Arginase induction promotes Trypanosoma cruzi intracellular replication of Cruzipain-treated J774 cells through the activation of multiple signaling pathways
Given that arginase activation may effectively influence nitric oxide (NO) production in macrophages, we have investigated the intracellular signals that regulate L-arginine metabolism and its influence on Trypanosoma cruzi growth. We demonstrate that cruzipain (Cz), a parasite antigen, induces argi...
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2004
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| LEADER | 17247caa a22018977a 4500 | ||
|---|---|---|---|
| 001 | PAPER-4711 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203417.0 | ||
| 008 | 190411s2004 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-1642554787 | |
| 024 | 7 | |2 cas |a 2 (2 amino 3 methoxyphenyl)chromone, 167869-21-8; 4 (4 fluorophenyl) 2 (4 methylsulfinylphenyl) 5 (4 pyridyl)imidazole, 152121-47-6; arginase, 9000-96-8; arginine, 1119-34-2, 15595-35-4, 7004-12-8, 74-79-3; calphostin C, 121263-19-2; cysteine proteinase, 37353-41-6; genistein, 446-72-0; kt 5720, 108068-98-0; mitogen activated protein kinase, 142243-02-5; nitric oxide, 10102-43-9; protein tyrosine kinase, 80449-02-1; urea, 57-13-6; Arginase, EC 3.5.3.1; Arginine, 74-79-3; Carbazoles; cruzipain, EC 3.4.22.-; Cyclic AMP-Dependent Protein Kinases, EC 2.7.1.37; Cysteine Endopeptidases, EC 3.4.22.-; Genistein, 446-72-0; Growth Inhibitors; Imidazoles; Indoles; KT 5720, 108068-98-0; Mitogen-Activated Protein Kinases, EC 2.7.1.37; N(omega)-hydroxyarginine, 53054-07-2; p38 Mitogen-Activated Protein Kinases, EC 2.7.1.37; Protein-Tyrosine Kinases, EC 2.7.1.112; Pyridines; Pyrroles; SB 203580 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a EJIMA | ||
| 100 | 1 | |a Stempin, C.C. | |
| 245 | 1 | 0 | |a Arginase induction promotes Trypanosoma cruzi intracellular replication of Cruzipain-treated J774 cells through the activation of multiple signaling pathways |
| 260 | |c 2004 | ||
| 270 | 1 | 0 | |m Cerban, F.M.; Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Haya de la Torre Medina Allende s/n, 5000 Cordoba, Argentina; email: fcerban@bioclin.fcq.unc.edu.ar |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Tanowitz, H., Kirchhoff, L., Simon, D., Morris, S., Wiess, L., Wittner, M., Chagas disease (1992) Clin. Microbiol. Rev., 5, pp. 400-419 | ||
| 504 | |a Seljelid, R., Eskeland, T., The biology of macrophage: I. General principles and properties (1993) Eur. J. Haematol., 51, pp. 267-275 | ||
| 504 | |a Hibbs Jr., J.B., Taintor, R.R., Vavrin, Z., Rachlin, E.M., Nitric Oxide: A cytotoxic activated macrophage effector molecule (1988) Biochem. Biophys. Res. Commun., 157, pp. 87-94 | ||
| 504 | |a Aderem, A., Ulevitch, R.J., Toll-like receptors in the induction of the innate immune response (2000) Nature, 406, pp. 782-787 | ||
| 504 | |a Goerdt, S., Orfanos, C.E., Other functions, other genes: Alternative activation of antigen-presenting cells (1999) Immunity, 10, pp. 137-142 | ||
| 504 | |a Gordon, S., Alternative activation of macrophages (2003) Nat. Rev. Immunol., 3, pp. 23-35 | ||
| 504 | |a Munder, M., Eichmann, K., Modolell, M., Alternative metabolic states in murine macrophage reflected by the nitric oxide synthase/arginase balance: Competitive regulation by CD4+ T cells correlates with Th1/Th2 phenotype (1998) J. Immunol., 160, pp. 5347-5354 | ||
| 504 | |a Saheki, T., Sato, Y., Takada, S., Katsunuma, T., Regulation of urea synthesis in rat liver (1979) J. Biochem., 86, pp. 745-750 | ||
| 504 | |a Gotoh, T., Sonoki, T., Nagasaki, A., Terada, K., Takiguchi, M., Mori, M., Molecular cloning of cDNA for nonhepatic mitochondrial arginase (arginase II) and comparison of its induction with nitric oxide synthase in a murine macrophage-like cell line (1996) FEBS Lett., 395, pp. 119-122 | ||
| 504 | |a Wang, W.W., Jenkinson, C.P., Griscavage, J.M., Kern, R.M., Arabolos, N.S., Byrns, R.E., Cederbaum, S.D., Ignarro, L.J., Co-induction of arginase and nitric oxide synthase in murine macrophages activated by lipopolysaccharide (1995) Biochem. Biophys. Res. Commun., 210, pp. 1009-1016 | ||
| 504 | |a Aminlari, M., Vaseghi, T., Arginase distribution in tissues of domestic animals (1992) Comp. Biochem. Physiol. B., 103, pp. 385-389 | ||
| 504 | |a Vockley, J.G., Jenkinson, C.P., Shukla, H., Kern, R.M., Grody, W.W., Cederbaum, S.D., Cloning and characterization of the human type II arginase gene (1996) Genomics, 38, pp. 118-123 | ||
| 504 | |a Sonoki, T., Nagasaki, A., Gotoh, T., Takiguchi, M., Takeya, M., Matsuzaki, H., Mori, M., Coinduction of nitric-oxide synthase and arginase I in cultured rat peritoneal macrophages and rat tissues in vitro by lipopolysaccharide (1997) J. Biol. Chem., 272, pp. 3689-3693 | ||
| 504 | |a Boutard, V., Havouis, R., Fouqueray, B., Philippe, C., Moulinoux, J.P., Baud, L., Transforming growth factor beta stimulates arginase activity in macrophages: Implications for the regulation of macrophage cytotoxicity (1995) J. Immunol., 155, pp. 2077-2084 | ||
| 504 | |a Waddington, S.N., Tam, F.W.K., Cook, H.T., Cattell, V., Arginase activity is modulated by IL-4 and HOArg in nephritic glomeruli and mesangial cells (1998) Am. J. Physiol. Renal Physiol., 274, pp. 473-480 | ||
| 504 | |a Corraliza, I.M., Soler, G., Eichmann, K., Modolell, M., Arginase induction by suppressors of nitric oxide synthesis (IL-4, IL-10 and PGE2) in murine bone-marrow-derived macrophages (1995) Biochem. Biophys. Res. Comm., 206, pp. 667-673 | ||
| 504 | |a Modolell, M., Corraliza, I.M., Link, F., Soler, G., Eichmann, K., Reciprocal regulation of the nitric oxide synthase/arginase balance in mouse bone marrow-derived macrophages by Th1 and Th2 cytokines (1995) Eur. J. Immunol., 25, pp. 1101-1104 | ||
| 504 | |a Louis, C.A., Mody, V., Henry, W.L., Reichner, J.S., Albina Jr., J.E., Regulation of arginase isoforms I and II by IL-4 in cultured murine peritoneal macrophages (1999) Am. J. Physiol. Regul. Integrative Comp. Physiol., 276, pp. 237-242 | ||
| 504 | |a Chang, C.I., Zoghi, B., Liao, J.C., Kuo, L., The involvement of tyrosine kinases, cyclic AMP/protein kinase A, and p38 mitogen-activated protein kinase in IL-13-mediated arginase I induction in macrophages: Its implications in IL-13-inhibited nitric oxide production (2000) J. Immunol., 165, pp. 2134-2141 | ||
| 504 | |a Munder, M., Eichmann, K., Morán, J.M., Centeno, F., Soler, G., Modolell, M., Th1/Th2-regulated expression of arginase isoforms in murine macrophages and dendritic cells (1999) J. Immunol., 163, pp. 3771-3777 | ||
| 504 | |a Stempin, C., Giordanengo, L., Gea, S., Cerbán, F., Alternative activation and increase of Trypanosoma cruzi survival in murine macrophages stimulated by cruzipain, a parasite antigen (2002) J. Leukoc. Biol., 72, pp. 727-734 | ||
| 504 | |a Carrera, L., Gazzinelli, R.T., Badolato, R., Hieny, S., Muller, W., Jun, R., Sacks, D.L., Leishmania promastigotes selectively inhibit interleukin-12 induction in bone-marrow-derived macrophages from susceptible and resistant mice (1996) J. Exp. Med., 183, pp. 515-526 | ||
| 504 | |a Butcher, B.A., Kim, L., Johnson, P.F., Denkers, E.Y., Toxoplasma gondii tachyzoites inhibit proinflamatory cytokine induction in infected macrophages by prevening nuclear translocation of the transcription factor NFkB (2001) J. Immunol., 167, pp. 2193-2201 | ||
| 504 | |a Denkers, E.Y., Kim, L., Butcher, B.A., In the belly of the beast: Subversion of macrophage proinflamatory signaling cascades during Toxoplasma gondii infection (2003) Cell. Microbiol., 5, pp. 75-83 | ||
| 504 | |a Roach, S.K., Schorey, J.S., Differential regulation of the mitogen-activated protein kinases by pathogenic and nonpathogenic mycobacteria (2002) Infect. Immun., 70, pp. 3040-3052 | ||
| 504 | |a Schorey, J.S., Cooper, A.M., Macrophage signaling upon mycobacterial infection: The MAP kinases lead the way (2003) Cell Microbiol., 5, pp. 133-142 | ||
| 504 | |a Lahti, A., Lahde, M., Kankaanranta, H., Moilanen, E., Inhibition of extracellular signal-regulated kinase suppresses endotoxin-induced nitric oxide synthesis in mouse macrophages and in human colon epithelial cells (2000) J. Pharmacol. Exp. Ther., 294, pp. 1188-1194 | ||
| 504 | |a Nathan, C., Xie, Q.W., Regulation of biosynthesis of nitric oxide (1994) J. Biol. Chem., 269, pp. 13725-13728 | ||
| 504 | |a Wang, Y., Marsden, P.A., Nitric oxide synthases: Gene structure and regulation (1995) Adv. Pharmacol., 34, pp. 71-90 | ||
| 504 | |a Iniesta, V., Gomez Nieto, C., Corraliza, I., The inhibition of arginase by N-omega-hydroxy-L-arginine controls the growth of Leishmania inside macrophages (2001) J. Exp. Med., 193, pp. 777-783 | ||
| 504 | |a Gobert, A., Daulouede, S., Lepoivre, M., Boucher, J., Bouteille, B., Buguet, A., Cespuglio, R., Vincendau, P., L-Arginine availability modulates local nitric oxide production and parasite killing in experimental trypanosomiasis (2000) Infect. Immun., 68, pp. 4653-4657 | ||
| 504 | |a Wei, S., Marches, F., Daniel, B., Sonda, S., Heidenreich, K., Curiel, T., Pyridinylimidazole p38 mitogen-activated protein kinase inhibitors block intracellular Toxoplasma gondii replication (2002) Int. J. Parasitol., 32, pp. 969-977 | ||
| 504 | |a Junghae, M., Raynes, J.G., Activation of p38 mitogen-activated protein kinase attenuates Leishmania donovani infection in macrophages (2002) Infect. Immun., 70, pp. 5026-5035 | ||
| 504 | |a Welham, M.J., Learmonth, L., Bone, H., Schrader, J.W., Interleukin-13 signal transduction in lymphohemopoietic cells. Similarities and differences in signal transduction with interleukin-4 and insulin (1995) J. Biol. Chem., 270, pp. 12286-12296 | ||
| 504 | |a Raingeaud, J., Whitmarsh, A.J., Barrett, T., Derijard, B., Davis, R.J., MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway (1996) Mol. Cell. Biol., 16, pp. 247-255 | ||
| 504 | |a Chen, K.D., Chen, L.Y., Huang, H.L., Lieu, C.H., Chang, Y.N., Chang, M.D., Lai, Y.K., Involvement of p38 mitogen-activated protein kinase signaling pathway in the rapid induction of the 78-kDa glucose-regulated protein in 9L rat brain tumor cells (1998) J. Biol. Chem., 273, pp. 749-755 | ||
| 504 | |a Vincendeau, P., Gobert, A.P., Daulouede, S., Moynet, D., Mossalayi, M.D., Arginases in parasitic diseases (2003) Trends Parasitol., 19, pp. 9-12 | ||
| 504 | |a Hesse, M., Modollel, M., La Flamme, A.C., Schito, M., Fuentes, J.M., Cheever, A.W., Pearce, E.J., Wynn, T.A., Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: Granulomatous pathology is shaped by the pattern of L-arginine metabolism (2001) J. Immunol., 167, pp. 6533-6544 | ||
| 504 | |a Abdallahi, O.M., Bensalem, H., Augier, R., Diagana, M., De Reggi, M., Gharib, B., Arginase expression in peritoneal macrophages and increase in circulating polyamine levels in mice infected with Schistosoma mansoni (2001) Cell Mol. Life Sci., 58, pp. 1350-1357 | ||
| 504 | |a Namangala, B., De Baetselier, P., Noël, W., Brys, L., Beschin, A., Alternative versus classical macrophage activation during experimental African trypanosomosis (2001) J. Leukoc. Biol., 69, pp. 387-396 | ||
| 504 | |a Giordanengo, L., Guiñazu, N., Stempin, C., Fretes, R., Cerban, F., Gea, S., Cruzipain, a major Trypanosoma cruzi antigen, conditions the host immune response in favor of parasite (2002) Eur. J. Immunol., 32, pp. 1003-1011 | ||
| 504 | |a Labriola, C., Souza, M., Cazzulo, J.J., Purification of the major cystein proteinase (cruzipain) from Trypanosoma cruzi by affinity chromatography (1993) Biol. Res., 26, pp. 101-107 | ||
| 504 | |a Campetella, O., Martinez, J., Cazzulo, J.J., A major cystein proteinase is developmentally regulated in Trypanosoma cruzi (1990) FEMS Microbiol. Lett., 55, pp. 145-149 | ||
| 504 | |a Cazzulo, J.J., Couso, R., Raimondi, A., Wernstedt, C., Hellman, U., Further characterization and partial amino acid sequence of a cystein proteinase from Trypanosoma cruzi (1989) Mol. Biochem. Parasitol., 33, pp. 33-42 | ||
| 504 | |a Corraliza, I.M., Campo, M.L., Soler, G., Modollel, M., Determination of arginase activity in macrophages: A micro-method (1994) J. Immunol. Methods, 174, pp. 231-235 | ||
| 520 | 3 | |a Given that arginase activation may effectively influence nitric oxide (NO) production in macrophages, we have investigated the intracellular signals that regulate L-arginine metabolism and its influence on Trypanosoma cruzi growth. We demonstrate that cruzipain (Cz), a parasite antigen, induces arginase I expression in J774 cells, and the pretreatment of Cz-treated cells with N-omega-hydroxy-L-arginine (arginase inhibitor) leads to a dramatic decrease in amastigote growth. The study of intracellular signals shows that genistein [tyrosine kinase (TK) inhibitor], KT5720 [protein kinase (PK) A inhibitor] and SB203580 [p38 mitogen-activated protein kinase (MAPK) inhibitor] significantly decrease Cz-induced arginase activation. However, calphostin C (PKC inhibitor) and PD98059 [p44/p42 MAPK kinase (MEK) inhibitor] did not cause a significant change. To determine if signaling pathways triggered by Cz were involved in the T. cruzi growth, we studied the effect of those inhibitors. In Cz-treated cells- pre-incubated with TK, PKA or p38 MAPK inhibitors - the balance of NO/urea was biased towards NO, and the amastigote growth was diminished. Besides, genistein and mainly KT5720 induced down-regulation of arginase I expression in Cz-treated cells. Thus, activation of TK, PKA and p38 MAPK by Cz induces an increase of arginase activity in macrophages and the subsequent T. cruzi growth. |l eng | |
| 593 | |a Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Haya de la Torre Medina Allende s/n, 5000 Cordoba, Argentina | ||
| 593 | |a Dept. de Fisiol. Biol. Molec. y Cel., Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a ARGINASE |
| 690 | 1 | 0 | |a MACROPHAGE |
| 690 | 1 | 0 | |a PARASITE ANTIGEN |
| 690 | 1 | 0 | |a PROTEIN KINASE |
| 690 | 1 | 0 | |a TRYPANOSOMA CRUZI |
| 690 | 1 | 0 | |a 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE |
| 690 | 1 | 0 | |a 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE |
| 690 | 1 | 0 | |a ARGINASE |
| 690 | 1 | 0 | |a ARGININE |
| 690 | 1 | 0 | |a CALPHOSTIN C |
| 690 | 1 | 0 | |a CARBAZOLE DERIVATIVE |
| 690 | 1 | 0 | |a CRUZIPAIN |
| 690 | 1 | 0 | |a CYCLIC AMP DEPENDENT PROTEIN KINASE |
| 690 | 1 | 0 | |a CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR |
| 690 | 1 | 0 | |a CYSTEINE PROTEINASE |
| 690 | 1 | 0 | |a DRUG DERIVATIVE |
| 690 | 1 | 0 | |a GENISTEIN |
| 690 | 1 | 0 | |a GROWTH INHIBITOR |
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| 690 | 1 | 0 | |a INDOLE DERIVATIVE |
| 690 | 1 | 0 | |a KT 5720 |
| 690 | 1 | 0 | |a MITOGEN ACTIVATED PROTEIN KINASE |
| 690 | 1 | 0 | |a MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR |
| 690 | 1 | 0 | |a MITOGEN ACTIVATED PROTEIN KINASE P38 |
| 690 | 1 | 0 | |a N(G) HYDROXYARGININE |
| 690 | 1 | 0 | |a N(OMEGA) HYDROXYARGININE |
| 690 | 1 | 0 | |a N(OMEGA)-HYDROXYARGININE |
| 690 | 1 | 0 | |a NITRIC OXIDE |
| 690 | 1 | 0 | |a PARASITE ANTIGEN |
| 690 | 1 | 0 | |a PROTEIN KINASE C INHIBITOR |
| 690 | 1 | 0 | |a PROTEIN P42 |
| 690 | 1 | 0 | |a PROTEIN P44 |
| 690 | 1 | 0 | |a PROTEIN TYROSINE KINASE |
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| 690 | 1 | 0 | |a PYRIDINE DERIVATIVE |
| 690 | 1 | 0 | |a PYRROLE DERIVATIVE |
| 690 | 1 | 0 | |a UNCLASSIFIED DRUG |
| 690 | 1 | 0 | |a UREA |
| 690 | 1 | 0 | |a AMASTIGOTE |
| 690 | 1 | 0 | |a AMINO ACID METABOLISM |
| 690 | 1 | 0 | |a ANIMAL |
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| 690 | 1 | 0 | |a ENZYME INHIBITION |
| 690 | 1 | 0 | |a ENZYMOLOGY |
| 690 | 1 | 0 | |a GROWTH, DEVELOPMENT AND AGING |
| 690 | 1 | 0 | |a INCUBATION TIME |
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| 700 | 1 | |a Coso, O.A. | |
| 700 | 1 | |a Cerbán, F.M. | |
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