Trypanosoma cruzi poly-zinc finger protein: A novel DNA/RNA-binding CCHC-zinc finger protein
A poly-zinc finger protein, designated PZFP1 was identified in Trypanosoma cruzi for the first time. The protein has 191 amino acids, contains seven motifs Cys(X)2Cys(X)4His(X)4Cys. A recombinant PZFP1 was generated in E. coli and the expected 21kDa polypeptide co-purified with two other inducible p...
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Elsevier
2003
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 13884caa a22014177a 4500 | ||
|---|---|---|---|
| 001 | PAPER-4870 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203428.0 | ||
| 008 | 190411s2003 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-10744230300 | |
| 024 | 7 | |2 Molecular Sequence Numbers |a GENBANK: AA879389, AF420314, AI077277, AW324930, AW324958, AF091396; | |
| 024 | 7 | |2 cas |a arginine, 1119-34-2, 15595-35-4, 7004-12-8, 74-79-3; protein, 67254-75-5; serine, 56-45-1, 6898-95-9 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a MBIPD | ||
| 100 | 1 | |a Espinosa, J.M. | |
| 245 | 1 | 0 | |a Trypanosoma cruzi poly-zinc finger protein: A novel DNA/RNA-binding CCHC-zinc finger protein |
| 260 | |b Elsevier |c 2003 | ||
| 270 | 1 | 0 | |m Torres, H.N.; Fac. de Ciencias Exactas y Naturales, Inst. Invest. Ing. Genet. Biol. M., Universidad de Buenos Aires, Buenos Aires, Argentina; email: torres@dna.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Cavaloc, Y., Popielarz, M., Fuchs, J.P., Gattoni, R., Stevenin, J., Characterization and cloning of the human splicing factor 9G8: A novel 35 kDa factor of the serine/arginine protein family (1994) EMBO J., 13, pp. 2639-2649 | ||
| 520 | 3 | |a A poly-zinc finger protein, designated PZFP1 was identified in Trypanosoma cruzi for the first time. The protein has 191 amino acids, contains seven motifs Cys(X)2Cys(X)4His(X)4Cys. A recombinant PZFP1 was generated in E. coli and the expected 21kDa polypeptide co-purified with two other inducible products of about 42 and 63kDa. Western blot analysis of cell extracts using an anti-PZFP1 antibody recognized a major band of 41kDa. Electrophoretic mobility shift analysis demonstrated that both, recombinant and native PZFP1, specifically interact with single-stranded DNA or RNA oligonucleotides carrying recognition sequences of other CCHC proteins. The protein was localized mainly in the cytoplasm and nucleus as observed by indirect immunofluorescence analysis. PZFP1 interacted specifically with a T. cruzi serine-arginine-rich protein (TcSR) in a yeast two-hybrid assay, suggesting a role in pre-mRNA processing. © 2003 Elsevier B.V. All rights reserved. |l eng | |
| 536 | |a Detalles de la financiación: Agencia Nacional de Promoción Científica y Tecnológica | ||
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: We thank Mrs. Aneliess Zechel for excellent technical assistance, Dr. Cristina Paveto for valuable support and Fiona Jones for critical reading. This study was supported in part by the Consejo Nacional de Investigaciones Cientı́ficas y Técnicas (Argentina), the University of Buenos Aires (Argentina), the Agencia Nacional de Promoción Cientı́fica y Tecnológica (Argentina), the Fundacion Antorchas (Argentina), the International Center for Genetic Engineering and Biotechnology (Trieste, Italy), WHO-TDR and the Argentine-Brazilian Center for Biotechnology. | ||
| 593 | |a Fac. de Ciencias Exactas y Naturales, Inst. Invest. Ing. Genet. Biol. M., Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a Department of Molecular Biology, Max Planck Inst. Biophysical Chem., Am Fassberg 11, D-37077 Göttingen, Germany | ||
| 690 | 1 | 0 | |a CCHC-TYPE ZINC FINGER |
| 690 | 1 | 0 | |a POLY-ZINC FINGER PROTEIN |
| 690 | 1 | 0 | |a SERINE-ARGININE-RICH PROTEIN |
| 690 | 1 | 0 | |a TCPZFP1 |
| 690 | 1 | 0 | |a TCSR |
| 690 | 1 | 0 | |a TRYPANOSOMA CRUZI |
| 690 | 1 | 0 | |a ARGININE |
| 690 | 1 | 0 | |a CELL EXTRACT |
| 690 | 1 | 0 | |a DOUBLE STRANDED DNA |
| 690 | 1 | 0 | |a OLIGONUCLEOTIDE |
| 690 | 1 | 0 | |a PROTEIN |
| 690 | 1 | 0 | |a PROTEIN ANTIBODY |
| 690 | 1 | 0 | |a PROTOZOAL PROTEIN |
| 690 | 1 | 0 | |a RECOMBINANT PROTEIN |
| 690 | 1 | 0 | |a SERINE |
| 690 | 1 | 0 | |a ZINC FINGER PROTEIN |
| 690 | 1 | 0 | |a AMINO ACID SEQUENCE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CELL NUCLEUS |
| 690 | 1 | 0 | |a CELLULAR DISTRIBUTION |
| 690 | 1 | 0 | |a CYTOPLASM |
| 690 | 1 | 0 | |a ESCHERICHIA COLI |
| 690 | 1 | 0 | |a GEL MOBILITY SHIFT ASSAY |
| 690 | 1 | 0 | |a IMMUNOFLUORESCENCE |
| 690 | 1 | 0 | |a MOLECULAR RECOGNITION |
| 690 | 1 | 0 | |a MOLECULAR WEIGHT |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a NUCLEOTIDE SEQUENCE |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROTEIN ANALYSIS |
| 690 | 1 | 0 | |a PROTEIN DNA INTERACTION |
| 690 | 1 | 0 | |a PROTEIN INDUCTION |
| 690 | 1 | 0 | |a PROTEIN LOCALIZATION |
| 690 | 1 | 0 | |a PROTEIN MOTIF |
| 690 | 1 | 0 | |a PROTEIN PROTEIN INTERACTION |
| 690 | 1 | 0 | |a PROTEIN PURIFICATION |
| 690 | 1 | 0 | |a PROTEIN RNA BINDING |
| 690 | 1 | 0 | |a TRYPANOSOMA CRUZI |
| 690 | 1 | 0 | |a TWO HYBRID SYSTEM |
| 690 | 1 | 0 | |a WESTERN BLOTTING |
| 690 | 1 | 0 | |a YEAST |
| 690 | 1 | 0 | |a TRYPANOSOMA |
| 690 | 1 | 0 | |a TRYPANOSOMA CRUZI |
| 700 | 1 | |a Portal, D. | |
| 700 | 1 | |a Lobo, G.S. | |
| 700 | 1 | |a Pereira, C.A. | |
| 700 | 1 | |a Alonso, G.D. | |
| 700 | 1 | |a Gómez, E.B. | |
| 700 | 1 | |a Lan, G.H. | |
| 700 | 1 | |a Pomar, R.V.R. | |
| 700 | 1 | |a Flawiá, M.M. | |
| 700 | 1 | |a Torres, H.N. | |
| 773 | 0 | |d Elsevier, 2003 |g v. 131 |h pp. 35-44 |k n. 1 |p Mol. Biochem. Parasitol. |x 01666851 |w (AR-BaUEN)CENRE-6136 |t Molecular and Biochemical Parasitology | |
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