Teratogenic Evaluation of Metronidazole and Ornidazole Using Drosophila melanogaster as an Experimental Model
BACKGROUND: Drosophila and vertebrates show similarities that suggest that the mechanisms involved in the induction of developmental defects may be similar in both. Therefore, Drosophila has been proposed as a useful, rapid, and economical model in the preliminary screening for teratology studies. T...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
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2004
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 09887caa a22012257a 4500 | ||
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| 001 | PAPER-4627 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203412.0 | ||
| 008 | 190411s2004 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-2342466701 | |
| 024 | 7 | |2 cas |a metronidazole, 39322-38-8, 443-48-1; ornidazole, 16773-42-5; Antiprotozoal Agents; Metronidazole, 443-48-1; Ornidazole, 16773-42-5 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a BDRPB | ||
| 100 | 1 | |a Palermo, A.M. | |
| 245 | 1 | 0 | |a Teratogenic Evaluation of Metronidazole and Ornidazole Using Drosophila melanogaster as an Experimental Model |
| 260 | |c 2004 | ||
| 270 | 1 | 0 | |m Palermo, A.M.; CITEFA, DEIMAT-Section ESEM, Juan Bautista de La Salle 4397, B1603ALO, Buenos Aires, Argentina; email: apalermo@citefa.gov.ar |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Bone, W., Yeung, C.H., Skupin, R., Toxicity of ornidazole and its analogues to rat spermatozoa as reflected in motility parameters (1997) Int J Androl, 20, pp. 347-355 | ||
| 504 | |a Bourget, P., Dechelette, N., Fernandez, H., Desmaris, V.Q., Disposition of ornidazole and its metabolites during pregnancy (1995) J Antimicrob Chemother, 35, pp. 691-696 | ||
| 504 | |a Bournias-Vardiabasis, N., Teplitz, R.L., Chernoff, G.F., Seecof, R.L., Detection of teratogens in the Drosophila embryonic cell culture test: Assay of 100 chemicals (1983) Teratology, 28, pp. 109-122 | ||
| 504 | |a Carballo, M.A., Palermo, A.M., López Nigro, M., Mutagenicidad química y evaluación de daño potencial mediante ensayos de corto plazo (ECT) (2001) Acta Toxicol Argent, 9, pp. 4-8 | ||
| 504 | |a Cooper, T.G., Yeung, Ch.-H., Skupin, R., Haufe, G., Antifertility potential of ornidazole analogues in rats (1997) J Androl, 18, pp. 431-438 | ||
| 504 | |a Czeizel, A.E., Rockenbauer, M., A population based case-control teratologic study of oral metronidazole treatment during pregnancy (1998) Br J Obstet Gynaecol, 105, pp. 322-327 | ||
| 504 | |a Diav-Citrin, O., Gotteiner, T., Shechtman, S., Pregnancy outcome following gestational exposure to metronidazole: A prospective controlled cohort study (2000) Teratology, 61, p. 440 | ||
| 504 | |a Dobiáš, L., Černá, M., Rössner, P., Šrám, R., Genotoxicity and carcinogenicity of metronidazole (1994) Mutat Res, 317, pp. 177-194 | ||
| 504 | |a Ivanov, I., The effect of "Trichomonacid" on pregnancy in experimental animals (1969) Akusherstvo, Gynecology, 8, pp. 241-244 | ||
| 504 | |a Linder, R.E., Strader, L.F., Slott, V.L., Suarez, J.D., Endpoints of spermatotoxicity in the rat after short duration exposures to fourteen reproductive toxicants (1992) Reprod Toxicol, 6, pp. 491-505 | ||
| 504 | |a López Nigro, M., Palermo, A.M., Mudry, M.D., Carballo, M.A., Cytogenetic evaluation of two nitroimidazole derivatives (2003) Toxicol in Vitro, 17, pp. 35-40 | ||
| 504 | |a Lynch, D.W., Schuler, R.L., Hood, R.D., Davis, D.G., Evaluation for Drosophila for Screening Developmental Toxicants: Test Results with Eighteen Chemicals and Presentation of a New Drosophila Bioassay (1991) Teratog Carcinog Mutagen, 11, pp. 147-173 | ||
| 504 | |a McClain, R.M., Downing, J.C., Reproduction studies in rats treated with Ornidazole (1988) Toxicol Appl Pharmacol, 92, pp. 480-487 | ||
| 504 | |a Morgan, I.F.K., Metronidazole treatment in pregnancy (1979) Metronidazole, pp. 229-235. , Proceedings, Geneva, April 25-27. New York: Academic Press | ||
| 504 | |a Mudry, M.D., Carballo, M., Labal De Vinuesa, M., Mutagenic bioassay of certain pharmacological drugs: III Metronidazole (MTZ) (1994) Mutat Res, 305, pp. 127-132 | ||
| 504 | |a Mudry, M.D., Gadano, A., González, M., Carballo, M., Mutagénesis química: Riesgo y beneficio en el consumo de antiparasitarios (1995) Interciencia, 20, pp. 204-211 | ||
| 504 | |a Mudry, M.D., Martinez-Flores, I., Palermo, A.M., Embryolethality induced by metronidazole (MTZ) in Rattus norvegicus (2001) Teratog Carcinog Mutagen, 21, pp. 197-205 | ||
| 504 | |a Petersen, N.S., Effects of heath and chemical stress on development (1990) Adv Genet, 28, pp. 275-296 | ||
| 504 | |a Piper, J.M., Mitchel, E.F., Ray, W.A., Prenatal use of metronidazole and birth defects: No association (1993) Obstet Gynecol, 82, pp. 348-352 | ||
| 504 | |a Ranganathan, S., Davia, D.G., Hood, R.D., Developmental toxicity of ethanol in Drososphila melanogaster (1987) Teratology, 36, pp. 45-49 | ||
| 504 | |a Ricciardi, C., Complex biological systems as experimental and prenatal toxicology models (1997) Ann Ist Super Sanita, 33, pp. 531-539 | ||
| 504 | |a Rodriguez, F.G., Cancino, B.L., López, N.M., DNA single strand breaks in peripheral blood lymphocytes induced by three nitroimidazole derivatives (2002) Toxicol Lett, 132, pp. 109-115 | ||
| 504 | |a Roe, F.J.C., Safety of nitroimidazoles (1985) Scand J Infect Dis, 46 (SUPPL.), pp. 72-81 | ||
| 504 | |a Schuler, R.L., Harding, B.D., Niemeier, R.W., Drosophila as a tool for the rapid assessment of chemicals for teratogenicity (1982) Teratog Carcinog Mutagen, 2, pp. 293-301 | ||
| 504 | |a Schuller, R.L., Radike, M.A., Harding, B.D., Niemeier, R.W., Pattern of response of intact Drosophila to known teratogens (1985) J Am Coll Toxicol, 4, pp. 291-303 | ||
| 504 | |a Thapa, P.B., Whitlock, J.A., Brockman Worrel, K.G., Prenatal exposure to metronidazole and risk of childhood cancer: A retrospective cohort study of children younger than 5 years (1998) Cancer, 83, pp. 1461-1468 | ||
| 520 | 3 | |a BACKGROUND: Drosophila and vertebrates show similarities that suggest that the mechanisms involved in the induction of developmental defects may be similar in both. Therefore, Drosophila has been proposed as a useful, rapid, and economical model in the preliminary screening for teratology studies. The objective of the present study was to investigate the effect of metronidazole (MTZ) and omidazole (ONZ) on the developmental stages of Drosophila melanogaster. METHODS: Samarkand wild-type females were allowed to lay eggs for 24 hr in media containing MTZ or ONZ at concentrations of 0, 500, 1000, and 2000 μg/ml. When larvae completed their development, the emerging flies were counted and examined for morphological abnormalities. RESULTS: After the analysis of 400-1000 flies for each concentration, ONZ-treated flies did not show an incidence of malformations above control values, although a significant high number of individuals with reduced body size was observed (p < 0.005, χ2 test). On the other hand, the 1000- and 2000-μg/ml MTZ-treated series presented higher frequencies of total abnormalities than did concurrent and historic controls (p < 0.05, χ2 test), indicating an MTZ effect during developmental morphogenesis. CONCLUSIONS: These findings contribute to the characterization of both nitroimidazoles, which are widely used, especially in underdeveloped countries. At the same time, this Drosophila bioassay is sensitive enough to detect differential effects of MTZ and ONZ (abnormalities vs. growth effects), showing specificity and selectivity. © 2004 Wiley-Liss, Inc. |l eng | |
| 593 | |a CITEFA, Inst. Invest. Cie./Tec. de las FFAA, Buenos Aires, Argentina | ||
| 593 | |a Dpto. Ecologia, Genetica y Evolucion, Fac. Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a Ctro. de Invest. en Genet. Toxicol., Fac. Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a CITEFA, DEIMAT-Section ESEM, Juan Bautista de La Salle 4397, B1603ALO, Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a METRONIDAZOLE |
| 690 | 1 | 0 | |a NITROIMIDAZOLE DERIVATIVE |
| 690 | 1 | 0 | |a ORNIDAZOLE |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ANIMAL MODEL |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a BIOASSAY |
| 690 | 1 | 0 | |a CONCENTRATION RESPONSE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a DEVELOPING COUNTRY |
| 690 | 1 | 0 | |a DEVELOPMENTAL BIOLOGY |
| 690 | 1 | 0 | |a DEVELOPMENTAL DISORDER |
| 690 | 1 | 0 | |a DROSOPHILA MELANOGASTER |
| 690 | 1 | 0 | |a EVALUATION |
| 690 | 1 | 0 | |a EXPERIMENTAL MODEL |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a INCIDENCE |
| 690 | 1 | 0 | |a LARVAL DEVELOPMENT |
| 690 | 1 | 0 | |a MORPHOLOGICAL TRAIT |
| 690 | 1 | 0 | |a NEWBORN |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a REGULATORY MECHANISM |
| 690 | 1 | 0 | |a SCREENING TEST |
| 690 | 1 | 0 | |a SENSITIVITY ANALYSIS |
| 690 | 1 | 0 | |a SENSITIVITY AND SPECIFICITY |
| 690 | 1 | 0 | |a TERATOGENICITY |
| 690 | 1 | 0 | |a TOXICITY TESTING |
| 690 | 1 | 0 | |a VERTEBRATE |
| 690 | 1 | 0 | |a WILD TYPE |
| 690 | 1 | 0 | |a ABNORMALITIES, DRUG-INDUCED |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a ANTIPROTOZOAL AGENTS |
| 690 | 1 | 0 | |a DROSOPHILA MELANOGASTER |
| 690 | 1 | 0 | |a LARVA |
| 690 | 1 | 0 | |a METRONIDAZOLE |
| 690 | 1 | 0 | |a ORNIDAZOLE |
| 690 | 1 | 0 | |a THORAX |
| 690 | 1 | 0 | |a DROSOPHILA MELANOGASTER |
| 690 | 1 | 0 | |a MELANOGASTER |
| 690 | 1 | 0 | |a VERTEBRATA |
| 650 | 1 | 7 | |2 spines |a ABDOMEN |
| 700 | 1 | |a Reynoso, A.S. | |
| 700 | 1 | |a López Nigro, M. | |
| 700 | 1 | |a Carballo, M.A. | |
| 700 | 1 | |a Mudry, M.D. | |
| 773 | 0 | |d 2004 |g v. 70 |h pp. 157-162 |k n. 4 |p Birth Defects Res. Part A Clin. Mol. Teratol. |x 15420752 |t Birth Defects Research Part A - Clinical and Molecular Teratology | |
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| 856 | 4 | 0 | |u https://doi.org/10.1002/bdra.20008 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_15420752_v70_n4_p157_Palermo |y Handle |
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