Heparin increases the adhesion of murine mammary adenocarcinoma cells (LM3). Correlation with the presence of heparin receptors on cell surface
Mastocytosis is a common feature around solid tumors. Due to mast cell (MC) degranulation, heparin and other chemical mediators are released to surrounding tissues. The aim of this paper is to investigate the role of heparin and chemically modified heparins, on a murine mammary adenocarcinoma cell l...
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Wichtig Editore s.r.l.
2005
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| 001 | PAPER-4264 | ||
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| 030 | |a JBRAE | ||
| 100 | 1 | |a Bertolesi, G. | |
| 245 | 1 | 0 | |a Heparin increases the adhesion of murine mammary adenocarcinoma cells (LM3). Correlation with the presence of heparin receptors on cell surface |
| 260 | |b Wichtig Editore s.r.l. |c 2005 | ||
| 270 | 1 | 0 | |m de Cidre, L.L.; Laboratorio de Histología Animal, Departamento de Ciencias Biológicas, Universidad de Buenos Aires, Pab. II, 2do. piso, 1428 Buenos Aires, Argentina; email: laurial@bg.fcen.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Theoharides, T.C., Conti, P., Mast cells: The JEKYLL and HYDE of tumor growth (2004) Trends in Immunology, 25, pp. 235-241 | ||
| 504 | |a Lauría de Cidre, L.S., Eijan, A.M., Bertolesi, G., Isturiz, M., Sacerdote de Lustig, E., Influence of mast cells on two murine mammary adenocarcinomas (1996) Tumour. Biol., 17, pp. 345-353 | ||
| 504 | |a Bertolesi, G.E., Stockert, J.C., Lauría de Cidre, L., Microfluorometry and image analysis of peritoneal mast cells reveals differences in the morphology and content of sulfated polyanions between normal and tumor-bearing mice (1997) Int. J. Oncol., 11, pp. 1221-1225 | ||
| 504 | |a Bertolesi, G.E., Lauria de Cidre, L., Eijan, A.M., Growth inhibition in vitro of murine mammary adenocarcinoma cells by heparin and chemically modified heparins (1994) Tumour. Biol., 15, pp. 275-283 | ||
| 504 | |a Bertolesi, G.E., Lauria de Cidre, L., Sacerdote de Lustig, E., Eijan, A.M., Heparin receptors in two murine mammary adenocarcinomas with different metastatic ability: Relationship with growth inhibition (1995) Cancer Letters, 90, pp. 123-131 | ||
| 504 | |a Alonso, D.F., Bertolesi, G.E., Farias, E.F., Eiján, A.M., Bal de Kier Joffé, E., Lauría de Cidre, L., Antimetastatic effects associated with anticoagulant properties of heparin and chemically modified heparin species in a mouse mammary tumor model (1996) Oncol. Reports, 3, pp. 219-222 | ||
| 504 | |a Engelberg, H., Actions of heparin that may affect the malignant process (1999) Cancer, 85, pp. 257-272 | ||
| 504 | |a Hulett, M.D., Freeman, C., Hamdorf, B.J., Baker, R.T., Harris, M.J., Parish, C.R., Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis (1999) Nature, 5, pp. 803-809 | ||
| 504 | |a Borsig, L., Wong, R., Feramisco, J., Nadeau, D.R., Varki, N.M., Varki, A., Heparin and cancer revisited: Mechanistic connections involving platelets, P-selectin, carcinoma mucins, and tumor metastasis (2001) Proc. Natl. Acad. Sci. U. S. A., 98, pp. 3352-3357 | ||
| 504 | |a Ruoslahti, E., RGD and other recognition sequences for integrins (1996) Annu. Rev. Cell Dev. Biol., 12, pp. 697-715 | ||
| 504 | |a Chattopadhyay, N., Chatterjee, A., Studies on the expression of alpha(v)beta3 integrin receptors in non-malignant and malignant human cervical tumor tissues (2001) J. Exp. Clin. Cancer Res., 20, pp. 269-275 | ||
| 504 | |a LeBaron, R.G., Hook, A., Esko, J.D., Gay, S., Hook, M., Binding of heparan sulfate to type V collagen. A mechanism of cell- substrate adhesion (1989) J. Biol. Chem., 264, pp. 7950-7956 | ||
| 504 | |a Woods, A., Couchman, J.R., Heparan sulfate proteoglycans and signalling in cell adhesion (1992) Adv. Exp. Med. Biol., 313, pp. 87-96 | ||
| 504 | |a San Antonio, J.D., Slover, J., Lawler, J., Karnovsky, M.J., Lander, A.D., Specificity in the interactions of extracellular matrix proteins with subpopulations of the glycosaminoglycan heparin (1993) Biochemistry, 32, pp. 4746-4755 | ||
| 504 | |a Savage, J.M., Gilotti, A.C., Granzow, C.A., Molina, F., Lowe-Krentz, L.J., Antibodies against a putative heparin receptor slow cell proliferation and decrease MAPK activation in vascular smooth muscle cells (2001) J. Cell Physiol., 187, pp. 283-293 | ||
| 504 | |a Castellot Jr., J.J., Wong, K., Herman, B., Binding and internalization of heparin by vascular smooth muscle cells (1985) J. Cell Physiol., 124, pp. 13-20 | ||
| 504 | |a Bilozur, M.E., Biswas, C., Identification and characterization of heparan sulfate-binding proteins from human lung carcinoma cells (1990) J. Biol. Chem., 265, pp. 19697-19703 | ||
| 504 | |a Redini, F., Moczar, E., Antoine, E., Poupon, M.F., Binding and internalization of exogenous glycosaminoglycans in weakly and highly metastatic rhabdomyosarcoma cells (1989) Biochim. Biophys. Acta, 991, pp. 359-366 | ||
| 504 | |a Pukac, L.A., Castellot Jr., J.J., Wright Jr., T.C., Caleb, B.L., Karnovsky, M.J., Heparin inhibits c-fos and c-myc mRNA expression in vascular smooth muscle cells (1990) Cell Regul., 1, pp. 435-443 | ||
| 504 | |a Templeton, D.M., Zhao, Y., Fan, M.Y., Heterogeneity in the response of vascular smooth muscle to heparin: Altered signaling in heparin-resistant cells (2000) Cardiovasc. Res., 45, pp. 503-512 | ||
| 504 | |a Rozenberg, G., Espada, J., Lauria de Cidre, L., Eijan, A.M., Calvo, J.C., Bertolesi, G.E., Heparan sulfate, heparin and heparinase activity detection on polyacrilamide gel electrophoresis using a fluorochrome tris (2, 2′-bipyridine)ruthenium (II) (2001) Electrophoresis, 22, pp. 3-11 | ||
| 504 | |a Bal de Kier Joffe, E., Puricelli, L., Sacerdote de Lustig, E., Modified adhesion behavior after in vitro passage of two related murine mammary adenocarcinomas with different metastasizing ability (1986) Invasion Metastasis, 6, pp. 302-312 | ||
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| 504 | |a Lundmark, K., Tran, P.K., Kinsella, M.G., Clowes, A.W., Wight, T.N., Hedin, U., Perlecan inhibits smooth muscle cell adhesion to fibronectin: Role of heparan sulfate (2001) J. Cell Physiol., 188, pp. 67-74 | ||
| 504 | |a Iozzo, R.V., Proteoglycans and neoplasia (1988) Cancer & Met. Rev., 7, pp. 39-50 | ||
| 504 | |a Lindahl, U., Thunberg, L., Backstrom, G., Riesenfeld, J., Nordling, K., Bjork, I., Extension and structural variability of the antithrombin-binding sequence in heparin (1984) J. Biol. Chem., 259, pp. 12368-12376 | ||
| 504 | |a Koyama, N., Kinsella, M.G., Wight, T.N., Hedin, U., Clowes, A.W., Heparan sulfate proteoglycans mediate inhibitory signal for migration of vascular smooth muscle cells (1988) Circ. Res., 83 (3), pp. 305-313 | ||
| 504 | |a Culp, L.A., Rollins, B.J., Buniel, J., Hitri, S., Two functionally distinct pools of glycosaminoglycan in the substrate adhesion site of murine cells (1978) J. Cell Biol., 79, pp. 788-801 | ||
| 504 | |a Miura, R., Aspberg, A., Ethell, I.M., The proteoglycan lectin domain binds sulfated cell surface glycolipids and promotes cell adhesion (1999) J. Biol. Chem., 274, pp. 11431-11438 | ||
| 504 | |a Puleo, D.A., Bizios, R., RGDS tetrapeptide binds to osteoblasts and inhibits fibronectin- mediated adhesion (1991) Bone, 12, pp. 271-276 | ||
| 504 | |a Lauría de Cidre, L., Sacerdote de Lustig, E., Mast cell kinetics during tumor growth 196-201 (1990) Tumor. Biol., 11 | ||
| 520 | 3 | |a Mastocytosis is a common feature around solid tumors. Due to mast cell (MC) degranulation, heparin and other chemical mediators are released to surrounding tissues. The aim of this paper is to investigate the role of heparin and chemically modified heparins, on a murine mammary adenocarcinoma cell line adhesion properties, and the relationship with the presence of heparin binding sites in tumor cells. We show that heparin increases tumor cell adhesion in a dose-dependent manner. When the number of heparin binding sites was regulated, by culturing the cells with different FCS concentration for 24 hours, a correlation between binding capacity and heparin effect on cell adhesion was observed. The increment on cell adhesion by heparin was lower on cells with less heparin binding sites. Moreover, only heparin and a chemically modified heparin (partially N-desulfated N-acetylated), which bound to heparin-receptor, retained the ability to stimulate cell adhesion, while other modified heparins lost both effects. The increase in cell adhesion was observed on plastic dishes, albumin, as well as on fibronectin pre-coated ones suggesting that heparin effect is substratum independent. Our results show a direct relation between heparin binding to specific cell receptors and increase in cell attachment. © Wichtig Editore, 2005. |l eng | |
| 593 | |a Facultad de Ciencias Exactas y Naturales, Departamento de Biodiversidad y Biología Experimental, Universidad de Buenos Aires, Pab. II, 2do. piso, 1428 Buenos Aires, Argentina | ||
| 650 | 1 | 7 | |2 spines |a ADHESION |
| 690 | 1 | 0 | |a CELL RECEPTOR |
| 690 | 1 | 0 | |a FIBRONECTIN |
| 690 | 1 | 0 | |a HEPARIN |
| 690 | 1 | 0 | |a TUMOR |
| 690 | 1 | 0 | |a ALBUMIN |
| 690 | 1 | 0 | |a CELL RECEPTOR |
| 690 | 1 | 0 | |a FIBRONECTIN |
| 690 | 1 | 0 | |a HEPARIN |
| 690 | 1 | 0 | |a HEPARIN DERIVATIVE |
| 690 | 1 | 0 | |a TRITIUM |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a BINDING AFFINITY |
| 690 | 1 | 0 | |a BINDING SITE |
| 690 | 1 | 0 | |a BREAST ADENOCARCINOMA |
| 690 | 1 | 0 | |a CANCER CELL CULTURE |
| 690 | 1 | 0 | |a CELL ADHESION |
| 690 | 1 | 0 | |a CELL STIMULATION |
| 690 | 1 | 0 | |a CELL SURFACE |
| 690 | 1 | 0 | |a CONCENTRATION RESPONSE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a CORRELATION ANALYSIS |
| 690 | 1 | 0 | |a DRUG RECEPTOR BINDING |
| 690 | 1 | 0 | |a MOUSE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a MURINAE |
| 700 | 1 | |a Eijan, A.M. | |
| 700 | 1 | |a Calvo, J.C. | |
| 700 | 1 | |a de Cidre, L.L. | |
| 773 | 0 | |d Wichtig Editore s.r.l., 2005 |g v. 19 |h pp. 33-40 |k n. 1-2 |p J. Biol. Regul. Homeostatic Agents |x 0393974X |t Journal of Biological Regulators and Homeostatic Agents | |
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