Description of a new human breast cancer cell line, IIB-BR-G, established from a primary undifferentiated tumor

The establishment of a new human breast cancer cell line (IIB-BR-G) was successful after a previous growth of the cells isolated from a breast primary tumor in a female nude mouse. The IIB-BR-G cell line and the primary tumor do not express estrogen or progesterone receptors. Vimentin and keratin ex...

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Autor principal: Bover, L.
Otros Autores: Barrio, M., Slavutsky, I., Bravo, A.I, Quintans, C., Bagnati, A., Lema, B., Schiaffi, J., Yomha, R., Mordoh, J.
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: Kluwer Academic Publishers 1991
Acceso en línea:Registro en Scopus
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024 7 |2 cas  |a Culture Media; Receptors, Cell Surface 
040 |a Scopus  |b spa  |c AR-BaUEN  |d AR-BaUEN 
030 |a BCTRD 
100 1 |a Bover, L. 
245 1 0 |a Description of a new human breast cancer cell line, IIB-BR-G, established from a primary undifferentiated tumor 
260 |b Kluwer Academic Publishers  |c 1991 
270 1 0 |m Mordoh, J.; Instituto de Investigaciones Bioquimicas 'Fundacion Campomar', and Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Avda. Patricias Argentinas 435, Buenos Aires, 1405, Argentina 
506 |2 openaire  |e Política editorial 
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504 |a Langlois, A.J., Holder, W.D., Inglehart, J.D., Nelson-Rees, W.A., Wells, S.A., Jr, Bolognesi, D.P., Morphological and biochemical properties of a new human breast cancer cell line (1979) Cancer Res, 39, pp. 2604-2613 
504 |a Young, R.K., Cailleau, R.M., Mackay, B., Reeves, W.J., Jr, Establishment of epithelial cell line MDA-MB-157 from metastatic pleural effusion of human breast carcinoma (1974) In Vitro, 9, pp. 239-245 
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504 |a Keydar, I., Chen, L., Karby, S., Weiss, F.R., Delarea, J., Radu, M., Chaitcick, S., Brenner, H.J., Establishment and characterization of a cell line of human breast carcinoma origin (1979) Eur J Cancer, 15, pp. 659-670 
504 |a Lasfargues, E.Y., Coutinho, W.G., Redfield, E.S., Isolation of two human tumor epithelial cell lines from solid breast carcinomas (1978) J Natl Cancer Inst, 61, pp. 967-978 
504 |a Nordquist, R.E., Ishmael, D.R., Lovig, C.A., Hyder, D.M., Hoge, A.F., The tissue culture and morphology of human breast tumor cell line BOT-2 (1975) Cancer Res, 35, pp. 3100-3105 
504 |a Vignon F, Chalbos D, Derocq D, Rochefort H: Stimulation by estrogen of the proliferation of T-47D and MCF-7 breast cancer cells (Abstract). 64th Annual Meeting of the Endocrine Society, 719, 1982; Vic, P., Vignon, F., Derocq, D., Rochefort, H., Effect of estradiol on the ultrastructure of the MCF-7 human breast cancer cells in culture (1982) Cancer Res, 42, pp. 667-673 
504 |a Sutherland, R.L., Hall, R.E., Pang, G.Y.N., Musgrove, E.A., Clarke, C.L., Effect of medroxyprogesterone acetate on proliferation and cell cycle kinetics of human mammary carcinoma cells (1988) Cancer Res, 48, pp. 5084-5091 
504 |a Westley, B., Rochefort, H., A secreted glycoprotein induced by estrogen in human breast cancer cell lines (1980) Cell, 20, pp. 353-362 
504 |a Masiakowski, P., Breathnach, R., Bloch, J., Gannon, F., Krust, A., Chambon, P., Cloning of cDNA sequences of hormoneregulated genes from the MCF-7 human breast cancer cell line (1982) Nucleic Acids Res, 10, pp. 7895-7903 
504 |a Sutherland, R.L., Green, M.D., Hall, R.E., Redell, R.R., Taylor, I.W., Tamoxifen induces accumulation of MCF-7 human mammary carcinoma cells in the G<inf>0</inf>-G<inf>1</inf> phase of the cell cycle (1983) Eur J Cancer Clin Oncol, 19, pp. 615-621 
504 |a Osborne, C.K., Boldt, D.D., Estrada, P., Human breast cancer cell cycle synchronization by estrogens and antiestrogens in culture (1984) Cancer Res, 44, pp. 1433-1439 
504 |a Thompson, E.W., Reich, R., Shima, T.B., Albini, A., Graf, J., Martin, G.R., Dickson, R.B., Lippman, M.E., Differential regulation of growth and invasiveness of MCF-7 breast cancer cells by antiestrogens (1988) Cancer Res, 48, pp. 6764-6768 
504 |a Smith, H.S., Wolman, S.R., Hackett, A.J., The biology of breast cancer at the cellular level (1984) Biochim Biophys Acta, 738, pp. 103-123 
504 |a Podhajcer, O., Bravo, A., Sorin, I., Guman, N., Cerdeiro, R., Mordoh, J., Determination of DNA synthesis, estrogen receptors, and carcinoembryonic antigen in isolated cellular subpopulations of human breast cancer (1986) Cancer, 58, pp. 720-729 
504 |a Brunner, N., Bronzert, D., Vindelov, L.L., Rygaard, K., Spang-Thoen, M., Lippman, M.E., Effect on growth and cell cycle kinetics of estradiol and tamoxifen on MCF-7 human breast cancer cells grown in vitro and in nude mice (1989) Cancer Res, 49, pp. 1515-1520 
504 |a Giovanella, B., Fogh, J., The nude mouse in cancer research (1985) Adv Cancer Res, 44, pp. 69-120 
504 |a Ballare, C., Bravo, A.I., Laucella, S., Sorin, I., Cerdeiro, R., Loza, J., Sousa Martinez, F., Mordoh, J., DNA synthesis in estrogen receptor-positive human breast cancer takes place preferentially in estrogen receptor-negative cells (1989) Cancer, 64, pp. 842-848 
504 |a Mackillop, W.J., Buick, R.N., Cellular heterogeneity in human ovarian carcinoma studied by density gradient fractionation (1981) Stem Cells, 1, pp. 355-366 
504 |a Hamburger, A.W., Salmon, S.E., Primary bioassay of human tumor stem cells (1977) Science, 197, pp. 461-463 
504 |a Seabright, M., Rapid banding technique for human chromosomes (1971) Lancet, 2, pp. 971-972 
504 |a ISCN: An International System for Human Cytogenetic Nomenclature. Birth Defects: Original Article Series, Vol. 14, N° 8 (The National Foundation, New York) 1978; and also in Cytogenet Cell Genet 21: 309–404, 1978; Bloom, H.J., Richardson, W.W., Histological grading and prognosis in breast cancer (1957) Br J Cancer, 11, pp. 359-366 
504 |a Shin, S-I, Use of nude mice for tumorigenicity testing and mass propagation (1979) Meth Enzymol, 58, pp. 370-379 
504 |a Bernal, S.D., Stahel, R.A., Cytoskeleton-associated proteins: their role as cellular integrators in the neoplastic process (1985) CRC Crit Rev Oncol Hematol, 3, pp. 191-204 
504 |a Sommers, C.L., Walker Jones, D., Heckford, S.E., Worland, P., Valverius, E., Clark, R., McCormick, F., Gelmann, E.P., Vimentin rather than keratin expression in some hormone-independent breast cancer cell lines and in oncogene-transformed mammary epithelial cells (1989) Cancer Res, 49, pp. 4258-4263 
504 |a Cattoretti, G., Andreola, S., Clemente, C., D'Amato, L., Rilke, F., Vimentin and p53 expression on epidermal growth factor receptor-positive, estrogen receptor-negative breast carcinomas (1988) Br J Cancer, 57, pp. 353-357 
504 |a Franke, W.W., Mayer, D., Schmid, E., Denk, H., Borenfreund, E., Differences of expression of cytoskeletal proteins in cultured rat hepatocytes and hepatoma cells (1981) Exp Cell Res, 134, pp. 345-365 
504 |a Franke, W.W., Schmid, E., Osborn, M., Weber, K., Different intermediate-sized filaments distinguished by immunofluorescence microscopy (1978) Proc Natl Acad Sci (USA), 75, pp. 5034-5038 
504 |a Franke, W.W., Schmid, E., Winter, S., Osborn, M., Weber, K., Widespread occurrence of intermediate-sized filaments of the vimentin-type in cultured cells from diverse vertebrates (1979) Exp Cell Res, 123, pp. 25-46 
504 |a Summerhayes, I.C., Cheng, Y.S.E., Sun, T.T., Chen, L.B., Expression of keratin and vimentin intermediate filaments in rabbit bladder epithelial cells at different stage of benzo(a) pyrene-induced neoplastic progression (1981) J Cell Biol, 90, pp. 63-69 
504 |a Schmid, E., Schiller, D.L., Grund, C., Stadler, J., Franke, W.W., Tissue type-specific expression of intermediate filament proteins in a cultured epithelial cell line from bovine mammary gland (1982) J Cell Biol, 95, pp. 37-50 
504 |a Bravo, A.I., Sorin, I., Guman, N., Mordoh, J., Carcinoembryonic antigen and differentiation in human breast cancer (1985) J Exp Clin Cancer Res, 4, pp. 3-9 
504 |a Trent, J.M., Cytogenetic and molecular biological alterations in human breast cancer: a review (1985) Breast Cancer Res Treat, 5, pp. 221-229 
504 |a Pathak, S., Cytogenetics of solid tumors (1986) The Human Oncogenic Viruses, pp. 43-87. , Luderer, AA, Weetall, HH, Human Press, Clifton NJ 
504 |a Hill, S.M., Rodgers, C.S., Hulten, M.A., Cytogenetic analysis in human breast carcinoma. II. Seven cases in triploid/tetraploid range investigated using direct preparations (1987) Cancer Genet Cytogenet, 24, pp. 45-62 
504 |a Satya-Prakash, K.L., Pathak, S., Hsu, T.C., Olive, M., Cailleau, R., Cytogenetic analysis on eight human breast tumor cell lines: High frequencies of 1q, 11q and HeLa-like marker chromosomes (1981) Cytogenet Cell Genet, 3, pp. 61-73 
504 |a Nielsen, K.V., Briand, P., Cytogenetic analysis of in vitro karyotype evolution in a cell line established from non-malignant human mammary epithelium (1989) Cancer Genet Cytogenet, 39, pp. 103-118 
504 |a Ferti-Passantonopoulou, A.D., Panai, A.D., Common cytogenetic findings in primary breast cancer (1987) Cancer Genet Cytogenet, 27, pp. 289-298 
504 |a Ferti, A., Panani, A., Raptis, S., Involvement of chromosome 11 in breast cancer (1989) Cancer Genetics and Cytogenetics, 38, p. 185 
504 |a Pathak, S., Cytogenetic analysis in human breast tumors (1980) Cancer Genet Cytogenet, 1, pp. 281-289 
504 |a Barker, P.E., Hsu, T.C., Double minutes in human carcinoma cell lines, with special reference to breast tumors (1979) J Natl Cancer Inst, 62, pp. 257-261 
504 |a Band, V., Zajchowski, D., Stenman, G., Morton, C.C., Kulesa, V., Connolly, J., Sager, R., A newly established metastatic breast tumor cell line with integrated amplified copies of erb B<inf>2</inf> and double minute chromosomes (1990) Genes, Chromosomes, & Cancer, 1, pp. 48-58 
504 |a Tenth International Workshop on Human Gene Mapping (1989) Cytogenet Cell Genet, 51, pp. 1-4. , HGM 10 (Human Gene Mapping 10) 
504 |a Remvikos, Y., Gerbault-Seurreau, M., Vielh, P., Zafrani, B., Magdelenat, H., Dutrillaux, B., Relevance of DNA ploidy as a measure of genetic deviation: A comparison of flow cytometry and cytogenetics in 25 cases of human breast cancer (1988) Cytometry, 9, pp. 612-618 
520 3 |a The establishment of a new human breast cancer cell line (IIB-BR-G) was successful after a previous growth of the cells isolated from a breast primary tumor in a female nude mouse. The IIB-BR-G cell line and the primary tumor do not express estrogen or progesterone receptors. Vimentin and keratin expression were found in the cell line and in the nude mouse tumor. This cell line displays high morphological heterogeneity with atypical multinucleated megacells, and it is capable of anchorage-independent growth and tumor formation in nude mice. The cytogenetic analysis confirmed its human origin and revealed multiple marker chromosomes and extensive chromosomal alterations including rearrangements, gains, losses, isochromosomes, and double minutes (DMs). © 1991 Kluwer Academic Publishers.  |l eng 
593 |a Instituto de Investigaciones Bioquimicas 'Fundacion Campomar', and Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Avda. Patricias Argentinas 435, Buenos Aires, 1405, Argentina 
593 |a Academic Nacional de Medicina, J.A. Pacheco de Melo 3081, Buenos Aires, 1425, Argentina 
593 |a Hospital Mariano R. Castex, Balcarce 900, San Martin, 1650, Argentina 
593 |a Comision Nacional de Energia Atomica, Ezeiza, 1804, Argentina 
593 |a Hospital Nacional Bernardino Rivadavia, Avda. Las Heras 2670, Buenos Aires, 1425, Argentina 
690 1 0 |a BREAST CANCER 
690 1 0 |a CELL LINE 
690 1 0 |a CYTOGENETICS 
690 1 0 |a MORPHOLOGY 
690 1 0 |a ARTICLE 
690 1 0 |a BREAST CANCER 
690 1 0 |a CHROMOSOME ABERRATION 
690 1 0 |a FEMALE 
690 1 0 |a HUMAN 
690 1 0 |a HUMAN CELL 
690 1 0 |a TUMOR CELL LINE 
690 1 0 |a UNDIFFERENTIATED CARCINOMA 
690 1 0 |a ANIMAL 
690 1 0 |a BREAST NEOPLASMS 
690 1 0 |a CARCINOMA, INTRADUCTAL, NONINFILTRATING 
690 1 0 |a CELL DIFFERENTIATION 
690 1 0 |a CELL DIVISION 
690 1 0 |a COMPARATIVE STUDY 
690 1 0 |a CULTURE MEDIA 
690 1 0 |a FEMALE 
690 1 0 |a HUMAN 
690 1 0 |a IMMUNOHISTOCHEMISTRY 
690 1 0 |a KARYOTYPING 
690 1 0 |a KINETICS 
690 1 0 |a MAMMARY NEOPLASMS, EXPERIMENTAL 
690 1 0 |a MENOPAUSE 
690 1 0 |a MICE 
690 1 0 |a MICE, NUDE 
690 1 0 |a NEOPLASM TRANSPLANTATION 
690 1 0 |a RECEPTORS, CELL SURFACE 
690 1 0 |a SUPPORT, NON-U.S. GOV'T 
690 1 0 |a TUMOR CELLS, CULTURED 
700 1 |a Barrio, M. 
700 1 |a Slavutsky, I. 
700 1 |a Bravo, A.I. 
700 1 |a Quintans, C. 
700 1 |a Bagnati, A. 
700 1 |a Lema, B. 
700 1 |a Schiaffi, J. 
700 1 |a Yomha, R. 
700 1 |a Mordoh, J. 
773 0 |d Kluwer Academic Publishers, 1991  |g v. 19  |h pp. 47-56  |k n. 1  |p Breast Cancer Res Tr  |x 01676806  |t Breast Cancer Research and Treatment 
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856 4 0 |u https://doi.org/10.1007/BF01975204  |y DOI 
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