Regulation of phenobarbital-induced ferrochelatase mRNA activity by dibutyryl cAMP and glucose in normal and diabetic rat hepatocytes.
The induction of ferrochelatase activity by phenobarbital and its potentiation by dibutyryl cAMP assayed in normal rat hepatocytes are associated with increased activity of ferrochelatase mRNA. Glucose inhibits this stimulatory effect. This inhibition can be reversed with increasing concentrations o...
Guardado en:
| Autor principal: | |
|---|---|
| Otros Autores: | , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1992
|
| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 03843caa a22006857a 4500 | ||
|---|---|---|---|
| 001 | PAPER-355 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518202943.0 | ||
| 008 | 190411s1992 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0026451453 | |
| 024 | 7 | |2 cas |a bucladesine, 16980-89-5, 362-74-3; ferrochelatase, 9012-93-5; glucose, 50-99-7, 84778-64-3; phenobarbital, 50-06-6, 57-30-7, 8028-68-0; Bucladesine, 362-74-3; Ferrochelatase, EC 4.99.1.1; Glucose, 50-99-7; Phenobarbital, 50-06-6, 362-74-3; RNA, Messenger | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 100 | 1 | |a Cánepa, E.T. | |
| 245 | 1 | 0 | |a Regulation of phenobarbital-induced ferrochelatase mRNA activity by dibutyryl cAMP and glucose in normal and diabetic rat hepatocytes. |
| 260 | |c 1992 | ||
| 270 | 1 | 0 | |m Cánepa, E.T. |
| 506 | |2 openaire |e Política editorial | ||
| 520 | 3 | |a The induction of ferrochelatase activity by phenobarbital and its potentiation by dibutyryl cAMP assayed in normal rat hepatocytes are associated with increased activity of ferrochelatase mRNA. Glucose inhibits this stimulatory effect. This inhibition can be reversed with increasing concentrations of dibutyryl cAMP. The inducing effect exerted by phenobarbital on the activity of ferrochelatase mRNA in diabetic hepatocytes is greater than that observed in normal cells. This enhanced response in diabetic rat hepatocytes is neither potentiated by adding dibutyryl cAMP nor repressed by glucose. The absence of a glucose effect persists even when the endogenous cAMP content is lowered to normal levels. The results obtained in this study are consistent with those reported in other published studies of ferrochelatase activity. This adds more experimental evidence to support the concept that ferrochelatase is inducible. The results obtained suggest that ferrochelatase is more susceptible to induction with phenobarbital in diabetic rat hepatocytes than in normal rat hepatocytes. |l eng | |
| 593 | |a Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a BUCLADESINE |
| 690 | 1 | 0 | |a FERROCHELATASE |
| 690 | 1 | 0 | |a GLUCOSE |
| 690 | 1 | 0 | |a MESSENGER RNA |
| 690 | 1 | 0 | |a PHENOBARBITAL |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a BIOSYNTHESIS |
| 690 | 1 | 0 | |a DRUG EFFECT |
| 690 | 1 | 0 | |a ENZYME INDUCTION |
| 690 | 1 | 0 | |a EXPERIMENTAL DIABETES MELLITUS |
| 690 | 1 | 0 | |a GENE EXPRESSION REGULATION |
| 690 | 1 | 0 | |a LIVER |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a METABOLISM |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a RAT STRAIN |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a BUCLADESINE |
| 690 | 1 | 0 | |a DIABETES MELLITUS, EXPERIMENTAL |
| 690 | 1 | 0 | |a ENZYME INDUCTION |
| 690 | 1 | 0 | |a FERROCHELATASE |
| 690 | 1 | 0 | |a GENE EXPRESSION REGULATION |
| 690 | 1 | 0 | |a GLUCOSE |
| 690 | 1 | 0 | |a LIVER |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a PHENOBARBITAL |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a RATS, INBRED STRAINS |
| 690 | 1 | 0 | |a RNA, MESSENGER |
| 700 | 1 | |a Pereda, M.P. | |
| 700 | 1 | |a Llambías, E.B. | |
| 700 | 1 | |a Grinstein, M. | |
| 773 | 0 | |d 1992 |g v. 70 |h pp. 26-33 |k n. 1 |p Biochem. Cell Biol. |x 08298211 |w (AR-BaUEN)CENRE-3918 |t Biochemistry and cell biology = Biochimie et biologie cellulaire | |
| 856 | 4 | 1 | |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026451453&doi=10.1139%2fo92-004&partnerID=40&md5=ba3488a536c1d212b68c2fd0b49e3930 |y Registro en Scopus |
| 856 | 4 | 0 | |u https://doi.org/10.1139/o92-004 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_08298211_v70_n1_p26_Canepa |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08298211_v70_n1_p26_Canepa |y Registro en la Biblioteca Digital |
| 961 | |a paper_08298211_v70_n1_p26_Canepa |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 61308 | ||