Rheological and drug-release behaviour of a scleroglucan gel matrix at different drug loadings
The aim of this study was to investigate the drug-loading effects on release and mechanical properties of a scleroglucan gel, with the intention of considering them in delivery systems formulations. The rheological and kinetic properties of a 2% w/w scleroglucan gel matrix loaded and 0, 0.02, 0.04,...
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| Formato: | Capítulo de libro |
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| Publicado: |
2005
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 09604caa a22009377a 4500 | ||
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| 001 | PAPER-3883 | ||
| 003 | AR-BaUEN | ||
| 005 | 20250328094424.0 | ||
| 008 | 190411s2005 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-28444493330 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 100 | 1 | |a François, Nora Judith | |
| 245 | 1 | 0 | |a Rheological and drug-release behaviour of a scleroglucan gel matrix at different drug loadings |
| 260 | |c 2005 | ||
| 270 | 1 | 0 | |m Daraio, M.E.; Laboratorio de Química de Sistemas Heterogéneos, Departamento de Química, Facultad de Ingeniería, Paseo Colón 850, C1063ACV Buenos Aires, Argentina; email: medit@fi.uba.ar |
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| 506 | |2 openaire |e Política editorial | ||
| 520 | 3 | |a The aim of this study was to investigate the drug-loading effects on release and mechanical properties of a scleroglucan gel, with the intention of considering them in delivery systems formulations. The rheological and kinetic properties of a 2% w/w scleroglucan gel matrix loaded and 0, 0.02, 0.04, 0.06, 0.2 0.4% w/w of theophylline (Th, used as a model drug) were investigated. Rheological measurements were performed in a controlled-stress rotational-shear rheometer under isothermal conditions. For theophylline release from the gel a flat Franz cell was used and the kinetic parameters were derived applying a semi-empirical power law. The influence of scleroglucan molar weight on kinetic and rheological behaviour was also studied. Results suggest two possible effects of drug loading on the gel network: in the 0.04-0.06% w/ w Th range a plasticizing effect and in the 0.2-0.4% w/w Th range a rigidization effect. In the first range mentioned, the changes in the gel structural properties tested by means of rheological measurements are coincident with changes in drug-release kinetics. © 2005 Society of Chemical Industry. |l eng | |
| 593 | |a Laboratorio de Química de Sistemas Heterogéneos, Departamento de Química, Facultad de Ingeniería, Paseo Colón 850, C1063ACV Buenos Aires, Argentina | ||
| 593 | |a Departamento de Industrias, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, C1428EHA Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a BIOPOLYMER |
| 690 | 1 | 0 | |a DRUG LOADING |
| 690 | 1 | 0 | |a DRUG RELEASE |
| 690 | 1 | 0 | |a DYNAMIC RHEOLOGY |
| 690 | 1 | 0 | |a SCLEROGLUCAN |
| 690 | 1 | 0 | |a THEOPHYLLINE |
| 690 | 1 | 0 | |a BIOPOLYMERS |
| 690 | 1 | 0 | |a CONTROLLED DRUG DELIVERY |
| 690 | 1 | 0 | |a MATERIALS TESTING |
| 690 | 1 | 0 | |a MOLECULAR STRUCTURE |
| 690 | 1 | 0 | |a MOLECULAR WEIGHT |
| 690 | 1 | 0 | |a PHARMACOKINETICS |
| 690 | 1 | 0 | |a RHEOLOGY |
| 690 | 1 | 0 | |a DRUG LOADINGS |
| 690 | 1 | 0 | |a DRUG-RELEASE BEHAVIOUR |
| 690 | 1 | 0 | |a DYNAMIC RHEOLOGY |
| 690 | 1 | 0 | |a GEL STRUCTURAL PROPERTIES |
| 690 | 1 | 0 | |a SCLEROGLUCAN GEL MATRIX |
| 690 | 1 | 0 | |a THEOPHYLLINE |
| 690 | 1 | 0 | |a GELS |
| 690 | 1 | 0 | |a DRUG DELIVERY |
| 700 | 1 | |a Rojas, A.M. | |
| 700 | 1 | |a Daraio, Marta Edit | |
| 773 | 0 | |d 2005 |g v. 54 |h pp. 1613-1619 |k n. 12 |p Polym. Int. |x 09598103 |t Polymer International | |
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| 856 | 4 | 0 | |u https://doi.org/10.1002/pi.1889 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_09598103_v54_n12_p1613_Francois |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09598103_v54_n12_p1613_Francois |y Registro en la Biblioteca Digital |
| 961 | |a paper_09598103_v54_n12_p1613_Francois |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 64836 | ||