Bisphosphonates derived from fatty acids are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase
Studies on the mode of action of a series of bisphosphonates derived from fatty acids, which had previously proved to be potent inhibitors against Trypanosoma cruzi proliferation in in vitro assays, have been performed. Some of these drugs proved to be potent inhibitors against the intracellular for...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
Elsevier Ltd
2003
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| 003 | AR-BaUEN | ||
| 005 | 20230518203424.0 | ||
| 008 | 190411s2003 xx ||||fo|||| 00| 0 eng|d | ||
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| 024 | 7 | |2 cas |a geranyltransferase, 37277-79-5, 50812-36-7 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a BMCLE | ||
| 100 | 1 | |a Szajnman, S.H. | |
| 245 | 1 | 0 | |a Bisphosphonates derived from fatty acids are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase |
| 260 | |b Elsevier Ltd |c 2003 | ||
| 270 | 1 | 0 | |m Rodriguez, J.B.; Depto. de Quím. Orgán., Fac. de Ciencias Exactas y Naturales, Ciudad Universitaria, C1428EHA Buenos Aires, Argentina; email: jbr@qo.fcen.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a Studies on the mode of action of a series of bisphosphonates derived from fatty acids, which had previously proved to be potent inhibitors against Trypanosoma cruzi proliferation in in vitro assays, have been performed. Some of these drugs proved to be potent inhibitors against the intracellular form of the parasite, exhibiting IC50 values at the low micromolar level. As bisphosphonates are FDA clinically approved for treatment of bone resorption disorders, their potential innocuousness makes them good candidates to control tropical diseases. © 2003 Elsevier Ltd. All rights reserved. |l eng | |
| 536 | |a Detalles de la financiación: Fundación Antorchas | ||
| 536 | |a Detalles de la financiación: National Council for Scientific Research, PIP 635/98 | ||
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires, X-080 | ||
| 536 | |a Detalles de la financiación: This work was supported by grants from Fundación Antorchas, the National Research Council of Argentina (PIP 635/98), and the Universidad de Buenos Aires (X-080) to J.B.R., and the Illinois Governor's Venture Technology Program to R.D. | ||
| 593 | |a Depto. de Quím. Orgán., Fac. de Ciencias Exactas y Naturales, Ciudad Universitaria, C1428EHA Buenos Aires, Argentina | ||
| 593 | |a Department of Pathobiology, Center for Zoonoses Research, Univ. of IL at Urbana-Champaign, 2001 South Lincoln Avenue, Urbana, IL 61802, United States | ||
| 690 | 1 | 0 | |a FATTY ACID DERIVATIVE |
| 690 | 1 | 0 | |a GERANYLTRANSFERASE |
| 690 | 1 | 0 | |a PHOSPHONIC ACID DERIVATIVE |
| 690 | 1 | 0 | |a ANOREXIA |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CELL PROLIFERATION |
| 690 | 1 | 0 | |a DRUG APPROVAL |
| 690 | 1 | 0 | |a DRUG POTENCY |
| 690 | 1 | 0 | |a FOOD AND DRUG ADMINISTRATION |
| 690 | 1 | 0 | |a IC 50 |
| 690 | 1 | 0 | |a IN VITRO STUDY |
| 690 | 1 | 0 | |a INHIBITION KINETICS |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a OSTEOLYSIS |
| 690 | 1 | 0 | |a PARASITE |
| 690 | 1 | 0 | |a PERIPHERAL NEUROPATHY |
| 690 | 1 | 0 | |a SKIN ALLERGY |
| 690 | 1 | 0 | |a TROPICAL DISEASE |
| 690 | 1 | 0 | |a TRYPANOSOMA CRUZI |
| 690 | 1 | 0 | |a VOMITING |
| 690 | 1 | 0 | |a TRYPANOSOMA |
| 690 | 1 | 0 | |a TRYPANOSOMA CRUZI |
| 700 | 1 | |a Montalvetti, A. | |
| 700 | 1 | |a Wang, Y. | |
| 700 | 1 | |a Docampo, R. | |
| 700 | 1 | |a Rodriguez, J.B. | |
| 773 | 0 | |d Elsevier Ltd, 2003 |g v. 13 |h pp. 3231-3235 |k n. 19 |p Bioorg. Med. Chem. Lett. |x 0960894X |w (AR-BaUEN)CENRE-3990 |t Bioorganic and Medicinal Chemistry Letters | |
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