Antiherpetic activity of S1, an algal derived sulphated galactan

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The sulphated galactan S1 isolated from the red seaweed Pterocladia capillacea proved to be a selective antiviral compound against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), human cytomegalovirus and pseudorabies virus. No cytotoxicity was observed with S1 at concentrations about 500 μg/m...

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Detalles Bibliográficos
Autor principal: Pujol, C.A
Otros Autores: Errea, M.I, Matulewicz, M.C, Damonte, E.B
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: 1996
Acceso en línea:Registro en Scopus
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Registro en la Biblioteca Digital
Aporte de:Registro referencial: Solicitar el recurso aquí
Biblioteca Central Dr. Luis F. Leloir (FCEN) de Universidad de Buenos Aires
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100 1 |a Pujol, C.A. 
245 1 0 |a Antiherpetic activity of S1, an algal derived sulphated galactan 
260 |c 1996 
270 1 0 |m Damonte, E.B.; Laboratorio de Virologia, Departamento de Quimica Biologica, Universidad de Buenos Aires, Pabellon 2, 1428 Buenos Aires, Argentina 
506 |2 openaire  |e Política editorial 
504 |a Beress, A., Wassermann, O., Bruhn, T., A new procedure for the isolation of anti-HIV compounds (polysaccharides and polyphenols) from the marine alga Fucus vesiculosus (1993) J. Nat. Prod., 56, pp. 478-488 
504 |a Bourgougnon, N., Lahaye, M., Chermann, J.C., Kornprobst, J.M., Composition and antiviral activities of a sulphated polysaccharide from Schizymenia dubyi (Rodophyta, Gigartinales) (1993) Bioorg. Med. Chem. Lett., 3, pp. 1141-1146 
504 |a Damonte, E., Neyts, J., Pujol, C.A., Antiviral activity of a sulphated polysaccharide from the red seaweed Nothogenia fastigiata (1994) Biochem. Pharmacol., 47, pp. 2187-2192 
504 |a Englund, J.A., Zimmerman, M.E., Swierkosz, E.U., Goodman, J.L., School, D.R., Balfour Jr., H.H., Herpes simplex virus resistant to acyclovir: A study in a tertiary care center (1990) Ann. Intern. Med., 112, pp. 416-422 
504 |a Errea, M.I., Matulewicz, M.C., Cold water-soluble polysaccharides from tetrasporic Pterocladia capillacea (1994) Phytochemistry, 37, pp. 1075-1078 
504 |a Herold, B.C., WuDunn, D., Soltys, N., Spear, P.G., Glycoprotein C of herpes simplex virus type 1 plays a principal role in the adsorption of virus to cells and in infectivity (1991) J. Virol., 65, pp. 1090-1098 
504 |a Lycke, E., Johansson, M., Svennerholm, B., Lindahl, U., Binding of herpes simplex virus to cellular heparan sulphate, an initial step in the adsorption process (1991) J. Gen. Virol., 72, pp. 1131-1137 
504 |a Nakashima, H., Kido, Y., Kobashayi, N., Motoki, Y., Neushul, M., Yamamoto, N., Purification and characterization of an avian myeloblastosis and human immunodeficiency virus reverse transcriptase inhibitor sulphated polysaccharide extracted from sea algae (1987) Antimicrob. Agents Chemother, 31, pp. 1524-1528 
504 |a Reefschlager, J., Herrmann, G., Barwolff, D., Schwartz, B., Cech, D., Langen, P., Antiherpes activity of (E)-5-(2-bromovinyl)- and 5-vinyl-1-β-D-arabinofuranosyluracil and some other 5-substituted uracil arabinosyl nucleosides in two different cell lines (1983) Antiviral Res., 3, pp. 175-187 
504 |a Suzutani, T., Machida, H., Sakuma, T., Efficacies of antiherpesvirus nucleosides against two strains of herpes simplex virus type 1 in Vero and human embryo lung fibroblast cells (1988) Antimicrob. Agents Chemother, 32, pp. 1046-1052 
504 |a Whitley, R.J., Gnann, J.W., Acyclovir: A decade later (1992) N. Eng. J. Med., 327, pp. 782-789 
504 |a Whitley, R.J., Gnann, J.W., The epidemiology and clinical manifestations of herpes simplex virus infections (1993) The Human Herpesviruses, pp. 69-105. , ed. by B. Roizman, R. J. Whitley and C. Lopez, Raven Press, New York 
504 |a Witorouw, M., Este, J.A., Mateu, M.Q., Activity of a sulphated polysaccharide extracted from the red seaweed Aghardiella tenera against human immunodeficiency virus and other enveloped viruses (1994) Antiviral Chem. Chemother., 5, pp. 297-303 
504 |a WuDunn, D., Spear, P.G., Initial interaction of herpes simplex virus with cells is binding to heparan sulphate (1989) J. Virol., 63, pp. 52-58 
520 3 |a The sulphated galactan S1 isolated from the red seaweed Pterocladia capillacea proved to be a selective antiviral compound against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), human cytomegalovirus and pseudorabies virus. No cytotoxicity was observed with S1 at concentrations about 500 μg/mL that were in excess of the IC 50 values (range from 3.2 to 12.0 μg/mL for the different herpesviruses assayed). The antiherpetic action of S1 was independent of the host cell and the antiviral assay. The kinetics of infectious virus adsorption to the host cell was highly inhibited in the presence of S1 whereas the subsequent stage of virus penetration was not affected. The binding of radiolabelled HSV-1 particles was inhibited in a dose dependent manner confirming that the mode of action of S1 could be attributable to an inhibition of initial virus attachment to the host cell.  |l eng 
593 |a Laboratorio de Virologia, Departamento de Química Biológica, Ciudad Universitaria, Pabellón 2, 1428 Buenos Aires, Argentina 
593 |a Departamento de Química Or̀gánica, Facultad de Ciencias Exactas y Naturales, Ciudad Universitaria, Pabellón 2, 1428 Buenos Aires, Argentina 
690 1 0 |a HERPES SIMPLEX VIRUS 
690 1 0 |a NATURAL ANTIVIRAL 
690 1 0 |a PTEROCLADIA CAPILLACEA 
690 1 0 |a RED SEAWEED 
690 1 0 |a SULPHATED POLYSACCHARIDE 
690 1 0 |a VIRUS ATTACHMENT 
690 1 0 |a ANTIVIRUS AGENT 
690 1 0 |a GALACTANE SULFATE 
690 1 0 |a PLANT EXTRACT 
690 1 0 |a UNCLASSIFIED DRUG 
690 1 0 |a ANIMAL CELL 
690 1 0 |a ANTIVIRAL ACTIVITY 
690 1 0 |a ARTICLE 
690 1 0 |a CONCENTRATION RESPONSE 
690 1 0 |a CONTROLLED STUDY 
690 1 0 |a CYTOTOXICITY 
690 1 0 |a DRUG MECHANISM 
690 1 0 |a HERPES SIMPLEX VIRUS 1 
690 1 0 |a HERPES SIMPLEX VIRUS 2 
690 1 0 |a HERPES VIRUS 
690 1 0 |a HOST CELL 
690 1 0 |a HUMAN 
690 1 0 |a HUMAN CELL 
690 1 0 |a HUMAN CYTOMEGALOVIRUS 
690 1 0 |a NONHUMAN 
690 1 0 |a PSEUDORABIES HERPETOVIRUS 
690 1 0 |a RED ALGA 
690 1 0 |a VIRUS ADSORPTION 
690 1 0 |a ALGAE 
690 1 0 |a ANIMALIA 
690 1 0 |a HERPES 
690 1 0 |a HERPESVIRIDAE 
690 1 0 |a HERPETOVIRUS 
690 1 0 |a HUMAN HERPESVIRUS 1 
690 1 0 |a HUMAN HERPESVIRUS 2 
690 1 0 |a HUMAN HERPESVIRUS 5 
690 1 0 |a PTEROCLADIA 
690 1 0 |a PTEROCLADIELLA CAPILLACEA 
690 1 0 |a RHODOPHYTA 
690 1 0 |a SIMPLEXVIRUS 
690 1 0 |a SUID HERPESVIRUS 1 
700 1 |a Errea, M.I. 
700 1 |a Matulewicz, M.C. 
700 1 |a Damonte, E.B. 
773 0 |d 1996  |g v. 10  |h pp. 410-413  |k n. 5  |p PHYTOTHER. RES.  |x 0951418X  |t Phytotherapy Research 
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999 |c 64472 

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