growth of both anaerobic bacteria and certain anaerobic protozoa such as Trichomonas vaginalis, Entamoeba histolytica and Giardia lamblia. The aim of the present study is to achieve a precise characterization of the genotoxic activity of these compounds and to establish the value of cytogenetic assays in order to determine the effect of these drugs, at therapeutic doses, to settle an improved risk assessment. Two nitroimidazole were studied, metronidazole and ornidazole, at four different concentrations (0.1, 1, 10 and 50 μg/ml of peripheral blood lymphocyte culture). Endpoints analyzed included: mitotic index (MI), replication index (RI), sister chromatid exchange (SCE) and chromosomal aberrations (CA). An analysis of variance test (ANOVA) was performed to evaluate the results. A significant decrease (P<0.0001) in MI as well as an increase in SCE (P<0.0001) and CA (0.0001) frequencies for both drugs was observed. No modifications in RI were found. The results suggest a genotoxic and cytotoxic effect of MTZ and ONZ in human peripheral blood cultures in vitro. © 2002 Elsevier Science Ltd. All rights reserved. |l eng | |
| 536 | |a Detalles de la financiación: Secretaría de Ciencia y Técnica, Universidad de Buenos Aires, TB15 | ||
| 536 | |a Detalles de la financiación: Fundación Alberto J. Roemmers | ||
| 536 | |a Detalles de la financiación: The authors wish to thank Sabina Domené for review of the manuscript. This work was supported by grants from UBACYT TB15, TB24 and Alberto J. Roemmers Foundation. | ||
| 593 | |a CIGETOX-Citogenetica y Genet. T., Dpto de Bioquím. Clín., Facultad de Farmacia y B. (FFyB), Buenos Aires, Argentina | ||
| 593 | |a CITEFA (I. I. C. y T. de las FFAA), Buenos Aires, Argentina | ||
| 593 | |a GIBE-Grupo de Invest. en Biologia E., Dpto de Ecologia, Genet. y Evolucion, Facultad de Cie. Exact. y N. (FCEyN), Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a BIOMARKERS |
| 690 | 1 | 0 | |a CYTOGENETICS |
| 690 | 1 | 0 | |a GENETIC TOXICOLOGY |
| 690 | 1 | 0 | |a METRONIDAZOLE |
| 690 | 1 | 0 | |a ORNIDAZOLE |
| 690 | 1 | 0 | |a METRONIDAZOLE |
| 690 | 1 | 0 | |a NITROIMIDAZOLE DERIVATIVE |
| 690 | 1 | 0 | |a ORNIDAZOL RICHET |
| 690 | 1 | 0 | |a ORNIDAZOLE |
| 690 | 1 | 0 | |a ADULT |
| 690 | 1 | 0 | |a ANALYSIS OF VARIANCE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CELL CULTURE |
| 690 | 1 | 0 | |a CELL DIVISION |
| 690 | 1 | 0 | |a CHEMICAL ANALYSIS |
| 690 | 1 | 0 | |a CHROMOSOME ABERRATION |
| 690 | 1 | 0 | |a CHROMOSOME ANALYSIS |
| 690 | 1 | 0 | |a CLINICAL TRIAL |
| 690 | 1 | 0 | |a CONTROLLED CLINICAL TRIAL |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a CYTOGENETICS |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a GENOTOXICITY |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a HUMAN CELL |
| 690 | 1 | 0 | |a LYMPHOCYTE |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MITOSIS |
| 690 | 1 | 0 | |a NORMAL HUMAN |
| 690 | 1 | 0 | |a RISK ASSESSMENT |
| 690 | 1 | 0 | |a SISTER CHROMATID EXCHANGE |
| 690 | 1 | 0 | |a ADULT |
| 690 | 1 | 0 | |a ANTITRICHOMONAL AGENTS |
| 690 | 1 | 0 | |a CELL CULTURE TECHNIQUES |
| 690 | 1 | 0 | |a CELL DIVISION |
| 690 | 1 | 0 | |a CHROMOSOME ABERRATIONS |
| 690 | 1 | 0 | |a DNA DAMAGE |
| 690 | 1 | 0 | |a DOSE-RESPONSE RELATIONSHIP, DRUG |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a LYMPHOCYTES |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a METRONIDAZOLE |
| 690 | 1 | 0 | |a MITOSIS |
| 690 | 1 | 0 | |a MUTAGENICITY TESTS |
| 690 | 1 | 0 | |a ORNIDAZOLE |
| 690 | 1 | 0 | |a RISK ASSESSMENT |
| 690 | 1 | 0 | |a SISTER CHROMATID EXCHANGE |
| 690 | 1 | 0 | |a ENTAMOEBA HISTOLYTICA |
| 690 | 1 | 0 | |a GIARDIA INTESTINALIS |
| 690 | 1 | 0 | |a PROTOZOA |
| 690 | 1 | 0 | |a TRICHOMONAS VAGINALIS |
| 653 | 0 | 0 | |a flagyl, Rhone Poulenc Rorer, Argentina; ornidazol richet, Richet, Argentina |
| 700 | 1 | |a Palermo, A.M. | |
| 700 | 1 | |a Mudry, M.D. | |
| 700 | 1 | |a Carballo, M.A. | |
| 773 | 0 | |d 2003 |g v. 17 |h pp. 35-40 |k n. 1 |p Toxicol. Vitro |x 08872333 |w (AR-BaUEN)CENRE-7046 |t Toxicology in Vitro | |
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