Ca2+ channels and synaptic transmission at the adult, neonatal, and P/Q-type deficient neuromuscular junction
Different types of voltage-activated Ca2+ channels have been established based on their molecular structure and pharmacological and biophysical properties. One of them, the P/Q-type, is the main channel involved in nerve-evoked neurotransmitter release at neuromuscular junctions and the immunologica...
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| Otros Autores: | , , , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
New York Academy of Sciences
2003
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 12665caa a22018137a 4500 | ||
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| 003 | AR-BaUEN | ||
| 005 | 20230518203425.0 | ||
| 008 | 190411s2003 xx ||||fo|||| 00| 0 eng|d | ||
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| 024 | 7 | |2 cas |a immunoglobulin, 9007-83-4; nitrendipine, 39562-70-4; okadaic acid, 78111-17-8; potassium, 7440-09-7; Calcium Channels, L-Type; Calcium Channels, N-Type; Neurotransmitter Agents; Potassium, 7440-09-7 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a ANYAA | ||
| 100 | 1 | |a Nudler, S. | |
| 245 | 1 | 0 | |a Ca2+ channels and synaptic transmission at the adult, neonatal, and P/Q-type deficient neuromuscular junction |
| 260 | |b New York Academy of Sciences |c 2003 | ||
| 270 | 1 | 0 | |m Uchitel, O.D.; Depto. Fisiol., Biol. Molec. y Cel., Fac. de Ciencias Exactas y Naturales, Ciudad Universitaria, Pabellón II piso 2, Buenos Aires 1428, Argentina; email: odu@fbmc.fcen.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Katz, B., (1969) The Release of Neural Transmitter Substances, , Liverpool University Press. Liverpool | ||
| 504 | |a Llinas, R., Steinberg, I.Z., Walton, K., Presynaptic calcium currents and their relation to synaptic transmission: Voltage clamp study in squid giant synapse and theoretical model for the calcium gate (1976) Proc. Natl. Acad. Sci. USA, 73, pp. 2913-2922 | ||
| 504 | |a Llinas, R., Moreno, H., Local Ca2+ signaling in neurons (1998) Cell Calcium, 24, pp. 359-366 | ||
| 504 | |a Catterall, W.A., Structure and regulation of voltage-gated Ca2+ channels (2000) Annu. Rev. Cell Dev. Biol., 16, pp. 521-555 | ||
| 504 | |a Uchitel, O.D., Toxins affecting calcium channels in neurons (1997) Toxicon, 35, pp. 1161-1191 | ||
| 504 | |a Ertel, E.A., Nomenclature of voltage-gated calcium channels (2000) Neuron, 25, pp. 533-535 | ||
| 504 | |a Hans, M., Functional consequences of mutations in the human alpha1A calcium channel subunit linked to familial hemiplegic migraine (1999) J. Neurosci., 19, pp. 1610-1619 | ||
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| 504 | |a Toru, S., Spinocerebellar ataxia type 6 mutation alters P-type calcium channel function (2000) J. Biol. Chem., 275, pp. 10893-10898 | ||
| 504 | |a Jen, J., Calcium channelopathies in the central nervous system (1999) Curr. Opin. Neurobiol., 9, pp. 274-280 | ||
| 504 | |a Ophoff, R.A., P/Q-type Ca2+ channel defects in migraine, ataxia, and epilepsy (1998) Trends Pharmacol. Sci., 19, pp. 121-127 | ||
| 504 | |a Zhuchenko, O., Autosomal dominant cerebellar ataxia (SCA6) associated with small polyglutamine expansions in the alpha1A-voltage-dependent calcium channel (1997) Nat. Genet., 15, pp. 62-69 | ||
| 504 | |a Fletcher, C.F., Absence epilepsy in tottering mutant mice is associated with calcium channel defects (1996) Cell, 87, pp. 607-617 | ||
| 504 | |a Doyle, J., Mutations in the Cacnl1a4 calcium channel gene are associated with seizures, cerebellar degeneration, and ataxia in tottering and leaner mutant mice (1997) Mamm. Genome, 8, pp. 113-120 | ||
| 504 | |a Jun, K., Ablation of P/Q-type Ca(2+) channel currents, altered synaptic transmission, and progressive ataxia in mice lacking the alpha(1A)-subunit (1999) Proc. Natl. Acad. Sci. USA, 96, pp. 15245-15250 | ||
| 504 | |a Reuter, H., Diversity and function of presynaptic calcium channels in the brain (1996) Curr. Opin. Neurobiol., 6, pp. 331-337 | ||
| 504 | |a Catterall, W.A., Structure and function of neuronal Ca2+ channels and their role in neurotransmitter release (1998) Cell Calcium, 24, pp. 307-323 | ||
| 504 | |a Uchitel, O.D., P-type voltage-dependent calcium channel mediates presynaptic calcium influx and transmitter release in mammalian synapses (1992) Proc. Natl. Acad. Sci. USA, 89, pp. 3330-3333 | ||
| 504 | |a Protti, D.A., Uchitel, O.D., Transmitter release and presynaptic Ca2+ currents blocked by the spider toxin omega-Aga-IVA (1993) Neuroreport, 5, pp. 333-336 | ||
| 504 | |a Protti, D.A., Calcium channel blockers and transmitter release at the normal human neuromuscular junction (1996) Neurology, 46, pp. 1391-1396 | ||
| 504 | |a Katz, E., Effects of Ca2+ channel blocker neurotoxins on transmitter release and presynaptic currents at the mouse neuromuscular junction (1997) Br. J. Pharmacol., 121, pp. 1531-1540 | ||
| 504 | |a Vincent, A., Beeson, D., Lang, B., Molecular targets for autoimmune and genetic disorders of neuromuscular transmission (2000) Eur. J. Biochem., 267, pp. 6717-6728 | ||
| 504 | |a Urbano, F.J., Uchitel, O.D., L-type calcium channels unmasked by cell-permeant Ca2+ buffer at mouse motor nerve terminals (1999) Pflüg. Arch., 437, pp. 523-528 | ||
| 504 | |a Urbano, F.J., Depetris, R.S., Uchitel, O.D., Coupling of L-type calcium channels to neurotransmitter release at mouse motor nerve terminals (2001) Pflüg. Arch., 441, pp. 824-831 | ||
| 504 | |a Xu, Y.F., Hewett, S.J., Atchison, W.D., Passive transfer of Lambert-Eaton myasthenic syndrome induces dihydropyridine sensitivity of ICa in mouse motor nerve terminals (1998) J. Neurophysiol., 80, pp. 1056-1069 | ||
| 504 | |a Fratantoni, S.A., Amyotrophic lateral sclerosis IgG-treated neuromuscular junctions develop sensitivity to L-type calcium channel blocker (2000) Muscle Nerve, 23, pp. 543-550 | ||
| 504 | |a Katz, E., Calcium channels involved in synaptic transmission at the mature and regenerating mouse neuromuscular junction (1996) J. Physiol., 497 (3 PART), pp. 687-697 | ||
| 504 | |a Santafe, M.M., Multiple types of calcium channels mediate transmitter release during functional recovery of botulinum toxin type A-poisoned mouse motor nerve terminals (2000) Neuroscience, 95, pp. 227-234 | ||
| 504 | |a Rosato-Siri, M.D., Uchitel, O.D., Calcium channels coupled to neurotransmitter release at neonatal rat neuromuscular junctions (1999) J. Physiol., 514 (2 PART), pp. 533-540 | ||
| 504 | |a Rosato-Siri, M.D., Differential Ca2+-dependence of transmitter release mediated by P/Q- and N-type calcium channels at neonatal rat neuromuscular junctions (2002) Eur. J. Neurosci., 15, pp. 1874-1880 | ||
| 504 | |a Urbano, F.J., Short term facilitation and Ca2+ dependence of transmitter release are altered at the neuromuscular junction of P/Q Ca2+ channel knock out mice (2001) Biophys. J., 80, pp. 234a | ||
| 504 | |a Depetris, R.S., Loss of temporal precision of neurotransmitter release at neuromuscular junctions of mice lacking P/Q-type Ca2+ channels (2001) Soc. Neurosci. | ||
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| 520 | 3 | |a Different types of voltage-activated Ca2+ channels have been established based on their molecular structure and pharmacological and biophysical properties. One of them, the P/Q-type, is the main channel involved in nerve-evoked neurotransmitter release at neuromuscular junctions and the immunological target in Eaton-Lambert Syndrome. At adult neuromuscular junctions, L- and N-type Ca2+ channels become involved in transmitter release only under certain experimental or pathological conditions. In contrast, at neonatal rat neuromuscular junctions, nerve-evoked synaptic transmission depends jointly on both N- and P/Q-type channels. Synaptic transmission at neuromuscular junctions of the ataxic P/Q-type Ca2+ channel knockout mice is also dependent on two different types of channels, N- and R-type. At both neonatal and P/Q knockout junctions, the K +-evoked increase in miniature endplate potential frequency was not affected by N-type channel blockers, but strongly reduced by both P/Q- and R-type channel blockers. These differences could be accounted for by a differential location of the channels at the release site, being either P/Q- or R-type Ca2+ channels located closer to the release site than N-type Ca2+ channels. Thus, Ca2+ channels may be recruited to mediate neurotransmitter release where P/Q-type channels seem to be the most suited type of Ca2+ channel to mediate exocytosis at neuromuscular junctions. |l eng | |
| 593 | |a Lab. de Fisiol. y Biol. Molecular, Depto. Fisiol., Biol. Molec. y Cel., IFIBYNE-CONICET, Buenos Aires, Argentina | ||
| 593 | |a Dept. of Molec./Cellular Physiology, Stanford University, Stanford, CA, United States | ||
| 593 | |a Dept. of Physiology and Neuroscience, NYU School of Medicine, 550 First Avenue, New York, NY 10016, United States | ||
| 593 | |a Biophysics Sector, S.I.S.S.A./I.S.A.S., Via Beirut 2-4, 34014 Trieste, Italy | ||
| 593 | |a Department of Physiology, Loyola University Chicago, Maywood, IL 60153, United States | ||
| 593 | |a Depto. Fisiol., Biol. Molec. y Cel., Fac. de Ciencias Exactas y Naturales, Ciudad Universitaria, Pabellón II piso 2, Buenos Aires 1428, Argentina | ||
| 690 | 1 | 0 | |a CALCIUM CHANNELS |
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| 690 | 1 | 0 | |a CALCIUM CHANNEL |
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| 690 | 1 | 0 | |a CALCIUM CHANNEL P TYPE |
| 690 | 1 | 0 | |a CALCIUM CHANNEL Q TYPE |
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| 690 | 1 | 0 | |a ELECTROPHYSIOLOGY |
| 690 | 1 | 0 | |a ENDPLATE POTENTIAL |
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| 700 | 1 | |a Piriz, J. | |
| 700 | 1 | |a Urbano, F.J. | |
| 700 | 1 | |a Rosato-Siri, M.D. | |
| 700 | 1 | |a Piedras Renteria, E.S. | |
| 700 | 1 | |a Uchitel, O.D. | |
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