Mouse mammary carcinoma porphobilinogenase and hydroxymethylbilane synthetase
1. 1. Porphobilinogenase (PBGase) and hydroxymethylbilane synthetase (HMB-S) were investigated in crude extracts from mouse mammary carcinoma, normal mouse liver and tumor bearing mouse liver. 2. 2. A Michaelis-Menten kinetics for both enzymes in either source was observed. Km values of 87 to 108 μM...
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1991
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 09301caa a22009977a 4500 | ||
|---|---|---|---|
| 001 | PAPER-376 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518202944.0 | ||
| 008 | 190411s1991 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0026078957 | |
| 024 | 7 | |2 cas |a Ammonia-Lyases, EC 4.3.1.; Hydroxymethylbilane Synthase, EC 4.3.1.8; porphobilinogenase, EC 5.-; Porphyrins | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 100 | 1 | |a Navone, N.M. | |
| 245 | 1 | 0 | |a Mouse mammary carcinoma porphobilinogenase and hydroxymethylbilane synthetase |
| 260 | |c 1991 | ||
| 270 | 1 | 0 | |m M. del C. Batlle, A.; Centro de Investigaciones sobre Porfirinas y Porfirias (CIPYP), CONICET-FCEN, UBA, Ciudad Universitaria, Pabellon II, 2do Piso, 1428 Buenos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Batlle, Rosetti, Enzymic polymerization of porphobilinogen into uroporphyrinogens—Review (1977) Int. J. Biochem., 8, pp. 251-267 | ||
| 504 | |a Batlle, Ferramola, Grinstein, Purification and general properties of delta-amino-laevulate dehydratase from cow liver (1967) Biochem. J., 104, pp. 244-249 | ||
| 504 | |a Batlle, Wider de Xifra, Stella, A simple method for measuring erythrocyte porphobilinogenase, and its use in the diagnosis of acute intermittent porphyria (1978) Int. J. Biochem., 9, pp. 871-876 | ||
| 504 | |a Battersby, Fookes, Matcham, McDonald, Hollenstein, Biosynthesis of porphyrins and related macrocycles Part 20 Purification of deaminase and studies on its mode of action (1983) Journal of the Chemical Society, Perkin Transactions 1, 1, pp. 3031-3040 | ||
| 504 | |a Battersby, Fookes, Matcham, Pandey, Biosynthesis of porphyrisn and related macrocycle Part 21 The interaction of deaminase and its products (hydroxymethylbilane) and the relationship between deaminase and cosynthetase (1983) Journal of the Chemical Society, Perkin Transactions 1, 1, pp. 3041-3047 | ||
| 504 | |a Bogorad, The enzymatic synthesis of porphyrins from porphobilinogen. I. Uroporphyrinogen I (1958) J. biol. Chem., 233, pp. 501-509 | ||
| 504 | |a Bogorad, The enzymatic synthesis of porphysins from porphobilinogen. II. Uroporphyrinogen III (1958) J. biol. Chem., 233, pp. 510-519 | ||
| 504 | |a Falk, Benson, Separation of uropophyrin esters I and III by paper chromatography (1953) Biochem. J., 55, pp. 101-107 | ||
| 504 | |a Fumagalli, (1988) Doctoral Thesis, , University of Buenos, Aires | ||
| 504 | |a Fumagalli, Kotler, Rossetti, Batlle, Human red cell porphobilinogen deaminase A simpler method of purification and some unusual properties (1985) Int. J. Biochem., 17, pp. 485-489 | ||
| 504 | |a Hart, Abell, Battersby, Purification, N-terminal amino acid sequence and properties of hydroxymethylbilane synthetase (porphobilinogen deaminase) from Escherichia coli (1986) Biochem.J., 240, pp. 273-276 | ||
| 504 | |a Jordan, Berry, Mechanism of action of porphobilinogen deaminase (1981) Biochem. J., 195, pp. 177-181 | ||
| 504 | |a Jordan, Burton, Nordlov, Schneider, Pryde, Scott, Pre-uroporphyrinogen a substrate for uroporphyrinogen III ocsynthetase (1979) Journal of the Chemical Society, Chemical Communications, pp. 204-205 | ||
| 504 | |a Jordan, Seehra, The biosynthesis of uroporphynnogen III. Order of assembly of the four porphobilinogen molecules in the formation of the tetrapyrrole ring (1979) FEBS Lett., 104, pp. 364-366 | ||
| 504 | |a Lowry, Rosebrough, Farr, Randall, Protein measurement with the Folin-phenol reagent (1951) J. biol. Chem., 193, pp. 265-275 | ||
| 504 | |a Llambías, Batlle, Porphyrin biosynthesis in soybean callus V The porphobilinogen deaminase—uroporphyrinogen III cosynthetase Kinetic studies (1970) Biochimica et Biophysica Acta (BBA) - Enzymology, 220, pp. 552-559 | ||
| 504 | |a Llambías, Batlle, Porphyrin biosynthesis VIII Avian erythrocyte porphobilinogen deaminse—uroporphyrinogen III cosynthetase Its purification properties and the separation of its components (1971) Biochimica et Biophysica Acta (BBA) - Enzymology, 227, pp. 180-191 | ||
| 504 | |a Navone, Frisardi, Resnik, Batlle, Polo, Porphyrin biosynthesis in human breast cancer Preliminary mimetic in vitro studies (1988) Med. Sci. Res., 16, pp. 61-62 | ||
| 504 | |a Navone, Polo, Frisardi, Batlle, Heme enzyme pattern in mouse mammary carcinoma (1991) Int. J. Biochem., , (in press) | ||
| 504 | |a Polo, Afonso, Batlle, Un método simplificado para la esterificación y la extracción de ésteres metílicos de porfirinas (1988) Acta Bioq. Clin. Latinoamer, 22, pp. 430-431 | ||
| 504 | |a Sancovich, Batlle, Grinstein, The porphobilinogen deaminase—uroporphyrinogen III cosynthetase system (porphobilinogenase) from bovine liver Kinetic studies (1969) FEBS Lett., 3, pp. 223-226 | ||
| 504 | |a Sassa, Zalar, Kappas, Studies in porphyria. VII. Induction of uroporphyrinogen I synthase and expression of the gene defect of acute intermittent porphyria in mitogen-stimulated human lymphocytes (1978) J. clin. Invest., 61, pp. 499-508 | ||
| 504 | |a Schoenfeld, Epstein, Klein, Lahav, Atsmon, The relation between porphobilinogen deaminase (PBGD) activity and growth (1985) lsr. J. Med. Sci., 21, pp. 870-871 | ||
| 504 | |a Stout, Becker, Heme enzyme patterns in genetically and chemically induced mouse liver tumors (1986) Cancer Res., 46, pp. 2756-2759 | ||
| 504 | |a Stout, Becker, Heme enzyme patterns in rat liver nodules and tumors (1987) Cancer Res., 47, pp. 963-966 | ||
| 520 | 3 | |a 1. 1. Porphobilinogenase (PBGase) and hydroxymethylbilane synthetase (HMB-S) were investigated in crude extracts from mouse mammary carcinoma, normal mouse liver and tumor bearing mouse liver. 2. 2. A Michaelis-Menten kinetics for both enzymes in either source was observed. Km values of 87 to 108 μM, Vmax of 1.57-1.83 nmol porphyrins/2 hr and a Hill coefficient of n = 1 were obtained for PBGase and Km values of 13 to 19 μM and Vmax of 2.6-4.8 were obtained for HMB-S. 3. 3. Porphyrin synthesis was linear up to 180 min of incubation in all cases for PBGase and HMB-S, and greatly increased with higher incubation temperature being maximal at 60°C and nil at 70°C, optimal temperature was 37°C for either enzyme in either source. 4. 4. Uroporphyrinogen III synthetase was heat inactivated while HMB-S was a heat stable enzyme. Optimum pH was 8.2 for PBGase and HMB-S in either tissue. © 1991. |l eng | |
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: Acknowledgements--This work was supportedb y grants from the CONICET, UBA and Banco de la Naci6n Argentina.A . L. Frisardi is grateful to Laboratorios PROMECO for a fellowshipW. e thankD r N. Andradea nd Dr S. Bonapartefr, omthe InstitutoN ationadl eOncologia "Angel H. Roffo", for providingu s with the originalt umor specimenfso r transplantatioann,d Joy Ricciardif or some chemicalsW. e are mostg ratefutlo Lic S. G. Afonso for the excellendt rawing. A. M. del C. Batlleh oldst hepost of SuperiorS cientific Researcheinr the CONICET. N. Navonea ndC. Polo are Researcha ssistantast the CONICET. A. M. del C. Batlle also thankst heM inisteriod e Educacitny Ciencia( MEC), Spain and the Association for InternationaCl ancer Research( AICR), United Kingdom for specials upport. | ||
| 593 | |a Centro de Investigaciones sobre Porfirinas y Porfirias (CIPYP), CONICET-FCEN, UBA, Ciudad Universitaria, Pabellon II, 2do Piso, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a PORPHOBILINOGEN DEAMINASE |
| 690 | 1 | 0 | |a PORPHOBILINOGENASE |
| 690 | 1 | 0 | |a UNCLASSIFIED DRUG |
| 690 | 1 | 0 | |a UROPORPHYRINOGEN III SYNTHASE |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a BREAST ADENOCARCINOMA |
| 690 | 1 | 0 | |a LIVER |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MOUSE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a AMMONIA-LYASES |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a HYDROGEN-ION CONCENTRATION |
| 690 | 1 | 0 | |a HYDROXYMETHYLBILANE SYNTHASE |
| 690 | 1 | 0 | |a KINETICS |
| 690 | 1 | 0 | |a LIVER |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MAMMARY NEOPLASMS, EXPERIMENTAL |
| 690 | 1 | 0 | |a MICE |
| 690 | 1 | 0 | |a MICE, INBRED BALB C |
| 690 | 1 | 0 | |a NEOPLASM TRANSPLANTATION |
| 690 | 1 | 0 | |a PORPHYRINS |
| 690 | 1 | 0 | |a SUPPORT, NON-U.S. GOV'T |
| 690 | 1 | 0 | |a TEMPERATURE |
| 690 | 1 | 0 | |a ANIMALIA |
| 700 | 1 | |a Polo, C.F. | |
| 700 | 1 | |a Frisardi, A.L. | |
| 700 | 1 | |a M. del C. Batlle, A. | |
| 773 | 0 | |d 1991 |g v. 98 |h pp. 67-71 |k n. 1 |x 03050491 |w (AR-BaUEN)CENRE-2752 |t Comparative Biochemistry and Physiology -- Part B: Biochemistry and | |
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| 856 | 4 | 0 | |u https://doi.org/10.1016/0305-0491(91)90309-2 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_03050491_v98_n1_p67_Navone |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03050491_v98_n1_p67_Navone |y Registro en la Biblioteca Digital |
| 961 | |a paper_03050491_v98_n1_p67_Navone |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 963 | |a VARI | ||
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