Synthesis and biological activivity of juvenele hormone analogues (JHA) for Trypanosoma cruzi

Several derivatives of geraniol, geranylacetone, and farnesol bearing carbonate and thiolcarbonate functional groups as well as several derivatives of 4-phenoxyphenol were synthesized and tested for their respective biological activity as growth inhibitors for Trypanosoma cruzi, and for inhibition o...

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Autor principal: Rodriguez, J.B
Otros Autores: Gros, E.G, Stoka, A.M
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: 1991
Acceso en línea:Registro en Scopus
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Registro en la Biblioteca Digital
Aporte de:Registro referencial: Solicitar el recurso aquí
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100 1 |a Rodriguez, J.B. 
245 1 0 |a Synthesis and biological activivity of juvenele hormone analogues (JHA) for Trypanosoma cruzi 
260 |c 1991 
270 1 0 |m Rodriguez, J.B.; Departamento de Química orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pab. 2, Ciudad Universitaria, 1428 Buenos Aires, Argentina 
506 |2 openaire  |e Política editorial 
504 |a Wiggleswoth, Assays on Rhodnius for juvenile hormone activity (1973) Journal of Insect Physiology, 19, p. 205 
504 |a Pinchin, Oliveira Filho, Figueiredo, Muller, Gilbert, Szumlewicz, Benson, (1978) J. Econ. Entomol., 71, p. 950 
504 |a Picollo Villar, Seccacini, Fontan, Zerba, (1987) Comp. Biochem. Physiol., 87 C, p. 367 
504 |a Stoka, (1988) Rev. Arg. Microb., 20, p. 86 
504 |a Rodriguez, Gros, Stoka, (1988) Z. Naturforsch., 43 b, p. 1038 
504 |a Rodriguez, Gros, Stoka, (1989) Z. Naturforsch., 44 b, p. 983 
504 |a Perlawagora-Szumlewicz, Petana, Figueiredo, (1975) Rev. Inst. Med. Trop., 17, p. 97 
504 |a Stoka, Rivas, Segura, Rodriguez, Gros, (1990) Z. Naturforsch, 45 b, p. 96 
504 |a Corey, Lansbury, (1983) J. Am. Chem. Soc., 105, p. 4093 
504 |a Corey, Ohuchida, Hahl, (1984) J. Am. Chem. Soc., 106, p. 3875 
504 |a Dorman, Jautelat, Roberts, (1971) J. Org. Chem., 36, p. 2757 
504 |a Breitmaier, Voelter, (1987) Carbon-13 NMR Spectroscopy, , 3rd Ed., VCH, New York 
504 |a Fijisawa, Sato, Gotoh, Kawashima, Kawara, Reaction of diketene with Grignard reagents in the presence of cobalt catalyst. A convenient method for the synthesis of 3-methylenealkanoic acids leading to terpenoids. (1982) Bulletin of the Chemical Society of Japan, 55, p. 3555 
520 3 |a Several derivatives of geraniol, geranylacetone, and farnesol bearing carbonate and thiolcarbonate functional groups as well as several derivatives of 4-phenoxyphenol were synthesized and tested for their respective biological activity as growth inhibitors for Trypanosoma cruzi, and for inhibition of tritium-labelled thymidine incorporation in T. cruzi cells. The results indicated that some JHA showed important activity against the development of the cells. © 1991.  |l eng 
593 |a Departamento de Química orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pab. 2, Ciudad Universitaria, 1428 Buenos Aires, Argentina 
593 |a Instituto Nacional de Diagnostico e Investigacin de la Enfermedad de Chagas Dr. M Fatala Chaben (IND, Paseo Colón 568, 1063 Buenos Aires, Argentina 
690 1 0 |a JUVENILE HORMONE DERIVATIVE 
690 1 0 |a METHOPRENE 
690 1 0 |a ARTICLE 
690 1 0 |a CYTOTOXICITY 
690 1 0 |a DNA SYNTHESIS 
690 1 0 |a NONHUMAN 
690 1 0 |a TRYPANOSOMA CRUZI 
700 1 |a Gros, E.G. 
700 1 |a Stoka, A.M. 
773 0 |d 1991  |g v. 1  |h pp. 679-682  |k n. 12  |p Bioorg. Med. Chem. Lett.  |x 0960894X  |w (AR-BaUEN)CENRE-3990  |t Bioorganic and Medicinal Chemistry Letters 
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