Effect of in vivo administered hexachlorobenzene on epidermal growth factor receptor levels, protein tyrosine kinase activity, and phosphotyrosine content in rat liver
In the present study, the effects of hexachlorobenzene (HCB) on epidermal growth factor receptor (EGFR) content of liver microsomes and plasma membrane, and on EGFR-tyrosine kinase activity in the microsomal fraction were investigated. In addition, we studied the parameters of the tyrosine kinase si...
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Elsevier Inc.
2003
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| LEADER | 14316caa a22012737a 4500 | ||
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| 001 | PAPER-4983 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203436.0 | ||
| 008 | 190411s2003 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0038555827 | |
| 024 | 7 | |2 cas |a epidermal growth factor receptor, 79079-06-4; hexachlorobenzene, 118-74-1, 55600-34-5; phosphotyrosine, 21820-51-9; protein tyrosine kinase, 80449-02-1 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a BCPCA | ||
| 100 | 1 | |a Randi, A.S. | |
| 245 | 1 | 0 | |a Effect of in vivo administered hexachlorobenzene on epidermal growth factor receptor levels, protein tyrosine kinase activity, and phosphotyrosine content in rat liver |
| 260 | |b Elsevier Inc. |c 2003 | ||
| 270 | 1 | 0 | |m Kleiman De Pisarev, D.L.; Depto. de Bioquímica Humana, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 5to piso, Buenos Aires, CP 1121, Argentina; email: dkleiman@fmed.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Courtney, K.D., Hexachlorobenzene: A review (1979) Environ. Res., 20, pp. 225-266 | ||
| 504 | |a Koss, G., Koransky, W., Steinbach, K., Studies on the toxicology of hexachlorobenzene. II. Identification and determination of metabolites (1976) Arch. Toxicol., 35, pp. 107-114 | ||
| 504 | |a Brady, M.N., Siyali, D.S., Hexachlorobenzene in human body fat (1972) Med. J. Aust., 1, pp. 158-161 | ||
| 504 | |a Van Raaij, J.A.G.M., Kaptein, E., Visser, T.J., Van den Berg, K.J., Increased glucuronidation of thyroid hormone in hexachlorobenzene-treated rats (1993) Biochem. Pharmacol., 45, pp. 627-631 | ||
| 504 | |a Kleiman de Pisarev, D.L., Ríos de Molina del, C., San Martín de Viale, L.C., Thyroid function and thyroxine metabolism in hexachlorobenzene-induced porphyria (1990) Biochem. Pharmacol., 39, pp. 817-825 | ||
| 504 | |a Sopena de Kracoff, Y.E., Ferramola de Sancovich, A.M., Sancovich, H.A., Kleiman de Pisarev, D.L., Effect of thyroidectomy and thyroxine on hexachlorobenzene induced porphyria (1994) J. Endocrinol. Invest., 17, pp. 301-305 | ||
| 504 | |a Billi de Catabbi, S., Sterin-Speziale, N., Fernandez, M.C., Minutolo, C., San Martín de Viale, L.C., Time course of hexachlorobenzene-induced alteration of lipid metabolism and their relation to porphyria (1997) Int. J. Biochem. Cell Biol., 29, pp. 335-344 | ||
| 504 | |a Rozman, K., Gorski, J.R., Rozman, P., Parkinson, A., Reduced serum thyroid hormone levels in hexachlorobenzene induced porphyria (1986) Toxicol. Lett., 30, pp. 71-78 | ||
| 504 | |a Kleiman de Pisarev, D.L., Sancovich, H.A., Ferramola de Sancovich, A.M., Enhanced thyroxine metabolism in hexachlorobenzene-intoxicated rats (1989) J. Endocrinol. Invest., 12, pp. 767-772 | ||
| 504 | |a Cabral, J.R.P., Shubik, P., Mollner, T., Raitano, F., Carcinogenic activity of hexachlorobenzene in hamsters (1977) Nature, 269, pp. 510-511 | ||
| 504 | |a Erturk, E., Lambrecht, R.W., Peters, H.A., Cripps, D.J., Gocmen, A., Morris, C.R., Bryan, G.T., Oncogenicity of hexachlorobenzene (1986) IARC Sci. Publ., 77, pp. 417-423 | ||
| 504 | |a Stewart, F.P., Manson, M.M., Cabral, J.R.P., Smith, A.G., Hexachlorobenzene as a promoter of diethylnitrosamine-initiated hepatocarcinogenesis in rats and comparison with induction of porphyria (1989) Carcinogenesis, 10, pp. 1225-1230 | ||
| 504 | |a Mylchreest, E., Charbonneau, M., Studies on the mechanism of uroporphyrinogen decarboxylase inhibition in hexachlorobenzene-induced porphyria in the female rat (1997) Toxicol. Appl. Pharmacol., 145, pp. 23-33 | ||
| 504 | |a Hahn, M.E., Goldstein, J.A., Linko, P., Gasiewicz, T.A., Interaction of hexachlorobenzene with the receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in vitro and in vivo (1989) Arch. Biochem. Biophys., 270, pp. 344-355 | ||
| 504 | |a Matsumura, F., How important is the protein phosphorylation pathway in the toxic expression of dioxin-type chemicals (1994) Biochem. Pharmacol., 48, pp. 215-224 | ||
| 504 | |a Kafafi, S.A., Afeffy, H.Y., Ali, A.H., Said, H.K., Kafafi, A.G., Binding of polychlorinated biphenyls to the aryl hydrocarbon receptor (1993) Environ. Health Perspect., 101, pp. 422-428 | ||
| 504 | |a Fisher, L.J., Seagal, R.F., Ganey, P.E., Pessah, I.N., Kodavanti, P.R.S., Symposium overview: Toxicity of non-coplanar PCBs (1998) Toxicol. Sci., 41, pp. 49-61 | ||
| 504 | |a Randi, A.S., Sancovich, H.A., Ferramola de Sancovich, A.M., Loaiza, A.I., Krawiec, L., Kleiman de Pisarev, D.L., Hexachlorobenzene-induced alterations of rat hepatic microsomal membrane function (1998) Toxicology, 125, pp. 83-94 | ||
| 504 | |a Hunter, T., Cooper, J.A., Protein-tyrosine kinases. Review (1985) Annu. Rev. Biochem., 54, pp. 897-930 | ||
| 504 | |a Lai, W.H., Cameron, P.H., Wada, I., Doherty J.J. II, Kay, D.G., Posner, B.I., Bergeron, J.J.M., Ligand-mediated internalization, recycling, and downregulation of the epidermal growth factor receptor in vivo (1989) J. Cell Biol., 109, pp. 2741-2749 | ||
| 504 | |a Carpenter, G., Wahl, M.I., The epidermal growth factor family (1991) Peptide Growth Factors and their Receptors, pp. 69-133. , Sporn MB, Roberts AB, editors. New York: Springer | ||
| 504 | |a McCune, B.K., Earp, H.S., The epidermal growth factor receptor tyrosine kinase in liver epithelial cells (1989) J. Biol. Chem., 264, pp. 15501-15507 | ||
| 504 | |a Madhukar, B.V., Brewster, D.W., Matsumura, F., Effects of in vivo administered 2,3,7,8-tetrachlorodibenzo-p-dioxin on receptor binding of epidermal growth factor in the hepatic plasma membrane of rat, guinea pig, mouse and hamster (1984) Proc. Natl. Acad. Sci. U.S.A., 81, pp. 7407-7411 | ||
| 504 | |a Madhukar, B.V., Ebner, K., Matsumura, F., Bombick, D.W., Brewster, D.W., Kawamoto, T., 2,3,7,8-Tetrachlorodibenzo-p-dioxin causes an increase in protein kinases associated with epidermal growth factor receptor in the hepatic plasma membrane (1988) J. Biochem. Toxicol., 3, pp. 261-277 | ||
| 504 | |a Hudson, L.G., Toscano W.A., Jr., Greenlee, W.F., Regulation of epidermal growth factor binding in a human keratinocyte cell line by 2,3,7,8-tetrachlorodibenzo-p-dioxin (1985) Toxicol. Appl. Pharmacol., 77, pp. 251-259 | ||
| 504 | |a Hubbard, A.L., Wall, D.A., Ma, A., Isolation of rat hepatocyte plasma membranes. I. Presence of the three major domains (1983) J. Cell Biol., 96, pp. 217-229 | ||
| 504 | |a Widnell, C.C., Unkeless, J.C., Partial purification of a lipoprotein with 5′-nucleotidase activity from membranes of rat liver cells (1968) Proc. Natl. Acad. Sci. U.S.A., 61, pp. 1050-1057 | ||
| 504 | |a Rubin, R.A., O'Keefe, E.J., Earp, H.S., Alteration of epidermal growth factor-dependent phosphorylation during rat liver regeneration (1982) Proc. Natl. Acad. Sci. U.S.A., 79, pp. 776-780 | ||
| 504 | |a Bradford, M.M., A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding (1976) Anal. Biochem., 72, pp. 248-254 | ||
| 504 | |a Laemmli, U.K., Cleavage of structural proteins during the assembly of the head of bacteriophage T4 (1970) Nature, 227, pp. 680-685 | ||
| 504 | |a Countaway, J.L., Nairn, A.C., Davis, R.J., Mechanism of desensitization of the epidermal growth factor receptor protein-tyrosine kinase (1992) J. Biol. Chem., 267, pp. 1129-1140 | ||
| 504 | |a Fresno Vara, J.Á., Carretero, M.V., Gerónimo, H., Ballmer-Hofer, K., Martín-Pérez, J., Stimulation of c-Src by prolactin is independent of Jak2a (2000) Biochem. J., 345, pp. 17-24 | ||
| 504 | |a Tremblay, L., Beliveau, R., Protein tyrosine phosphorylation in normal rat tissues (1994) Int. J. Biochem., 26, pp. 29-34 | ||
| 504 | |a Lim, C.K., Li, F.M., Peters, T.J., High-performance liquid chromatography of porphyrins (1988) J. Chromatogr., 429, pp. 123-153 | ||
| 504 | |a Wainstock de Calmanovici, R., Billi, S., Aldonatti, C., San Martín de Viale, L.C., Effect of desferrioxamine on the development of hexachlorobenzene-induced porphyria (1986) Biochem. Pharmacol., 35, pp. 2399-2405 | ||
| 504 | |a Blankenship, A., Matsumura, F., 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced activation of a protein kinase, pp60src, in murine hepatic cytosol using a cell-free system (1997) Mol. Pharmacol., 52, pp. 667-675 | ||
| 504 | |a Enan, E., Matsumura, F., Evidence for a second pathway in the action mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Significance of Ah-receptor mediated activation of protein kinase under cell-free conditions (1995) Biochem. Pharmacol., 49, pp. 249-261 | ||
| 504 | |a Wright, J.D., Reuter, C.W.M., Weber, M.J., An incomplete program of cellular tyrosine phosphorylations induced by kinase-defective epidermal growth factor receptors (1995) J. Biol. Chem., 270, pp. 12085-12093 | ||
| 504 | |a Sewall, C.H., Clark, G.C., Lucier, G.W., TCDD reduces rat hepatic epidermal growth factor receptor: Comparison of binding, immunodetection, and autophosphorylation (1995) Toxicol. Appl. Pharmacol., 132, pp. 263-272 | ||
| 504 | |a Gustafson, D.L., Long, M.E., Thomas, R.S., Benjamin, S.A., Yang, R.S.H., Comparative hepatocarcinogenicity of hexachlorobenzene, pentachlorobenzene, 1,2,4,5-tetrachlorobenzene, and 1,4-dichlorobenzene: Application of a medium-term liver focus bioassay and molecular and cellular indices (2000) Toxicol. Sci., 53, pp. 245-252 | ||
| 504 | |a Quilley, C.P., Rifkind, A.B., Prostaglandin release by the chick embryo heart is increased by 2,3,7,8-tetrachlorodibenzo-p-dioxin and by other cytochrome P-448 inducers (1986) Biochem. Biophys. Res. Commun., 136, pp. 582-589 | ||
| 504 | |a Schrenk, D., Karger, A., Lipp, H.P., Bock, K.W., 2,3,7,8-Tetrachlorodibenzo-p-dioxin and ethinylestradiol as co-mitogens in cultured rat hepatocytes (1992) Carcinogenesis, 13, pp. 453-456 | ||
| 520 | 3 | |a In the present study, the effects of hexachlorobenzene (HCB) on epidermal growth factor receptor (EGFR) content of liver microsomes and plasma membrane, and on EGFR-tyrosine kinase activity in the microsomal fraction were investigated. In addition, we studied the parameters of the tyrosine kinase signalling pathway such as protein tyrosine kinase (PTK) activity and phosphotyrosine content in microsomal and cytosolic protein. To determine whether the observed alterations were correlated with a manifestation of overt toxicity, a single very low dose of HCB (1mg/kg body wt) and two much higher doses (100 and 1000mg/kg body wt), the highest being toxicologically significant in that it reduced serum thyroxine (T4) and inhibited uroporphyrinogen decarboxylase (URO-D) (EC 4.1.1.37) activity, were tested. Our results demonstrated that liver microsomes of rats treated with HCB had higher levels of EGFR than untreated rats; treated rats also had less EGFR present in hepatocyte plasma membrane fractions than did untreated rats. HCB altered the phosphotyrosine content and protein phosphorylation of some microsomal and cytosolic proteins in a biphasic dose-response relationship. At the low dose, phosphorylation and phosphotyrosine content of several microsomal proteins were increased; however, these effects were diminished or reversed at the higher doses. Our results suggest that chronic HCB treatment produces a down-regulation of the EGFR and a dose-dependent increase in EGFR-tyrosine kinase activity in the microsomal fraction. This effect may contribute to the alteration of membrane and cytosolic protein tyrosine phosphorylation. The level of sensitivity encountered in our studies is extraordinary, occurring at 1/10 to 1/1000 the doses of HCB known to cause other toxicological lesions. © 2003 Elsevier Science Inc. All rights reserved. |l eng | |
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires | ||
| 536 | |a Detalles de la financiación: National Council for Scientific Research | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: This work was supported by grants from the University of Buenos Aires, the National Agency of Scientific and Technological Promotion, and the National Council of Scientific and Technological Research (CONICET). | ||
| 593 | |a Depto. de Bioquímica Humana, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 5to piso, Buenos Aires, CP 1121, Argentina | ||
| 593 | |a Depto. de Quím. Biol., Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a EGFR KINASE ACTIVITY |
| 690 | 1 | 0 | |a EGFR LEVELS |
| 690 | 1 | 0 | |a HEXACHLOROBENZENE |
| 690 | 1 | 0 | |a PHOSPHOTYROSINE CONTENT |
| 690 | 1 | 0 | |a PROTEIN TYROSINE KINASE |
| 690 | 1 | 0 | |a RAT LIVER |
| 690 | 1 | 0 | |a EPIDERMAL GROWTH FACTOR RECEPTOR |
| 690 | 1 | 0 | |a HEXACHLOROBENZENE |
| 690 | 1 | 0 | |a PHOSPHOTYROSINE |
| 690 | 1 | 0 | |a PROTEIN TYROSINE KINASE |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CELL MEMBRANE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a CYTOSOL |
| 690 | 1 | 0 | |a ENZYME ACTIVITY |
| 690 | 1 | 0 | |a ENZYME INHIBITION |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a LIVER |
| 690 | 1 | 0 | |a LIVER CELL |
| 690 | 1 | 0 | |a LIVER MICROSOME |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROTEIN PHOSPHORYLATION |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a REDUCTION |
| 690 | 1 | 0 | |a SIGNAL TRANSDUCTION |
| 690 | 1 | 0 | |a TOXICITY |
| 700 | 1 | |a Sancovich, H.A. | |
| 700 | 1 | |a Ferramola De Sancovich, A.M. | |
| 700 | 1 | |a Loaiza, A. | |
| 700 | 1 | |a Kölliker Frers, R.A. | |
| 700 | 1 | |a Spinelli, F. | |
| 700 | 1 | |a Kleiman De Pisarev, D.L. | |
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