Studies on the decrease of liver cytochrome P-450 content by triiodothyronine
In the rat liver, the microsomal content of cytochrome P-450 decreased by 50% after triiodothyronine (T3) administration. The molecular basis for the decreased cytochrome P-450 levels was investigated. The activities of the enzymes involved in heme synthesis or degradation were not altered by thyroi...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1991
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 07074caa a22011297a 4500 | ||
|---|---|---|---|
| 001 | PAPER-452 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518202949.0 | ||
| 008 | 190411s1991 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0025774218 | |
| 024 | 7 | |2 cas |a 5-Aminolevulinate Synthetase, EC 2.3.1.37; Aminolevulinic Acid, 106-60-5; Cytochrome P-450 Enzyme System, 9035-51-2; Heme, 14875-96-8; Hydroxymethylbilane Synthase, EC 4.3.1.8; Porphobilinogen Synthase, EC 4.2.1.24; Proteins; Serum Albumin; Triiodothyronine, 6893-02-3 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a BBGSB | ||
| 100 | 1 | |a Kleiman de Pisarev, D.L. | |
| 245 | 1 | 0 | |a Studies on the decrease of liver cytochrome P-450 content by triiodothyronine |
| 260 | |c 1991 | ||
| 270 | 1 | 0 | |m Kleiman de Pisarev, D.L. |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a In the rat liver, the microsomal content of cytochrome P-450 decreased by 50% after triiodothyronine (T3) administration. The molecular basis for the decreased cytochrome P-450 levels was investigated. The activities of the enzymes involved in heme synthesis or degradation were not altered by thyroid hormone administration. The incorporation of 3H-δ-aminolaevulinate into the liver microsomal heme was markedly reduced in T3-treated rats. The latter appeared not to reflect a lowered binding affinity of the apoprotein moiety of cytochrome P-450 for heme. The sodium dodecyl sulfate gel electrophoresis of the microsomal preparation showed a decrease in apocytochrome P-450. It is suggested that the amount of the apocytochrome may be the primary event affected in the formation of cytochrome P-450, by triiodothyronine treatment of thyroidectommized rats. © 1991. |l eng | |
| 536 | |a Detalles de la financiación: Umweltbundesamt | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: We thank Mrs. Lilia Lescano for her technical assistance. This work was supported in part by grants from the CONICET and UBA. The authors are Career Scientific Researchers in CONICET (Consejo Nacional de lnvestigaciones Cientlficas y T~cnicas). | ||
| 593 | |a Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Núnez, Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a (RAT LIVER) |
| 690 | 1 | 0 | |a CYTOCHROME P-450 |
| 690 | 1 | 0 | |a TRIIODOTHYRONINE |
| 690 | 1 | 0 | |a CYTOCHROME P450 |
| 690 | 1 | 0 | |a LIOTHYRONINE |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a HYPOTHYROIDISM |
| 690 | 1 | 0 | |a INTRAPERITONEAL DRUG ADMINISTRATION |
| 690 | 1 | 0 | |a LIVER LEVEL |
| 690 | 1 | 0 | |a LIVER MICROSOME |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a THYROIDECTOMY |
| 690 | 1 | 0 | |a 5-AMINOLEVULINATE SYNTHETASE |
| 690 | 1 | 0 | |a AMINOLEVULINIC ACID |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a CYTOCHROME P-450 ENZYME SYSTEM |
| 690 | 1 | 0 | |a ELECTROPHORESIS, POLYACRYLAMIDE GEL |
| 690 | 1 | 0 | |a HEME |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a HYDROXYMETHYLBILANE SYNTHASE |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MICROSOMES, LIVER |
| 690 | 1 | 0 | |a PORPHOBILINOGEN SYNTHASE |
| 690 | 1 | 0 | |a PROTEINS |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a RATS, INBRED STRAINS |
| 690 | 1 | 0 | |a SERUM ALBUMIN |
| 690 | 1 | 0 | |a SUPPORT, NON-U.S. GOV'T |
| 690 | 1 | 0 | |a TRIIODOTHYRONINE |
| 690 | 1 | 0 | |a ANIMALIA |
| 700 | 1 | |a Ferramola de Sancovich, A.M. | |
| 700 | 1 | |a Sancovich, H.A. | |
| 773 | 0 | |d 1991 |g v. 1074 |h pp. 172-177 |k n. 1 |p Biochim. Biophys. Acta Gen. Subj. |x 03044165 |w (AR-BaUEN)CENRE-2260 |t BBA - General Subjects | |
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| 856 | 4 | 0 | |u https://doi.org/10.1016/0304-4165(91)90057-N |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_03044165_v1074_n1_p172_KleimandePisarev |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03044165_v1074_n1_p172_KleimandePisarev |y Registro en la Biblioteca Digital |
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| 963 | |a VARI | ||
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