Nifedipine-mediated mobilization of intracellular calcium stores increases spontaneous neurotransmitter release at neonatal rat motor nerve terminals
The modulation of spontaneous release of acetylcholine by specific Ca2+ channel blockers was studied at neonatal rat neuromuscular junction. During early postnatal periods (0-4 days), blockers of N- and P/Q-type Ca2+ channels did not affect miniature endplate potential (MEPP) frequency. Unexpectedly...
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| Formato: | Capítulo de libro |
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2003
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 11251caa a22012857a 4500 | ||
|---|---|---|---|
| 001 | PAPER-4895 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203430.0 | ||
| 008 | 190411s2003 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0037960952 | |
| 024 | 7 | |2 cas |a calciseptine, 134710-25-1; calcium ion, 14127-61-8; isradipine, 75695-93-1, 88977-22-4; nifedipine, 21829-25-4; nitrendipine, 39562-70-4; ryanodine, 15662-33-6; thapsigargin, 67526-95-8; Calcium Channel Blockers; Calcium, 7440-70-2; Neurotransmitter Agents; Nifedipine, 21829-25-4 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a JPETA | ||
| 100 | 1 | |a Piriz, J. | |
| 245 | 1 | 0 | |a Nifedipine-mediated mobilization of intracellular calcium stores increases spontaneous neurotransmitter release at neonatal rat motor nerve terminals |
| 260 | |c 2003 | ||
| 270 | 1 | 0 | |m Uchitel, O.D.; Lab. de Fisiol. y Biologia Molecular, Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Buenos Aires 1428, Argentina; email: odu@fibertel.com.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Protti, D.A., Szczupak, L., Scornik, F.S., Uchitel, O.D., Effect of α-conotoxin GVIA on neurotransmitter release at the mouse neuromuscular junction (1991) Brain Res, 557, pp. 336-339 | ||
| 504 | |a Protti, D.A., Uchitel, O.D., Transmitter release and presynaptic Ca2+ currents blocked by the spider toxin omega-Aga-IVA (1993) Neuroreport, 5, pp. 333-336 | ||
| 504 | |a Rahamimoff, R., Alnaes, E., Inhibitory action of ruthenium red on neuromuscular transmission (1973) Proc Natl Acad Sci USA, 70, pp. 3413-3416 | ||
| 504 | |a Redfern, P.A., Neuromuscular transmission in new-born rats (1970) J Physiol (Lond), 209, pp. 701-709 | ||
| 504 | |a Rosato Siri, M.D., Uchitel, O.D., Calcium channels coupled to neurotransmitter release at neonatal rat neuromuscular junctions (1999) J Physiol (Lond), 514, pp. 533-540 | ||
| 504 | |a Scholze, A., Plant, T.D., Dolphin, A.C., Nurnberg, B., Functional expression and characterization of a voltage-gated CaV1.3 (α1D) calcium channel subunit from an insulin-secreting cell line (2001) Mol Endocrinol, 15, pp. 1211-1221 | ||
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| 504 | |a Uchitel, O.D., Protti, D.A., Sanchez, V., Cherksey, B.D., Sugimori, M., Llinas, R., P-type voltage-dependent calcium channel mediates presynaptic calcium influx and transmitter release in mammalian synapses (1992) Proc Natl Acad Sci USA, 89, pp. 3330-3333 | ||
| 504 | |a Urbano, F.J., Uchitel, O.D., L-Type calcium channels unmasked by cell-permeant Ca2+ buffer at mouse motor nerve terminals (1999) Pfluegers Arch, 437, pp. 523-528 | ||
| 504 | |a Weigl, L.G., Hohenegger, M., Kress, H.G., Dihydropyridine-induced Ca2+ release from ryanodine-sensitive Ca2+ pools in human skeletal muscle cells (2000) J Physiol (Lond), 525, pp. 461-469 | ||
| 504 | |a Yasuda, O., Morimoto, S., Chen, Y., Jiang, B., Kimura, T., Sakakibara, S., Koh, E., Ogihara, T., Calciseptine binding to a 1,4-dihydropyridine recognition site of the L-type calcium channel of rat synaptosomal membranes (1993) Biochem Biophys Res Commun, 194, pp. 587-594 | ||
| 520 | 3 | |a The modulation of spontaneous release of acetylcholine by specific Ca2+ channel blockers was studied at neonatal rat neuromuscular junction. During early postnatal periods (0-4 days), blockers of N- and P/Q-type Ca2+ channels did not affect miniature endplate potential (MEPP) frequency. Unexpectedly, treatment with the L-type Ca2+ channel antagonist nifedipine, although not when treated with isradipine, nitrendipine, or calciseptine, resulted in strong increase in MEPP frequency. The potentiation effect of nifedipine was dose-dependent with a 56-fold maximum effect with 15 μM. The effect decreased during the first two postnatal weeks and disappeared by the third. The effect of nifedipine was not dependent on extracellular Ca2+ and was not altered by the presence of other Ca2+ channel blockers. In contrast, it was abolished by depleting intracellular Ca2+ stores with μM thapsigargin and was partially inhibited by 10 μM ryanodine. In conclusion, we report a new ryanodine receptor-mediated effect of nifedipine on neonatal neuromuscular junction that may indicate the developmental expression of a specific receptor channel that interacts with intracellular Ca2+ stores. This effect of nifedipine should also be considered when using this drug as either atherapeutic or a research tool. |l eng | |
| 593 | |a Depto. Fisiol. Biol. Cel. Molec., Instituto de Fisiología, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a Instituto Cajal, Consejo Sup. de Invest. Cientificas, Avenida Doctor Arce 37, 28002 Madrid, Spain | ||
| 593 | |a Biophysics Sector, Ist. Naz. di Fis. della Materia Unit, Intl. School for Advanced Studies, Via Beirut 2-4 (34014), Trieste, Italy | ||
| 593 | |a Lab. de Fisiol. y Biologia Molecular, Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Buenos Aires 1428, Argentina | ||
| 690 | 1 | 0 | |a CALCISEPTINE |
| 690 | 1 | 0 | |a CALCIUM CHANNEL BLOCKING AGENT |
| 690 | 1 | 0 | |a CALCIUM CHANNEL L TYPE |
| 690 | 1 | 0 | |a CALCIUM ION |
| 690 | 1 | 0 | |a ISRADIPINE |
| 690 | 1 | 0 | |a NEUROTRANSMITTER |
| 690 | 1 | 0 | |a NIFEDIPINE |
| 690 | 1 | 0 | |a NITRENDIPINE |
| 690 | 1 | 0 | |a OMEGA AGATOXIN VIA |
| 690 | 1 | 0 | |a RYANODINE |
| 690 | 1 | 0 | |a RYANODINE RECEPTOR |
| 690 | 1 | 0 | |a THAPSIGARGIN |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CALCIUM CELL LEVEL |
| 690 | 1 | 0 | |a CALCIUM TRANSPORT |
| 690 | 1 | 0 | |a CONCENTRATION RESPONSE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a DIAGNOSTIC VALUE |
| 690 | 1 | 0 | |a DRUG EFFECT |
| 690 | 1 | 0 | |a DRUG MECHANISM |
| 690 | 1 | 0 | |a DRUG USE |
| 690 | 1 | 0 | |a LONG TERM POTENTIATION |
| 690 | 1 | 0 | |a MINIATURE ENDPLATE POTENTIAL |
| 690 | 1 | 0 | |a NERVE ENDING |
| 690 | 1 | 0 | |a NEUROMUSCULAR SYNAPSE |
| 690 | 1 | 0 | |a NEUROTRANSMITTER RELEASE |
| 690 | 1 | 0 | |a NEWBORN |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROTEIN EXPRESSION |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a TIME SERIES ANALYSIS |
| 690 | 1 | 0 | |a AGE FACTORS |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a CALCIUM |
| 690 | 1 | 0 | |a CALCIUM CHANNEL BLOCKERS |
| 690 | 1 | 0 | |a ELECTROPHYSIOLOGY |
| 690 | 1 | 0 | |a INTRACELLULAR FLUID |
| 690 | 1 | 0 | |a MOTOR ENDPLATE |
| 690 | 1 | 0 | |a MOTOR NEURONS |
| 690 | 1 | 0 | |a NEUROTRANSMITTER AGENTS |
| 690 | 1 | 0 | |a NIFEDIPINE |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a RATS, SPRAGUE-DAWLEY |
| 700 | 1 | |a Siri, M.D.R. | |
| 700 | 1 | |a Pagani, R. | |
| 700 | 1 | |a Uchitel, O.D. | |
| 773 | 0 | |d 2003 |g v. 306 |h pp. 658-663 |k n. 2 |p J. Pharmacol. Exp. Ther. |x 00223565 |w (AR-BaUEN)CENRE-825 |t Journal of Pharmacology and Experimental Therapeutics | |
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| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00223565_v306_n2_p658_Piriz |y Handle |
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