The circling training rat model as a behavioral teratology test
The properties of circling training (CT) for detecting behavioral teratologic drug-induced effects was evaluated by prenatal administration of two behavioral teratogenic drugs: vitamin A (80,000 IU/kg/day) and haloperidol (2.5 mg/kg/day). The circling training was started at 30 days of age and perfo...
Guardado en:
| Autor principal: | |
|---|---|
| Otros Autores: | , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1991
|
| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 08361caa a22011177a 4500 | ||
|---|---|---|---|
| 001 | PAPER-467 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518202949.0 | ||
| 008 | 190411s1991 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0025819533 | |
| 024 | 7 | |2 cas |a Haloperidol, 52-86-8; Teratogens; Vitamin A, 11103-57-4 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a PBBHA | ||
| 100 | 1 | |a Brusés, J.L. | |
| 245 | 1 | 4 | |a The circling training rat model as a behavioral teratology test |
| 260 | |c 1991 | ||
| 270 | 1 | 0 | |m Brusés, J.L.; Laboratorio de Biologia Celular, Depto. de Ciencias Biológicas Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Alexander, DeLong, Strick, Parallel organization of functionally segregated circuits linking basal ganglia and cortex (1986) Annu. Rev. Neurosci., 9, pp. 357-381 | ||
| 504 | |a Burton, Determination of DNA concentration with diphenylamine (1965) Methods Enzymol., 12, pp. 163-166 | ||
| 504 | |a Cuomo, Perinatal neurotoxicology of psychotropic drugs (1987) Trends Pharmacol. Sci., 8, pp. 346-350 | ||
| 504 | |a de Villares, Hernstein, Toward a law of response strength (1976) Psychol. Bull., 83, pp. 1131-1153 | ||
| 504 | |a Duggleby, A nonlinear regression program for small computers (1981) Anal. Biochem., 110, pp. 9-18 | ||
| 504 | |a Freed, Yamamoto, Regional brain dopamine metabolism: A marker for the speed, direction, and posture of moving animals (1985) Science, 229, pp. 62-65 | ||
| 504 | |a Goldman-Rakic, Prenatal formation of cortical input and development of cytoarchitectonic compartments in the neostriatum of the Rhesus monkey (1981) J. Neurosci., 1, pp. 721-737 | ||
| 504 | |a Heyman, Beer, A new approach for evaluating the behavioral effects of antipsychotic drugs (1987) Trends Pharmacol. Sci., 8, pp. 388-393 | ||
| 504 | |a Kirk, (1968) Experimental design: Procedures for the behavioral sciences, , Wadsworth Publishing Company, Inc, Belmont, CA | ||
| 504 | |a Klaassen, Principles of toxicology (1980) Goodman and Gilman's The pharmacological basis of therapeutics, pp. 1602-1614. , A. Goodman Gilman, L.S. Goodman, A. Gilman, 6th ed., Macmillan Publishing Co., Inc, New York | ||
| 504 | |a Lowry, Rosebrough, Lewis Farr, Randall, Protein measurement with the Folin phenol reagent (1951) J. Biol. Chem., 158, pp. 265-275 | ||
| 504 | |a Scatchard, The attractions of proteins for small molecules and ions (1949) Annals of the New York Academy of Sciences, 51, pp. 660-672 | ||
| 504 | |a Schwarting, Huston, Dopamine and serotonin metabolism in brain sites ipsi- and contralateral to direction of conditioned turning in rats (1987) J. Neurochem., 48, pp. 1473-1479 | ||
| 504 | |a Swaab, Boer, Feenstra, Concept of functional neuroteratology and the importance of neurochemistry (1988) Biochemical basis of functional neuroteratology, vol. 73, Progress in brain research, pp. 3-14. , 2nd ed., G.J. Boer, M.G.P. Feenstra, M. Mirmiran, D.F. Swaab, F. Van Haaren, Elsevier Science Publishers, Amsterdam | ||
| 504 | |a Tilson, Behavioral indices of neurotoxicity: What can be measured? (1987) Neurotoxicol. Teratol., 9, pp. 427-443 | ||
| 504 | |a Vorhees, Some behavioral effects of maternal hypervitaminosis A in rats (1974) Teratology, 10, pp. 269-274 | ||
| 504 | |a Vorhees, Reliability, sensitivity and validity of behavioral indices of neurotoxicity (1987) Neurotoxicol. Teratol., 9, pp. 445-464 | ||
| 504 | |a Vorhees, Brunner, Butcher, Psychotropic drugs as behavioral teratogens (1979) Science, 205, pp. 1220-1225 | ||
| 504 | |a Vorhees, Brunner, McDaniel, Butcher, The relationship of gestational age to vitamin A induced postnatal dysfunction (1978) Teratology, 17, pp. 271-275 | ||
| 504 | |a Woodworth, Schlosberg, (1963) Experimental psychology, , Holt, Rinehart and Winston, Inc, New York | ||
| 504 | |a Yamamoto, Freed, The trained circling rat: A model for inducing unilateral caudate dopamine metabolism (1982) Nature, 298, pp. 467-468 | ||
| 520 | 3 | |a The properties of circling training (CT) for detecting behavioral teratologic drug-induced effects was evaluated by prenatal administration of two behavioral teratogenic drugs: vitamin A (80,000 IU/kg/day) and haloperidol (2.5 mg/kg/day). The circling training was started at 30 days of age and performed for 8 days in an automated apparatus. Statistically significant differences between drug-treated and control animals regarding the measured response (turns per minute) were found. Two components may affect the response measured by the CT: associative learning and motor performance. The incidence of these components was discriminated with behavioral and mathematical approaches. In the experimental conditions used the most affected parameter was motor performance. The results indicate that CT can be used as an instrumental conditioning test where the quantifiable endpoint is the on-going motor performance. Further applications of the CT for neurochemical evaluation of drug induced effects are also discussed. © 1991. |l eng | |
| 536 | |a Detalles de la financiación: Universidad Nacional del Centro de la Provincia de Buenos Aires | ||
| 536 | |a Detalles de la financiación: Universidad Nacional del Centro de la Provincia de Buenos Aires | ||
| 536 | |a Detalles de la financiación: Comisión de Investigaciones Científicas | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: This work was supported with grants from Universidad Nacional de Buenos Aires (UBA) and Comisi6n de Investigaciones Cientificas de la Provincia de Buenos Aires (CIC), Argentina. J.L.B. and S.I.O. gratefully acknowledge CIC and P.M.B. Concejo Nacional de Ciencia y T6cnica (CONICET), Argentina; for the granting of a fellowship. We also thank Ing. E. M. Zaritzky for the collaboration in the designing and construction of the CT automated apparatus and E. Katz for revising the translation of the manuscript. | ||
| 593 | |a Laboratorio de Biologia Celular, Depto. de Ciencias Biológicas Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a BEHAVIORAL TERATOLOGY |
| 690 | 1 | 0 | |a CAUDATE NUCLEI |
| 690 | 1 | 0 | |a CIRCLING TRAINING |
| 690 | 1 | 0 | |a HALOPERIDOL |
| 690 | 1 | 0 | |a OPERANT CONDITIONING |
| 690 | 1 | 0 | |a VITAMIN A |
| 690 | 1 | 0 | |a HALOPERIDOL |
| 690 | 1 | 0 | |a RETINOL |
| 690 | 1 | 0 | |a ADOLESCENT |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ANIMAL MODEL |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a BEHAVIOR TERATOLOGY |
| 690 | 1 | 0 | |a CIRCLING BEHAVIOR |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a INSTRUMENTAL CONDITIONING |
| 690 | 1 | 0 | |a INTRAPERITONEAL DRUG ADMINISTRATION |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MATHEMATICAL ANALYSIS |
| 690 | 1 | 0 | |a MAZE TEST |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRENATAL DRUG EXPOSURE |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a TRAINING |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a BEHAVIOR, ANIMAL |
| 690 | 1 | 0 | |a CAUDATE NUCLEUS |
| 690 | 1 | 0 | |a CONDITIONING, OPERANT |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a HALOPERIDOL |
| 690 | 1 | 0 | |a MATERNAL-FETAL EXCHANGE |
| 690 | 1 | 0 | |a PREGNANCY |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a RATS, INBRED STRAINS |
| 690 | 1 | 0 | |a SUPPORT, NON-U.S. GOV'T |
| 690 | 1 | 0 | |a TERATOGENS |
| 690 | 1 | 0 | |a VITAMIN A |
| 700 | 1 | |a Berninsone, P.M. | |
| 700 | 1 | |a Ojea, S.I. | |
| 700 | 1 | |a Azcurra, J.M. | |
| 773 | 0 | |d 1991 |g v. 38 |h pp. 739-745 |k n. 4 |p Pharmacol. Biochem. Behav. |x 00913057 |w (AR-BaUEN)CENRE-235 |t Pharmacology, Biochemistry and Behavior | |
| 856 | 4 | 1 | |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025819533&doi=10.1016%2f0091-3057%2891%2990235-T&partnerID=40&md5=14b8deb9ab6938a1b50ff72286daaf92 |y Registro en Scopus |
| 856 | 4 | 0 | |u https://doi.org/10.1016/0091-3057(91)90235-T |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00913057_v38_n4_p739_Bruses |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00913057_v38_n4_p739_Bruses |y Registro en la Biblioteca Digital |
| 961 | |a paper_00913057_v38_n4_p739_Bruses |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 61420 | ||