Antioxidants and methimazole in the treatment of Graves' disease: Effect on urinary malondialdehyde levels
We have postulated that metabolic oxidation could be the source of signs and symptoms of hyperthyroidism. The present study was designed to evaluate urinary malondialdehyde levels in Graves' disease and compare this oxidative stress biomarker with the clinical evolution of patients suffering th...
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| Otros Autores: | , , , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
2005
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 10533caa a22012137a 4500 | ||
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| 001 | PAPER-4230 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203346.0 | ||
| 008 | 190411s2005 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-11844271928 | |
| 024 | 7 | |2 cas |a malonaldehyde, 542-78-9; thiamazole, 60-56-0; Antioxidants; Malondialdehyde, 542-78-9; Methimazole, 60-56-0 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a CCATA | ||
| 100 | 1 | |a Guerra, L.N. | |
| 245 | 1 | 0 | |a Antioxidants and methimazole in the treatment of Graves' disease: Effect on urinary malondialdehyde levels |
| 260 | |c 2005 | ||
| 270 | 1 | 0 | |m Endocrinology Unit, Hospital Israelita EZRAH, Buenos Aires, ArgentinaArgentina; email: liliana@qb.fcen.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Videla, L.A., Sir, T., Wolff, C., Increased lipid peroxidation in hyperthyroid patients: Suppression by propylthiouracil treatment (1988) Free Radic. Res. Commun., 5, pp. 1-10 | ||
| 504 | |a Fernandez, V., Simizu, K., Barros, S.B., Azzalis, L.A., Pimentel, R., Junqueira, V.B., Effects of hyperthyroidism on rat live glutathione metabolism: Related enzymes' activities, efflux and turnover (1991) Endocrinology, 129, pp. 85-91 | ||
| 504 | |a Lissi, E.A., Salim-Hanna, M., Sir, T., Videla, L.A., Is spontaneous urinary visible chemiluminescence a reflection of in vivo oxidative stress? (1992) Free Radic. Biol. Med., 12, pp. 317-322 | ||
| 504 | |a Venditti, P., Balestrini, M., Di Meo, S., De Leo, T., Effect of thyroid state on lipid peroxidation, antioxidant defenses, and susceptibility to oxidative stress in rat tissues (1997) J. Endocrinol., 155, pp. 151-157 | ||
| 504 | |a Abalovich, M., Llesuy, S., Gutierrez, S., Repetto, M., Peripheral parameters of oxidative stress in Graves' disease: The effects of methimazole and 131 iodine treatments (2003) Clin. Endocrinol., 59, pp. 321-327 | ||
| 504 | |a Tapia, G., Pepper, I., Smok, G., Videla, L.A., Kumpfer cell function in thyroid hormone-induced liver oxidative stress in the rat (1997) Free Radic. Res., 26, pp. 267-279 | ||
| 504 | |a Guerra, L.N., Moiguer, S., Karner, M., Rios De Molina, M.C., Sreider, C.M., Burdman, J.A., Antioxidants in the treatment of Graves' disease (2001) IUBMB Life, 51, pp. 105-109 | ||
| 504 | |a Kim, H., Lee, T.H., Hwang, Y.S., Bang, M.A., Kim, K.H., Suh, J.M., Methimazole as an antioxidant and immunomodulator in thyroid cells: Mechanisms involving interferon-gamma signaling and H 2O 2 scavenging (2001) Mol. Pharmacol., 60, pp. 972-980 | ||
| 504 | |a Hagfors, L., Leanderson, P., Skoldstam, L., Andersson, J., Johansson, G., Antioxidant intake, plasma antioxidants and oxidative stress in randomized, controlled, parallel, Mediterranean dietary innervation study on patients with rheumatoid arthritis (2003) Nutr. J., 2, pp. 5-9 | ||
| 504 | |a Aboutwerat, A., Pemberton, P.W., Smith, A., Burrows, P.C., McMahon, R.F., Jain, S.K., Oxidant stress in a significant feature of primary biliary cirrhosis (2003) Biochim. Biophys. Acta, 1637, pp. 142-150 | ||
| 504 | |a Buege, J.A., Aust, S.D., Microsomal lipid peroxidation (1978) Methods Enzymol., 52, pp. 302-310 | ||
| 504 | |a Bradford, M.M., A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding (1976) Anal. Biochem., 72, pp. 248-254 | ||
| 504 | |a Glantz, S.A., (1992) Primer of Biostatistics: The Program, , McGraw Hill New York | ||
| 504 | |a (2003) Analytical Software, Statistix 8, , Thallahase Florida | ||
| 504 | |a Komosinska, V.K., Olczyk, K., Kucharz, E.J., Marcisz, C., Winsz-Szcotka, K., Kotulska, A., Free radical activity and antioxidant defense mechanisms in patients with hyperthyroidism due to Graves' disease during therapy (2000) Clin. Chim. Acta, 300, pp. 107-117 | ||
| 504 | |a Bustamante, J., Guerra, L.N., Bredeston, J., Mordoh, J., Boveris, A., Melanin content and hydroperoxide metabolism in human melanoma cells (1991) Exp. Cell Res., 196, pp. 172-176 | ||
| 504 | |a Feillet-Coudray, C., Chone, F., Michel, F., Rock, E., Thieblot, P., Rayssiguier, Divergence in plasmatic and urinary isoprostane levels in type 2 diabetes (2002) Clin. Chim. Acta, 324, pp. 25-30 | ||
| 504 | |a Chehade, J., Kim, J., Pinas, J.L., Mooradian, A.D., Age-related changes in the thyroid hormone effects on malondialdehyde modified proteins in the rat heart (1999) Proc. Soc. Exp. Biol. Med., 222, pp. 59-64 | ||
| 504 | |a Mano, T., Shinohara, R., Iwase, K., Kotake, M., Kamada, M., Uchimuro, K., Changes in free radical scavengers and lipid peroxide in thyroid glands of various thyroid disorders (1997) Horm. Metab. Res., 29, pp. 351-354 | ||
| 504 | |a Cooper, D.S., Antithyroid drugs (1984) N. Engl. J. Med., 321, pp. 1353-1362 | ||
| 504 | |a Sewerynek, J., Wiktorska, J., Nowak, D., Lewinski, A., Methimazole protection against oxidative stress induced by hyperthyroidism in Graves' disease (2000) Endocr. Regul., 34, pp. 83-89 | ||
| 504 | |a Guerra, L.N., Rios De Molina, M.C., Basso, M.F., Moiguer, S., Karner, M., Burdman, J.A., Thyroid hormone and oxidative metabolism: In vitro model (2002) Program 84th Annual Meeting of the Endocrine Society, San Francisco, CA, p. 290 | ||
| 504 | |a Aliciguzel, Y., Ozdem, S.N., Ozdem, S.S., Karayalcin, U., Siedlak, S.L., Perry, G., Erythrocyte, plasma and serum antioxidant activities in untreated toxic multinodular goiter patients (2001) Free Radic. Biol. Med., 30, pp. 665-670 | ||
| 504 | |a Dumitriu, L., Bartoc, R., Ursu, H., Purice, M., Ionescu, V., Significance of high levels of serum malonyl dialdehyde (MDA) and ceruloplasmin (CP) in hyper- and hypothyroidism (1998) Endocrinology, 26, pp. 35-38 | ||
| 520 | 3 | |a We have postulated that metabolic oxidation could be the source of signs and symptoms of hyperthyroidism. The present study was designed to evaluate urinary malondialdehyde levels in Graves' disease and compare this oxidative stress biomarker with the clinical evolution of patients suffering this illness. We evaluated the concentration of urinary and serum malondialdehyde (MDA) in 36 patients with Graves' disease. Patients were treated with the antithyroid drug methimazole (MMI; Group A) or antioxidant mixture (200 mg vitamin E, 3 mg β-carotene, 250 mg vitamin C, 1 mg Cu, 7.5 mg Zn, 1.5 mg Mn, and 15 μg Se; Group B). MDA concentrations were higher in hyperthyroid patients compared to euthyroid controls, and a positive correlation was observed between serum and urinary MDA levels. Group A decreased urinary MDA to control values. There was a positive correlation between the clinical score and the heart rate of patients with urinary MDA before and during the treatment with MMI (Group A). Similar results were observed after treatment with the antioxidant mixture. Urinary MDA might be a good parameter in the follow-up of patients during MMI treatment. We proposed that oxidative stress correlates with signs and symptoms of hyperthyroidism. © 2004 Published by Elsevier B.V. |l eng | |
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires | ||
| 536 | |a Detalles de la financiación: Agencia Nacional de Promoción Científica y Tecnológica | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: 98-3406 | ||
| 536 | |a Detalles de la financiación: Roche | ||
| 536 | |a Detalles de la financiación: These studies were supported by grants from CONICET (Consejo Nacional de Investigaciones Científicas y Técnicas), from Agencia Nacional de Promoción Científica y Tecnológica PICT No. 98-3406, from University of Buenos Aires and by Roche S.A. José A. Burdman, Liliana N. Guerra, and MC Ríos de Molina are Career Scientific Researcher in CONICET. The Hospital Ethical Committee has approved these studies. | ||
| 593 | |a Endocrinology Unit, Hospital Israelita EZRAH, Buenos Aires, Argentina, Argentina | ||
| 593 | |a Departmento de Quím. Biol., Fac. de Ciencias Exactas Y Naturales, Univ. Buenos Aires, Intendente G., Argentina | ||
| 593 | |a Universidad Abierta Interamericana, Hospital Israelita, Terrada 1164, Buenos Aires, A., Argentina | ||
| 593 | |a Hospital Israelita, Terrada 1164, (1416) Buenos Aires, Argentina., Argentina | ||
| 690 | 1 | 0 | |a HYPERTHYROIDISM |
| 690 | 1 | 0 | |a MALONDIALDEHYDE |
| 690 | 1 | 0 | |a METHIMAZOLE (MMI) |
| 690 | 1 | 0 | |a ANTIOXIDANT |
| 690 | 1 | 0 | |a MALONALDEHYDE |
| 690 | 1 | 0 | |a THIAMAZOLE |
| 690 | 1 | 0 | |a ADULT |
| 690 | 1 | 0 | |a ANTIOXIDANT ACTIVITY |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CLINICAL ARTICLE |
| 690 | 1 | 0 | |a COMPARATIVE STUDY |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a CORRELATION ANALYSIS |
| 690 | 1 | 0 | |a EVALUATION |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a GRAVES DISEASE |
| 690 | 1 | 0 | |a HEART RATE |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a HYPERTHYROIDISM |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a OXIDATIVE STRESS |
| 690 | 1 | 0 | |a PARAMETER |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a ADULT |
| 690 | 1 | 0 | |a ANTIOXIDANTS |
| 690 | 1 | 0 | |a DOUBLE-BLIND METHOD |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a FOLLOW-UP STUDIES |
| 690 | 1 | 0 | |a GRAVES DISEASE |
| 690 | 1 | 0 | |a HEART RATE |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MALONDIALDEHYDE |
| 690 | 1 | 0 | |a METHIMAZOLE |
| 690 | 1 | 0 | |a MIDDLE AGED |
| 690 | 1 | 0 | |a OXIDATIVE STRESS |
| 653 | 0 | 0 | |a methimazole, Montpellier |
| 700 | 1 | |a Ríos De Molina, M.D.C. | |
| 700 | 1 | |a Miler, E.A. | |
| 700 | 1 | |a Moiguer, S. | |
| 700 | 1 | |a Karner, M. | |
| 700 | 1 | |a Burdman, J.A. | |
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