Synthesis of 6,19-sulfamidate bridged pregnanes

Conformationally restrained substituted pregnane-20-one derivatives were obtained by an intramolecular nitrene addition onto a C-5/C-6 double bond involving a tethered C-19 sulfamoyl moiety. The resulting aziridine underwent regioselective nucleophilic ring opening at C-5 at room temperature with cy...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autor principal: Duran, F.J
Otros Autores: Ghini, A.A, Dauban, P., Dodd, R.H, Burton, G.
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: 2005
Acceso en línea:Registro en Scopus
DOI
Handle
Registro en la Biblioteca Digital
Aporte de:Registro referencial: Solicitar el recurso aquí
LEADER 07227caa a22011057a 4500
001 PAPER-3904
003 AR-BaUEN
005 20230518203323.0
008 190411s2005 xx ||||fo|||| 00| 0 eng|d
024 7 |2 scopus  |a 2-s2.0-26844505734 
024 7 |2 cas  |a acetic acid, 127-08-2, 127-09-3, 64-19-7, 71-50-1; cyanide, 57-12-5; fluoride, 16984-48-8; sulfanilamide, 34612-79-8, 6101-31-1, 63-74-1; Bridged Compounds; Pregnanes; Sulfonic Acids 
040 |a Scopus  |b spa  |c AR-BaUEN  |d AR-BaUEN 
030 |a JOCEA 
100 1 |a Duran, F.J. 
245 1 0 |a Synthesis of 6,19-sulfamidate bridged pregnanes 
260 |c 2005 
270 1 0 |m Burton, G.; Departamento de Química Orgánica and UMYMFOR (CONICET-FCEN), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, C1428EGA Buenos Aires, Argentina; email: burton@qo.fcen.uba.ar 
506 |2 openaire  |e Política editorial 
504 |a Smith, S.S., (2003) Neurosteroid Effects in the Central Nervous System: The Role of the GABA-A Receptor, , Ed.; CRC Press: Boca Raton 
504 |a Mok, W.M., Herschkowitz, S., Krieger, N.R., (1991) J. Neurochem., 57, pp. 1296-1301 
504 |a Mendelson, W.B., Martin, J.V., Perlis, M., Wagner, R., Majewska, M.D., Paul, S.M., (1987) Psychopharmacology, 93, pp. 226-229 
504 |a Bitran, D., Hilvers, R.J., Kellogg, C.K., (1991) Brain Res., 561, pp. 157-161 
504 |a Brot, M.D., Akwa, Y., Purdy, R.H., Koob, G.F., Britton, K.T., (1997) Eur. J. Pharmacol., 325, pp. 1-7 
504 |a Rodgers, R.J., Johnson, N.J.T., (1998) Pharmacol. Biochem. Behav., 59, pp. 221-232 
504 |a Belelli, D., Bolger, M.B., Gee, K.W., (1989) Eur. J. Pharmacol., 166, pp. 325-329 
504 |a Kokate, T.G., Svensson, B.J., Rogawski, M.A., (1994) J. Pharmacol. Exp. Ther., 270, pp. 1223-1229 
504 |a Veleiro, A.S., Rosenstein, R.E., Jaliffa, C.O., Grilli, M.L., Speroni, F., Burton, G., (2003) Bioorg. Med. Chem. Lett., 13, pp. 343-346 
504 |a Anderson, A., Boyd, A.C., Campbell, A.C., Gemmel, D.K., Hamilton, N.M., Hill, D.R., Hill-Yenning, C., Stevenson, D., (1997) J. Med. Chem., 40, pp. 1668-1681 
504 |a Skoda-Foldes, R., Kollar, L., (2003) Chem. Rev., 103, pp. 4095-4129 
504 |a Burton, G., Galigniana, M.D., De Lavallaz, S., Brachet-Cota, A.L., Sproviero, E.M., Ghini, A.A., Lantos, C.P., Damasco, M.C., (1995) Mol. Pharmacol., 47, pp. 535-543 
504 |a Stone, T.W., (1996) CNS Neurotransmitters and Neuromodulators. Neuroactive Steroids, , Ed.; CRC Press: Boca Raton, Chapters 2 and 4 
504 |a Di Chenna, P.H., Dauban, P., Ghini, A.A., Baggio, R., Garland, M.T., Burton, G., Dodd, R.H., (2003) Tetrahedron, 59, pp. 1009-1014 
504 |a Han, M., Zorumski, C.F., Covey, D.F., (1996) J. Med. Chem., 39, pp. 4218-4232 
504 |a Zeng, C.-M., Benz, A., Howell, M., Manion, B., Evers, A.S., Zorumski, C.F., Mennerick, S., Covey, D.F., (2001) Abstracts of Papers, 222nd National Meeting of the American Chemical Society, , Chicago, IL, August 26-30, 2001; American Chemical Society: Washington, DC 
504 |a Nicoletti, D., Ghini, A.A., Furtmüller, R., Sieghart, W., Dodd, R.H., Burton, G., (2000) Steroids, 65, pp. 349-356 
504 |a Kasal, A., Matyas, L., Budesinsky, M., (2005) Tetrahedron, 61, pp. 2269-2278 
504 |a Durán, F.J., Leman, L., Ghini, A.A., Burton, G., Dauban, P., Dodd, R.H., (2002) Org. Lett., 4, pp. 2481-2483 
504 |a Joselevich, M., Ghini, A.A., Burton, G., (2003) Org. Biomol. Chem., 1, pp. 939-943 
504 |a Eduardo, S.L., Ghini, A.A., Burton, G., (2003) ARKIVOC, (PART X), pp. 468-476 
504 |a Appel, B., Berger, G., (1958) Chem. Ber., 91, pp. 1339-1341 
504 |a Okada, M., Iwashita, S., Koizumi, N., (2000) Tetrahedron Lett., 41, pp. 7047-7051 
504 |a Dauban, P., Sanière, L., Tarrade, A., Dodd, R.H., (2001) J. Am. Chem. Soc., 123, pp. 7707-7708 
504 |a note; Gee, K.W., Bolger, M.B., Brinton, R.E., Coirini, H., McEwen, B.S., (1988) J. Pharmacol. Exp. Ther., 246, pp. 803-812 
504 |a Valls, J., Toromanoff, E., (1961) Bull. Soc. Chim. Fr., pp. 758-764 
504 |a Deslongchamps, P., (1983) Stereoelectronic Effects in Organic Chemistry, pp. 165-166. , Pergamon Press: Oxford 
504 |a note 
520 3 |a Conformationally restrained substituted pregnane-20-one derivatives were obtained by an intramolecular nitrene addition onto a C-5/C-6 double bond involving a tethered C-19 sulfamoyl moiety. The resulting aziridine underwent regioselective nucleophilic ring opening at C-5 at room temperature with cyanide, fluoride, and acetate. In the isolated case of acetate, a reversal of regioselectivity was observed at higher temperatures, a result attributed to a rearrangement process involving aziridine ring opening at the C-5 position and subsequent migration of the acetyl meiety to C-6. © 2005 American Chemical Society.  |l eng 
593 |a Departamento de Química Orgánica and UMYMFOR (CONICET-FCEN), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, C1428EGA Buenos Aires, Argentina 
593 |a Institut de Chimie des Substances Naturelles, CNRS, Avenue de la Terrasse, F-91198 Gif-sur-Yvette Cedex, France 
690 1 0 |a ADDITION REACTIONS 
690 1 0 |a CONFORMATIONS 
690 1 0 |a RING OPENING POLYMERIZATION 
690 1 0 |a STEREOCHEMISTRY 
690 1 0 |a SUBSTITUTION REACTIONS 
690 1 0 |a SULFUR COMPOUNDS 
690 1 0 |a 6,9-SULFAMIDATE BRIDGED PREGNANES 
690 1 0 |a NITRENE 
690 1 0 |a NUCLEOPHILIC RING OPENING 
690 1 0 |a REGIOSELECTIVITY 
690 1 0 |a AROMATIC COMPOUNDS 
690 1 0 |a 4 AMINOBUTYRIC ACID A RECEPTOR 
690 1 0 |a ACETIC ACID 
690 1 0 |a AZIRIDINE DERIVATIVE 
690 1 0 |a CYANIDE 
690 1 0 |a FLUORIDE 
690 1 0 |a NEUROSTEROID 
690 1 0 |a PREGNANE DERIVATIVE 
690 1 0 |a SULFANILAMIDE 
690 1 0 |a ANTICONVULSANT ACTIVITY 
690 1 0 |a ARTICLE 
690 1 0 |a CHEMICAL REACTION 
690 1 0 |a CONFORMATIONAL TRANSITION 
690 1 0 |a DERIVATIZATION 
690 1 0 |a MOLECULAR INTERACTION 
690 1 0 |a REACTION ANALYSIS 
690 1 0 |a RING OPENING 
690 1 0 |a SOLUBILITY 
690 1 0 |a SYNTHESIS 
690 1 0 |a BRIDGED COMPOUNDS 
690 1 0 |a MOLECULAR STRUCTURE 
690 1 0 |a PREGNANES 
690 1 0 |a SULFONIC ACIDS 
700 1 |a Ghini, A.A. 
700 1 |a Dauban, P. 
700 1 |a Dodd, R.H. 
700 1 |a Burton, G. 
773 0 |d 2005  |g v. 70  |h pp. 8613-8616  |k n. 21  |p J. Org. Chem.  |x 00223263  |w (AR-BaUEN)CENRE-337  |t Journal of Organic Chemistry 
856 4 1 |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-26844505734&doi=10.1021%2fjo051290a&partnerID=40&md5=03f3c91ad542c89125220d4bebd5db8a  |y Registro en Scopus 
856 4 0 |u https://doi.org/10.1021/jo051290a  |y DOI 
856 4 0 |u https://hdl.handle.net/20.500.12110/paper_00223263_v70_n21_p8613_Duran  |y Handle 
856 4 0 |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00223263_v70_n21_p8613_Duran  |y Registro en la Biblioteca Digital 
961 |a paper_00223263_v70_n21_p8613_Duran  |b paper  |c PE 
962 |a info:eu-repo/semantics/article  |a info:ar-repo/semantics/artículo  |b info:eu-repo/semantics/publishedVersion 
963 |a VARI 
999 |c 64857