Protective effect of a natural carrageenan on genital herpes simplex virus infection in mice
In the present study, the protective effect of 1T1, a λ-carrageenan extracted from the red seaweed Gigartina skottsbergii was evaluated in a murine model of herpes simplex virus type 2 (HSV-2) genital infection. Six to eight-week-old female BALB/c mice were intravaginally inoculated with a lethal do...
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2004
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 10568caa a22013097a 4500 | ||
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| 001 | PAPER-4374 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203355.0 | ||
| 008 | 190411s2004 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-7444259596 | |
| 024 | 7 | |2 cas |a carrageenan, 9000-07-1, 9049-05-2, 9061-82-9, 9064-57-7; Antiviral Agents; Carrageenan, 9000-07-1 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a ARSRD | ||
| 100 | 1 | |a Carlucci, M.J. | |
| 245 | 1 | 0 | |a Protective effect of a natural carrageenan on genital herpes simplex virus infection in mice |
| 260 | |c 2004 | ||
| 270 | 1 | 0 | |m Laboratorio de Virología, Depto. de Quím. Biol., Fac. Cie. Exact. Y Nat., Univ. B.Argentina; email: edamonte@qb.fcen.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Arvin, A.M., Prober, C.G., Herpes simplex virus type 2 - A persistent problem (1997) N. Engl. J. Med., 337, pp. 1158-1159 | ||
| 504 | |a Baba, M., Pauwels, R., Balzarini, J., Arnout, J., Desmyter, J., De Clercq, E., Mechanism of inhibitory effect of dextran sulfate and heparin on replication of human immunodeficiency virus in vitro (1988) Proc. Natl. Acad. Sci. U.S.A., 85, pp. 6132-6136 | ||
| 504 | |a Bourne, K.Z., Bourne, N., Reising, S.F., Stanberry, L.R., Plant products as topical microbicide candidates: Assessment of in vitro and in vivo activity against herpes simplex virus type 2 (1999) Antiviral Res., 42, pp. 219-226 | ||
| 504 | |a Bourne, N., Bernstein, D.I., Ireland, J., Sonderfan, A.J., Profy, A.T., Stanberry, L.R., The topical microbicide PRO 2000 protects against genital herpes infection in a mouse model (1999) J. Infect. Dis., 180, pp. 203-205 | ||
| 504 | |a Carlucci, M.J., Pujol, C.A., Ciancia, M., Noseda, M.D., Matulewicz, M.C., Damonte, E.B., Cerezo, A.S., Antiherpetic and anticoagulant properties of carrageenans from the red seaweed Gigartina skottsbergii and their cyclized derivatives: Correlation between structure and biological activity (1997) Int. J. Biol. Macromol., 20, pp. 97-105 | ||
| 504 | |a Carlucci, M.J., Ciancia, M., Matulewicz, M.C., Cerezo, A.S., Damonte, E.B., Antiherpetic activity and mode of action of natural carrageenans of diverse structural types (1999) Antiviral Res., 43, pp. 93-102 | ||
| 504 | |a Carlucci, M.J., Scolaro, L.A., Damonte, E.B., Inhibitory action of natural carrageenans on herpes simplex virus infection of mouse astrocytes (1999) Chemotherapy, 45, pp. 429-436 | ||
| 504 | |a Coggins, C., Blanchard, K., Alvarez, B., Brache, V., Weisberg, E., Kilmarx, P.H., Lacarra, M., Ellertson, C., Preliminary safety and acceptability of a carrageenan gel for possible use as a vaginal microbicide (2000) Sex. Transm. Infect., 76, pp. 480-483 | ||
| 504 | |a Cohen, M.S., Sexually transmitted diseases enhance HIV transmission: No longer a hypothesis (1998) Lancet, 351, pp. 5-7 | ||
| 504 | |a Corey, L., Handsfield, H.H., Genital herpes and public health: Addressing a global problem (2000) JAMA, 283, pp. 791-794 | ||
| 504 | |a Herold, B.C., Bourne, N., Marcellino, D., Kirkpatrick, R., Strauss, D.M., Zaneveld, L.J.D., Waller, D.P., Cooper, M.D., Poly(sodium 4-styrene sulfonate): An effective candidate topical antimicrobial for the prevention of sexually transmitted diseases (2000) J. Infect. Dis., 181, pp. 770-773 | ||
| 504 | |a Jennings, R., Clegg, A., The inhibitory effect of spermicidal agents on replication of HSV-2 and HIV-1 in vitro (1993) J. Antimicrob. Chemother., 32, pp. 71-82 | ||
| 504 | |a Keller, M.J., Klotman, M.E., Herold, B.C., Development of topical microbicides for prevention of human immunodeficiency virus and herpes simplex virus (2003) Am. J. Reprod. Immunol., 49, pp. 279-284 | ||
| 504 | |a Maguire, R.A., Bergman, N., Phillips, D.M., Comparison of microbicides for efficacy in protecting mice against vaginal challenge with herpes simplex virus type 2, cytotoxicity, antibacterial properties, and sperm immobilization (2001) Sex. Transm. Dis., 28, pp. 259-265 | ||
| 504 | |a Neyts, J., De Clercq, E., Effect of polyanionic compounds on intracutaneous and intravaginal herpesvirus infection in mice: Impact on the search for vaginal microbicides with anti-HIV activity (1995) J. Acquir. Immune Defic. Syndr. Hum. Retrovirol., 10, pp. 8-12 | ||
| 504 | |a Neyts, J., Snoeck, R., Schols, D., Balzarini, J., Esko, J.D., Van Schepdael, A., De Clercq, E., Sulfated polymers inhibit the interaction of human cytomegalovirus with cell surface heparan sulfate (1992) Virology, 189, pp. 48-58 | ||
| 504 | |a Parr, M.B., Kepple, L., McDermott, M.R., Drew, M.D., Bozzola, J.J., Parr, E.L., A mouse model for studies of mucosal immunity to vaginal infection by herpes simplex virus type 2 (1994) Lab. Invest., 70, pp. 369-380 | ||
| 504 | |a Piret, J., Lamontagne, J., Bestman-Smith, J., Roy, S., Gourde, P., Désormeaux, A., Omar, R.F., Bergeron, M.G., In vitro and in vivo evaluations of sodium lauryl sulfate and dextran sulfate as microbicides against herpes simplex and human immunodeficiency viruses (2000) J. Clin. Microbiol., 38, pp. 110-119 | ||
| 504 | |a Spieler Trager, R., Raising new barriers against HIV infection (2003) Science, 299, p. 39 | ||
| 504 | |a Stafford, M.K., Ward, H., Flanagan, A., Rosenstein, I.J., Taylor-Robinson, D., Smith, J.R., Weber, J., Kitchen, V.S., Safety study of nonoxynol-9 as a vaginal microbicide: Evidence of adverse effects (1998) J. Acquir. Immune Defic. Syndr. Hum. Retrovirol., 17, pp. 327-331 | ||
| 504 | |a Witvrouw, M., Desmyter, J., De Clercq, E., Antiviral portrait series: 4. Polysulfates as inhibitors of HIV and other enveloped viruses (1994) Antiviral Chem. Chemother., 5, pp. 345-359 | ||
| 504 | |a Zacharopoulos, V.R., Phillips, D.M., Vaginal formulations of carrageenan protect mice from herpes simplex virus infection (1997) Clin. Diagn. Lab. Immunol., 4, pp. 465-468 | ||
| 504 | |a Zeitlin, L., Whaley, K.J., Hegarty, T.A., Moench, T.R., Cone, R.A., Tests of vaginal microbicides in the mouse genital herpes model (1997) Contraception, 56, pp. 329-335 | ||
| 520 | 3 | |a In the present study, the protective effect of 1T1, a λ-carrageenan extracted from the red seaweed Gigartina skottsbergii was evaluated in a murine model of herpes simplex virus type 2 (HSV-2) genital infection. Six to eight-week-old female BALB/c mice were intravaginally inoculated with a lethal dose of HSV-2 (MS strain) and pre- or post-infection treated with different doses of a 10 mg/ml solution of 1T1. A single topical administration of 1T1 shortly before infection of BALB/c mice with HSV-2 protected 9 out of 10 mice from HSV-2-induced lesions and mortality, compared with only 10% survival in control mice. In addition, 1T1 produced a total blockade in virus shedding in the vaginal secretions. When 1T1 pre-treatment was reinforced with a second dose 2 h after infection, total protection was observed even when the prophylactic administration had taken place at 60 min before infection. The irreversible virucidal action of 1T1 against herpes virus seems to be responsible of its protective effect against virus replication and mortality following vaginal HSV-2 infection. © 2004 Elsevier B.V. All rights reserved. |l eng | |
| 536 | |a Detalles de la financiación: Adhesives and Sealant Council | ||
| 536 | |a Detalles de la financiación: Agencia Nacional de Promoción Científica y Tecnológica | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: This work was supported by Agencia Nacional de Promoción Científica y Tecnológica and Universidad de Buenos Aires (Argentina). MJC, LAS, ASC, and EBD are members of Research Career from Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET, Argentina). | ||
| 593 | |a Laboratorio de Virología, Depto. de Quím. Biol., Fac. Cie. Exact. Y Nat., Univ. B., Argentina | ||
| 593 | |a Departamento de Bioquímica, Univ. Federal Do Paraná, Curitiba, Brazil, Brazil | ||
| 593 | |a Depto. de Quím. Orgán., Fac. de Ciencias Exactas Y Naturales, Univ. Buenos Aires, Buenos Aires, A., Argentina | ||
| 690 | 1 | 0 | |a HERPES SIMPLEX VIRUS TYPE 2 |
| 690 | 1 | 0 | |a NATURAL CARRAGEENAN |
| 690 | 1 | 0 | |a SEXUALLY TRANSMITTED DISEASE |
| 690 | 1 | 0 | |a VAGINAL INFECTION |
| 690 | 1 | 0 | |a VIRUCIDAL ACTIVITY |
| 690 | 1 | 0 | |a CARRAGEENAN |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ANIMAL MODEL |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a DOSE RESPONSE |
| 690 | 1 | 0 | |a DRUG EFFECT |
| 690 | 1 | 0 | |a DRUG ISOLATION |
| 690 | 1 | 0 | |a DRUG MECHANISM |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a GENITAL HERPES |
| 690 | 1 | 0 | |a HERPES SIMPLEX VIRUS 2 |
| 690 | 1 | 0 | |a INFECTION PREVENTION |
| 690 | 1 | 0 | |a INOCULATION |
| 690 | 1 | 0 | |a LETHAL DOSE |
| 690 | 1 | 0 | |a MORTALITY |
| 690 | 1 | 0 | |a MOUSE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a SEAWEED |
| 690 | 1 | 0 | |a SURVIVAL RATE |
| 690 | 1 | 0 | |a TIME |
| 690 | 1 | 0 | |a VAGINA SECRETION |
| 690 | 1 | 0 | |a VIRUS REPLICATION |
| 690 | 1 | 0 | |a VIRUS SHEDDING |
| 690 | 1 | 0 | |a VIRUS STRAIN |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a ANTIVIRAL AGENTS |
| 690 | 1 | 0 | |a CARRAGEENAN |
| 690 | 1 | 0 | |a CERCOPITHECUS AETHIOPS |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a HERPES GENITALIS |
| 690 | 1 | 0 | |a HERPESVIRUS 2, HUMAN |
| 690 | 1 | 0 | |a MICE |
| 690 | 1 | 0 | |a MICE, INBRED BALB C |
| 690 | 1 | 0 | |a VAGINAL DISEASES |
| 690 | 1 | 0 | |a VERO CELLS |
| 690 | 1 | 0 | |a VIRUS SHEDDING |
| 690 | 1 | 0 | |a ALGAE |
| 690 | 1 | 0 | |a GIGARTINA |
| 690 | 1 | 0 | |a GIGARTINA SKOTTSBERGII |
| 690 | 1 | 0 | |a HERPESVIRIDAE |
| 690 | 1 | 0 | |a HUMAN HERPESVIRUS 2 |
| 690 | 1 | 0 | |a MURINAE |
| 690 | 1 | 0 | |a SIMPLEXVIRUS |
| 650 | 1 | 7 | |2 spines |a VAGINA |
| 700 | 1 | |a Scolaro, L.A. | |
| 700 | 1 | |a Noseda, M.D. | |
| 700 | 1 | |a Cerezo, A.S. | |
| 700 | 1 | |a Damonte, E.B. | |
| 773 | 0 | |d 2004 |g v. 64 |h pp. 137-141 |k n. 2 |p Antiviral Res. |x 01663542 |w (AR-BaUEN)CENRE-3746 |t Antiviral Research | |
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