Synthesis of [20,21‐13C2]‐progesterone

The synthesis of, [20,21‐13C2]‐progesterone (9) from androst‐4‐ene‐3,17‐dione (1) is described. Labels were introduced by two procedures, namely, condensation of 1 with K13CN and Grignard reaction of nitrile derivative 7 with [13C]‐methylmagnesium iodide. Location of labels was confirmed by 13C‐NMR...

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Detalles Bibliográficos
Autor principal: Caballero, G.M
Otros Autores: Gros, E.G
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: 1991
Acceso en línea:Registro en Scopus
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Registro en la Biblioteca Digital
Aporte de:Registro referencial: Solicitar el recurso aquí
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100 1 |a Caballero, G.M. 
245 1 0 |a Synthesis of [20,21‐13C2]‐progesterone 
260 |c 1991 
270 1 0 |m Caballero, G.M.; Departamento de Quimica Orgánica, Facultad de Ciencias Exactas Y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón 2, Buenos Aires, 1428, Argentina 
506 |2 openaire  |e Política editorial 
504 |a von Wartburg, A., (1964) Helvetica Chimica Acta, 47, p. 1228 
504 |a Porto, A.M., Baralle, F.E., Gros, E.G., (1972) J. Steroid Biochem., 3, p. 11 
504 |a Galagovsky, L.R., Porto, A.M., Burton, G., Maier, M.S., Seldes, A.M., Gros, E.G., (1982) An. Asoc. Quim. Argent., 70, p. 327 
504 |a Galagovsky, L.R., Porto, A.M., Burton, G., Gros, E.G., (1984) Z. Naturforsch., 39 c, p. 38 
504 |a Garraffo, H.M., Gros, E.G., (1982) J. Lab. Compds. Radiopharm., 19, p. 149 
504 |a Porto, A.M., Gros, E.G., Synthesis of PREGN-5-en-3β-o1-20-one-20-14C (1968) Journal of Labelled Compounds, 4, p. 276 
504 |a Nitta, I., Fujimori, S., Ueno, H., (1985) Bull. Chem. Soc. Jpn., 58, p. 978 
504 |a Meyer, K., (1946) Helv. Chim. Acta, 29, p. 1580 
504 |a Hershberg, E.B., Oliveto, E.P., Gerold, C., Johnson, L., (1951) J. Am. Chem. Soc., 73, p. 5073 
504 |a Loewenthal, H.J.E., (1959) Tetrahedron, 6, p. 269 
504 |a Kaye, I.A., Kogon, I.C., (1951) J. Am. Chem. Soc., 73, p. 4893 
504 |a Grieco, P.A., Nishizawa, M., Oguri, T., Burke, S.D., Marinovic, N., (1977) J. Am. Chem. Soc., 99, p. 5773 
504 |a Williams, J.R., Sarkisian, G.M., (1974), p. 32. , ‐ Synthesis; Marker, R.E., (1940) J. Am. Chem. Soc., 62, p. 3350 
504 |a Caballero, G.M., Gros, E.G., (1989), p. 320. , ‐ J. Chem. Res; Bigler, P., (1983) J. Magn. Reson., 55, p. 468 
520 3 |a The synthesis of, [20,21‐13C2]‐progesterone (9) from androst‐4‐ene‐3,17‐dione (1) is described. Labels were introduced by two procedures, namely, condensation of 1 with K13CN and Grignard reaction of nitrile derivative 7 with [13C]‐methylmagnesium iodide. Location of labels was confirmed by 13C‐NMR spectroscopy. Copyright © 1991 John Wiley & Sons, Ltd.  |l eng 
593 |a Departamento de Quimica Orgánica, Facultad de Ciencias Exactas Y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón 2, Buenos Aires, 1428, Argentina 
690 1 0 |a SYNTHESIS 
690 1 0 |a [20,21‐13C2]‐PROGESTERONE 
690 1 0 |a CARBON 13 
690 1 0 |a PROGESTERONE 
690 1 0 |a ARTICLE 
690 1 0 |a CONTROLLED STUDY 
690 1 0 |a HORMONE SYNTHESIS 
690 1 0 |a ISOTOPE LABELING 
700 1 |a Gros, E.G. 
773 0 |d 1991  |g v. 29  |h pp. 805-812  |k n. 7  |p J. Label. Compd. Radiopharm.  |x 03624803  |w (AR-BaUEN)CENRE-1949  |t Journal of Labelled Compounds and Radiopharmaceuticals 
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