Adrenal 11-beta hydroxysteroid dehydrogenase activity in response to stress

This work studied the effect of stresses produced by simulated gavage or gavage with 200 mmol/L HCl two hours before adrenal extraction, on the activities of the 11β-hydroxysteroid dehydrogenase 1 and 11β-hydroxysteroid dehydrogenase 2 isoforms present in the rat adrenal gland. These activities were...

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Autor principal: Zallocchi, M.
Otros Autores: Matković, L., Damasco, M.C
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: National Research Council of Canada 2004
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Acceso en línea:Registro en Scopus
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024 7 |2 cas  |a 11beta hydroxysteroid dehydrogenase, 9041-46-7; corticosterone, 50-22-6; dehydrocorticosterone, 72-23-1; hydrochloric acid, 7647-01-0; nicotinamide adenine dinucleotide, 53-84-9; nicotinamide adenine dinucleotide phosphate, 53-59-8; phenylethanolamine n methyltransferase, 9037-68-7 
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100 1 |a Zallocchi, M. 
245 1 0 |a Adrenal 11-beta hydroxysteroid dehydrogenase activity in response to stress 
260 |b National Research Council of Canada  |c 2004 
270 1 0 |m Matković, L.; Dpto. Quím. Biológica, Pabellón 2, Ciudad Universitaria, Cd. Auton. de (1428) Buenos Aires, Argentina; email: mzallo@qb.fcen.uba.ar 
506 |2 openaire  |e Política editorial 
504 |a Audigé, A., Dick, B., Frey, B.M., Frey, F.J., Corman, B., Vogt, B., Glucocorticoids and 11β-hydroxysteroid dehydrogenase type 2 gene expression in the aging kidney (2002) Eur. J. Clin. Invest., 32, pp. 411-420 
504 |a Axelrod, J., Reisine, T., Stress hormones: Their interaction and regulation (1984) Science, 224, pp. 452-459 
504 |a Baylis, C., Brenner, B.M., Mechanism of the glucocorticoid-induced increase in glomerular filtration rate (1978) Am. J. Physiol., 234, pp. F166-F170 
504 |a Borruel, M., Lantos, C., Poumeau-Delille, G., Action in vitro of adrenaline on the synthesis of corticosteroids in rats and mice (1968) C. R. Acad. Sci. Hebd. Seances Acad. Sci. D, 266, pp. 2463-2464 
504 |a Bradford, M., A rapid and sensitive method for the quantitation of microgram quantities of protein utilising the principle of protein dye binding (1976) Anal. Biochem., 72, pp. 248-254 
504 |a Carlton, B.D., Barlett, P., Basaran, A., Colling, K., Osis, I., Smith, M.K., Reproductive effects of alternative disinfectants (1986) Environ. Health Perspect., 69, pp. 237-241 
504 |a Chen, K., Suh, J., Carr, A.C., Morrow, J.D., Zeind, J., Frei, B., Vitamin C suppresses oxidative lipid damage in vivo, even in the presence of iron overload (2000) Am. J. Physiol. Endocrinol. Metab., 279, pp. E1406-E1412 
504 |a Doupe, A., Landis, S., Patterson, P., Environmental influence in the development of neural crests derivatives: Glucocorticoids, growth factors and chromaffin cells plasticity (1985) J. Neurosci., 5, pp. 2119-2142 
504 |a Ehrhart-Bornstein, M., Hinson, J., Bornstein, S., Scherbaum, W., Vinson, G., Intraadrenal interactions in the regulation of adrenocortical steroidogenesis (1998) Endocr. Rev., 19, pp. 101-143 
504 |a Gomez-Sanchez, C.E., Murry, B.A., Kem, D.C., Kaplan, N.M., A direct radioimmunoassay of corticosterone in rat serum (1975) Endocrinology, 96, pp. 796-798 
504 |a Gomez-Sanchez, E.P., Ganjam, V., Chen, Y.J., Liu, Y., Clark, S.A., Gomez-Sanchez, C.E., The 11β-hydroxysteroid dehydrogenase 2 exists as an inactive dimer (2001) Steroids, 66, pp. 845-848 
504 |a Hirasawa, G., Sasano, H., Takahashi, K., Fukushima, K., Suzuki, T., Hiwatashi, N., Toyota, T., Nagura, H., Colocalization of 11 beta-hydroxysteroid dehydrogenase type II and mineralocorticoid receptor in human epithelia (1997) J. Clin. Endocrinol. Metab., 82, pp. 3859-3863 
504 |a Igarreta, P., Calvo, J.C., Damasco, C., Activity of renal 11βhydroxysteroid dehydrogenase 2 (11βHSD2) in stressed animals (1999) Life Sci., 64, pp. 2285-2290 
504 |a Malnic, G., Ansaldo, M., Lantos, C.P., Damasco, M.C., Regulation of nephron acidification by corticosteroids (1997) Braz. J. Med. Biol. Res., 30, pp. 479-486 
504 |a Meaney, M.J., Diorio, J., Francis, D., Widdowson, J., LaPlante, P., Caldji, C., Sharma, S., Plotsky, P., Early environmental regulation of forebrain glucocorticoid receptor gene expression: Implications for adrenocortical responses to stress (1996) Dev. Neurosci., 18, pp. 49-72 
504 |a Monder, C., Miroff, Y., Marandici, A., Hardy, M.P., 11β-hydroxysteroid dehydrogenase alleviates glucocorticoid-mediated inhibition of steroidogenesis in rat Leydig cells (1994) Endocrinology, 134, pp. 1199-1204 
504 |a Roland, B., Funder, J.W., Localization of 11β-hydroxysteroid dehydrogenase type 2 in rat tissues: In situ studies (1996) Endocrinology, 137, pp. 1123-1128 
504 |a Rusvai, E., Náray-Fejes-Tóth, A., A new isoform of 11β-hydroxysteroid dehydrogenase in aldosterone target cells (1993) J. Biol. Chem., 268, pp. 10717-10720 
504 |a Shimojo, M., Condon, J., Whorwood, C.B., Stewart, P.M., Adrenal 11-beta-hydroxysteroid dehydrogenase (1996) Endocr. Res., 22, pp. 771-780 
504 |a Zuckerman-Levin, N., Tiosano, D., Eisenhofer, G., Bornstein, S., Hochberg, Z., The importance of adrenocortical glucocorticoids for adrenomedullary and physiological response to stress: A study in isolated glucocorticoid deficiency (2001) J. Clin. Endocrinol. Metab., 86, pp. 5920-5924 
520 3 |a This work studied the effect of stresses produced by simulated gavage or gavage with 200 mmol/L HCl two hours before adrenal extraction, on the activities of the 11β-hydroxysteroid dehydrogenase 1 and 11β-hydroxysteroid dehydrogenase 2 isoforms present in the rat adrenal gland. These activities were determined on immediately prepared adrenal microsomes following incubations with 3H-corticosterone and NAD + or NADP+. 11-dehydrocorticosterone was measured as an end-product by TLC, and controls were adrenal microsomes from rats kept under basal (unstressed) conditions. 11β-hydroxysteroid dehydrogenase 1 activity, but not 11β-hydroxysteroid dehydrogenase 2 activity, was increased under both stress-conditions. Homeostatically, the stimulation of 11β- hydroxysteroid dehydrogenase 1 activity would increase the supply of glucocorticoids. These, in turn, would activate the enzyme phenylethanolamine N-methyl transferase, thereby improving the synthesis of epinephrine as part of the stress-response.  |l eng 
593 |a Dpto. Quím. Biológica, Pabellón 2, Ciudad Universitaria, Cd. Auton. de (1428) Buenos Aires, Argentina 
690 1 0 |a ACIDOSIS 
690 1 0 |a ADRENAL 
690 1 0 |a HSD 
690 1 0 |a STRESS 
690 1 0 |a 11BETA HYDROXYSTEROID DEHYDROGENASE 
690 1 0 |a ADRENALIN 
690 1 0 |a CORTICOSTERONE 
690 1 0 |a DEHYDROCORTICOSTERONE 
690 1 0 |a GLUCOCORTICOID 
690 1 0 |a HYDROCHLORIC ACID 
690 1 0 |a ISOENZYME 
690 1 0 |a NICOTINAMIDE ADENINE DINUCLEOTIDE 
690 1 0 |a NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE 
690 1 0 |a PHENYLETHANOLAMINE N METHYLTRANSFERASE 
690 1 0 |a ADRENAL GLAND 
690 1 0 |a ANIMAL EXPERIMENT 
690 1 0 |a ANIMAL TISSUE 
690 1 0 |a ARTICLE 
690 1 0 |a CONTROLLED STUDY 
690 1 0 |a ENZYME ACTIVATION 
690 1 0 |a ENZYME ACTIVITY 
690 1 0 |a EXPERIMENTAL RAT 
690 1 0 |a FEEDING 
690 1 0 |a MALE 
690 1 0 |a MEASUREMENT 
690 1 0 |a MICROSOME 
690 1 0 |a NONHUMAN 
690 1 0 |a PRIORITY JOURNAL 
690 1 0 |a PROTEIN SYNTHESIS 
690 1 0 |a RAT 
690 1 0 |a SIMULATION 
690 1 0 |a STRESS 
690 1 0 |a THIN LAYER CHROMATOGRAPHY 
650 1 7 |2 spines  |a HOMEOSTASIS 
700 1 |a Matković, L. 
700 1 |a Damasco, M.C. 
773 0 |d National Research Council of Canada, 2004  |g v. 82  |h pp. 422-425  |k n. 6  |p Can. J. Physiol. Pharmacol.  |x 00084212  |w (AR-BaUEN)CENRE-2805  |t Canadian Journal of Physiology and Pharmacology 
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